ZP2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (task, replaced: J. Cell. Sci. → J. Cell Sci. using AWB)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zona pellucida sperm-binding protein 2''' is a [[protein]] that in humans is encoded by the ''ZP2'' [[gene]].<ref name="pmid8385033">{{cite journal | vauthors = Liang LF, Dean J | title = Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes | journal = Dev Biol | volume = 156 | issue = 2 | pages = 399–408 | date = Apr 1993 | pmid = 8385033 | pmc = | doi = 10.1006/dbio.1993.1087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7783| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zona pellucida glycoprotein 2 (sperm receptor)
| HGNCid = 13188
| Symbol = ZP2
| AltSymbols =; ZPA
| OMIM = 182888
| ECnumber = 
| Homologene = 48194
| MGIid = 99214
| GeneAtlas_image1 = PBB_GE_ZP2_207933_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0032190 |text = acrosin binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0007339 |text = binding of sperm to zona pellucida}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7783
    | Hs_Ensembl = ENSG00000103310
    | Hs_RefseqProtein = NP_003451
    | Hs_RefseqmRNA = NM_003460
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 21116274
    | Hs_GenLoc_end = 21130369
    | Hs_Uniprot = Q05996
    | Mm_EntrezGene = 22787
    | Mm_Ensembl = ENSMUSG00000030911
    | Mm_RefseqmRNA = NM_011775
    | Mm_RefseqProtein = NP_035905
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 119923510
    | Mm_GenLoc_end = 119936439
    | Mm_Uniprot = Q3UX44
  }}
}}
'''Zona pellucida glycoprotein 2 (sperm receptor)''', also known as '''ZP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7783| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[zona pellucida]] is an extracellular matrix that surrounds the [[oocyte]] and early embryo. It is composed primarily of three (mouse) or four (human) [[glycoprotein]]s (ZP1-4) with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of [[acrosome]]-reacted [[spermatozoa]]. The nascent protein contains a [[N-terminal]] [[signal peptide]] sequence, a conserved [[Zona pellucida-like domain|ZP domain]], a consensus [[furin]] cleavage site, and a [[C-terminal]] transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.<ref name="entrez">{{cite web | title = Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7783| accessdate = }}</ref>
}}


==References==
The sperm-binding domain on the ZP2 protein is necessary in both humans and mice for oocyte-sperm recognition and penetration of the zona pellucida. It is also responsible for the primary block to polyspermy in mammals.  The oocyte has cortical granules peripherally located under the cortex that contain a proteolytic protein called [[ASTL|ovastacin]]. After the sperm binds to ZP2, the cortical granules are exocytosed releasing ovastacin into the [[perivitelline space]].  Ovastacin cleaves ZP2 at the N terminus, preventing more sperm from binding and penetrating the oocyte, thus hardening the zona pellucida. Ovastacin is only found in oocytes, and is part of the astacin family of [[metalloproteinase|metalloendoproteases]]. Female mice engineered without ovastacin showed that ZP2 was not cleaved after fertilization.<ref>{{cite journal | vauthors = Burkart AD, Xiong B, Baibakov B, Jiménez-Movilla M, Dean J | title = Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. | journal = J Cell Biol | volume = 197 | pages = 37–44 | pmid = 22472438 | doi=10.1083/jcb.201112094 | pmc=3317803}}</ref><ref>{{cite journal | vauthors = Avella MA, Baibakov B, Dean J | title = A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. | journal = J Cell Biol | volume = 205 | pages = 801–809 | pmid = 24934154 | doi=10.1083/jcb.201404025 | pmc=4068139}}</ref>
{{reflist|2}}
 
