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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nucleoside diphosphate kinase B''' is an [[enzyme]] that in humans is encoded by the ''NME2'' [[gene]].<ref name="pmid1988104">{{cite journal | vauthors = Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS | title = Identification of a second human nm23 gene, nm23-H2 | journal = Cancer Res. | volume = 51 | issue = 1 | pages = 445–9  | date = February 1991 | pmid = 1988104 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4831| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_NME2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1be4.
| PDB = {{PDB2|1be4}}, {{PDB2|1bhn}}, {{PDB2|1nsk}}, {{PDB2|1nue}}
| Name = Non-metastatic cells 2, protein (NM23B) expressed in
| HGNCid = 7850
| Symbol = NME2
| AltSymbols =; MGC111212; NDPKB; NM23-H2; NM23B; puf
| OMIM = 156491
| ECnumber = 
| Homologene = 39553
| MGIid = 97356
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004550 |text = nucleoside diphosphate kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0006183 |text = GTP biosynthetic process}} {{GNF_GO|id=GO:0006228 |text = UTP biosynthetic process}} {{GNF_GO|id=GO:0006241 |text = CTP biosynthetic process}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009117 |text = nucleotide metabolic process}} {{GNF_GO|id=GO:0009142 |text = nucleoside triphosphate biosynthetic process}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4831
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001018147
    | Hs_RefseqmRNA = NM_001018137
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 18103
    | Mm_Ensembl = ENSMUSG00000020857
    | Mm_RefseqmRNA = NM_001077529
    | Mm_RefseqProtein = NP_001070997
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 93765906
    | Mm_GenLoc_end = 93772346
    | Mm_Uniprot = Q5NC82
  }}
}}
'''Non-metastatic cells 2, protein (NM23B) expressed in''', also known as '''NME2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4831| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein comprised of sequence sharing identity with each individual gene product.<ref name="entrez">{{cite web | title = Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4831| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
NME2 has been shown to [[Protein-protein interaction|interact]] with [[NME3]]<ref name=pmid16169070>{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68  | date = September 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}</ref><ref name=pmid11042679>{{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death Differ. | volume = 7 | issue = 9 | pages = 843–50  | date = September 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}</ref> and [[HERC5]].<ref name=pmid18535780>{{cite journal | vauthors = Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J | title = Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B | journal = Cell. Mol. Life Sci. | volume = 65 | issue = 13 | pages = 2105–17  | date = July 2008 | pmid = 18535780 | doi = 10.1007/s00018-008-8148-5 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Thakur RK, Kumar P, Halder K, Verma A, Kar A, Parent JL, Basundra R, Kumar A, Chowdhury S | title = Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression | journal = Nucleic Acids Res. | volume = 37 | issue = 1 | pages = 172–83 | year = 2009 | pmid = 19033359 | pmc = 2615625 | doi = 10.1093/nar/gkn919 }}
| citations =
* {{cite journal | vauthors = Gilles AM, Presecan E, Vonica A, Lascu I | title = Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme | journal = J. Biol. Chem. | volume = 266 | issue = 14 | pages = 8784–9 | year = 1991 | pmid = 1851158 | doi =  }}
*{{cite journal | author=Gilles AM, Presecan E, Vonica A, Lascu I |title=Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. |journal=J. Biol. Chem. |volume=266 |issue= 14 |pages= 8784-9 |year= 1991 |pmid= 1851158 |doi= }}
* {{cite journal | vauthors = Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS | title = Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development | journal = Nature | volume = 342 | issue = 6246 | pages = 177–80 | year = 1989 | pmid = 2509941 | doi = 10.1038/342177a0 }}
*{{cite journal | author=Stahl JA, Leone A, Rosengard AM, ''et al.'' |title=Identification of a second human nm23 gene, nm23-H2. |journal=Cancer Res. |volume=51 |issue= 1 |pages= 445-9 |year= 1991 |pmid= 1988104 |doi=  }}
* {{cite journal | vauthors = Webb PA, Perisic O, Mendola CE, Backer JM, Williams RL | title = The crystal structure of a human nucleoside diphosphate kinase, NM23-H2 | journal = J. Mol. Biol. | volume = 251 | issue = 4 | pages = 574–87 | year = 1995 | pmid = 7658474 | doi = 10.1006/jmbi.1995.0457 }}
*{{cite journal | author=Rosengard AM, Krutzsch HC, Shearn A, ''et al.'' |title=Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. |journal=Nature |volume=342 |issue= 6246 |pages= 177-80 |year= 1989 |pmid= 2509941 |doi= 10.1038/342177a0 }}
* {{cite journal | vauthors = Chandrasekharappa SC, Gross LA, King SE, Collins FS | title = The human NME2 gene lies within 18kb of NME1 in chromosome 17 | journal = Genes Chromosomes Cancer | volume = 6 | issue = 4 | pages = 245–8 | year = 1993 | pmid = 7685630 | doi = 10.1002/gcc.2870060411 }}
*{{cite journal | author=Webb PA, Perisic O, Mendola CE, ''et al.'' |title=The crystal structure of a human nucleoside diphosphate kinase, NM23-H2. |journal=J. Mol. Biol. |volume=251 |issue= 4 |pages= 574-87 |year= 1995 |pmid= 7658474 |doi= }}
* {{cite journal | vauthors = Ji L, Arcinas M, Boxer LM | title = The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma | journal = J. Biol. Chem. | volume = 270 | issue = 22 | pages = 13392–8 | year = 1995 | pmid = 7768941 | doi = 10.1074/jbc.270.22.13392 }}
*{{cite journal | author=Chandrasekharappa SC, Gross LA, King SE, Collins FS |title=The human NME2 gene lies within 18kb of NME1 in chromosome 17. |journal=Genes Chromosomes Cancer |volume=6 |issue= 4 |pages= 245-8 |year= 1993 |pmid= 7685630 |doi= }}
* {{cite journal | vauthors = MacDonald NJ, De la Rosa A, Benedict MA, Freije JM, Krutsch H, Steeg PS | title = A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential | journal = J. Biol. Chem. | volume = 268 | issue = 34 | pages = 25780–9 | year = 1993 | pmid = 8245015 | doi =  }}
*{{cite journal | author=Ji L, Arcinas M, Boxer LM |title=The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13392-8 |year= 1995 |pmid= 7768941 |doi= }}
* {{cite journal | vauthors = Backer JM, Mendola CE, Kovesdi I, Fairhurst JL, O'Hara B, Eddy RL, Shows TB, Mathew S, Murty VV, Chaganti RS | title = Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2 | journal = Oncogene | volume = 8 | issue = 2 | pages = 497–502 | year = 1993 | pmid = 8381224 | doi =  }}
