ALOX15B: Difference between revisions

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{{Infobox_gene}}
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'''Arachidonate 15-lipoxygenase type II''' is an [[enzyme]] that in humans is encoded by the ''ALOX15B'' [[gene]].<ref name = "Brash_1997">{{cite journal | vauthors = Brash AR, Boeglin WE, Chang MS | title = Discovery of a second 15S-lipoxygenase in humans | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 12 | pages = 6148–52 | date = Jun 1997 | pmid = 9177185 | pmc = 21017 | doi = 10.1073/pnas.94.12.6148 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247| accessdate = }}</ref>  ALOX15B, also known as '''15-lipoxygenase-2''' ('''15-LO-2''' or '''15-LOX-2'''), is distinguished from its related oxygenase, [[ALOX15]] or 15-lipoxygenase-1.
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arachidonate 15-lipoxygenase, type B
| HGNCid = 434
| Symbol = ALOX15B
| AltSymbols =;
| OMIM = 603697
| ECnumber = 
| Homologene = 886
| MGIid = 1098228
| GeneAtlas_image1 = PBB_GE_ALOX15B_206714_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016165 |text = lipoxygenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050473 |text = arachidonate 15-lipoxygenase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0019370 |text = leukotriene biosynthetic process}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0030850 |text = prostate gland development}} {{GNF_GO|id=GO:0030856 |text = regulation of epithelial cell differentiation}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045926 |text = negative regulation of growth}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 247
    | Hs_Ensembl = ENSG00000179593
    | Hs_RefseqProtein = NP_001034219
    | Hs_RefseqmRNA = NM_001039130
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 7883086
    | Hs_GenLoc_end = 7893177
    | Hs_Uniprot = O15296
    | Mm_EntrezGene = 11688
    | Mm_Ensembl = ENSMUSG00000020891
    | Mm_RefseqmRNA = NM_009661
    | Mm_RefseqProtein = NP_033791
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 69000080
    | Mm_GenLoc_end = 69014034
    | Mm_Uniprot = Q3TYK7
  }}
}}
'''Arachidonate 15-lipoxygenase, type B''', also known as '''ALOX15B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and [[12-lipoxygenase]] and 44% amino acid sequence identity to human [[5-lipoxygenase]].<ref name = "Brash_1997"/>  15-LOX-2 converts [[arachidonic acid]] almost exclusively to the ''S'' stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the ''S'' stereoisomer [[15-Hydroxyeicosatetraenoic acid]] by ubiquitous cellular [[peroxidases]]; it metabolizes linoleic acid less effectively, converting this fatty acid to the ''S'' stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the ''S'' stereoisomer of [[13-Hydroxyoctadecadienoic acid]].<ref name = "Brash_1997"/> The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247| accessdate = }}</ref>
}}


==References==
== See also ==
{{reflist|2}}
* [[Arachidonate 15-lipoxygenase]]
==Further reading==
* [[15-hydroxyicosatetraenoic acid]]
* [[ALOX15]]
 