==Further reading==
== 3D structure ==
 
The crystal structure of the sperm-binding domain of ZP2 at 0.95 Å resolution ({{PDB|5II6}})<ref name="pmid28622512">{{cite journal |vauthors=Raj I, Sadat Al Hosseini H, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L |title=Structural Basis of Egg Coat-Sperm Recognition at Fertilization |journal=Cell |volume=169 |issue=7 |pages=1315–1326 |year=2017 |pmid=28622512 |doi=10.1016/j.cell.2017.05.033}} {{PDB|5II6|5II4|5II5|5MR2|5IIC|5IIA|5IIB|5MR3}}</ref> showed that is shares the same ZP-N fold first identified in structures of [[ZP3]] ({{PDB|3D4C|3D4G|3EF7|3NK3|3NK4}}).<ref name="pmid19052627">{{cite journal | vauthors = Monné M, Han L, Schwend T, Burendahl S, Jovine L |title = Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats | journal = Nature | volume = 456 | issue = 7222 | pages = 653–7 | year = 2008 | pmid = 19052627 | doi = 10.1038/nature07599 }} {{PDB|3D4C|3D4G|3EF7}}</ref><ref>{{cite journal | vauthors = Han L, Monné M, Okumura H, Schwend T, Cherry AL, Flot D, Matsuda T, Jovine L |title = Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3 | journal = Cell | volume = 143 | issue = 3 | pages = 404–15 | year = 2010 | pmid = 20970175 | doi = 10.1016/j.cell.2010.09.041 }} {{PDB|3NK3|3NK4}}</ref> This provided experimental evidence for the suggestion that the N-terminal region of ZP2 consists of three ZP-N repeats <ref name="pmid19052627"/><ref name="pmid17510169">{{cite journal | vauthors = Callebaut I, Mornon JP, Monget P | title = Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins. | journal = Bioinformatics | volume = 23 | pages = 1871–1874 | pmid = 17510169 | doi=10.1093/bioinformatics/btm265}}</ref> and revealed that - despite insignificant sequence identity - ZP2 is structurally similar to VERL, the vitelline envelope receptor for [[egg lysin]] of the mollusk [[abalone]] ({{PDB|5II4|5II5|5MR2|5IIC|5IIA|5IIB|5MR3}}). This established a link between invertebrate and vertebrate [[fertilization]] by suggesting that, despite being separated by 600 million years of evolution, mollusk and human use a common protein fold to interact with sperm.<ref name="pmid28622512"/>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rankin T, Dean J | title = The zona pellucida: using molecular genetics to study the mammalian egg coat | journal = Rev. Reprod. | volume = 5 | issue = 2 | pages = 114–121 | year = 2000 | pmid = 10864856 | doi = 10.1530/ror.0.0050114 }}
| citations =
* {{cite journal | vauthors = Mori T, Guo MW, Sato E, Baba T, Takasaki S, Mori E | title = Molecular and immunological approaches to mammalian fertilization | journal = J. Reprod. Immunol. | volume = 47 | issue = 2 | pages = 139–158 | year = 2000 | pmid = 10924747 | doi = 10.1016/S0165-0378(00)00055-3 }}
*{{cite journal | author=Rankin T, Dean J |title=The zona pellucida: using molecular genetics to study the mammalian egg coat. |journal=Rev. Reprod. |volume=5 |issue= 2 |pages= 114-21 |year= 2000 |pmid= 10864856 |doi= }}
* {{cite journal | vauthors = Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | year = 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 }}
*{{cite journal | author=Mori T, Guo MW, Sato E, ''et al.'' |title=Molecular and immunological approaches to mammalian fertilization. |journal=J. Reprod. Immunol. |volume=47 |issue= 2 |pages= 139-58 |year= 2000 |pmid= 10924747 |doi=  }}
* {{cite journal | vauthors = Tsubamoto H, Hasegawa A, Nakata Y, Naito S, Yamasaki N, Koyama K | title = Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa | journal = Biol. Reprod. | volume = 61 | issue = 6 | pages = 1649–1654 | year = 1999 | pmid = 10570015 | doi = 10.1095/biolreprod61.6.1649 }}
*{{cite journal  | author=Liang LF, Dean J |title=Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. |journal=Dev. Biol. |volume=156 |issue= 2 |pages= 399-408 |year= 1993 |pmid= 8385033 |doi= 10.1006/dbio.1993.1087 }}
* {{cite journal | vauthors = Howes E, Pascall JC, Engel W, Jones R | title = Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization | journal = J. Cell Sci. | volume = 114 | issue = Pt 22 | pages = 4127–36 | year = 2002 | pmid = 11739644 | doi =  }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
* {{cite journal | vauthors = Tanii I, Oh-oka T, Yoshinaga K, Toshimori K | title = A mouse acrosomal cortical matrix protein, MC41, has ZP2-binding activity and forms a complex with a 75-kDa serine protease | journal = Dev. Biol. | volume = 238 | issue = 2 | pages = 332–341 | year = 2002 | pmid = 11784014 | doi = 10.1006/dbio.2001.0380 }}
