GABARAPL2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Gamma-aminobutyric acid receptor-associated protein-like 2''' is a [[protein]] that in humans is encoded by the ''GABARAPL2'' [[gene]].<ref name="pmid11414770">{{cite journal | vauthors = Xin Y, Yu L, Chen Z, Zheng L, Fu Q, Jiang J, Zhang P, Gong R, Zhao S | title = Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein | journal = Genomics | volume = 74 | issue = 3 | pages = 408–13 | date = Jun 2001 | pmid = 11414770 | pmc = | doi = 10.1006/geno.2001.6555 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11345| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_GABARAPL2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eo6.
| PDB = {{PDB2|1eo6}}
| Name = GABA(A) receptor-associated protein-like 2
| HGNCid = 13291
| Symbol = GABARAPL2
| AltSymbols =; ATG8; GEF-2; GEF2
| OMIM = 607452
| ECnumber = 
| Homologene = 68550
| MGIid = 1890602
| GeneAtlas_image1 = PBB_GE_GABARAPL2_209046_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0048487 |text = beta-tubulin binding}} {{GNF_GO|id=GO:0050811 |text = GABA receptor binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11345
    | Hs_Ensembl = ENSG00000034713
    | Hs_RefseqProtein = NP_009216
    | Hs_RefseqmRNA = NM_007285
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 74157750
    | Hs_GenLoc_end = 74169279
    | Hs_Uniprot = P60520
    | Mm_EntrezGene = 93739
    | Mm_Ensembl = ENSMUSG00000031950
    | Mm_RefseqmRNA = NM_026693
    | Mm_RefseqProtein = NP_080969
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 114827386
    | Mm_GenLoc_end = 114839587
    | Mm_Uniprot = P60521
  }}
}}
'''GABA(A) receptor-associated protein-like 2''', also known as '''GABARAPL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11345| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
GABARAPL2 has been shown to [[Protein-protein interaction|interact]] with [[ULK1]],<ref name=pmid11146101>{{cite journal | vauthors = Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M | title = Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation | journal = Brain Research. Molecular Brain Research | volume = 85 | issue = 1-2 | pages = 1–12 | date = Dec 2000 | pmid = 11146101 | doi = 10.1016/S0169-328X(00)00218-7 }}</ref> [[ATG4B]],<ref name="pmid17353931">{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name="pmid16169070">{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}</ref> and [[FAM135B|FAM134B]].<ref>{{Cite journal|last=Khaminets|first=Aliaksandr|last2=Heinrich|first2=Theresa|last3=Mari|first3=Muriel|last4=Grumati|first4=Paolo|last5=Huebner|first5=Antje K.|last6=Akutsu|first6=Masato|last7=Liebmann|first7=Lutz|last8=Stolz|first8=Alexandra|last9=Nietzsche|first9=Sandor|date=2015-06-18|title=Regulation of endoplasmic reticulum turnover by selective autophagy|url=http://www.nature.com/nature/journal/v522/n7556/abs/nature14498.html|journal=Nature|language=en|volume=522|issue=7556|pages=354–358|doi=10.1038/nature14498|issn=0028-0836}}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rohwer A, Kittstein W, Marks F, Gschwendt M | title = Cloning, expression and characterization of an A6-related protein | journal = European Journal of Biochemistry / FEBS | volume = 263 | issue = 2 | pages = 518–25 | date = Jul 1999 | pmid = 10406962 | doi = 10.1046/j.1432-1327.1999.00537.x }}
| citations =
* {{cite journal | vauthors = Sagiv Y, Legesse-Miller A, Porat A, Elazar Z | title = GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28 | journal = The EMBO Journal | volume = 19 | issue = 7 | pages = 1494–504 | date = Apr 2000 | pmid = 10747018 | pmc = 310219 | doi = 10.1093/emboj/19.7.1494 }}
*{{cite journal | author=Rohwer A, Kittstein W, Marks F, Gschwendt M |title=Cloning, expression and characterization of an A6-related protein. |journal=Eur. J. Biochem. |volume=263 |issue= 2 |pages= 518-25 |year= 1999 |pmid= 10406962 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Sagiv Y, Legesse-Miller A, Porat A, Elazar Z |title=GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. |journal=EMBO J. |volume=19 |issue= 7 |pages= 1494-504 |year= 2000 |pmid= 10747018 |doi= 10.1093/emboj/19.7.1494 }}
* {{cite journal | vauthors = Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M | title = Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation | journal = Brain Research. Molecular Brain Research | volume = 85 | issue = 1-2 | pages = 1–12 | date = Dec 2000 | pmid = 11146101 | doi = 10.1016/S0169-328X(00)00218-7 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Okazaki N, Yan J, Yuasa S, ''et al.'' |title=Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. |journal=Brain Res. Mol. Brain Res. |volume=85 |issue= 1-2 |pages= 1-12 |year= 2001 |pmid= 11146101 |doi= }}
* {{cite journal | vauthors = Tanida I, Tanida-Miyake E, Nishitani T, Komatsu M, Yamazaki H, Ueno T, Kominami E | title = Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs | journal = Biochemical and Biophysical Research Communications | volume = 292 | issue = 1 | pages = 256–62 | date = Mar 2002 | pmid = 11890701 | doi = 10.1006/bbrc.2002.6645 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z | title = The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A | journal = The Journal of Biological Chemistry | volume = 278 | issue = 16 | pages = 14053–8 | date = Apr 2003 | pmid = 12473658 | doi = 10.1074/jbc.M212108200 }}
*{{cite journal | author=Xin Y, Yu L, Chen Z, ''et al.'' |title=Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. |journal=Genomics |volume=74 |issue= 3 |pages= 408-13 |year= 2001 |pmid= 11414770 |doi= 10.1006/geno.2001.6555 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Tanida I, Tanida-Miyake E, Nishitani T, ''et al.'' |title=Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 1 |pages= 256-62 |year= 2002 |pmid= 11890701 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z |title=The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14053-8 |year= 2003 |pmid= 12473658 |doi= 10.1074/jbc.M212108200 }}
* {{cite journal | vauthors = Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E | title = Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 6 | pages = 3017–24 | date = Feb 2006 | pmid = 16303767 | doi = 10.1074/jbc.M505888200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Sou YS, Tanida I, Komatsu M, ''et al.'' |title=Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. |journal=J. Biol. Chem. |volume=281 |issue= 6 |pages= 3017-24 |year= 2006 |pmid= 16303767 |doi= 10.1074/jbc.M505888200 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=11345}}
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{{gene-16-stub}}

Latest revision as of 08:35, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gamma-aminobutyric acid receptor-associated protein-like 2 is a protein that in humans is encoded by the GABARAPL2 gene.[1][2]

Interactions

GABARAPL2 has been shown to interact with ULK1,[3] ATG4B,[4][5] and FAM134B.[6]

References

  1. ↑ Xin Y, Yu L, Chen Z, Zheng L, Fu Q, Jiang J, Zhang P, Gong R, Zhao S (Jun 2001). "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein". Genomics. 74 (3): 408–13. doi:10.1006/geno.2001.6555. PMID 11414770.
  2. ↑ "Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2".
  3. ↑ Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
  4. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  6. ↑ Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K.; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor (2015-06-18). "Regulation of endoplasmic reticulum turnover by selective autophagy". Nature. 522 (7556): 354–358. doi:10.1038/nature14498. ISSN 0028-0836.

Further reading


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