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{{Infobox_gene}}
{{PBB_Controls
'''Nucleolar protein 3''' is a [[protein]] that in humans is encoded by the ''NOL3'' [[gene]].<ref name="pmid9560245">{{cite journal | vauthors = Koseki T, Inohara N, Chen S, Núñez G | title = ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 9 | pages = 5156–60  | date = Jun 1998 | pmid = 9560245 | pmc = 20230 | doi = 10.1073/pnas.95.9.5156 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8996| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Nucleolar protein 3 (apoptosis repressor with CARD domain)
| HGNCid = 7869
| Symbol = NOL3
| AltSymbols =; MYC; ARC; NOP; NOP30
| OMIM = 605235
| ECnumber = 
| Homologene = 31208
| MGIid = 1925938
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016528 |text = sarcoplasm}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8996
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003937
    | Hs_RefseqmRNA = NM_003946
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 78688
    | Mm_Ensembl = ENSMUSG00000014776
    | Mm_RefseqmRNA = NM_030152
    | Mm_RefseqProtein = NP_084428
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 108168105
    | Mm_GenLoc_end = 108168909
    | Mm_Uniprot = Q53YU5
  }}
}}
'''Nucleolar protein 3 (apoptosis repressor with CARD domain)''', also known as '''NOL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8996| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
NOL3 has been shown to [[Protein-protein interaction|interact]] with [[SFRS9]]<ref name=pmid10196175>{{cite journal | vauthors = Stoss O, Schwaiger FW, Cooper TA, Stamm S | title = Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 10951–62  | date = Apr 1999 | pmid = 10196175 | doi = 10.1074/jbc.274.16.10951 }}</ref> and [[Caspase 8]].<ref name=pmid9560245 />
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Stoss O, Schwaiger FW, Cooper TA, Stamm S | title = Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 10951–62 | year = 1999 | pmid = 10196175 | doi = 10.1074/jbc.274.16.10951 }}
| citations =
* {{cite journal | vauthors = Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo CH, Taira E, Miki N | title = Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells | journal = J. Biol. Chem. | volume = 275 | issue = 4 | pages = 2647–53 | year = 2000 | pmid = 10644725 | doi = 10.1074/jbc.275.4.2647 }}
*{{cite journal | author=Koseki T, Inohara N, Chen S, Núñez G |title=ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 9 |pages= 5156-60 |year= 1998 |pmid= 9560245 |doi=  }}
* {{cite journal | vauthors = Li PF, Li J, Müller EC, Otto A, Dietz R, von Harsdorf R | title = Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC | journal = Mol. Cell | volume = 10 | issue = 2 | pages = 247–58 | year = 2002 | pmid = 12191471 | doi = 10.1016/S1097-2765(02)00600-7 }}
*{{cite journal  | author=Stoss O, Schwaiger FW, Cooper TA, Stamm S |title=Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10951-62 |year= 1999 |pmid= 10196175 |doi= }}
* {{cite journal | vauthors = Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX | title = Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents | journal = Am. J. Physiol., Cell Physiol. | volume = 284 | issue = 6 | pages = C1405-10 | year = 2003 | pmid = 12734105 | doi = 10.1152/ajpcell.00279.2002 }}
*{{cite journal | author=Irie Y, Yamagata K, Gan Y, ''et al.'' |title=Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2647-53 |year= 2000 |pmid= 10644725 |doi= }}
* {{cite journal | vauthors = Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN | title = Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 901–12 | year = 2004 | pmid = 15383280 | doi = 10.1016/j.molcel.2004.08.020 }}
*{{cite journal | author=Li PF, Li J, Müller EC, ''et al.'' |title=Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. |journal=Mol. Cell |volume=10 |issue= 2 |pages= 247-58 |year= 2002 |pmid= 12191471 |doi= }}
* {{cite journal | vauthors = Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH, Shim SM, Lee HJ, Cho C, Kim DH, Jung YK | title = Calcium binding of ARC mediates regulation of caspase 8 and cell death | journal = Mol. Cell. Biol. | volume = 24 | issue = 22 | pages = 9763–70 | year = 2004 | pmid = 15509781 | pmc = 525473 | doi = 10.1128/MCB.24.22.9763-9770.2004 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wang M, Qanungo S, Crow MT, Watanabe M, Nieminen AL | title = Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei | journal = FEBS Lett. | volume = 579 | issue = 11 | pages = 2411–5 | year = 2005 | pmid = 15848180 | doi = 10.1016/j.febslet.2005.03.040 }}
*{{cite journal | author=Ekhterae D, Platoshyn O, Zhang S, ''et al.'' |title=Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1405-10 |year= 2003 |pmid= 12734105 |doi= 10.1152/ajpcell.00279.2002 }}
* {{cite journal | vauthors = Mercier I, Vuolo M, Madan R, Xue X, Levalley AJ, Ashton AW, Jasmin JF, Czaja MT, Lin EY, Armstrong RC, Pollard JW, Kitsis RN | title = ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance | journal = Cell Death Differ. | volume = 12 | issue = 6 | pages = 682–6 | year = 2005 | pmid = 15861191 | doi = 10.1038/sj.cdd.4401631 }}
*{{cite journal | author=Nam YJ, Mani K, Ashton AW, ''et al.'' |title=Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 901-12 |year= 2004 |pmid= 15383280 |doi= 10.1016/j.molcel.2004.08.020 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R |author-link9=Johann Bauersachs| title = Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress | journal = Circulation | volume = 113 | issue = 9 | pages = 1203–12 | year = 2006 | pmid = 16505176 | doi = 10.1161/CIRCULATIONAHA.105.576785 }}
*{{cite journal  | author=Jo DG, Jun JI, Chang JW, ''et al.'' |title=Calcium binding of ARC mediates regulation of caspase 8 and cell death. |journal=Mol. Cell. Biol. |volume=24 |issue= 22 |pages= 9763-70 |year= 2004 |pmid= 15509781 |doi= 10.1128/MCB.24.22.9763-9770.2004 }}
* {{cite journal | vauthors = Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS, Krishnamurthy B, Miao W, Ashton AW, Lefer DJ, Kitsis RN | title = The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant | journal = J. Biol. Chem. | volume = 282 | issue = 8 | pages = 5522–8 | year = 2007 | pmid = 17142452 | doi = 10.1074/jbc.M609186200 }}
*{{cite journal | author=Wang M, Qanungo S, Crow MT, ''et al.'' |title=Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei. |journal=FEBS Lett. |volume=579 |issue= 11 |pages= 2411-5 |year= 2005 |pmid= 15848180 |doi= 10.1016/j.febslet.2005.03.040 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Mercier I, Vuolo M, Madan R, ''et al.'' |title=ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance. |journal=Cell Death Differ. |volume=12 |issue= 6 |pages= 682-6 |year= 2005 |pmid= 15861191 |doi= 10.1038/sj.cdd.4401631 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Donath S, Li P, Willenbockel C, ''et al.'' |title=Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. |journal=Circulation |volume=113 |issue= 9 |pages= 1203-12 |year= 2006 |pmid= 16505176 |doi= 10.1161/CIRCULATIONAHA.105.576785 }}
*{{cite journal | author=Nam YJ, Mani K, Wu L, ''et al.'' |title=The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. |journal=J. Biol. Chem. |volume=282 |issue= 8 |pages= 5522-8 |year= 2007 |pmid= 17142452 |doi= 10.1074/jbc.M609186200 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 02:31, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.[1][2]

