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:''Disambiguation: For the animated series see [[She-Ra: Princess of Power]].''
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Speckle-type POZ protein''' is a [[protein]] that in humans is encoded by the ''SPOP'' [[gene]].<ref name="pmid9414087">{{cite journal | vauthors = Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M | title = Identification of a novel nuclear speckle-type protein, SPOP | journal = FEBS Letters | volume = 418 | issue = 1-2 | pages = 23–6 | date = Nov 1997 | pmid = 9414087 | pmc =  | doi = 10.1016/S0014-5793(97)01340-9 }}</ref><ref name="pmid11279055">{{cite journal | vauthors = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24242–52 | date = Jun 2001 | pmid = 11279055 | doi = 10.1074/jbc.M100354200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPOP speckle-type POZ protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8405| accessdate = }}</ref>
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[protein]] that may modulate the transcriptional repression activities of death-associated protein 6 ([[Death associated protein 6|DAXX]]), which interacts with [[histone deacetylase]], core [[histone]]s, and other histone-associated proteins. In mouse, the encoded protein binds to the putative [[leucine zipper]] [[protein domain|domain]] of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. [[Alternative splicing]] of this gene results in multiple transcript variants encoding the same protein.<ref name="entrez"/>
{{GNF_Protein_box
| image = PBB_Protein_SPOP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cr2.
| PDB = {{PDB2|2cr2}}
| Name = Speckle-type POZ protein
| HGNCid = 11254
| Symbol = SPOP
| AltSymbols =; TEF2
| OMIM = 602650
| ECnumber = 
| Homologene = 68354
| MGIid = 1343085
| GeneAtlas_image1 = PBB_GE_SPOP_208927_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPOP_204640_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8405
    | Hs_Ensembl = ENSG00000121067
    | Hs_RefseqProtein = NP_001007227
    | Hs_RefseqmRNA = NM_001007226
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 45031247
    | Hs_GenLoc_end = 45110524
    | Hs_Uniprot = O43791
    | Mm_EntrezGene = 20747
    | Mm_Ensembl = ENSMUSG00000057522
    | Mm_RefseqmRNA = NM_025287
    | Mm_RefseqProtein = NP_079563
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 95230204
    | Mm_GenLoc_end = 95309103
    | Mm_Uniprot = A0JLP8
  }}
}}
'''Speckle-type POZ protein''', also known as '''SPOP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPOP speckle-type POZ protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8405| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical relevance ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: SPOP speckle-type POZ protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8405| accessdate = }}</ref>
}}


