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'''Vacuolar protein sorting-associated protein 4B''' is a [[protein]] that in humans is encoded by the ''VPS4B'' [[gene]].<ref name="pmid11563910">{{cite journal | vauthors = Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K | title = Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking | journal = J Mol Biol | volume = 312 | issue = 3 | pages = 469–80 |date=Sep 2001 | pmid = 11563910 | pmc =  | doi = 10.1006/jmbi.2001.4917 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9525| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_VPS4B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wr0.
| PDB = {{PDB2|1wr0}}, {{PDB2|1xwi}}, {{PDB2|2cpt}}
| Name = Vacuolar protein sorting 4 homolog B (S. cerevisiae)
| HGNCid = 10895
| Symbol = VPS4B
| AltSymbols =; MIG1; SKD1; VPS4-2
| OMIM = 609983
| ECnumber = 
| Homologene = 37976
| MGIid = 1100499
| GeneAtlas_image1 = PBB_GE_VPS4B_218171_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0042623 |text = ATPase activity, coupled}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005773 |text = vacuole}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0007031 |text = peroxisome organization and biogenesis}} {{GNF_GO|id=GO:0016197 |text = endosome transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9525
    | Hs_Ensembl = ENSG00000119541
    | Hs_RefseqProtein = NP_004860
    | Hs_RefseqmRNA = NM_004869
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 59207407
    | Hs_GenLoc_end = 59240673
    | Hs_Uniprot = O75351
    | Mm_EntrezGene = 20479
    | Mm_Ensembl = ENSMUSG00000009907
    | Mm_RefseqmRNA = NM_009190
    | Mm_RefseqProtein = NP_033216
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 108596985
    | Mm_GenLoc_end = 108623994
    | Mm_Uniprot = Q3TN07
  }}
}}
'''Vacuolar protein sorting 4 homolog B (S. cerevisiae)''', also known as '''VPS4B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9525| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.<ref name="entrez">{{cite web | title = Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9525| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal | author=Périer F, Coulter KL, Liang H, ''et al.'' |title=Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast. |journal=FEBS Lett. |volume=351 |issue= 2 |pages= 286-90 |year= 1994 |pmid= 8082782 |doi=  }}
*{{cite journal   |vauthors=Périer F, Coulter KL, Liang H, etal |title=Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast |journal=FEBS Lett. |volume=351 |issue= 2 |pages= 286–90 |year= 1994 |pmid= 8082782 |doi=10.1016/0014-5793(94)00879-5 }}
*{{cite journal | author=Mao M, Fu G, Wu JS, ''et al.'' |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175-80 |year= 1998 |pmid= 9653160 |doi= }}
*{{cite journal   |vauthors=Mao M, Fu G, Wu JS, etal |title=Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=10.1073/pnas.95.14.8175  | pmc=20949  }}
*{{cite journal | author=Scheuring S, Bodor O, Röhricht RA, ''et al.'' |title=Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. |journal=Gene |volume=234 |issue= 1 |pages= 149-59 |year= 1999 |pmid= 10393249 |doi=  }}
*{{cite journal   |vauthors=Scheuring S, Bodor O, Röhricht RA, etal |title=Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking |journal=Gene |volume=234 |issue= 1 |pages= 149–59 |year= 1999 |pmid= 10393249 |doi=10.1016/S0378-1119(99)00163-8 }}
*{{cite journal  | author=Bishop N, Woodman P |title=ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 227-39 |year= 2000 |pmid= 10637304 |doi=  }}
*{{cite journal  | vauthors=Bishop N, Woodman P |title=ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 227–39 |year= 2000 |pmid= 10637304 |doi= 10.1091/mbc.11.1.227| pmc=14770 }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 }}
*{{cite journal  | author=Howard TL, Stauffer DR, Degnin CR, Hollenberg SM |title=CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. |journal=J. Cell. Sci. |volume=114 |issue= Pt 13 |pages= 2395-404 |year= 2002 |pmid= 11559748 |doi=  }}
*{{cite journal  | vauthors=Howard TL, Stauffer DR, Degnin CR, Hollenberg SM |title=CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins |journal=J. Cell Sci. |volume=114 |issue= Pt 13 |pages= 2395–404 |year= 2002 |pmid= 11559748 |doi=  }}
*{{cite journal | author=Scheuring S, Röhricht RA, Schöning-Burkhardt B, ''et al.'' |title=Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. |journal=J. Mol. Biol. |volume=312 |issue= 3 |pages= 469-80 |year= 2001 |pmid= 11563910 |doi= 10.1006/jmbi.2001.4917 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Beyer A, Scheuring S, Müller S, etal |title=Comparative sequence and expression analyses of four mammalian VPS4 genes |journal=Gene |volume=305 |issue= 1 |pages= 47–59 |year= 2003 |pmid= 12594041 |doi=10.1016/S0378-1119(02)01205-2  }}
