RRN3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''RNA polymerase I-specific transcription initiation factor RRN3''' is an [[enzyme]] that in humans is encoded by the ''RRN3'' [[gene]].<ref name="pmid10758157">{{cite journal | vauthors = Moorefield B, Greene EA, Reeder RH | title = RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 9 | pages = 4724–9  | date = May 2000 | pmid = 10758157 | pmc = 18300 | doi = 10.1073/pnas.080063997 }}</ref><ref name="pmid11250903">{{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82  | date = Mar 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54700| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
| HGNCid = 30346
| Symbol = RRN3
| AltSymbols =; DKFZp566E104; MGC104238; TIFIA
| OMIM = 605121
| ECnumber = 
| Homologene = 39531
| MGIid = 1925255
| GeneAtlas_image1 = PBB_GE_RRN3_216902_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RRN3_216908_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_RRN3_222204_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003701 |text = RNA polymerase I transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006360 |text = transcription from RNA polymerase I promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54700
    | Hs_Ensembl = ENSG00000085721
    | Hs_RefseqProtein = NP_060897
    | Hs_RefseqmRNA = NM_018427
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 15061380
    | Hs_GenLoc_end = 15095613
    | Hs_Uniprot = Q9NYV6
    | Mm_EntrezGene = 106298
    | Mm_Ensembl = ENSMUSG00000022682
    | Mm_RefseqmRNA = NM_001039521
    | Mm_RefseqProtein = NP_001034610
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 13694277
    | Mm_GenLoc_end = 13728419
    | Mm_Uniprot = 
  }}
}}
'''RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)''', also known as '''RRN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54700| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RRN3 has been shown to [[Protein-protein interaction|interact]] with [[TAF1B]].<ref name=pmid11250903 />
{{PBB_Summary
| section_title =  
| summary_text =
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==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I | title = TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p | journal = EMBO Rep. | volume = 1 | issue = 2 | pages = 171–5 | year = 2000 | pmid = 11265758 | pmc = 1084264 | doi = 10.1038/sj.embor.embor605 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I | title = Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter | journal = EMBO Rep. | volume = 3 | issue = 11 | pages = 1082–7 | year = 2002 | pmid = 12393749 | pmc = 1307603 | doi = 10.1093/embo-reports/kvf212 }}
*{{cite journal  | author=Moorefield B, Greene EA, Reeder RH |title=RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4724-9 |year= 2000 |pmid= 10758157 |doi= 10.1073/pnas.080063997 }}
* {{cite journal | vauthors = Zhao J, Yuan X, Frödin M, Grummt I | title = ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth | journal = Mol. Cell | volume = 11 | issue = 2 | pages = 405–13 | year = 2003 | pmid = 12620228 | doi = 10.1016/S1097-2765(03)00036-4 }}
*{{cite journal  | author=Miller G, Panov KI, Friedrich JK, ''et al.'' |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373-82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373 }}
* {{cite journal | vauthors = Mayer C, Zhao J, Yuan X, Grummt I | title = mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability | journal = Genes Dev. | volume = 18 | issue = 4 | pages = 423–34 | year = 2004 | pmid = 15004009 | pmc = 359396 | doi = 10.1101/gad.285504 }}
*{{cite journal | author=Bodem J, Dobreva G, Hoffmann-Rohrer U, ''et al.'' |title=TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p. |journal=EMBO Rep. |volume=1 |issue= 2 |pages= 171-5 |year= 2001 |pmid= 11265758 |doi= 10.1038/sj.embor.embor605 }}
* {{cite journal | vauthors = Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I | title = Nuclear actin and myosin I are required for RNA polymerase I transcription | journal = Nat. Cell Biol. | volume = 6 | issue = 12 | pages = 1165–72 | year = 2004 | pmid = 15558034 | doi = 10.1038/ncb1190 }}
*{{cite journal | author=Yuan X, Zhao J, Zentgraf H, ''et al.'' |title=Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. |journal=EMBO Rep. |volume=3 |issue= 11 |pages= 1082-7 |year= 2003 |pmid= 12393749 |doi= 10.1093/embo-reports/kvf212 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Zhao J, Yuan X, Frödin M, Grummt I |title=ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. |journal=Mol. Cell |volume=11 |issue= 2 |pages= 405-13 |year= 2003 |pmid= 12620228 |doi= }}
*{{cite journal | author=Mayer C, Zhao J, Yuan X, Grummt I |title=mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. |journal=Genes Dev. |volume=18 |issue= 4 |pages= 423-34 |year= 2004 |pmid= 15004009 |doi= 10.1101/gad.285504 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Philimonenko VV, Zhao J, Iben S, ''et al.'' |title=Nuclear actin and myosin I are required for RNA polymerase I transcription. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1165-72 |year= 2005 |pmid= 15558034 |doi= 10.1038/ncb1190 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:29, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.[1][2][3]

Interactions

RRN3 has been shown to interact with TAF1B.[2]

References

  1. ↑ Moorefield B, Greene EA, Reeder RH (May 2000). "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4724–9. doi:10.1073/pnas.080063997. PMC 18300. PMID 10758157.
  2. ↑ 2.0 2.1 Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (Mar 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
  3. ↑ "Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)".

Further reading


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