RPH3AL: Difference between revisions

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{{Infobox_gene}}
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'''Rab effector Noc2''' is a [[protein]] that in humans is encoded by the ''RPH3AL'' [[gene]].<ref name="pmid10395805">{{cite journal |vauthors=Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C | title = Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus | journal = Genomics | volume = 59 | issue = 1 | pages = 97–101 |date=Aug 1999 | pmid = 10395805 | pmc =  | doi = 10.1006/geno.1999.5864 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9501| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Rabphilin 3A-like (without C2 domains)
| HGNCid = 10296
| Symbol = RPH3AL
| AltSymbols =; NOC2
| OMIM = 604881
| ECnumber =
| Homologene = 5078
| MGIid = 1923492
  | GeneAtlas_image1 = PBB_GE_RPH3AL_221614_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017137 |text = Rab GTPase binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006887 |text = exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9501
    | Hs_Ensembl = ENSG00000181031
    | Hs_RefseqProtein = NP_008918
    | Hs_RefseqmRNA = NM_006987
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 62293
    | Hs_GenLoc_end = 202888
    | Hs_Uniprot = 
    | Mm_EntrezGene = 380714
    | Mm_Ensembl = ENSMUSG00000020847
    | Mm_RefseqmRNA = XM_358900
    | Mm_RefseqProtein = XP_358900
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 75648332
    | Mm_GenLoc_end = 75742086
    | Mm_Uniprot = 
  }}
}}
'''Rabphilin 3A-like (without C2 domains)''', also known as '''RPH3AL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9501| accessdate = }}</ref>
 