*{{cite journal | author=MacDonald NJ, De la Rosa A, Benedict MA, ''et al.'' |title=A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25780-9 |year= 1994 |pmid= 8245015 |doi=  }}
* {{cite journal | vauthors = Postel EH, Berberich SJ, Flint SJ, Ferrone CA | title = Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis | journal = Science | volume = 261 | issue = 5120 | pages = 478–80 | year = 1993 | pmid = 8392752 | doi = 10.1126/science.8392752 }}
*{{cite journal | author=Backer JM, Mendola CE, Kovesdi I, ''et al.'' |title=Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2. |journal=Oncogene |volume=8 |issue= 2 |pages= 497-502 |year= 1993 |pmid= 8381224 |doi=  }}
* {{cite journal | vauthors = Kelsell DP, Black DM, Solomon E, Spurr NK | title = Localization of a second NM23 gene, NME2, to chromosome 17q21-q22 | journal = Genomics | volume = 17 | issue = 2 | pages = 522–4 | year = 1993 | pmid = 8406509 | doi = 10.1006/geno.1993.1362 }}
*{{cite journal | author=Postel EH, Berberich SJ, Flint SJ, Ferrone CA |title=Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. |journal=Science |volume=261 |issue= 5120 |pages= 478-80 |year= 1993 |pmid= 8392752 |doi= }}
* {{cite journal | vauthors = Engel M, Véron M, Theisinger B, Lacombe ML, Seib T, Dooley S, Welter C | title = A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase | journal = Eur. J. Biochem. | volume = 234 | issue = 1 | pages = 200–7 | year = 1995 | pmid = 8529641 | doi = 10.1111/j.1432-1033.1995.200_c.x }}
*{{cite journal | author=Kelsell DP, Black DM, Solomon E, Spurr NK |title=Localization of a second NM23 gene, NME2, to chromosome 17q21-q22. |journal=Genomics |volume=17 |issue= 2 |pages= 522-4 |year= 1993 |pmid= 8406509 |doi= 10.1006/geno.1993.1362 }}
* {{cite journal | vauthors = Guignard F, Markert M | title = The nucleoside diphosphate kinase of human neutrophils | journal = Biochem. J. | volume = 316 ( Pt 1) | issue = 1 | pages = 233–8 | year = 1996 | pmid = 8645210 | pmc = 1217327 | doi =  }}
*{{cite journal | author=Engel M, Véron M, Theisinger B, ''et al.'' |title=A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase. |journal=Eur. J. Biochem. |volume=234 |issue= 1 |pages= 200-7 |year= 1996 |pmid= 8529641 |doi= }}
* {{cite journal | vauthors = Moréra S, Lacombe ML, Xu Y, LeBras G, Janin J | title = X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution | journal = Structure | volume = 3 | issue = 12 | pages = 1307–14 | year = 1995 | pmid = 8747457 | doi = 10.1016/S0969-2126(01)00268-4 }}
*{{cite journal | author=Guignard F, Markert M |title=The nucleoside diphosphate kinase of human neutrophils. |journal=Biochem. J. |volume=316 ( Pt 1) |issue= |pages= 233-8 |year= 1996 |pmid= 8645210 |doi=  }}
* {{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7 | year = 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}
*{{cite journal | author=Moréra S, Lacombe ML, Xu Y, ''et al.'' |title=X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution. |journal=Structure |volume=3 |issue= 12 |pages= 1307-14 |year= 1996 |pmid= 8747457 |doi= }}
* {{cite journal | vauthors = Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H | title = Association of nucleoside diphosphate kinase nm23-H2 with human telomeres | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 342–8 | year = 1998 | pmid = 9480811 | doi = 10.1006/bbrc.1997.8097 }}
*{{cite journal | author=Paravicini G, Steinmayr M, André E, Becker-André M |title=The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 1 |pages= 82-7 |year= 1996 |pmid= 8858107 |doi= 10.1006/bbrc.1996.1471 }}
* {{cite journal | vauthors = Pinon VP, Millot G, Munier A, Vassy J, Linares-Cruz G, Capeau J, Calvo F, Lacombe ML | title = Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit | journal = Exp. Cell Res. | volume = 246 | issue = 2 | pages = 355–67 | year = 1999 | pmid = 9925751 | doi = 10.1006/excr.1998.4318 }}
*{{cite journal | author=Nosaka K, Kawahara M, Masuda M, ''et al.'' |title=Association of nucleoside diphosphate kinase nm23-H2 with human telomeres. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 342-8 |year= 1998 |pmid= 9480811 |doi= 10.1006/bbrc.1997.8097 }}
* {{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death Differ. | volume = 7 | issue = 9 | pages = 843–50 | year = 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}
*{{cite journal | author=Pinon VP, Millot G, Munier A, ''et al.'' |title=Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit. |journal=Exp. Cell Res. |volume=246 |issue= 2 |pages= 355-67 |year= 1999 |pmid= 9925751 |doi= 10.1006/excr.1998.4318 }}
* {{cite journal | vauthors = Roymans D, Willems R, Vissenberg K, De Jonghe C, Grobben B, Claes P, Lascu I, Van Bockstaele D, Verbelen JP, Van Broeckhoven C, Slegers H | title = Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma | journal = Exp. Cell Res. | volume = 261 | issue = 1 | pages = 127–38 | year = 2000 | pmid = 11082283 | doi = 10.1006/excr.2000.5037 }}
*{{cite journal | author=Negroni A, Venturelli D, Tanno B, ''et al.'' |title=Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis. |journal=Cell Death Differ. |volume=7 |issue= 9 |pages= 843-50 |year= 2000 |pmid= 11042679 |doi= 10.1038/sj.cdd.4400720 }}
* {{cite journal | vauthors = Baillat G, Gaillard S, Castets F, Monneron A | title = Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 18961–6 | year = 2002 | pmid = 11872741 | doi = 10.1074/jbc.M108818200 }}
*{{cite journal | author=Roymans D, Willems R, Vissenberg K, ''et al.'' |title=Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 127-38 |year= 2000 |pmid= 11082283 |doi= 10.1006/excr.2000.5037 }}
* {{cite journal | vauthors = Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C | title = Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement | journal = J. Biol. Chem. | volume = 277 | issue = 23 | pages = 20895–902 | year = 2002 | pmid = 11919189 | doi = 10.1074/jbc.M200200200 }}
*{{cite journal | author=Baillat G, Gaillard S, Castets F, Monneron A |title=Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18961-6 |year= 2002 |pmid= 11872741 |doi= 10.1074/jbc.M108818200 }}
*{{cite journal  | author=Fournier HN, Dupé-Manet S, Bouvard D, ''et al.'' |title=Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20895-902 |year= 2002 |pmid= 11919189 |doi= 10.1074/jbc.M200200200 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4831}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 13:06, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.[1][2]

