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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Galectin-3-binding protein''' is a [[protein]] that in humans is encoded by the ''LGALS3BP'' [[gene]].<ref name="pmid7698018">{{cite journal |vauthors=Calabrese G, Sures I, Pompetti F, Natoli G, Palka G, Iacobelli S | title = The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25 | journal = Cytogenet Cell Genet | volume = 69 | issue = 3-4 | pages = 223–5 |date=May 1995 | pmid = 7698018 | pmc =  | doi =10.1159/000133969  }}</ref><ref name="pmid8034587">{{cite journal |vauthors=Ullrich A, Sures I, D'Egidio M, Jallal B, Powell TJ, Herbst R, Dreps A, Azam M, Rubinstein M, Natoli C | title = The secreted tumor-associated antigen 90K is a potent immune stimulator | journal = J Biol Chem | volume = 269 | issue = 28 | pages = 18401–7 |date=Aug 1994 | pmid = 8034587  | doi =  |display-authors=etal}}</ref><ref name="pmid8390986">{{cite journal |vauthors=Koths K, Taylor E, Halenbeck R, Casipit C, Wang A | title = Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain | journal = J. Biol. Chem. | volume = 268 | issue = 19 | pages = 14245–9 |date=July 1993 | pmid = 8390986 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3959| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_LGALS3BP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1by2.
| PDB = {{PDB2|1by2}}
| Name = Lectin, galactoside-binding, soluble, 3 binding protein
| HGNCid = 6564
| Symbol = LGALS3BP
| AltSymbols =; 90K; MAC-2-BP
| OMIM = 600626
| ECnumber = 
| Homologene = 4067
| MGIid = 99554
| GeneAtlas_image1 = PBB_GE_LGALS3BP_200923_at_tn.png
| Function = {{GNF_GO|id=GO:0005044 |text = scavenger receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3959
    | Hs_Ensembl = ENSG00000108679
    | Hs_RefseqProtein = NP_005558
    | Hs_RefseqmRNA = NM_005567
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 74478932
    | Hs_GenLoc_end = 74487656
    | Hs_Uniprot = Q08380
    | Mm_EntrezGene = 19039
    | Mm_Ensembl = ENSMUSG00000033880
    | Mm_RefseqmRNA = NM_011150
    | Mm_RefseqProtein = NP_035280
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 118208839
    | Mm_GenLoc_end = 118218049
    | Mm_Uniprot = 
  }}
}}
'''Lectin, galactoside-binding, soluble, 3 binding protein''', also known as '''LGALS3BP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3959| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[galectin]]s are a family of [[beta-galactoside]]-binding proteins implicated in modulating cell–cell and cell–matrix interactions.  Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.<ref name="entrez">{{cite web | title = Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3959| accessdate = }}</ref>
 
}}
LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus ([[HIV]]). It appears to be implicated in immune response associated with [[natural killer]] (NK) and [[lymphokine-activated killer cell|lymphokine-activated killer]] (LAK) cell cytotoxicity.<ref name="entrez"/>
 