Interactions

NOL3 has been shown to interact with SFRS9[3] and Caspase 8.[1]

References

  1. ↑ 1.0 1.1 Koseki T, Inohara N, Chen S, Núñez G (Jun 1998). "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5156–60. doi:10.1073/pnas.95.9.5156. PMC 20230. PMID 9560245.
  2. ↑ "Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)".
  3. ↑ Stoss O, Schwaiger FW, Cooper TA, Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.

Further reading

  • Stoss O, Schwaiger FW, Cooper TA, Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.
  • Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo CH, Taira E, Miki N (2000). "Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells". J. Biol. Chem. 275 (4): 2647–53. doi:10.1074/jbc.275.4.2647. PMID 10644725.
  • Li PF, Li J, Müller EC, Otto A, Dietz R, von Harsdorf R (2002). "Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC". Mol. Cell. 10 (2): 247–58. doi:10.1016/S1097-2765(02)00600-7. PMID 12191471.
  • Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX (2003). "Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents". Am. J. Physiol., Cell Physiol. 284 (6): C1405–10. doi:10.1152/ajpcell.00279.2002. PMID 12734105.
  • Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN (2004). "Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions". Mol. Cell. 15 (6): 901–12. doi:10.1016/j.molcel.2004.08.020. PMID 15383280.
  • Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH, Shim SM, Lee HJ, Cho C, Kim DH, Jung YK (2004). "Calcium binding of ARC mediates regulation of caspase 8 and cell death". Mol. Cell. Biol. 24 (22): 9763–70. doi:10.1128/MCB.24.22.9763-9770.2004. PMC 525473. PMID 15509781.
  • Wang M, Qanungo S, Crow MT, Watanabe M, Nieminen AL (2005). "Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei". FEBS Lett. 579 (11): 2411–5. doi:10.1016/j.febslet.2005.03.040. PMID 15848180.
  • Mercier I, Vuolo M, Madan R, Xue X, Levalley AJ, Ashton AW, Jasmin JF, Czaja MT, Lin EY, Armstrong RC, Pollard JW, Kitsis RN (2005). "ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance". Cell Death Differ. 12 (6): 682–6. doi:10.1038/sj.cdd.4401631. PMID 15861191.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R (2006). "Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress". Circulation. 113 (9): 1203–12. doi:10.1161/CIRCULATIONAHA.105.576785. PMID 16505176.
  • Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS, Krishnamurthy B, Miao W, Ashton AW, Lefer DJ, Kitsis RN (2007). "The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant". J. Biol. Chem. 282 (8): 5522–8. doi:10.1074/jbc.M609186200. PMID 17142452.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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