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{{Infobox_gene}}
{{PBB_Controls
'''Pyrroline-5-carboxylate reductase 1, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''PYCR1'' [[gene]].<ref name="pmid1730675">{{cite journal | vauthors = Dougherty KM, Brandriss MC, Valle D | title = Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae | journal = J Biol Chem | volume = 267 | issue = 2 | pages = 871–5 |date=Feb 1992 | pmid = 1730675 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5831| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PYCR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ger.
| PDB = {{PDB2|2ger}}, {{PDB2|2gr9}}, {{PDB2|2gra}}, {{PDB2|2izz}}
| Name = Pyrroline-5-carboxylate reductase 1
| HGNCid = 9721
| Symbol = PYCR1
| AltSymbols =; P5C; P5CR; PIG45; PP222; PYCR
| OMIM = 179035
| ECnumber = 
| Homologene = 56002
| MGIid = 2384795
| GeneAtlas_image1 = PBB_GE_PYCR1_202148_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004735 |text = pyrroline-5-carboxylate reductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component =  
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006561 |text = proline biosynthetic process}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5831
    | Hs_Ensembl = ENSG00000183010
    | Hs_RefseqProtein = NP_008838
    | Hs_RefseqmRNA = NM_006907
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77483560
    | Hs_GenLoc_end = 77488443
    | Hs_Uniprot = P32322
    | Mm_EntrezGene = 209027
    | Mm_Ensembl = ENSMUSG00000025140
    | Mm_RefseqmRNA = NM_144795
    | Mm_RefseqProtein = NP_659044
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120455506
    | Mm_GenLoc_end = 120459792
    | Mm_Uniprot = Q3UTR5
  }}
}}
'''Pyrroline-5-carboxylate reductase 1''', also known as '''PYCR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5831| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5831| accessdate = }}</ref>
| summary_text = This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of [[pyrroline-5-carboxylate]] to [[proline]]. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Herzfeld A, Legg MA, Greengard O |title=Human colon tumors: enzymic and histological characteristics. |journal=Cancer |volume=42 |issue= 3 |pages= 1280-3 |year= 1978 |pmid= 212173 |doi= }}
*{{cite journal  | vauthors=Herzfeld A, Legg MA, Greengard O |title=Human colon tumors: enzymic and histological characteristics |journal=Cancer |volume=42 |issue= 3 |pages= 1280–3 |year= 1978 |pmid= 212173 |doi=10.1002/1097-0142(197809)42:3<1280::AID-CNCR2820420337>3.0.CO;2-P }}
*{{cite journal  | author=Dougherty KM, Brandriss MC, Valle D |title=Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 871-5 |year= 1992 |pmid= 1730675 |doi= }}
*{{cite journal  | vauthors=Merrill MJ, Yeh GC, Phang JM |title=Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH |journal=J. Biol. Chem. |volume=264 |issue= 16 |pages= 9352–8 |year= 1989 |pmid= 2722838 |doi=  }}
*{{cite journal  | author=Merrill MJ, Yeh GC, Phang JM |title=Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. |journal=J. Biol. Chem. |volume=264 |issue= 16 |pages= 9352-8 |year= 1989 |pmid= 2722838 |doi=  }}
*{{cite journal   |vauthors=Yeh GC, Roth EF, Phang JM, etal |title=The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects |journal=J. Biol. Chem. |volume=259 |issue= 9 |pages= 5454–8 |year= 1984 |pmid= 6201483 |doi=  }}
*{{cite journal | author=Yeh GC, Roth EF, Phang JM, ''et al.'' |title=The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects. |journal=J. Biol. Chem. |volume=259 |issue= 9 |pages= 5454-8 |year= 1984 |pmid= 6201483 |doi=  }}
*{{cite journal  | vauthors=Herzfeld A, Greengard O |title=Enzyme activities in human fetal and neoplastic tissues |journal=Cancer |volume=46 |issue= 9 |pages= 2047–54 |year= 1981 |pmid= 6253048 |doi=10.1002/1097-0142(19801101)46:9<2047::AID-CNCR2820460924>3.0.CO;2-Q }}
*{{cite journal  | author=Herzfeld A, Greengard O |title=Enzyme activities in human fetal and neoplastic tissues. |journal=Cancer |volume=46 |issue= 9 |pages= 2047-54 |year= 1981 |pmid= 6253048 |doi=  }}
*{{cite journal  | vauthors=Yeh GC, Harris SC, Phang JM |title=Pyrroline-5-carboxylate reductase in human erythrocytes |journal=J. Clin. Invest. |volume=67 |issue= 4 |pages= 1042–6 |year= 1981 |pmid= 6894153 |doi=10.1172/JCI110115  | pmc=370662 }}
*{{cite journal  | author=Yeh GC, Harris SC, Phang JM |title=Pyrroline-5-carboxylate reductase in human erythrocytes. |journal=J. Clin. Invest. |volume=67 |issue= 4 |pages= 1042-6 |year= 1981 |pmid= 6894153 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Basch JJ, Wickham ED, Farrell HM |title=Pyrroline-5-carboxylate reductase in lactating bovine mammary glands |journal=J. Dairy Sci. |volume=79 |issue= 8 |pages= 1361–8 |year= 1997 |pmid= 8880459 |doi=10.3168/jds.S0022-0302(96)76493-7 }}
*{{cite journal  | author=Basch JJ, Wickham ED, Farrell HM |title=Pyrroline-5-carboxylate reductase in lactating bovine mammary glands. |journal=J. Dairy Sci. |volume=79 |issue= 8 |pages= 1361-8 |year= 1997 |pmid= 8880459 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Meng Z, Lou Z, Liu Z, etal |title=Crystal structure of human pyrroline-5-carboxylate reductase |journal=J. Mol. Biol. |volume=359 |issue= 5 |pages= 1364–77 |year= 2006 |pmid= 16730026 |doi= 10.1016/j.jmb.2006.04.053 }}
*{{cite journal | author=Meng Z, Lou Z, Liu Z, ''et al.'' |title=Crystal structure of human pyrroline-5-carboxylate reductase. |journal=J. Mol. Biol. |volume=359 |issue= 5 |pages= 1364-77 |year= 2006 |pmid= 16730026 |doi= 10.1016/j.jmb.2006.04.053 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5831}}
{{Amino acid metabolism enzymes}}
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Latest revision as of 19:02, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.[1][2]

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.[2]

References

  1. ↑ Dougherty KM, Brandriss MC, Valle D (Feb 1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae". J Biol Chem. 267 (2): 871–5. PMID 1730675.
  2. ↑ 2.0 2.1 "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1".

Further reading



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