==Interactions==
LGALS3BP has been shown to [[Protein-protein interaction|interact]] with [[LGALS3]].<ref name="pmid8390986"/><ref name="pmid1917996">{{cite journal |vauthors=Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S | title = Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin | journal = J. Biol. Chem. | volume = 266 | issue = 28 | pages = 18731–6 |date=October 1991 | pmid = 1917996 | doi = }}</ref><ref name="pmid11146440">{{cite journal |vauthors=Tinari N, Kuwabara I, Huflejt ME, Shen PF, Iacobelli S, Liu FT | title = Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation | journal = Int. J. Cancer | volume = 91 | issue = 2 | pages = 167–72 |date=January 2001 | pmid = 11146440 | doi = 10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Grassadonia A, Tinari N, Iurisci I, etal |title=90K (Mac-2 BP) and galectins in tumor progression and metastasis. |journal=Glycoconj. J. |volume=19 |issue= 7-9 |pages= 551–6 |year= 2004 |pmid= 14758079 |doi= 10.1023/B:GLYC.0000014085.00706.d4 }}
| citations =
*{{cite journal  |vauthors=Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S |title=Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18731–6 |year= 1991 |pmid= 1917996 |doi=  }}
*{{cite journal | author=Grassadonia A, Tinari N, Iurisci I, ''et al.'' |title=90K (Mac-2 BP) and galectins in tumor progression and metastasis. |journal=Glycoconj. J. |volume=19 |issue= 7-9 |pages= 551-6 |year= 2004 |pmid= 14758079 |doi= 10.1023/B:GLYC.0000014085.00706.d4 }}
*{{cite journal  |vauthors=Yu B, Wright SD |title=LPS-dependent interaction of Mac-2-binding protein with immobilized CD14. |journal=J. Inflamm. |volume=45 |issue= 2 |pages= 115–25 |year= 1995 |pmid= 7583357 |doi=  }}
*{{cite journal  | author=Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S |title=Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18731-6 |year= 1991 |pmid= 1917996 |doi=  }}
*{{cite journal   |vauthors=Koths K, Taylor E, Halenbeck R, etal |title=Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. |journal=J. Biol. Chem. |volume=268 |issue= 19 |pages= 14245–9 |year= 1993 |pmid= 8390986 |doi=  }}
*{{cite journal  | author=Yu B, Wright SD |title=LPS-dependent interaction of Mac-2-binding protein with immobilized CD14. |journal=J. Inflamm. |volume=45 |issue= 2 |pages= 115-25 |year= 1995 |pmid= 7583357 |doi=  }}
*{{cite journal  |vauthors=Inohara H, Akahani S, Koths K, Raz A |title=Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. |journal=Cancer Res. |volume=56 |issue= 19 |pages= 4530–4 |year= 1996 |pmid= 8813152 |doi=  }}
*{{cite journal | author=Calabrese G, Sures I, Pompetti F, ''et al.'' |title=The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 223-5 |year= 1995 |pmid= 7698018 |doi=  }}
*{{cite journal   |vauthors=Brakebusch C, Jallal B, Fusco O, etal |title=Expression of the 90K immunostimulator gene is controlled by a promoter with unique features. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3674–82 |year= 1997 |pmid= 9013622 |doi=10.1074/jbc.272.6.3674 }}
*{{cite journal  | author=Ullrich A, Sures I, D'Egidio M, ''et al.'' |title=The secreted tumor-associated antigen 90K is a potent immune stimulator. |journal=J. Biol. Chem. |volume=269 |issue= 28 |pages= 18401-7 |year= 1994 |pmid= 8034587 |doi=  }}
*{{cite journal   |vauthors=Fusco O, Querzoli P, Nenci I, etal |title=90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells. |journal=Int. J. Cancer |volume=79 |issue= 1 |pages= 23–6 |year= 1998 |pmid= 9495353 |doi=10.1002/(SICI)1097-0215(19980220)79:1<23::AID-IJC5>3.0.CO;2-Y  }}
*{{cite journal | author=Koths K, Taylor E, Halenbeck R, ''et al.'' |title=Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. |journal=J. Biol. Chem. |volume=268 |issue= 19 |pages= 14245-9 |year= 1993 |pmid= 8390986 |doi=  }}
*{{cite journal |vauthors=Sasaki T, Brakebusch C, Engel J, Timpl R |title=Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. |journal=EMBO J. |volume=17 |issue= 6 |pages= 1606–13 |year= 1998 |pmid= 9501082 |doi= 10.1093/emboj/17.6.1606 | pmc=1170508 }}
*{{cite journal | author=Inohara H, Akahani S, Koths K, Raz A |title=Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. |journal=Cancer Res. |volume=56 |issue= 19 |pages= 4530-4 |year= 1996 |pmid= 8813152 |doi= }}
*{{cite journal  |vauthors=Trahey M, Weissman IL |title=Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 3006–11 |year= 1999 |pmid= 10077627 |doi=10.1073/pnas.96.6.3006  | pmc=15885 }}
*{{cite journal | author=Brakebusch C, Jallal B, Fusco O, ''et al.'' |title=Expression of the 90K immunostimulator gene is controlled by a promoter with unique features. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3674-82 |year= 1997 |pmid= 9013622 |doi=  }}
*{{cite journal   |vauthors=Tinari N, Kuwabara I, Huflejt ME, etal |title=Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. |journal=Int. J. Cancer |volume=91 |issue= 2 |pages= 167–72 |year= 2001 |pmid= 11146440 |doi=10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q  }}
*{{cite journal  | author=Fusco O, Querzoli P, Nenci I, ''et al.'' |title=90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells. |journal=Int. J. Cancer |volume=79 |issue= 1 |pages= 23-6 |year= 1998 |pmid= 9495353 |doi=  }}
*{{cite journal   |vauthors=Hellstern S, Sasaki T, Fauser C, etal |title=Functional studies on recombinant domains of Mac-2-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15690–6 |year= 2002 |pmid= 11867635 |doi= 10.1074/jbc.M200386200 }}
*{{cite journal | author=Sasaki T, Brakebusch C, Engel J, Timpl R |title=Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. |journal=EMBO J. |volume=17 |issue= 6 |pages= 1606-13 |year= 1998 |pmid= 9501082 |doi= 10.1093/emboj/17.6.1606 }}
*{{cite journal   |vauthors=Marchetti A, Tinari N, Buttitta F, etal |title=Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2535–9 |year= 2002 |pmid= 11980646 |doi=  }}
*{{cite journal | author=Trahey M, Weissman IL |title=Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 3006-11 |year= 1999 |pmid= 10077627 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Tinari N, Kuwabara I, Huflejt ME, ''et al.'' |title=Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. |journal=Int. J. Cancer |volume=91 |issue= 2 |pages= 167-72 |year= 2001 |pmid= 11146440 |doi=  }}
*{{cite journal  |vauthors=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 }}
*{{cite journal | author=Hellstern S, Sasaki T, Fauser C, ''et al.'' |title=Functional studies on recombinant domains of Mac-2-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15690-6 |year= 2002 |pmid= 11867635 |doi= 10.1074/jbc.M200386200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Marchetti A, Tinari N, Buttitta F, ''et al.'' |title=Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2535-9 |year= 2002 |pmid= 11980646 |doi= }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kristiansen TZ, Bunkenborg J, Gronborg M, etal |title=A proteomic analysis of human bile. |journal=Mol. Cell. Proteomics |volume=3 |issue= 7 |pages= 715–28 |year= 2005 |pmid= 15084671 |doi= 10.1074/mcp.M400015-MCP200 }}
*{{cite journal | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660-6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Kristiansen TZ, Bunkenborg J, Gronborg M, ''et al.'' |title=A proteomic analysis of human bile. |journal=Mol. Cell Proteomics |volume=3 |issue= 7 |pages= 715-28 |year= 2005 |pmid= 15084671 |doi= 10.1074/mcp.M400015-MCP200 }}
}}
{{refend}}
{{refend}}


