CDK5RAP3: Difference between revisions

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'''CDK5 regulatory subunit-associated protein 3''' is a [[protein]] that in humans is encoded by the ''CDK5RAP3'' [[gene]].<ref name="pmid10721722">{{cite journal | vauthors = Ching YP, Qi Z, Wang JH | title = Cloning of three novel neuronal Cdk5 activator binding proteins | journal = Gene | volume = 242 | issue = 1–2 | pages = 285–94 |date=Apr 2000 | pmid = 10721722 | pmc =  | doi =10.1016/S0378-1119(99)00499-0  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80279| accessdate = }}</ref>
Neuronal CDC2-like [[kinase]], which is involved in the regulation of [[neuron]]al [[Cellular differentiation|differentiation]], is composed of a catalytic subunit, [[CDK5]], and an activating subunit, [[CDK5R1|p25NCK5A]]. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates [[cell proliferation]].<ref name="entrez"/>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | vauthors=Wang X, Ching YP, Lam WH |title=Identification of a common protein association region in the neuronal Cdk5 activator |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31763–9 |year= 2000 |pmid= 10915792 |doi= 10.1074/jbc.M004358200 |display-authors=etal}}
*{{cite journal  | vauthors=Ching YP, Pang AS, Lam WH |title=Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15237–40 |year= 2002 |pmid= 11882646 |doi= 10.1074/jbc.C200032200 |display-authors=etal}}
*{{cite journal  | vauthors=Chen J, Liu B, Liu Y |title=A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 1 |pages= 161–6 |year= 2002 |pmid= 12054757 |doi= 10.1016/S0006-291X(02)00446-1 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Xie YH, He XH, Tang YT |title=Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein |journal=Cell Res. |volume=13 |issue= 2 |pages= 83–91 |year= 2003 |pmid= 12737517 |doi= 10.1038/sj.cr.7290153 |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | vauthors=Cen H, Zheng S, Fang YM |title=Induction of HSF1 expression is associated with sporadic colorectal cancer |journal=World J. Gastroenterol. |volume=10 |issue= 21 |pages= 3122–6 |year= 2004 |pmid= 15457556 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Jiang H, Luo S, Li H |title=Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint |journal=J. Biol. Chem. |volume=280 |issue= 21 |pages= 20651–9 |year= 2005 |pmid= 15790566 |doi= 10.1074/jbc.M413431200 }}
*{{cite journal  | vauthors=Yin X, Warner DR, Roberts EA |title=Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 |journal=Int. J. Mol. Med. |volume=16 |issue= 2 |pages= 251–6 |year= 2005 |pmid= 16012757 |doi=  10.3892/ijmm.16.2.251|display-authors=etal}}
*{{cite journal  | vauthors=Wang J, He X, Luo Y, Yarbrough WG |title=A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2 |journal=Biochem. J. |volume=393 |issue= Pt 2 |pages= 489–501 |year= 2006 |pmid= 16173922 |doi= 10.1042/BJ20050960  | pmc=1360699 }}
*{{cite journal  | vauthors=Kim E, Chen F, Wang CC, Harrison LE |title=CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation |journal=Int. J. Oncol. |volume=28 |issue= 1 |pages= 191–4 |year= 2006 |pmid= 16327995 |doi=  10.3892/ijo.28.1.191}}
*{{cite journal  | vauthors=Camargo LM, Collura V, Rain JC |title=Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia |journal=Mol. Psychiatry |volume=12 |issue= 1 |pages= 74–86 |year= 2007 |pmid= 17043677 |doi= 10.1038/sj.mp.4001880 |display-authors=etal}}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 |display-authors=etal}}
*{{cite journal  | vauthors=Stav D, Bar I, Sandbank J |title=Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma |journal=Int. J. Biol. Markers |volume=22 |issue= 2 |pages= 108–13 |year= 2007 |pmid= 17549666 |doi=  }}
*{{cite journal  | vauthors=Wang J, An H, Mayo MW |title=LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB |journal=Cancer Cell |volume=12 |issue= 3 |pages= 239–51 |year= 2007 |pmid= 17785205 |doi= 10.1016/j.ccr.2007.07.002 |display-authors=etal}}
}}
{{refend}}
==External links==
* {{UCSC gene info|CDK5RAP3}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = CDK5 regulatory subunit associated protein 3
| HGNCid = 18673
| Symbol = CDK5RAP3
| AltSymbols =; C53; HSF-27; IC53; MST016; OK/SW-cl.114
| OMIM = 608202
| ECnumber = 
| Homologene = 12718
| MGIid = 1933126
| GeneAtlas_image1 = PBB_GE_CDK5RAP3_218740_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042808 |text = neuronal Cdc2-like kinase binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0045664 |text = regulation of neuron differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80279