==References==
Mutations in ''SPOP'' lead to a type of prostate tumor thought to be involved in about 15% of all [[prostate cancer]]s.<ref name = "NYDNHeidiEvans">{{cite news |title=Scientists find new type of prostate cancer - discovery may lead to tailored treatments |author=Heidi Evans |url=http://www.nydailynews.com/life-style/health/scientists-find-type-prostate-cancer-discovery-lead-tailored-treatments-article-1.1081547 |newspaper=''New York Daily News |date=20 May 2012 |accessdate=20 May 2012}}</ref><ref name="doi.10.1038/ng.2279">{{cite journal | vauthors = Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA | title = Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer | journal = Nature Genetics | volume = 44 | issue = 6 | pages = 685–9 | date = Jun 2012 | pmid = 22610119 | pmc = 3673022 | doi = 10.1038/ng.2279 }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH | title = An activating immunoreceptor complex formed by NKG2D and DAP10 | journal = Science | volume = 285 | issue = 5428 | pages = 730–2 | date = Jul 1999 | pmid = 10426994 | doi = 10.1126/science.285.5428.730 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal  | author=Nagai Y, Kojima T, Muro Y, ''et al.'' |title=Identification of a novel nuclear speckle-type protein, SPOP. |journal=FEBS Lett. |volume=418 |issue= 1-2 |pages= 23-6 |year= 1998 |pmid= 9414087 |doi=  }}
* {{cite journal | vauthors = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24242–52 | date = Jun 2001 | pmid = 11279055 | doi = 10.1074/jbc.M100354200 }}
*{{cite journal | author=Wu J, Song Y, Bakker AB, ''et al.'' |title=An activating immunoreceptor complex formed by NKG2D and DAP10. |journal=Science |volume=285 |issue= 5428 |pages= 730-2 |year= 1999 |pmid= 10426994 |doi= }}
* {{cite journal | vauthors = Takahashi I, Kameoka Y, Hashimoto K | title = MacroH2A1.2 binds the nuclear protein Spop | journal = Biochimica et Biophysica Acta | volume = 1591 | issue = 1-3 | pages = 63–8 | date = Aug 2002 | pmid = 12183056 | doi = 10.1016/S0167-4889(02)00249-5 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M | title = NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation | journal = Nature Immunology | volume = 3 | issue = 12 | pages = 1150–5 | date = Dec 2002 | pmid = 12426564 | doi = 10.1038/ni857 }}
*{{cite journal | author=Zapata JM, Pawlowski K, Haas E, ''et al.'' |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242-52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200 }}
* {{cite journal | vauthors = Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, Raulet DH | title = Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D | journal = Nature Immunology | volume = 3 | issue = 12 | pages = 1142–9 | date = Dec 2002 | pmid = 12426565 | doi = 10.1038/ni858 }}
*{{cite journal | author=Takahashi I, Kameoka Y, Hashimoto K |title=MacroH2A1.2 binds the nuclear protein Spop. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 63-8 |year= 2002 |pmid= 12183056 |doi= }}
* {{cite journal | vauthors = Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ | title = NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway | journal = Nature Immunology | volume = 4 | issue = 6 | pages = 557–64 | date = Jun 2003 | pmid = 12740575 | doi = 10.1038/ni929 }}
*{{cite journal | author=Gilfillan S, Ho EL, Cella M, ''et al.'' |title=NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1150-5 |year= 2002 |pmid= 12426564 |doi= 10.1038/ni857 }}
* {{cite journal | vauthors = Liu A, Desai BM, Stoffers DA | title = Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity | journal = Molecular and Cellular Biology | volume = 24 | issue = 10 | pages = 4372–83 | date = May 2004 | pmid = 15121856 | pmc = 400448 | doi = 10.1128/MCB.24.10.4372-4383.2004 }}
*{{cite journal | author=Diefenbach A, Tomasello E, Lucas M, ''et al.'' |title=Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1142-9 |year= 2002 |pmid= 12426565 |doi= 10.1038/ni858 }}
* {{cite journal | vauthors = La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO | title = Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP | journal = Biochemical and Biophysical Research Communications | volume = 320 | issue = 3 | pages = 760–5 | date = Jul 2004 | pmid = 15240113 | doi = 10.1016/j.bbrc.2004.06.022 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Billadeau DD, Upshaw JL, Schoon RA, ''et al.'' |title=NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. |journal=Nat. Immunol. |volume=4 |issue= 6 |pages= 557-64 |year= 2003 |pmid= 12740575 |doi= 10.1038/ni929 }}
* {{cite journal | vauthors = Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M | title = Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 21 | pages = 7635–40 | date = May 2005 | pmid = 15897469 | pmc = 1140410 | doi = 10.1073/pnas.0408918102 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Liu A, Desai BM, Stoffers DA |title=Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 10 |pages= 4372-83 |year= 2004 |pmid= 15121856 |doi= }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=La M, Kim K, Park J, ''et al.'' |title=Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 3 |pages= 760-5 |year= 2004 |pmid= 15240113 |doi= 10.1016/j.bbrc.2004.06.022 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Hernández-Muñoz I, Lund AH, van der Stoop P, ''et al.'' |title=Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7635-40 |year= 2005 |pmid= 15897469 |doi= 10.1073/pnas.0408918102 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
{{refend}}
{{refend}}


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{{PDB Gallery|geneid=8405}}
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Revision as of 06:55, 11 September 2017

Disambiguation: For the animated series see She-Ra: Princess of Power.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.[1][2][3]

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.[3]

Clinical relevance

Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers.[4][5]

References

  1. ↑ Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M (Nov 1997). "Identification of a novel nuclear speckle-type protein, SPOP". FEBS Letters. 418 (1–2): 23–6. doi:10.1016/S0014-5793(97)01340-9. PMID 9414087.
  2. ↑ Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (Jun 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
  3. ↑ 3.0 3.1 "Entrez Gene: SPOP speckle-type POZ protein".
  4. ↑ Heidi Evans (20 May 2012). "Scientists find new type of prostate cancer - discovery may lead to tailored treatments". New York Daily News. Retrieved 20 May 2012.
  5. ↑ Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022. PMID 22610119.

Further reading


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