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{{Infobox_gene}}
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'''Cytochrome c oxidase subunit 4 isoform 1, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''COX4I1'' [[gene]].<ref name="pmid2444497">{{cite journal | vauthors = Zeviani M, Nakagawa M, Herbert J, Lomax MI, Grossman LI, Sherbany AA, Miranda AF, DiMauro S, Schon EA | title = Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase | journal = Gene | volume = 55 | issue = 2–3 | pages = 205–17 |date=Dec 1987 | pmid = 2444497 | pmc =  | doi =10.1016/0378-1119(87)90281-2  }}</ref><ref name="pmid2157630">{{cite journal | vauthors = Lomax MI, Welch MD, Darras BT, Francke U, Grossman LI | title = Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV | journal = Gene | volume = 86 | issue = 2 | pages = 209–16 |date=May 1990 | pmid = 2157630 | pmc =  | doi =10.1016/0378-1119(90)90281-U  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1327| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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[[Cytochrome c oxidase]] (COX) is the terminal enzyme of the [[Mitochondrion|mitochondrial]] [[electron transport chain|respiratory chain]]. It is a multi-subunit enzyme complex that couples the transfer of [[electron]]s from [[cytochrome c]] to molecular [[oxygen]] and contributes to a [[hydronium|proton]] [[electrochemical gradient]] across the inner [[mitochondrial membrane]]. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the [[electron transfer]] and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV [[protein isoform|isoform]] 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the [[COX4NB|NOC4]] (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.<ref name="entrez" /> Antibodies against Cox4 can be used to identify the inner membrane of mitochondria in immunfluorescence studies.<ref>http://www.genetex.com/WebPage/Product/ProductDetail.aspx?catno=GTX101499&CampaignId=</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cytochrome c oxidase subunit IV isoform 1
| HGNCid = 2265
| Symbol = COX4I1
| AltSymbols =; COX4; COXIV; MGC72016
| OMIM = 123864
| ECnumber = 
| Homologene = 37537
| MGIid = 88473
| GeneAtlas_image1 = PBB_GE_COX4I1_202698_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004129 |text = cytochrome-c oxidase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1327
    | Hs_Ensembl = ENSG00000131143
    | Hs_RefseqProtein = NP_001852
    | Hs_RefseqmRNA = NM_001861
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 84390697
    | Hs_GenLoc_end = 84398109
    | Hs_Uniprot = P13073
    | Mm_EntrezGene = 12857
    | Mm_Ensembl = ENSMUSG00000031818
    | Mm_RefseqmRNA = NM_009941
    | Mm_RefseqProtein = NP_034071
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 123554267
    | Mm_GenLoc_end = 123560184
    | Mm_Uniprot = P19783
  }}
}}
'''Cytochrome c oxidase subunit IV isoform 1''', also known as '''COX4I1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1327| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =  
 