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==Interactions==
RPH3AL has been shown to [[Protein-protein interaction|interact]] with [[RAB27A]].<ref name=pmid14593078>{{cite journal |last=Cheviet |first=Séverine |authorlink= |author2=Coppola Thierry |author3=Haynes Lee P |author4=Burgoyne Robert D |author5=Regazzi Romano  |date=Jan 2004 |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis |journal=Mol. Endocrinol. |volume=18 |issue=1 |pages=117–26 |publisher= |location = United States| issn = 0888-8809| pmid = 14593078 |doi = 10.1210/me.2003-0300 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12578829>{{cite journal |last=Fukuda |first=Mitsunori |date=Apr 2003 |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 |journal=J. Biol. Chem. |volume=278 |issue=17 |pages=15373–80 |publisher= |location = United States| issn = 0021-9258| pmid = 12578829 |doi = 10.1074/jbc.M212341200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kotake K, Ozaki N, Mizuta M, ''et al.'' |title=Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29407-10 |year= 1997 |pmid= 9367993 |doi=  }}
*{{cite journal  | author=Kotake K |title=Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29407–10 |year= 1997 |pmid= 9367993 |doi=10.1074/jbc.272.47.29407 |name-list-format=vanc| author2=Ozaki N | author3=Mizuta M  | display-authors=3 | last4=Sekiya  | first4=S  | last5=Inagaki  | first5=N  | last6=Seino  | first6=S  }}
*{{cite journal | author=Smith JS, Tachibana I, Allen C, ''et al.'' |title=Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus. |journal=Genomics |volume=59 |issue= 1 |pages= 97-101 |year= 1999 |pmid= 10395805 |doi= 10.1006/geno.1999.5864 }}
*{{cite journal  | author=Fenster SD |title=Piccolo, a presynaptic zinc finger protein structurally related to bassoon |journal=Neuron |volume=25 |issue= 1 |pages= 203–14 |year= 2000 |pmid= 10707984 |doi=10.1016/S0896-6273(00)80883-1  |name-list-format=vanc| author2=Chung WJ  | author3=Zhai R  | display-authors=3  | last4=Cases-Langhoff  | first4=Claudia  | last5=Voss  | first5=Britta  | last6=Garner  | first6=Abigail M  | last7=Kaempf  | first7=Udo  | last8=Kindler  | first8=Stefan  | last9=Gundelfinger  | first9=Eckart D }}
*{{cite journal  | author=Fenster SD, Chung WJ, Zhai R, ''et al.'' |title=Piccolo, a presynaptic zinc finger protein structurally related to bassoon. |journal=Neuron |volume=25 |issue= 1 |pages= 203-14 |year= 2000 |pmid= 10707984 |doi=  }}
*{{cite journal  |vauthors=Haynes LP, Evans GJ, Morgan A, Burgoyne RD |title=A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9726–32 |year= 2001 |pmid= 11134008 |doi= 10.1074/jbc.M006959200 }}
*{{cite journal  | author=Haynes LP, Evans GJ, Morgan A, Burgoyne RD |title=A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9726-32 |year= 2001 |pmid= 11134008 |doi= 10.1074/jbc.M006959200 }}
*{{cite journal  | author=Goi T |title=Mutations of rabphillin-3A-like gene in colorectal cancers |journal=Oncol. Rep. |volume=9 |issue= 6 |pages= 1189–92 |year= 2003 |pmid= 12375017 |doi= 10.3892/or.9.6.1189|name-list-format=vanc| author2=Takeuchi K  | author3=Katayama K  | display-authors=3  | last4=Hirose  | first4=K  | last5=Yamaguchi  | first5=A }}
*{{cite journal  | author=Goi T, Takeuchi K, Katayama K, ''et al.'' |title=Mutations of rabphillin-3A-like gene in colorectal cancers. |journal=Oncol. Rep. |volume=9 |issue= 6 |pages= 1189-92 |year= 2003 |pmid= 12375017 |doi=  }}
*{{cite journal  | author=Milkereit P |title=A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 4072–81 |year= 2003 |pmid= 12446671 |doi= 10.1074/jbc.M208898200 |name-list-format=vanc| author2=Strauss D  | author3=Bassler J  | display-authors=3  | last4=Gadal  | first4=O  | last5=Kühn  | first5=H  | last6=Schütz  | first6=S  | last7=Gas  | first7=N  | last8=Lechner  | first8=J  | last9=Hurt  | first9=E }}
*{{cite journal  | author=Milkereit P, Strauss D, Bassler J, ''et al.'' |title=A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 4072-81 |year= 2003 |pmid= 12446671 |doi= 10.1074/jbc.M208898200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373–80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 }}
*{{cite journal  | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373-80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 }}
*{{cite journal  | author=Cardoso C |title=Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3 |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918–30 |year= 2003 |pmid= 12621583 |doi=10.1086/374320  | pmc=1180354  |name-list-format=vanc| author2=Leventer RJ  | author3=Ward HL  | display-authors=3  | last4=Toyo-Oka  | first4=Kazuhito  | last5=Chung  | first5=June  | last6=Gross  | first6=Alyssa  | last7=Martin  | first7=Christa L.  | last8=Allanson  | first8=Judith  | last9=Pilz  | first9=Daniela T. }}
*{{cite journal  | author=Cardoso C, Leventer RJ, Ward HL, ''et al.'' |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918-30 |year= 2003 |pmid= 12621583 |doi=  }}
*{{cite journal  | author=Cheviet S |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis |journal=Mol. Endocrinol. |volume=18 |issue= 1 |pages= 117–26 |year= 2004 |pmid= 14593078 |doi= 10.1210/me.2003-0300 |name-list-format=vanc| author2=Coppola T  | author3=Haynes LP  | display-authors=3  | last4=Burgoyne  | first4=RD  | last5=Regazzi  | first5=R }}
*{{cite journal  | author=Cheviet S, Coppola T, Haynes LP, ''et al.'' |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. |journal=Mol. Endocrinol. |volume=18 |issue= 1 |pages= 117-26 |year= 2004 |pmid= 14593078 |doi= 10.1210/me.2003-0300 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Manabe S |title=Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 1 |pages= 218–25 |year= 2004 |pmid= 15003533 |doi= 10.1016/j.bbrc.2004.02.026 |name-list-format=vanc| author2=Nishimura N  | author3=Yamamoto Y  | display-authors=3  | last4=Kitamura  | first4=Hiroko  | last5=Morimoto  | first5=Shinya  | last6=Imai  | first6=Mayu  | last7=Nagahiro  | first7=Shinji  | last8=Seino  | first8=Susumu  | last9=Sasaki  | first9=Takuya }}
*{{cite journal  | author=Manabe S, Nishimura N, Yamamoto Y, ''et al.'' |title=Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 1 |pages= 218-25 |year= 2004 |pmid= 15003533 |doi= 10.1016/j.bbrc.2004.02.026 }}
*{{cite journal  | author=Matsumoto M |title=Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 22 |pages= 8313–8 |year= 2004 |pmid= 15159548 |doi= 10.1073/pnas.0306709101 | pmc=420391  |name-list-format=vanc| author2=Miki T  | author3=Shibasaki T  | display-authors=3  | last4=Kawaguchi  | first4=M  | last5=Shinozaki  | first5=H  | last6=Nio  | first6=J  | last7=Saraya  | first7=A  | last8=Koseki  | first8=H  | last9=Miyazaki  | first9=M }}
*{{cite journal  | author=Matsumoto M, Miki T, Shibasaki T, ''et al.'' |title=Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 22 |pages= 8313-8 |year= 2004 |pmid= 15159548 |doi= 10.1073/pnas.0306709101 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=1. Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U. |title=Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma |journal=Frontiers in Bioscience |volume=13 |issue= 1|pages= 1050–1061 |year= 2008 |pmid= 17981610 |doi= 10.2741/2742 | pmc=2667692 }}
 
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Revision as of 09:27, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.[1][2]

Interactions

RPH3AL has been shown to interact with RAB27A.[3][4]

References

  1. ↑ Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (Aug 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.
  2. ↑ "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".
  3. ↑ Cheviet, Séverine; Coppola Thierry; Haynes Lee P; Burgoyne Robert D; Regazzi Romano (Jan 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. United States. 18 (1): 117–26. doi:10.1210/me.2003-0300. ISSN 0888-8809. PMID 14593078.
  4. ↑ Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. United States. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.

Further reading



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