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Revision as of 17:43, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.[1][2][3][4]

Function

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.[4]

Clinical significance

LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity.[4]

Interactions

LGALS3BP has been shown to interact with LGALS3.[3][5][6]

References

  1. ↑ Calabrese G, Sures I, Pompetti F, Natoli G, Palka G, Iacobelli S (May 1995). "The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25". Cytogenet Cell Genet. 69 (3–4): 223–5. doi:10.1159/000133969. PMID 7698018.
  2. ↑ Ullrich A, Sures I, D'Egidio M, Jallal B, Powell TJ, Herbst R, Dreps A, Azam M, Rubinstein M, Natoli C, et al. (Aug 1994). "The secreted tumor-associated antigen 90K is a potent immune stimulator". J Biol Chem. 269 (28): 18401–7. PMID 8034587.
  3. ↑ 3.0 3.1 Koths K, Taylor E, Halenbeck R, Casipit C, Wang A (July 1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. 268 (19): 14245–9. PMID 8390986.
  4. ↑ 4.0 4.1 4.2 "Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein".
  5. ↑ Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S (October 1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. 266 (28): 18731–6. PMID 1917996.
  6. ↑ Tinari N, Kuwabara I, Huflejt ME, Shen PF, Iacobelli S, Liu FT (January 2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer. 91 (2): 167–72. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q. PMID 11146440.

Further reading


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