TUFM: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=June 2016}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Elongation factor Tu, mitochondrial''' is a [[protein]] that in humans is encoded by the ''TUFM'' [[gene]].<ref name="pmid9332382">{{cite journal | vauthors = Ling M, Merante F, Chen HS, Duff C, Duncan AM, Robinson BH | title = The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene | journal = Gene | volume = 197 | issue = 1-2 | pages = 325–36 |date=Nov 1997 | pmid = 9332382 | pmc =  | doi =10.1016/S0378-1119(97)00279-5 }}</ref><ref name="pmid9545647">{{cite journal | vauthors = Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT | title = Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus | journal = Genomics | volume = 48 | issue = 3 | pages = 384–8 |date=Jun 1998 | pmid = 9545647 | pmc =  | doi = 10.1006/geno.1997.5166 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TUFM Tu translation elongation factor, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7284| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TUFM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d2e.
| PDB = {{PDB2|1d2e}}, {{PDB2|1xb2}}
| Name = Tu translation elongation factor, mitochondrial
| HGNCid = 12420
| Symbol = TUFM
| AltSymbols =; COXPD4; EF-TuMT; EFTU
| OMIM = 602389
| ECnumber =
| Homologene = 2490
| MGIid = 1923686
  | GeneAtlas_image1 = PBB_GE_TUFM_201113_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003746 |text = translation elongation factor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
  | Process = {{GNF_GO|id=GO:0006414 |text = translational elongation}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7284
    | Hs_Ensembl = ENSG00000178952
    | Hs_RefseqProtein = NP_003312
    | Hs_RefseqmRNA = NM_003321
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 28761615
    | Hs_GenLoc_end = 28765144
    | Hs_Uniprot = P49411
    | Mm_EntrezGene = 233870
    | Mm_Ensembl = ENSMUSG00000073838
    | Mm_RefseqmRNA = NM_172745
    | Mm_RefseqProtein = NP_766333
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126278510
    | Mm_GenLoc_end = 126281871
    | Mm_Uniprot = Q497E7
  }}
}}
'''Tu translation elongation factor, mitochondrial''', also known as '''TUFM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TUFM Tu translation elongation factor, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7284| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 55: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wells J, Henkler F, Leversha M, Koshy R |title=A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues. |journal=FEBS Lett. |volume=358 |issue= 2 |pages= 119-25 |year= 1995 |pmid= 7828719 |doi=  }}
*{{cite journal  | vauthors=Wells J, Henkler F, Leversha M, Koshy R |title=A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues. |journal=FEBS Lett. |volume=358 |issue= 2 |pages= 119–25 |year= 1995 |pmid= 7828719 |doi=10.1016/0014-5793(94)01403-N }}
*{{cite journal  | author=Woriax VL, Burkhart W, Spremulli LL |title=Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu. |journal=Biochim. Biophys. Acta |volume=1264 |issue= 3 |pages= 347-56 |year= 1996 |pmid= 8547323 |doi=  }}
*{{cite journal  | vauthors=Woriax VL, Burkhart W, Spremulli LL |title=Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu. |journal=Biochim. Biophys. Acta |volume=1264 |issue= 3 |pages= 347–56 |year= 1996 |pmid= 8547323 |doi=  10.1016/0167-4781(95)00176-x}}
*{{cite journal  | author=Ling M, Merante F, Chen HS, ''et al.'' |title=The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene. |journal=Gene |volume=197 |issue= 1-2 |pages= 325-36 |year= 1997 |pmid= 9332382 |doi=  }}
*{{cite journal  | vauthors=Chang SY, Park SG, Kim S, Kang CY |title=Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8388–94 |year= 2002 |pmid= 11741979 |doi= 10.1074/jbc.M108792200 }}
*{{cite journal  | author=Shah ZH, Migliosi V, Miller SC, ''et al.'' |title=Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. |journal=Genomics |volume=48 |issue= 3 |pages= 384-8 |year= 1998 |pmid= 9545647 |doi= 10.1006/geno.1997.5166 }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal  | author=Chang SY, Park SG, Kim S, Kang CY |title=Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8388-94 |year= 2002 |pmid= 11741979 |doi= 10.1074/jbc.M108792200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Blagoev B, Kratchmarova I, Ong SE, etal |title=A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. |journal=Nat. Biotechnol. |volume=21 |issue= 3 |pages= 315–8 |year= 2003 |pmid= 12577067 |doi= 10.1038/nbt790 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Blagoev B, Kratchmarova I, Ong SE, ''et al.'' |title=A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. |journal=Nat. Biotechnol. |volume=21 |issue= 3 |pages= 315-8 |year= 2003 |pmid= 12577067 |doi= 10.1038/nbt790 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931–40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | vauthors=Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA |title=The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1. |journal=Hum. Mol. Genet. |volume=15 |issue= 11 |pages= 1835–46 |year= 2006 |pmid= 16632485 |doi= 10.1093/hmg/ddl106 }}
*{{cite journal  | author=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931-40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a }}
*{{cite journal   |vauthors=Smeitink JA, Elpeleg O, Antonicka H, etal |title=Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs. |journal=Am. J. Hum. Genet. |volume=79 |issue= 5 |pages= 869–77 |year= 2006 |pmid= 17033963 |doi= 10.1086/508434 | pmc=1698578 }}
*{{cite journal  | author=Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA |title=The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1. |journal=Hum. Mol. Genet. |volume=15 |issue= 11 |pages= 1835-46 |year= 2006 |pmid= 16632485 |doi= 10.1093/hmg/ddl106 }}
*{{cite journal   |vauthors=Valente L, Tiranti V, Marsano RM, etal |title=Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. |journal=Am. J. Hum. Genet. |volume=80 |issue= 1 |pages= 44–58 |year= 2007 |pmid= 17160893 |doi= 10.1086/510559 | pmc=1785320 }}
*{{cite journal | author=Smeitink JA, Elpeleg O, Antonicka H, ''et al.'' |title=Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs. |journal=Am. J. Hum. Genet. |volume=79 |issue= 5 |pages= 869-77 |year= 2006 |pmid= 17033963 |doi= 10.1086/508434 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Valente L, Tiranti V, Marsano RM, ''et al.'' |title=Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. |journal=Am. J. Hum. Genet. |volume=80 |issue= 1 |pages= 44-58 |year= 2007 |pmid= 17160893 |doi= 10.1086/510559 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7284}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{gene-16-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:27, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Elongation factor Tu, mitochondrial is a protein that in humans is encoded by the TUFM gene.[1][2][3]


References

  1. ↑ Ling M, Merante F, Chen HS, Duff C, Duncan AM, Robinson BH (Nov 1997). "The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene". Gene. 197 (1–2): 325–36. doi:10.1016/S0378-1119(97)00279-5. PMID 9332382.
  2. ↑ Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT (Jun 1998). "Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus". Genomics. 48 (3): 384–8. doi:10.1006/geno.1997.5166. PMID 9545647.
  3. ↑ "Entrez Gene: TUFM Tu translation elongation factor, mitochondrial".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=TUFM&oldid=1417382"