    | Hs_Ensembl = ENSG00000108465
    | Hs_RefseqProtein = NP_079473
    | Hs_RefseqmRNA = NM_025197
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43403521
    | Hs_GenLoc_end = 43414099
    | Hs_Uniprot = Q96JB5
    | Mm_EntrezGene = 80280
    | Mm_Ensembl = ENSMUSG00000018669
    | Mm_RefseqmRNA = NM_030248
    | Mm_RefseqProtein = NP_084524
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96723516
    | Mm_GenLoc_end = 96732586
    | Mm_Uniprot = Q3TSS9
  }}
}}
'''CDK5 regulatory subunit associated protein 3''', also known as '''CDK5RAP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80279| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.<ref name="entrez">{{cite web | title = Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80279| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Ching YP, Qi Z, Wang JH |title=Cloning of three novel neuronal Cdk5 activator binding proteins. |journal=Gene |volume=242 |issue= 1-2 |pages= 285-94 |year= 2000 |pmid= 10721722 |doi=  }}
*{{cite journal  | author=Wang X, Ching YP, Lam WH, ''et al.'' |title=Identification of a common protein association region in the neuronal Cdk5 activator. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31763-9 |year= 2000 |pmid= 10915792 |doi= 10.1074/jbc.M004358200 }}
*{{cite journal  | author=Ching YP, Pang AS, Lam WH, ''et al.'' |title=Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15237-40 |year= 2002 |pmid= 11882646 |doi= 10.1074/jbc.C200032200 }}
*{{cite journal  | author=Chen J, Liu B, Liu Y, ''et al.'' |title=A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 1 |pages= 161-6 |year= 2002 |pmid= 12054757 |doi= 10.1016/S0006-291X(02)00446-1 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Xie YH, He XH, Tang YT, ''et al.'' |title=Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. |journal=Cell Res. |volume=13 |issue= 2 |pages= 83-91 |year= 2003 |pmid= 12737517 |doi= 10.1038/sj.cr.7290153 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Cen H, Zheng S, Fang YM, ''et al.'' |title=Induction of HSF1 expression is associated with sporadic colorectal cancer. |journal=World J. Gastroenterol. |volume=10 |issue= 21 |pages= 3122-6 |year= 2004 |pmid= 15457556 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Jiang H, Luo S, Li H |title=Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. |journal=J. Biol. Chem. |volume=280 |issue= 21 |pages= 20651-9 |year= 2005 |pmid= 15790566 |doi= 10.1074/jbc.M413431200 }}
*{{cite journal  | author=Yin X, Warner DR, Roberts EA, ''et al.'' |title=Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. |journal=Int. J. Mol. Med. |volume=16 |issue= 2 |pages= 251-6 |year= 2005 |pmid= 16012757 |doi=  }}
*{{cite journal  | author=Wang J, He X, Luo Y, Yarbrough WG |title=A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. |journal=Biochem. J. |volume=393 |issue= Pt 2 |pages= 489-501 |year= 2006 |pmid= 16173922 |doi= 10.1042/BJ20050960 }}
*{{cite journal  | author=Kim E, Chen F, Wang CC, Harrison LE |title=CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. |journal=Int. J. Oncol. |volume=28 |issue= 1 |pages= 191-4 |year= 2006 |pmid= 16327995 |doi=  }}
*{{cite journal  | author=Camargo LM, Collura V, Rain JC, ''et al.'' |title=Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. |journal=Mol. Psychiatry |volume=12 |issue= 1 |pages= 74-86 |year= 2007 |pmid= 17043677 |doi= 10.1038/sj.mp.4001880 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Stav D, Bar I, Sandbank J |title=Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. |journal=Int. J. Biol. Markers |volume=22 |issue= 2 |pages= 108-13 |year= 2007 |pmid= 17549666 |doi=  }}
*{{cite journal  | author=Wang J, An H, Mayo MW, ''et al.'' |title=LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. |journal=Cancer Cell |volume=12 |issue= 3 |pages= 239-51 |year= 2007 |pmid= 17785205 |doi= 10.1016/j.ccr.2007.07.002 }}
}}
{{refend}}


{{protein-stub}}
{{gene-17-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:29, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.[1][2]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.[2]

References

  1. ↑ Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
  2. ↑ 2.0 2.1 "Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3".

Further reading

External links


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