== References ==
{{reflist}}
{{clear}}
 
==External links==
* {{UCSC gene info|ALOX15B}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS | title = Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related | journal = The Journal of Biological Chemistry | volume = 265 | issue = 9 | pages = 5113–20 | date = Mar 1990 | pmid = 2318885 | doi =  }}
| citations =
* {{cite journal | vauthors = Kilty I, Logan A, Vickers PJ | title = Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase | journal = European Journal of Biochemistry / FEBS | volume = 266 | issue = 1 | pages = 83–93 | date = Nov 1999 | pmid = 10542053 | doi = 10.1046/j.1432-1327.1999.00818.x }}
*{{cite journal | author=Sigal E, Grunberger D, Highland E, ''et al.'' |title=Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related. |journal=J. Biol. Chem. |volume=265 |issue= 9 |pages= 5113-20 |year= 1990 |pmid= 2318885 |doi=  }}
* {{cite journal | vauthors = Krieg P, Marks F, Fürstenberger G | title = A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression | journal = Genomics | volume = 73 | issue = 3 | pages = 323–30 | date = May 2001 | pmid = 11350124 | doi = 10.1006/geno.2001.6519 }}
*{{cite journal | author=Brash AR, Boeglin WE, Chang MS |title=Discovery of a second 15S-lipoxygenase in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6148-52 |year= 1997 |pmid= 9177185 |doi=  }}
* {{cite journal | vauthors = Tang S, Bhatia B, Maldonado CJ, Yang P, Newman RA, Liu J, Chandra D, Traag J, Klein RD, Fischer SM, Chopra D, Shen J, Zhau HE, Chung LW, Tang DG | title = Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 16189–201 | date = May 2002 | pmid = 11839751 | doi = 10.1074/jbc.M111936200 }}
*{{cite journal  | author=Kilty I, Logan A, Vickers PJ |title=Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. |journal=Eur. J. Biochem. |volume=266 |issue= 1 |pages= 83-93 |year= 2000 |pmid= 10542053 |doi= }}
* {{cite journal | vauthors = Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM | title = Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398 | journal = Neoplasia | volume = 5 | issue = 2 | pages = 121–7 | year = 2003 | pmid = 12659684 | pmc = 1502398 | doi = 10.1016/s1476-5586(03)80003-9 }}
*{{cite journal | author=Krieg P, Marks F, Fürstenberger G |title=A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. |journal=Genomics |volume=73 |issue= 3 |pages= 323-30 |year= 2001 |pmid= 11350124 |doi= 10.1006/geno.2001.6519 }}
* {{cite journal | vauthors = Bhatia B, Maldonado CJ, Tang S, Chandra D, Klein RD, Chopra D, Shappell SB, Yang P, Newman RA, Tang DG | title = Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants | journal = The Journal of Biological Chemistry | volume = 278 | issue = 27 | pages = 25091–100 | date = Jul 2003 | pmid = 12704195 | doi = 10.1074/jbc.M301920200 }}
*{{cite journal | author=Tang S, Bhatia B, Maldonado CJ, ''et al.'' |title=Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16189-201 |year= 2002 |pmid= 11839751 |doi= 10.1074/jbc.M111936200 }}
* {{cite journal | vauthors = Tang S, Bhatia B, Zhou J, Maldonado CJ, Chandra D, Kim E, Fischer SM, Butler AP, Friedman SL, Tang DG | title = Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells | journal = Oncogene | volume = 23 | issue = 41 | pages = 6942–53 | date = Sep 2004 | pmid = 15247906 | doi = 10.1038/sj.onc.1207913 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal  | author=Xu XC, Shappell SB, Liang Z, ''et al.'' |title=Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. |journal=Neoplasia |volume=5 |issue= 2 |pages= 121-7 |year= 2003 |pmid= 12659684 |doi= }}
* {{cite journal | vauthors = Limor R, Kaplan M, Sawamura T, Sharon O, Keidar S, Weisinger G, Knoll E, Naidich M, Stern N | title = Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway | journal = American Journal of Hypertension | volume = 18 | issue = 3 | pages = 299–307 | date = Mar 2005 | pmid = 15797645 | doi = 10.1016/j.amjhyper.2004.09.008 }}
*{{cite journal | author=Bhatia B, Maldonado CJ, Tang S, ''et al.'' |title=Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 25091-100 |year= 2003 |pmid= 12704195 |doi= 10.1074/jbc.M301920200 }}
* {{cite journal | vauthors = Subbarayan V, Xu XC, Kim J, Yang P, Hoque A, Sabichi AL, Llansa N, Mendoza G, Logothetis CJ, Newman RA, Lippman SM, Menter DG | title = Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia | journal = Neoplasia | volume = 7 | issue = 3 | pages = 280–93 | date = Mar 2005 | pmid = 15799828 | pmc = 1501140 | doi = 10.1593/neo.04457 }}
*{{cite journal | author=Tang S, Bhatia B, Zhou J, ''et al.'' |title=Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. |journal=Oncogene |volume=23 |issue= 41 |pages= 6942-53 |year= 2004 |pmid= 15247906 |doi= 10.1038/sj.onc.1207913 }}
* {{cite journal | vauthors = Jiang WG, Watkins G, Douglas-Jones A, Mansel RE | title = Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer | journal = Prostaglandins, Leukotrienes, and Essential Fatty Acids | volume = 74 | issue = 4 | pages = 235–45 | date = Apr 2006 | pmid = 16556493 | doi = 10.1016/j.plefa.2006.01.009 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Subbarayan V, Krieg P, Hsi LC, Kim J, Yang P, Sabichi AL, Llansa N, Mendoza G, Logothetis CJ, Newman RA, Lippman SM, Menter DG | title = 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma | journal = Oncogene | volume = 25 | issue = 44 | pages = 6015–25 | date = Sep 2006 | pmid = 16682954 | doi = 10.1038/sj.onc.1209617 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Lesueur F, Bouadjar B, Lefèvre C, Jobard F, Audebert S, Lakhdar H, Martin L, Tadini G, Karaduman A, Emre S, Saker S, Lathrop M, Fischer J | title = Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13 | journal = The Journal of Investigative Dermatology | volume = 127 | issue = 4 | pages = 829–34 | date = Apr 2007 | pmid = 17139268 | doi = 10.1038/sj.jid.5700640 }}
*{{cite journal | author=Limor R, Kaplan M, Sawamura T, ''et al.'' |title=Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway. |journal=Am. J. Hypertens. |volume=18 |issue= 3 |pages= 299-307 |year= 2005 |pmid= 15797645 |doi= 10.1016/j.amjhyper.2004.09.008 }}
*{{cite journal | author=Subbarayan V, Xu XC, Kim J, ''et al.'' |title=Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. |journal=Neoplasia |volume=7 |issue= 3 |pages= 280-93 |year= 2005 |pmid= 15799828 |doi= 10.1593/neo.04457 }}
*{{cite journal | author=Jiang WG, Watkins G, Douglas-Jones A, Mansel RE |title=Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=74 |issue= 4 |pages= 235-45 |year= 2006 |pmid= 16556493 |doi= 10.1016/j.plefa.2006.01.009 }}
*{{cite journal | author=Subbarayan V, Krieg P, Hsi LC, ''et al.'' |title=15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. |journal=Oncogene |volume=25 |issue= 44 |pages= 6015-25 |year= 2006 |pmid= 16682954 |doi= 10.1038/sj.onc.1209617 }}
*{{cite journal | author=Lesueur F, Bouadjar B, Lefèvre C, ''et al.'' |title=Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. |journal=J. Invest. Dermatol. |volume=127 |issue= 4 |pages= 829-34 |year= 2007 |pmid= 17139268 |doi= 10.1038/sj.jid.5700640 }}
}}
{{refend}}
{{refend}}


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{{Monooxygenases}}
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[[Category:EC 1.13.11]]

Latest revision as of 02:18, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[1][2] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

Function

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.[1] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.[1] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

See also

References

  1. ↑ 1.0 1.1 1.2 Brash AR, Boeglin WE, Chang MS (Jun 1997). "Discovery of a second 15S-lipoxygenase in humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6148–52. doi:10.1073/pnas.94.12.6148. PMC 21017. PMID 9177185.
  2. ↑ 2.0 2.1 "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B".

External links

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=ALOX15B&oldid=1418004"