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{{Infobox_gene}}
{{PBB_Controls
'''Adenylyl cyclase type 7''' is an [[enzyme]] that in humans is encoded by the ''ADCY7'' [[gene]].<ref name="pmid7860067">{{cite journal | vauthors = Hellevuo K, Berry R, Sikela JM, Tabakoff B | title = Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16 | journal = Hum Genet | volume = 95 | issue = 2 | pages = 197–200 |date=Mar 1995| pmid = 7860067 | pmc =  | doi =  10.1007/bf00209401}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADCY7 adenylate cyclase 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adenylate cyclase 7
| HGNCid = 238
| Symbol = ADCY7
| AltSymbols =; FLJ36387; KIAA0037
| OMIM = 600385
| ECnumber = 
| Homologene = 866
| MGIid = 102891
| GeneAtlas_image1 = PBB_GE_ADCY7_203741_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004016 |text = adenylate cyclase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 113
    | Hs_Ensembl = ENSG00000121281
    | Hs_RefseqProtein = NP_001105
    | Hs_RefseqmRNA = NM_001114
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 48879323
    | Hs_GenLoc_end = 48909536
    | Hs_Uniprot = P51828
    | Mm_EntrezGene = 11513
    | Mm_Ensembl = ENSMUSG00000031659
    | Mm_RefseqmRNA = NM_001037723
    | Mm_RefseqProtein = NP_001032812
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 91162508
    | Mm_GenLoc_end = 91220066
    | Mm_Uniprot = Q3U1P1
  }}
}}
'''Adenylate cyclase 7''', also known as '''ADCY7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY7 adenylate cyclase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of [[cyclic AMP]] from [[adenosine triphosphate|ATP]] and is inhibitable by [[calcium in biology|calcium]]. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.<ref name="entrez">{{cite web | title = Entrez Gene: ADCY7 adenylate cyclase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ADCY7}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 |display-authors=etal}}
*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi=  }}
*{{cite journal  | vauthors=Hellevuo K, Welborn R, Menninger JA, Tabakoff B |title=Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism |journal=Am. J. Med. Genet. |volume=74 |issue= 1 |pages= 95–8 |year= 1997 |pmid= 9034014 |doi=10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M }}
*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi=  }}
*{{cite journal  | vauthors=Barcova M, Speth C, Kacani L |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538–46 |year= 1999 |pmid= 10089566 |doi=10.1007/s004240050815  |display-authors=etal}}
*{{cite journal  | author=Hellevuo K, Berry R, Sikela JM, Tabakoff B |title=Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. |journal=Hum. Genet. |volume=95 |issue= 2 |pages= 197-200 |year= 1995 |pmid= 7860067 |doi=  }}
*{{cite journal  | vauthors=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones |journal=AIDS |volume=14 |issue= 6 |pages= 629–36 |year= 2000 |pmid= 10807185 |doi=10.1097/00002030-200004140-00001 }}
*{{cite journal  | author=Hellevuo K, Welborn R, Menninger JA, Tabakoff B |title=Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. |journal=Am. J. Med. Genet. |volume=74 |issue= 1 |pages= 95-8 |year= 1997 |pmid= 9034014 |doi= }}
*{{cite journal  | vauthors=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975–82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
*{{cite journal  | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi=  }}
*{{cite journal  | vauthors=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399–407 |year= 2001 |pmid= 11299302 |doi=10.1046/j.1471-4159.2001.00249.x  }}
*{{cite journal  | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi= }}
*{{cite journal  | vauthors=Yan SZ, Tang WJ |title=Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase |journal=Meth. Enzymol. |volume=345 |issue= |pages= 231–41 |year= 2002 |pmid= 11665607 |doi=10.1016/S0076-6879(02)45019-7 | series=Methods in Enzymology  | isbn=978-0-12-182246-0  }}
*{{cite journal  | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
*{{cite journal  | vauthors=Speth C, Schabetsberger T, Mohsenipour I |title=Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179–88 |year= 2002 |pmid= 11884542 |doi=10.1128/JVI.76.7.3179-3188.2002  | pmc=136041 |display-authors=etal}}
*{{cite journal  | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi=  }}
*{{cite journal  | vauthors=Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B |title=Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 4552–60 |year= 2003 |pmid= 12454008 |doi= 10.1074/jbc.M210386200 }}
*{{cite journal  | author=Yan SZ, Tang WJ |title=Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. |journal=Meth. Enzymol. |volume=345 |issue= |pages= 231-41 |year= 2002 |pmid= 11665607 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi= }}
*{{cite journal  | vauthors=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1–4 |pages= 79–110 |year= 2003 |pmid= 12503609 |doi=10.1081/RRS-120014589  }}
*{{cite journal  | author=Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B |title=Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 4552-60 |year= 2003 |pmid= 12454008 |doi= 10.1074/jbc.M210386200 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79-110 |year= 2003 |pmid= 12503609 |doi= }}
*{{cite journal  | vauthors=Beeler JA, Yan SZ, Bykov S |title=A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase |journal=Biochemistry |volume=43 |issue= 49 |pages= 15463–71 |year= 2005 |pmid= 15581358 |doi= 10.1021/bi049088+|display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Hines LM, Hoffman PL, Bhave S |title=A sex-specific role of type VII adenylyl cyclase in depression |journal=J. Neurosci. |volume=26 |issue= 48 |pages= 12609–19 |year= 2006 |pmid= 17135423 |doi= 10.1523/JNEUROSCI.1040-06.2006 |display-authors=etal}}
*{{cite journal  | author=Beeler JA, Yan SZ, Bykov S, ''et al.'' |title=A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. |journal=Biochemistry |volume=43 |issue= 49 |pages= 15463-71 |year= 2005 |pmid= 15581358 |doi= 10.1021/bi049088+ }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Hines LM, Hoffman PL, Bhave S, ''et al.'' |title=A sex-specific role of type VII adenylyl cyclase in depression. |journal=J. Neurosci. |volume=26 |issue= 48 |pages= 12609-19 |year= 2006 |pmid= 17135423 |doi= 10.1523/JNEUROSCI.1040-06.2006 }}
}}
{{refend}}
{{refend}}


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Revision as of 17:50, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.[1][2]

Function

This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.[2]

References

  1. ↑ Hellevuo K, Berry R, Sikela JM, Tabakoff B (Mar 1995). "Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16". Hum Genet. 95 (2): 197–200. doi:10.1007/bf00209401. PMID 7860067.
  2. ↑ 2.0 2.1 "Entrez Gene: ADCY7 adenylate cyclase 7".

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=ADCY7&oldid=1417393"