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{{Infobox_gene}}
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{{Infobox protein family
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| Symbol = Med31
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| Name = Med31
| update_protein_box = yes
| image =
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| width =
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| caption = structure of the mediator submodule med7n/31
| Pfam = PF05669
| Pfam_clan = 
| InterPro = IPR008831
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =  
| OPM family =  
| OPM protein =  
| CAZy =  
| CDD =  
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'''Mediator of RNA polymerase II transcription subunit 31''' is a protein in humans  encoded by the ''MED31'' [[gene]].<ref name="pmid10810093">{{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–713 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51003| accessdate = }}</ref> It represents subunit Med31 of the [[Mediator (coactivator)|Mediator complex]]. The family contains the ''Saccharomyces cerevisiae'' SOH1 [[Homology (biology)|homologues]]. SOH1 is responsible for the [[Repressor|repression]] of [[temperature]] sensitive [[cell growth|growth]] of the HPR1 [[mutant]] <ref name="pmid7982575">{{cite journal |vauthors=Fan HY, Klein HL | title = Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae | journal = Genetics | volume = 137 | issue = 4 | pages = 945–56 |date=August 1994 | pmid = 7982575 | pmc = 1206071 | doi = | url = }}</ref> and has been found to be a component of the RNA polymerase II [[transcription (genetics)|transcription]] complex. SOH1 not only interacts with factors involved in DNA repair, but [[Transcription (genetics)|transcription]] as well. Thus, the SOH1 protein may serve to couple these two processes.<ref name="pmid8849885">{{cite journal |vauthors=Fan HY, Cheng KK, Klein HL | title = Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae | journal = Genetics | volume = 142 | issue = 3 | pages = 749–59 |date=March 1996 | pmid = 8849885 | pmc = 1207016 | doi = | url = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)
| HGNCid = 24260
| Symbol = MED31
| AltSymbols =; 3110004H13Rik; CGI-125; FLJ27436; Soh1
| OMIM =
| ECnumber =
| Homologene = 9368
| MGIid = 1914529
| GeneAtlas_image1 = PBB_GE_MED31_219318_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51003
    | Hs_Ensembl = ENSG00000108590
    | Hs_RefseqProtein = NP_057144
    | Hs_RefseqmRNA = NM_016060
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 6487359
    | Hs_GenLoc_end = 6495678
    | Hs_Uniprot = Q9Y3C7
    | Mm_EntrezGene = 67279
    | Mm_Ensembl = ENSMUSG00000020801
    | Mm_RefseqmRNA = NM_026068
    | Mm_RefseqProtein = NP_080344
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 72027919
    | Mm_GenLoc_end = 72031787
    | Mm_Uniprot = Q9CXU1
  }}
}}
'''Mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)''', also known as '''MED31''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51003| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi=  }}
*{{cite journal  | author=Gu W |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1  |name-list-format=vanc| author2=Malik S  | author3=Ito M | display-authors=3  | last4=Yuan  | first4=Chao-Xing  | last5=Fondell | first5=Joseph D  | last6=Zhang  | first6=Xiaolong  | last7=Martinez  | first7=Ernest  | last8=Qin  | first8=Jun  | last9=Roeder  | first9=Robert G }}
*{{cite journal | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
*{{cite journal  | author=Suzuki H |title=Protein-protein interaction panel using mouse full-length cDNAs |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–1765 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163  |name-list-format=vanc| author2=Fukunishi Y  | author3=Kagawa I  | display-authors=3  | last4=Saito  | first4=R  | last5=Oda  | first5=H  | last6=Endo  | first6=T  | last7=Kondo  | first7=S  | last8=Bono  | first8=H  | last9=Okazaki  | first9=Y }}
*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
*{{cite journal  | author=Brower CS |title=Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10353–10358 |year= 2002 |pmid= 12149480 |doi= 10.1073/pnas.162424199 | pmc=124918  |name-list-format=vanc| author2=Sato S  | author3=Tomomori-Sato C  | display-authors=3  | last4=Kamura  | first4=T  | last5=Pause  | first5=A  | last6=Stearman  | first6=R  | last7=Klausner  | first7=RD  | last8=Malik  | first8=S  | last9=Lane  | first9=WS }}