*{{cite journal | author=Tsubamoto H, Hasegawa A, Nakata Y, ''et al.'' |title=Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. |journal=Biol. Reprod. |volume=61 |issue= 6 |pages= 1649-54 |year= 1999 |pmid= 10570015 |doi= }}
* {{cite journal | vauthors = Kiefer SM, Saling P | title = Proteolytic processing of human zona pellucida proteins | journal = Biol. Reprod. | volume = 66 | issue = 2 | pages = 407–414 | year = 2002 | pmid = 11804956 | doi = 10.1095/biolreprod66.2.407 }}
*{{cite journal | author=Howes E, Pascall JC, Engel W, Jones R |title=Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. |journal=J. Cell. Sci. |volume=114 |issue= Pt 22 |pages= 4127-36 |year= 2002 |pmid= 11739644 |doi=  }}
* {{cite journal | vauthors = Qi H, Williams Z, Wassarman PM | title = Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3 | journal = Mol. Biol. Cell | volume = 13 | issue = 2 | pages = 530–541 | year = 2002 | pmid = 11854410 | pmc = 65647 | doi = 10.1091/mbc.01-09-0440 }}
*{{cite journal | author=Tanii I, Oh-oka T, Yoshinaga K, Toshimori K |title=A mouse acrosomal cortical matrix protein, MC41, has ZP2-binding activity and forms a complex with a 75-kDa serine protease. |journal=Dev. Biol. |volume=238 |issue= 2 |pages= 332-41 |year= 2002 |pmid= 11784014 |doi= 10.1006/dbio.2001.0380 }}
* {{cite journal | vauthors = Zhao M, Gold L, Ginsberg AM, Liang LF, Dean J | title = Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice | journal = Mol. Cell. Biol. | volume = 22 | issue = 9 | pages = 3111–3120 | year = 2002 | pmid = 11940668 | pmc = 133755 | doi = 10.1128/MCB.22.9.3111-3120.2002 }}
*{{cite journal | author=Kiefer SM, Saling P |title=Proteolytic processing of human zona pellucida proteins. |journal=Biol. Reprod. |volume=66 |issue= 2 |pages= 407-14 |year= 2002 |pmid= 11804956 |doi= }}
* {{cite journal | vauthors = Rankin TL, Coleman JS, Epifano O, Hoodbhoy T, Turner SG, Castle PE, Lee E, Gore-Langton R, Dean J | title = Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs | journal = Dev. Cell | volume = 5 | issue = 1 | pages = 33–43 | year = 2003 | pmid = 12852850 | doi = 10.1016/S1534-5807(03)00195-3 }}
*{{cite journal | author=Qi H, Williams Z, Wassarman PM |title=Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. |journal=Mol. Biol. Cell |volume=13 |issue= 2 |pages= 530-41 |year= 2002 |pmid= 11854410 |doi= 10.1091/mbc.01-09-0440 }}
* {{cite journal | vauthors = Hinsch E, Groeger S, Oehninger S, Hinsch KD | title = Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies | journal = Theriogenology | volume = 60 | issue = 7 | pages = 1331–1344 | year = 2003 | pmid = 14511786 | doi = 10.1016/S0093-691X(03)00169-9 }}
*{{cite journal | author=Zhao M, Gold L, Ginsberg AM, ''et al.'' |title=Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3111-20 |year= 2002 |pmid= 11940668 |doi= }}
* {{cite journal | vauthors = Furlong LI, Harris JD, Vazquez-Levin MH | title = Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC | journal = Fertil. Steril. | volume = 83 | issue = 6 | pages = 1780–1790 | year = 2006 | pmid = 15950651 | doi = 10.1016/j.fertnstert.2004.12.042 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Caballero-Campo P, Chirinos M, Fan XJ, González-González ME, Galicia-Chavarría M, Larrea F, Gerton GL | title = Biological effects of recombinant human zona pellucida proteins on sperm function | journal = Biol. Reprod. | volume = 74 | issue = 4 | pages = 760–768 | year = 2006 | pmid = 16407501 | doi = 10.1095/biolreprod.105.047522 }}
*{{cite journal | author=Rankin TL, Coleman JS, Epifano O, ''et al.'' |title=Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs. |journal=Dev. Cell |volume=5 |issue= 1 |pages= 33-43 |year= 2003 |pmid= 12852850 |doi= }}
*{{cite journal | author=Hinsch E, Groeger S, Oehninger S, Hinsch KD |title=Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. |journal=Theriogenology |volume=60 |issue= 7 |pages= 1331-44 |year= 2003 |pmid= 14511786 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Furlong LI, Harris JD, Vazquez-Levin MH |title=Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. |journal=Fertil. Steril. |volume=83 |issue= 6 |pages= 1780-90 |year= 2006 |pmid= 15950651 |doi= 10.1016/j.fertnstert.2004.12.042 }}
*{{cite journal | author=Caballero-Campo P, Chirinos M, Fan XJ, ''et al.'' |title=Biological effects of recombinant human zona pellucida proteins on sperm function. |journal=Biol. Reprod. |volume=74 |issue= 4 |pages= 760-8 |year= 2006 |pmid= 16407501 |doi= 10.1095/biolreprod.105.047522 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-16-stub}}

