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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein CASC3''' is a [[protein]] that in humans is encoded by the ''CASC3'' [[gene]].<ref name="pmid7490069">{{cite journal |vauthors=Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC | title = Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17 | journal = Genomics | volume = 28 | issue = 3 | pages = 367–76 |date=Jan 1996 | pmid = 7490069 | pmc =  | doi = 10.1006/geno.1995.1163 }}</ref><ref name="pmid18332872">{{cite journal |vauthors=Arriola E, Marchio C, Tan DS, Drury SC, Lambros MB, Natrajan R, Rodriguez-Pinilla SM, Mackay A, Tamber N, Fenwick K, Jones C, Dowsett M, Ashworth A, Reis-Filho JS | title = Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines | journal = Lab Invest | volume = 88 | issue = 5 | pages = 491–503 |date=Apr 2008 | pmid = 18332872 | pmc =  | doi = 10.1038/labinvest.2008.19 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CASC3 cancer susceptibility candidate 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22794| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CASC3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hyi.
| PDB = {{PDB2|2hyi}}, {{PDB2|2j0q}}, {{PDB2|2j0s}}, {{PDB2|2j0u}}
| Name = Cancer susceptibility candidate 3
| HGNCid = 17040
| Symbol = CASC3
| AltSymbols =; BTZ; MLN51
| OMIM = 606504
| ECnumber = 
| Homologene = 7208
| MGIid = 2179723
| GeneAtlas_image1 = PBB_GE_CASC3_207842_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008298 |text = intracellular mRNA localization}} {{GNF_GO|id=GO:0051028 |text = mRNA transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22794
    | Hs_Ensembl = ENSG00000108349
    | Hs_RefseqProtein = NP_031385
    | Hs_RefseqmRNA = NM_007359
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 35550110
    | Hs_GenLoc_end = 35581950
    | Hs_Uniprot = O15234
    | Mm_EntrezGene = 192160
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_138660
    | Mm_RefseqProtein = NP_619601
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Cancer susceptibility candidate 3''', also known as '''CASC3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CASC3 cancer susceptibility candidate 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22794| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene is a core component of the [[exon junction complex]] (EJC), a protein complex that is deposited on spliced [[mRNA]]s at exon-exon junctions and functions in [[nonsense-mediated mRNA decay]] (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the [[cytoplasm]], but shuttles into the [[cell nucleus|nucleus]] where it localizes to [[Cell nucleus#Splicing speckles|nuclear speckles]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.<ref name="entrez">{{cite web | title = Entrez Gene: CASC3 cancer susceptibility candidate 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22794| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CASC3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Varis A |title=Targets of gene amplification and overexpression at 17q in gastric cancer |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2625–9 |year= 2002 |pmid= 11980659 |doi= |name-list-format=vanc| author2=Wolf M | author3=Monni O | display-authors=3  | last4=Vakkari  | first4=ML  | last5=Kokkola  | first5=A  | last6=Moskaluk  | first6=C  | last7=Frierson Jr  | first7=H | last8=Powell  | first8=SM  | last9=Knuutila  | first9=S  }}
| citations =
*{{cite journal  | author=Degot S |title=Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer |journal=Oncogene |volume=21 |issue= 28 |pages= 4422–34 |year= 2002 |pmid= 12080473 |doi= 10.1038/sj.onc.1205611  |name-list-format=vanc| author2=Régnier CH  | author3=Wendling C  | display-authors=3  | last4=Chenard  | first4=Marie-Pierre  | last5=Rio  | first5=Marie-Christine  | last6=Tomasetto  | first6=Catherine }}
*{{cite journal  | author=Tomasetto C, Régnier C, Moog-Lutz C, ''et al.'' |title=Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |journal=Genomics |volume=28 |issue= 3 |pages= 367-76 |year= 1996 |pmid= 7490069 |doi= 10.1006/geno.1995.1163 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Varis A, Wolf M, Monni O, ''et al.'' |title=Targets of gene amplification and overexpression at 17q in gastric cancer. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2625-9 |year= 2002 |pmid= 11980659 |doi=  }}
*{{cite journal  | author=Macchi P |title=Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner |journal=J. Neurosci. |volume=23 |issue= 13 |pages= 5778–88 |year= 2003 |pmid= 12843282 |doi=  |name-list-format=vanc| author2=Kroening S | author3=Palacios IM  | display-authors=3  | last4=Baldassa  | first4=S  | last5=Grunewald  | first5=B  | last6=Ambrosino  | first6=C  | last7=Goetze  | first7=B  | last8=Lupas  | first8=A  | last9=St Johnston  | first9=D  }}
*{{cite journal  | author=Degot S, Régnier CH, Wendling C, ''et al.'' |title=Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer. |journal=Oncogene |volume=21 |issue= 28 |pages= 4422-34 |year= 2002 |pmid= 12080473 |doi= 10.1038/sj.onc.1205611 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Palacios IM, Gatfield D, St Johnston D, Izaurralde E |title=An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay |journal=Nature |volume=427 |issue= 6976 |pages= 753–7 |year= 2004 |pmid= 14973490 |doi= 10.1038/nature02351 }}