| summary_text = Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.<ref name="entrez">{{cite web | title = Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1327| accessdate = }}</ref>
==External links==
}}
* {{UCSC gene info|COX4I1}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Lithgow T |title=Targeting of proteins to mitochondria |journal=FEBS Lett. |volume=476 |issue= 1–2 |pages= 22–6 |year= 2000 |pmid= 10878243 |doi=10.1016/S0014-5793(00)01663-X }}
| citations =
*{{cite journal  | vauthors=Van Kuilenburg AB, Van Beeumen JJ, Demol H |title=Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform |journal=Biochim. Biophys. Acta |volume=1119 |issue= 2 |pages= 218–24 |year= 1992 |pmid= 1311608 |doi=10.1016/0167-4838(92)90395-T |display-authors=etal}}
*{{cite journal  | author=Lithgow T |title=Targeting of proteins to mitochondria. |journal=FEBS Lett. |volume=476 |issue= 1-2 |pages= 22-6 |year= 2000 |pmid= 10878243 |doi=  }}
*{{cite journal  | vauthors=Lomax MI, Hewett-Emmett D, Yang TL, Grossman LI |title=Rapid evolution of the human gene for cytochrome c oxidase subunit IV |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5266–70 |year= 1992 |pmid= 1319058 |doi=10.1073/pnas.89.12.5266  | pmc=49272 }}
*{{cite journal  | author=Van Kuilenburg AB, Van Beeumen JJ, Demol H, ''et al.'' |title=Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform. |journal=Biochim. Biophys. Acta |volume=1119 |issue= 2 |pages= 218-24 |year= 1992 |pmid= 1311608 |doi=  }}
*{{cite journal  | vauthors=Romero N, Marsac C, Fardeau M |title=Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle |journal=Histochemistry |volume=94 |issue= 2 |pages= 211–5 |year= 1990 |pmid= 2162812 |doi=10.1007/BF02440190 |display-authors=etal}}
*{{cite journal  | author=Lomax MI, Hewett-Emmett D, Yang TL, Grossman LI |title=Rapid evolution of the human gene for cytochrome c oxidase subunit IV. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5266-70 |year= 1992 |pmid= 1319058 |doi= }}
*{{cite journal  | vauthors=Bonne G, Seibel P, Possekel S |title=Expression of human cytochrome c oxidase subunits during fetal development |journal=Eur. J. Biochem. |volume=217 |issue= 3 |pages= 1099–107 |year= 1993 |pmid= 8223633 |doi=10.1111/j.1432-1033.1993.tb18342.x |display-authors=etal}}
*{{cite journal  | author=Lomax MI, Welch MD, Darras BT, ''et al.'' |title=Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV. |journal=Gene |volume=86 |issue= 2 |pages= 209-16 |year= 1990 |pmid= 2157630 |doi=  }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Romero N, Marsac C, Fardeau M, ''et al.'' |title=Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle. |journal=Histochemistry |volume=94 |issue= 2 |pages= 211-5 |year= 1990 |pmid= 2162812 |doi= }}
*{{cite journal  | vauthors=Wu W, Goodman M, Lomax MI, Grossman LI |title=Molecular evolution of cytochrome c oxidase subunit IV: evidence for positive selection in simian primates |journal=J. Mol. Evol. |volume=44 |issue= 5 |pages= 477–91 |year= 1997 |pmid= 9115172 |doi=10.1007/PL00006172 }}
*{{cite journal | author=Zeviani M, Nakagawa M, Herbert J, ''et al.'' |title=Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase. |journal=Gene |volume=55 |issue= 2-3 |pages= 205-17 |year= 1987 |pmid= 2444497 |doi=  }}
*{{cite journal  | vauthors=Bachman NJ, Wu W, Schmidt TR |title=The 5' region of the COX4 gene contains a novel overlapping gene, NOC4 |journal=Mamm. Genome |volume=10 |issue= 5 |pages= 506–12 |year= 1999 |pmid= 10337626 |doi=10.1007/s003359901031 |display-authors=etal}}
*{{cite journal  | author=Bonne G, Seibel P, Possekel S, ''et al.'' |title=Expression of human cytochrome c oxidase subunits during fetal development. |journal=Eur. J. Biochem. |volume=217 |issue= 3 |pages= 1099-107 |year= 1993 |pmid= 8223633 |doi=  }}
*{{cite journal  | vauthors=Hüttemann M, Kadenbach B, Grossman LI |title=Mammalian subunit IV isoforms of cytochrome c oxidase |journal=Gene |volume=267 |issue= 1 |pages= 111–23 |year= 2001 |pmid= 11311561 |doi=10.1016/S0378-1119(01)00385-7 }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Wu W, Goodman M, Lomax MI, Grossman LI |title=Molecular evolution of cytochrome c oxidase subunit IV: evidence for positive selection in simian primates. |journal=J. Mol. Evol. |volume=44 |issue= 5 |pages= 477-91 |year= 1997 |pmid= 9115172 |doi=  }}
*{{cite journal  | vauthors=Williams SL, Valnot I, Rustin P, Taanman JW |title=Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1 |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7462–9 |year= 2004 |pmid= 14607829 |doi= 10.1074/jbc.M309232200 }}
*{{cite journal  | author=Bachman NJ, Wu W, Schmidt TR, ''et al.'' |title=The 5' region of the COX4 gene contains a novel overlapping gene, NOC4. |journal=Mamm. Genome |volume=10 |issue= 5 |pages= 506-12 |year= 1999 |pmid= 10337626 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Hüttemann M, Kadenbach B, Grossman LI |title=Mammalian subunit IV isoforms of cytochrome c oxidase. |journal=Gene |volume=267 |issue= 1 |pages= 111-23 |year= 2001 |pmid= 11311561 |doi=  }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Fukuda R, Zhang H, Kim JW |title=HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells |journal=Cell |volume=129 |issue= 1 |pages= 111–22 |year= 2007 |pmid= 17418790 |doi= 10.1016/j.cell.2007.01.047 |display-authors=etal}}
*{{cite journal  | author=Williams SL, Valnot I, Rustin P, Taanman JW |title=Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7462-9 |year= 2004 |pmid= 14607829 |doi= 10.1074/jbc.M309232200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Fukuda R, Zhang H, Kim JW, ''et al.'' |title=HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. |journal=Cell |volume=129 |issue= 1 |pages= 111-22 |year= 2007 |pmid= 17418790 |doi= 10.1016/j.cell.2007.01.047 }}
}}
{{refend}}
{{refend}}


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Revision as of 09:57, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
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Cytochrome c oxidase subunit 4 isoform 1, mitochondrial is an enzyme that in humans is encoded by the COX4I1 gene.[1][2][3]

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.[3] Antibodies against Cox4 can be used to identify the inner membrane of mitochondria in immunfluorescence studies.[4]

References

  1. ↑ Zeviani M, Nakagawa M, Herbert J, Lomax MI, Grossman LI, Sherbany AA, Miranda AF, DiMauro S, Schon EA (Dec 1987). "Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase". Gene. 55 (2–3): 205–17. doi:10.1016/0378-1119(87)90281-2. PMID 2444497.
  2. ↑ Lomax MI, Welch MD, Darras BT, Francke U, Grossman LI (May 1990). "Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV". Gene. 86 (2): 209–16. doi:10.1016/0378-1119(90)90281-U. PMID 2157630.
  3. ↑ 3.0 3.1 "Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1".
  4. ↑ http://www.genetex.com/WebPage/Product/ProductDetail.aspx?catno=GTX101499&CampaignId=

External links

Further reading


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