Revision as of 22:39, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zona pellucida sperm-binding protein 2 is a protein that in humans is encoded by the ZP2 gene.[1][2]

Function

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three (mouse) or four (human) glycoproteins (ZP1-4) with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.[2]

The sperm-binding domain on the ZP2 protein is necessary in both humans and mice for oocyte-sperm recognition and penetration of the zona pellucida. It is also responsible for the primary block to polyspermy in mammals. The oocyte has cortical granules peripherally located under the cortex that contain a proteolytic protein called ovastacin. After the sperm binds to ZP2, the cortical granules are exocytosed releasing ovastacin into the perivitelline space. Ovastacin cleaves ZP2 at the N terminus, preventing more sperm from binding and penetrating the oocyte, thus hardening the zona pellucida. Ovastacin is only found in oocytes, and is part of the astacin family of metalloendoproteases. Female mice engineered without ovastacin showed that ZP2 was not cleaved after fertilization.[3][4]

3D structure

The crystal structure of the sperm-binding domain of ZP2 at 0.95 Å resolution (PDB: 5II6​)[5] showed that is shares the same ZP-N fold first identified in structures of ZP3 (PDB: 3D4C, 3D4G, 3EF7, 3NK3, 3NK4​).[6][7] This provided experimental evidence for the suggestion that the N-terminal region of ZP2 consists of three ZP-N repeats [6][8] and revealed that - despite insignificant sequence identity - ZP2 is structurally similar to VERL, the vitelline envelope receptor for egg lysin of the mollusk abalone (PDB: 5II4, 5II5, 5MR2, 5IIC, 5IIA, 5IIB, 5MR3​). This established a link between invertebrate and vertebrate fertilization by suggesting that, despite being separated by 600 million years of evolution, mollusk and human use a common protein fold to interact with sperm.[5]

References

  1. ↑ Liang LF, Dean J (Apr 1993). "Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes". Dev Biol. 156 (2): 399–408. doi:10.1006/dbio.1993.1087. PMID 8385033.
  2. ↑ 2.0 2.1 "Entrez Gene: ZP2 zona pellucida glycoprotein 2 (sperm receptor)".
  3. ↑ Burkart AD, Xiong B, Baibakov B, Jiménez-Movilla M, Dean J. "Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy". J Cell Biol. 197: 37–44. doi:10.1083/jcb.201112094. PMC 3317803. PMID 22472438.
  4. ↑ Avella MA, Baibakov B, Dean J. "A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans". J Cell Biol. 205: 801–809. doi:10.1083/jcb.201404025. PMC 4068139. PMID 24934154.
  5. ↑ 5.0 5.1 Raj I, Sadat Al Hosseini H, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L (2017). "Structural Basis of Egg Coat-Sperm Recognition at Fertilization". Cell. 169 (7): 1315–1326. doi:10.1016/j.cell.2017.05.033. PMID 28622512. PDB: 5II6, 5II4, 5II5, 5MR2, 5IIC, 5IIA, 5IIB, 5MR3​
  6. ↑ 6.0 6.1 Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature. 456 (7222): 653–7. doi:10.1038/nature07599. PMID 19052627. PDB: 3D4C, 3D4G, 3EF7​
  7. ↑ Han L, Monné M, Okumura H, Schwend T, Cherry AL, Flot D, Matsuda T, Jovine L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell. 143 (3): 404–15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. PDB: 3NK3, 3NK4​
  8. ↑ Callebaut I, Mornon JP, Monget P. "Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins". Bioinformatics. 23: 1871–1874. doi:10.1093/bioinformatics/btm265. PMID 17510169.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=ZP2&oldid=1417613"