*{{cite journal  | author=Brower CS, Sato S, Tomomori-Sato C, ''et al.'' |title=Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10353-8 |year= 2002 |pmid= 12149480 |doi= 10.1073/pnas.162424199 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sato S |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123–15127 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 |name-list-format=vanc| author2=Tomomori-Sato C  | author3=Banks CA  | display-authors=3  | last4=Sorokina  | first4=I  | last5=Parmely  | first5=TJ  | last6=Kong  | first6=SE  | last7=Jin  | first7=J  | last8=Cai  | first8=Y  | last9=Lane  | first9=WS }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123-7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 }}
*{{cite journal  | author=Sato S |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–49674 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 |name-list-format=vanc| author2=Tomomori-Sato C  | author3=Banks CA  | display-authors=3  | last4=Parmely  | first4=TJ  | last5=Sorokina  | first5=I  | last6=Brower  | first6=CS  | last7=Conaway  | first7=RC  | last8=Conaway  | first8=JW }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal  | author=Tomomori-Sato C |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–5851 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 |name-list-format=vanc| author2=Sato S  | author3=Parmely TJ  | display-authors=3  | last4=Banks  | first4=CA  | last5=Sorokina  | first5=I  | last6=Florens  | first6=L  | last7=Zybailov  | first7=B  | last8=Washburn  | first8=MP  | last9=Brower  | first9=CS }}
*{{cite journal  | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Sato S |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–691 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 |name-list-format=vanc| author2=Tomomori-Sato C  | author3=Parmely TJ  | display-authors=3  | last4=Florens  | first4=Laurence  | last5=Zybailov  | first5=Boris  | last6=Swanson  | first6=Selene K  | last7=Banks  | first7=Charles A.S  | last8=Jin  | first8=Jingji  | last9=Cai  | first9=Yong }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Parmely TJ, ''et al.'' |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685-91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }}
*{{cite journal  | author=Goehler H |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–865 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 |name-list-format=vanc| author2=Lalowski M  | author3=Stelzl U  | display-authors=3  | last4=Waelter  | first4=Stephanie  | last5=Stroedicke  | first5=Martin  | last6=Worm  | first6=Uwe  | last7=Droege  | first7=Anja  | last8=Lindenberg  | first8=Katrin S.  | last9=Knoblich  | first9=Maria }}
*{{cite journal  | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stelzl U |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–968 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |name-list-format=vanc| author2=Worm U  | author3=Lalowski M  | display-authors=3  | last4=Haenig  | first4=Christian  | last5=Brembeck  | first5=Felix H.  | last6=Goehler  | first6=Heike  | last7=Stroedicke  | first7=Martin  | last8=Zenkner  | first8=Martina  | last9=Schoenherr  | first9=Anke }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
}}
{{refend}}
{{refend}}


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{{InterPro content|IPR008831}}
 
[[Category:Protein families]]
 
 
{{gene-17-stub}}

Latest revision as of 06:21, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
Med31
Identifiers
SymbolMed31
PfamPF05669
InterProIPR008831

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene.[1][2] It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant [3] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.[4]


References

  1. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  2. ↑ "Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)".
  3. ↑ Fan HY, Klein HL (August 1994). "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae". Genetics. 137 (4): 945–56. PMC 1206071. PMID 7982575.
  4. ↑ Fan HY, Cheng KK, Klein HL (March 1996). "Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae". Genetics. 142 (3): 749–59. PMC 1207016. PMID 8849885.

Further reading


This article incorporates text from the public domain Pfam and InterPro: IPR008831


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