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{{Infobox_gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''CpG-binding protein''' (CGBP) also known as '''CXXC-type zinc finger protein 1''' (CXXC1) or '''PHD finger and CXXC domain-containing protein 1''' (PCCX1) is a [[protein]] that in humans is encoded by the ''CXXC1'' [[gene]].<ref name="pmid10799292">{{cite journal |vauthors=Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T | title = PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis | journal = Biochem Biophys Res Commun | volume = 271 | issue = 2 | pages = 305–310 |date=Jun 2000 | pmid = 10799292 | pmc =  | doi = 10.1006/bbrc.2000.2614 }}</ref><ref name="pmid10688657">{{cite journal |vauthors=Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG | title = Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1 | journal = Mol Cell Biol | volume = 20 | issue = 6 | pages = 2108–2121 |date=Mar 2000 | pmid = 10688657 | pmc = 110827 | doi =10.1128/MCB.20.6.2108-2121.2000 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30827| accessdate = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = CXXC finger 1 (PHD domain)
| HGNCid = 24343
| Symbol = CXXC1
| AltSymbols =; SPP1; 2410002I16Rik; 5830420C16Rik; CFP1; CGBP; HsT2645; PCCX1; PHF18; hCGBP
| OMIM = 609150
| ECnumber = 
| Homologene = 32221
| MGIid = 1921572
| GeneAtlas_image1 = PBB_GE_CXXC1_48580_at_tn.png
| GeneAtlas_image2 = PBB_GE_CXXC1_218058_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0045322 |text = unmethylated CpG binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016363 |text = nuclear matrix}} {{GNF_GO|id=GO:0016607 |text = nuclear speck}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30827
    | Hs_Ensembl = ENSG00000154832
    | Hs_RefseqProtein = NP_055408
    | Hs_RefseqmRNA = NM_014593
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 46062717
    | Hs_GenLoc_end = 46068690
    | Hs_Uniprot = Q9P0U4
    | Mm_EntrezGene = 74322
    | Mm_Ensembl = ENSMUSG00000024560
    | Mm_RefseqmRNA = NM_028868
    | Mm_RefseqProtein = NP_083144
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 74342536
    | Mm_GenLoc_end = 74346574
    | Mm_Uniprot = Q3UIZ4
  }}
}}
'''CXXC finger 1 (PHD domain)''', also known as '''CXXC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30827| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize [[CpG site|CpG]] sequences and regulate [[gene expression]].<ref name="pmid10688657"/>
{{PBB_Summary
| section_title =
| summary_text = Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30827| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CXXC1}}
* {{UCSC gene info|SPP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Wiemann S |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–435 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072  |name-list-format=vanc| author2=Weil B  | author3=Wellenreuther R  | display-authors=3  | last4=Gassenhuber  | first4=J  | last5=Glassl | first5=S | last6=Ansorge  | first6=W  | last7=Böcher  | first7=M  | last8=Blöcker  | first8=H  | last9=Bauersachs  | first9=S }}
| citations =
*{{cite journal  | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–292 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732  |name-list-format=vanc| author2=Wellenreuther R  | author3=Poustka A  | display-authors=3  | last4=Pepperkok  | first4=R  | last5=Wiemann  | first5=S }}
*{{cite journal  | author=Voo KS, Carlone DL, Jacobsen BM, ''et al.'' |title=Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2108-21 |year= 2000 |pmid= 10688657 |doi= }}
*{{cite journal  |vauthors=Lee JH, Voo KS, Skalnik DG |title=Identification and characterization of the DNA binding domain of CpG-binding protein |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44669–44676 |year= 2002 |pmid= 11572867 |doi= 10.1074/jbc.M107179200 }}
*{{cite journal | author=Fujino T, Hasegawa M, Shibata S, ''et al.'' |title=PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 2 |pages= 305-10 |year= 2000 |pmid= 10799292 |doi= 10.1006/bbrc.2000.2614 }}
*{{cite journal  |vauthors=Carlone DL, Skalnik DG |title=CpG binding protein is crucial for early embryonic development |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7601–7606 |year= 2001 |pmid= 11604496 |doi= 10.1128/MCB.21.22.7601-7606.2001 | pmc=99931 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  |vauthors=Lee JH, Skalnik DG |title=CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42259–42267 |year= 2003 |pmid= 12200428 |doi= 10.1074/jbc.M205054200 }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Lee JH, Voo KS, Skalnik DG |title=Identification and characterization of the DNA binding domain of CpG-binding protein. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44669-76 |year= 2002 |pmid= 11572867 |doi= 10.1074/jbc.M107179200 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Carlone DL, Skalnik DG |title=CpG binding protein is crucial for early embryonic development. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7601-6 |year= 2001 |pmid= 11604496 |doi= 10.1128/MCB.21.22.7601-7606.2001 }}
*{{cite journal  | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–1625 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR  | author3=Ozdamar B  | display-authors=3  | last4=Bose  | first4=R  | last5=Liu  | first5=Z  | last6=Donovan  | first6=RS  | last7=Shinjo  | first7=F  | last8=Liu  | first8=Y  | last9=Dembowy  | first9=J }}
*{{cite journal  | author=Lee JH, Skalnik DG |title=CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42259-67 |year= 2003 |pmid= 12200428 |doi= 10.1074/jbc.M205054200 }}
*{{cite journal  |vauthors=Lee JH, Skalnik DG |title=CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41725–41731 |year= 2006 |pmid= 16253997 |doi= 10.1074/jbc.M508312200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–814 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-format=vanc| author2=Hao T  | author3=Shaw C  | display-authors=3  | last4=Patel  | first4=Akash J.  | last5=Szabó  | first5=Gábor  | last6=Rual  | first6=Jean-François  | last7=Fisk  | first7=C. Joseph  | last8=Li  | first8=Ning  | last9=Smolyar  | first9=Alex }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Young SR, Skalnik DG |title=CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line |journal=DNA Cell Biol. |volume=26 |issue= 2 |pages= 80–90 |year= 2007 |pmid= 17328666 |doi= 10.1089/dna.2006.0535 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Lee JH, Skalnik DG |title=CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41725-31 |year= 2006 |pmid= 16253997 |doi= 10.1074/jbc.M508312200 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Young SR, Skalnik DG |title=CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. |journal=DNA Cell Biol. |volume=26 |issue= 2 |pages= 80-90 |year= 2007 |pmid= 17328666 |doi= 10.1089/dna.2006.0535 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
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Latest revision as of 10:12, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.[1][2][3]

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.[2]

References

  1. ↑ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun. 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
  2. ↑ 2.0 2.1 Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol. 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657.
  3. ↑ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)".

External links

Further reading


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