Function

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.[2]

Interactions

NME2 has been shown to interact with NME3[3][4] and HERC5.[5]

References

  1. ↑ Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS (February 1991). "Identification of a second human nm23 gene, nm23-H2". Cancer Res. 51 (1): 445–9. PMID 1988104.
  2. ↑ 2.0 2.1 "Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in".
  3. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  4. ↑ Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
  5. ↑ Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J (July 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. PMID 18535780.

Further reading

  • Thakur RK, Kumar P, Halder K, Verma A, Kar A, Parent JL, Basundra R, Kumar A, Chowdhury S (2009). "Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression". Nucleic Acids Res. 37 (1): 172–83. doi:10.1093/nar/gkn919. PMC 2615625. PMID 19033359.
  • Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. PMID 1851158.
  • Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature. 342 (6246): 177–80. doi:10.1038/342177a0. PMID 2509941.
  • Webb PA, Perisic O, Mendola CE, Backer JM, Williams RL (1995). "The crystal structure of a human nucleoside diphosphate kinase, NM23-H2". J. Mol. Biol. 251 (4): 574–87. doi:10.1006/jmbi.1995.0457. PMID 7658474.
  • Chandrasekharappa SC, Gross LA, King SE, Collins FS (1993). "The human NME2 gene lies within 18kb of NME1 in chromosome 17". Genes Chromosomes Cancer. 6 (4): 245–8. doi:10.1002/gcc.2870060411. PMID 7685630.
  • Ji L, Arcinas M, Boxer LM (1995). "The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma". J. Biol. Chem. 270 (22): 13392–8. doi:10.1074/jbc.270.22.13392. PMID 7768941.
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