AP3D1: Difference between revisions

Jump to navigation Jump to search
Newer edit →
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''AP-3 complex subunit delta-1''' is a [[protein]] that in humans is encoded by the ''AP3D1'' [[gene]].<ref name="pmid9151686">{{cite journal | vauthors = Simpson F, Peden AA, Christopoulou L, Robinson MS | title = Characterization of the adaptor-related protein complex, AP-3 | journal = The Journal of Cell Biology | volume = 137 | issue = 4 | pages = 835–45 | date = May 1997 | pmid = 9151686 | pmc = 2139840 | doi = 10.1083/jcb.137.4.835 }}</ref><ref name="pmid9303295">{{cite journal | vauthors = Ooi CE, Moreira JE, Dell'Angelica EC, Poy G, Wassarman DA, Bonifacino JS | title = Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet | journal = The EMBO Journal | volume = 16 | issue = 15 | pages = 4508–18 | date = Aug 1997 | pmid = 9303295 | pmc = 1170077 | doi = 10.1093/emboj/16.15.4508 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8943| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adaptor-related protein complex 3, delta 1 subunit
| HGNCid = 568
| Symbol = AP3D1
| AltSymbols =; ADTD; hBLVR
| OMIM = 607246
| ECnumber = 
| Homologene = 2926
| MGIid = 107734
| GeneAtlas_image1 = PBB_GE_AP3D1_206592_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AP3D1_210974_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_AP3D1_208710_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006726 |text = eye pigment biosynthetic process}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0048007 |text = antigen processing and presentation, exogenous lipid antigen via MHC class Ib}} {{GNF_GO|id=GO:0051138 |text = positive regulation of NK T cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8943
    | Hs_Ensembl = ENSG00000065000
    | Hs_RefseqProtein = NP_001070991
    | Hs_RefseqmRNA = NM_001077523
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 2051993
    | Hs_GenLoc_end = 2102554
    | Hs_Uniprot = O14617
    | Mm_EntrezGene = 11776
    | Mm_Ensembl = ENSMUSG00000020198
    | Mm_RefseqmRNA = NM_007460
    | Mm_RefseqProtein = NP_031486
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80110086
    | Mm_GenLoc_end = 80145356
    | Mm_Uniprot = Q05CQ3
  }}
}}
'''Adaptor-related protein complex 3, delta 1 subunit''', also known as '''AP3D1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8943| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8943| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
AP3D1 has been shown to [[Protein-protein interaction|interact]] with [[SYBL1]].<ref name=pmid12853575>{{cite journal | vauthors = Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T | title = A dual mechanism controlling the localization and function of exocytic v-SNAREs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 15 | pages = 9011–6 | date = Jul 2003 | pmid = 12853575 | pmc = 166429 | doi = 10.1073/pnas.1431910100 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|AP3D1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Höning S, Sandoval IV, von Figura K | title = A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3 | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1304–14  | date = Aug 1998 | pmid = 9482728 | pmc = 1170479 | doi = 10.1093/emboj/17.5.1304 }}
| citations =
* {{cite journal | vauthors = Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M | title = Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles | journal = Neuron | volume = 21 | issue = 1 | pages = 111–22  | date = Jul 1998 | pmid = 9697856 | doi = 10.1016/S0896-6273(00)80519-X }}
*{{cite journal | author=Simpson F, Peden AA, Christopoulou L, Robinson MS |title=Characterization of the adaptor-related protein complex, AP-3. |journal=J. Cell Biol. |volume=137 |issue= 4 |pages= 835-45 |year= 1997 |pmid= 9151686 |doi=  }}
* {{cite journal | vauthors = Rehling P, Darsow T, Katzmann DJ, Emr SD | title = Formation of AP-3 transport intermediates requires Vps41 function | journal = Nature Cell Biology | volume = 1 | issue = 6 | pages = 346–53 | year = 2000 | date = Oct 1999 | pmid = 10559961 | doi = 10.1038/14037 }}
*{{cite journal  | author=Ooi CE, Moreira JE, Dell'Angelica EC, ''et al.'' |title=Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet. |journal=EMBO J. |volume=16 |issue= 15 |pages= 4508-18 |year= 1997 |pmid= 9303295 |doi= 10.1093/emboj/16.15.4508 }}
* {{cite journal | vauthors = Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC | title = Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif | journal = Virology | volume = 271 | issue = 1 | pages = 9–17  | date = May 2000 | pmid = 10814565 | doi = 10.1006/viro.2000.0277 }}
*{{cite journal  | author=Höning S, Sandoval IV, von Figura K |title=A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1304-14 |year= 1998 |pmid= 9482728 |doi= 10.1093/emboj/17.5.1304 }}
* {{cite journal | vauthors = Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G | title = PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2191–201  | date = May 2001 | pmid = 11331585 | pmc = 125242 | doi = 10.1093/emboj/20.9.2191 }}