*{{cite journal  | author=Macchi P, Kroening S, Palacios IM, ''et al.'' |title=Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. |journal=J. Neurosci. |volume=23 |issue= 13 |pages= 5778-88 |year= 2003 |pmid= 12843282 |doi=  }}
*{{cite journal  | author=Degot S |title=Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33702–15 |year= 2004 |pmid= 15166247 |doi= 10.1074/jbc.M402754200 |name-list-format=vanc| author2=Le Hir H  | author3=Alpy F  | display-authors=3  | last4=Kedinger  | first4=V  | last5=Stoll  | first5=I  | last6=Wendling  | first6=C  | last7=Seraphin | first7=B  | last8=Rio  | first8=MC  | last9=Tomasetto  | first9=C }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Palacios IM, Gatfield D, St Johnston D, Izaurralde E |title=An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. |journal=Nature |volume=427 |issue= 6976 |pages= 753-7 |year= 2004 |pmid= 14973490 |doi= 10.1038/nature02351 }}
*{{cite journal  |vauthors=Kim YK, Furic L, Desgroseillers L, Maquat LE |title=Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay |journal=Cell |volume=120 |issue= 2 |pages= 195–208 |year= 2005 |pmid= 15680326 |doi= 10.1016/j.cell.2004.11.050 }}
*{{cite journal | author=Degot S, Le Hir H, Alpy F, ''et al.'' |title=Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33702-15 |year= 2004 |pmid= 15166247 |doi= 10.1074/jbc.M402754200 }}
*{{cite journal  | author=Ballut L |title=The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 10 |pages= 861–9 |year= 2005 |pmid= 16170325 |doi= 10.1038/nsmb990  |name-list-format=vanc| author2=Marchadier B  | author3=Baguet A  | display-authors=3  | last4=Tomasetto  | first4=Catherine  | last5=Séraphin  | first5=Bertrand  | last6=Le Hir  | first6=Hervé }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Tange TØ, Shibuya T, Jurica MS, Moore MJ |title=Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core |journal=RNA |volume=11 |issue= 12 |pages= 1869–83 |year= 2006 |pmid= 16314458 |doi= 10.1261/rna.2155905  | pmc=1370875 }}
*{{cite journal  | author=Kim YK, Furic L, Desgroseillers L, Maquat LE |title=Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. |journal=Cell |volume=120 |issue= 2 |pages= 195-208 |year= 2005 |pmid= 15680326 |doi= 10.1016/j.cell.2004.11.050 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Ballut L, Marchadier B, Baguet A, ''et al.'' |title=The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 10 |pages= 861-9 |year= 2005 |pmid= 16170325 |doi= 10.1038/nsmb990 }}
*{{cite journal  |vauthors=Shibuya T, Tange TØ, Stroupe ME, Moore MJ |title=Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay |journal=RNA |volume=12 |issue= 3 |pages= 360–74 |year= 2006 |pmid= 16495234 |doi= 10.1261/rna.2190706  | pmc=1383576 }}
*{{cite journal  | author=Tange TØ, Shibuya T, Jurica MS, Moore MJ |title=Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. |journal=RNA |volume=11 |issue= 12 |pages= 1869-83 |year= 2006 |pmid= 16314458 |doi= 10.1261/rna.2155905 }}
*{{cite journal  | author=Andersen CB |title=Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA |journal=Science |volume=313 |issue= 5795 |pages= 1968–72 |year= 2006 |pmid= 16931718 |doi= 10.1126/science.1131981  |name-list-format=vanc| author2=Ballut L  | author3=Johansen JS  | display-authors=3  | last4=Chamieh  | first4=H  | last5=Nielsen  | first5=KH  | last6=Oliveira  | first6=CL  | last7=Pedersen  | first7=JS  | last8=Séraphin  | first8=B  | last9=Le Hir  | first9=H }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal | author=Shibuya T, Tange TØ, Stroupe ME, Moore MJ |title=Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. |journal=RNA |volume=12 |issue= 3 |pages= 360-74 |year= 2006 |pmid= 16495234 |doi= 10.1261/rna.2190706 }}
*{{cite journal  | author=Baguet A |title=The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly |journal=J. Cell Sci. |volume=120 |issue= Pt 16 |pages= 2774–84 |year= 2007 |pmid= 17652158 |doi= 10.1242/jcs.009225  |name-list-format=vanc| author2=Degot S  | author3=Cougot N  | display-authors=3  | last4=Bertrand  | first4=E.  | last5=Chenard  | first5=M.-P.  | last6=Wendling  | first6=C.  | last7=Kessler  | first7=P.  | last8=Le Hir  | first8=H.  | last9=Rio  | first9=M.-C. }}
*{{cite journal  | author=Andersen CB, Ballut L, Johansen JS, ''et al.'' |title=Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. |journal=Science |volume=313 |issue= 5795 |pages= 1968-72 |year= 2006 |pmid= 16931718 |doi= 10.1126/science.1131981 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Baguet A, Degot S, Cougot N, ''et al.'' |title=The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly. |journal=J. Cell. Sci. |volume=120 |issue= Pt 16 |pages= 2774-84 |year= 2007 |pmid= 17652158 |doi= 10.1242/jcs.009225 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=22794}}
{{WikiDoc Sources}}
 
 
{{gene-17-stub}}

Latest revision as of 19:28, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein CASC3 is a protein that in humans is encoded by the CASC3 gene.[1][2][3]

Function

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.[3]

References

  1. ↑ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
  2. ↑ Arriola E, Marchio C, Tan DS, Drury SC, Lambros MB, Natrajan R, Rodriguez-Pinilla SM, Mackay A, Tamber N, Fenwick K, Jones C, Dowsett M, Ashworth A, Reis-Filho JS (Apr 2008). "Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines". Lab Invest. 88 (5): 491–503. doi:10.1038/labinvest.2008.19. PMID 18332872.
  3. ↑ 3.0 3.1 "Entrez Gene: CASC3 cancer susceptibility candidate 3".

External links

Further reading


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