*{{cite journal | author=Beyer A, Scheuring S, Müller S, ''et al.'' |title=Comparative sequence and expression analyses of four mammalian VPS4 genes. |journal=Gene |volume=305 |issue= 1 |pages= 47-59 |year= 2003 |pmid= 12594041 |doi=  }}
*{{cite journal   |vauthors=Strack B, Calistri A, Craig S, etal |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding |journal=Cell |volume=114 |issue= 6 |pages= 689–99 |year= 2003 |pmid= 14505569 |doi=10.1016/S0092-8674(03)00653-6 }}
*{{cite journal | author=Strack B, Calistri A, Craig S, ''et al.'' |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. |journal=Cell |volume=114 |issue= 6 |pages= 689-99 |year= 2003 |pmid= 14505569 |doi= }}
*{{cite journal   |vauthors=von Schwedler UK, Stuchell M, Müller B, etal |title=The protein network of HIV budding |journal=Cell |volume=114 |issue= 6 |pages= 701–13 |year= 2003 |pmid= 14505570 |doi=10.1016/S0092-8674(03)00714-1  }}
*{{cite journal | author=von Schwedler UK, Stuchell M, Müller B, ''et al.'' |title=The protein network of HIV budding. |journal=Cell |volume=114 |issue= 6 |pages= 701-13 |year= 2003 |pmid= 14505570 |doi= }}
*{{cite journal   |vauthors=Fujita H, Umezuki Y, Imamura K, etal |title=Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B |journal=J. Cell Sci. |volume=117 |issue= Pt 14 |pages= 2997–3009 |year= 2005 |pmid= 15173323 |doi= 10.1242/jcs.01170 }}
*{{cite journal | author=Fujita H, Umezuki Y, Imamura K, ''et al.'' |title=Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. |journal=J. Cell. Sci. |volume=117 |issue= Pt 14 |pages= 2997-3009 |year= 2005 |pmid= 15173323 |doi= 10.1242/jcs.01170 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Katoh K, Suzuki H, Terasawa Y, etal |title=The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 677–85 |year= 2006 |pmid= 16004603 |doi= 10.1042/BJ20050398  | pmc=1276969 }}
*{{cite journal | author=Katoh K, Suzuki H, Terasawa Y, ''et al.'' |title=The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B. |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 677-85 |year= 2006 |pmid= 16004603 |doi= 10.1042/BJ20050398 }}
*{{cite journal   |vauthors=Takasu H, Jee JG, Ohno A, etal |title=Structural characterization of the MIT domain from human Vps4b |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 2 |pages= 460–5 |year= 2005 |pmid= 16018968 |doi= 10.1016/j.bbrc.2005.06.110 }}
*{{cite journal | author=Takasu H, Jee JG, Ohno A, ''et al.'' |title=Structural characterization of the MIT domain from human Vps4b. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 2 |pages= 460-5 |year= 2005 |pmid= 16018968 |doi= 10.1016/j.bbrc.2005.06.110 }}
*{{cite journal   |vauthors=Scott A, Chung HY, Gonciarz-Swiatek M, etal |title=Structural and mechanistic studies of VPS4 proteins |journal=EMBO J. |volume=24 |issue= 20 |pages= 3658–69 |year= 2005 |pmid= 16193069 |doi= 10.1038/sj.emboj.7600818  | pmc=1276703 }}
*{{cite journal | author=Scott A, Chung HY, Gonciarz-Swiatek M, ''et al.'' |title=Structural and mechanistic studies of VPS4 proteins. |journal=EMBO J. |volume=24 |issue= 20 |pages= 3658-69 |year= 2005 |pmid= 16193069 |doi= 10.1038/sj.emboj.7600818 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Welsch S, Habermann A, Jäger S, etal |title=Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function |journal=Traffic |volume=7 |issue= 11 |pages= 1551–66 |year= 2007 |pmid= 17014699 |doi= 10.1111/j.1600-0854.2006.00489.x }}
*{{cite journal | author=Welsch S, Habermann A, Jäger S, ''et al.'' |title=Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function. |journal=Traffic |volume=7 |issue= 11 |pages= 1551-66 |year= 2007 |pmid= 17014699 |doi= 10.1111/j.1600-0854.2006.00489.x }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Lambert C, Döring T, Prange R |title=Hepatitis B Virus Maturation Is Sensitive to Functional Inhibition of ESCRT-III, Vps4, and γ2-Adaptin |journal=J. Virol. |volume=81 |issue= 17 |pages= 9050–60 |year= 2007 |pmid= 17553870 |doi= 10.1128/JVI.00479-07 | pmc=1951427 }}
*{{cite journal | author=Lambert C, Döring T, Prange R |title=Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. |journal=J. Virol. |volume=81 |issue= 17 |pages= 9050-60 |year= 2007 |pmid= 17553870 |doi= 10.1128/JVI.00479-07 }}
}}
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{{PDB Gallery|geneid=9525}}
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Latest revision as of 22:36, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.[1][2]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.[2]

References

  1. ↑ Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
  2. ↑ 2.0 2.1 "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)".

Further reading



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