*{{cite journal | author=Kantheti P, Qiao X, Diaz ME, ''et al.'' |title=Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. |journal=Neuron |volume=21 |issue= 1 |pages= 111-22 |year= 1998 |pmid= 9697856 |doi= }}
* {{cite journal | vauthors = Austin C, Boehm M, Tooze SA | title = Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3 | journal = Biochemistry | volume = 41 | issue = 14 | pages = 4669–77  | date = Apr 2002 | pmid = 11926829 | doi = 10.1021/bi016064j }}
*{{cite journal | author=Rehling P, Darsow T, Katzmann DJ, Emr SD |title=Formation of AP-3 transport intermediates requires Vps41 function. |journal=Nat. Cell Biol. |volume=1 |issue= 6 |pages= 346-53 |year= 2000 |pmid= 10559961 |doi= 10.1038/14037 }}
* {{cite journal | vauthors = Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J | title = HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8725–32  | date = Mar 2003 | pmid = 12486136 | doi = 10.1074/jbc.M210115200 }}
*{{cite journal | author=Craig HM, Reddy TR, Riggs NL, ''et al.'' |title=Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. |journal=Virology |volume=271 |issue= 1 |pages= 9-17 |year= 2000 |pmid= 10814565 |doi= 10.1006/viro.2000.0277 }}
* {{cite journal | vauthors = Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T | title = A dual mechanism controlling the localization and function of exocytic v-SNAREs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 15 | pages = 9011–6  | date = Jul 2003 | pmid = 12853575 | pmc = 166429 | doi = 10.1073/pnas.1431910100 }}
*{{cite journal | author=Crump CM, Xiang Y, Thomas L, ''et al.'' |title=PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2191-201 |year= 2001 |pmid= 11331585 |doi= 10.1093/emboj/20.9.2191 }}
* {{cite journal | vauthors = Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA | title = Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1 | journal = Developmental Cell | volume = 5 | issue = 3 | pages = 513–21  | date = Sep 2003 | pmid = 12967569 | doi = 10.1016/S1534-5807(03)00234-X }}
*{{cite journal | author=Austin C, Boehm M, Tooze SA |title=Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3. |journal=Biochemistry |volume=41 |issue= 14 |pages= 4669-77 |year= 2002 |pmid= 11926829 |doi=  }}
* {{cite journal | vauthors = Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V | title = The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation | journal = Molecular Biology of the Cell | volume = 15 | issue = 2 | pages = 575–87  | date = Feb 2004 | pmid = 14657250 | pmc = 329249 | doi = 10.1091/mbc.E03-06-0401 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS | title = An ear-core interaction regulates the recruitment of the AP-3 complex to membranes | journal = Developmental Cell | volume = 7 | issue = 4 | pages = 619–25  | date = Oct 2004 | pmid = 15469849 | doi = 10.1016/j.devcel.2004.08.009 }}
*{{cite journal | author=Janvier K, Craig H, Hitchin D, ''et al.'' |title=HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8725-32 |year= 2003 |pmid= 12486136 |doi= 10.1074/jbc.M210115200 }}
* {{cite journal | vauthors = Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC | title = Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes | journal = Journal of Virology | volume = 79 | issue = 4 | pages = 2066–78  | date = Feb 2005 | pmid = 15681409 | pmc = 546596 | doi = 10.1128/JVI.79.4.2066-2078.2005 }}
*{{cite journal | author=Martinez-Arca S, Rudge R, Vacca M, ''et al.'' |title=A dual mechanism controlling the localization and function of exocytic v-SNAREs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 9011-6 |year= 2003 |pmid= 12853575 |doi= 10.1073/pnas.1431910100 }}
* {{cite journal | vauthors = Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P | title = AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly | journal = Cell | volume = 120 | issue = 5 | pages = 663–74  | date = Mar 2005 | pmid = 15766529 | doi = 10.1016/j.cell.2004.12.023 }}
*{{cite journal | author=Nie Z, Boehm M, Boja ES, ''et al.'' |title=Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1. |journal=Dev. Cell |volume=5 |issue= 3 |pages= 513-21 |year= 2003 |pmid= 12967569 |doi= }}
* {{cite journal | vauthors = Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G | title = Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes | journal = Molecular Biology of the Cell | volume = 16 | issue = 11 | pages = 5356–72 | year = 2006 | date = Nov 2005 | pmid = 16162817 | pmc = 1266432 | doi = 10.1091/mbc.E05-07-0626 }}
*{{cite journal | author=Salazar G, Love R, Werner E, ''et al.'' |title=The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. |journal=Mol. Biol. Cell |volume=15 |issue= 2 |pages= 575-87 |year= 2004 |pmid= 14657250 |doi= 10.1091/mbc.E03-06-0401 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | author=Lefrançois S, Janvier K, Boehm M, ''et al.'' |title=An ear-core interaction regulates the recruitment of the AP-3 complex to membranes. |journal=Dev. Cell |volume=7 |issue= 4 |pages= 619-25 |year= 2004 |pmid= 15469849 |doi= 10.1016/j.devcel.2004.08.009 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Coleman SH, Van Damme N, Day JR, ''et al.'' |title=Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. |journal=J. Virol. |volume=79 |issue= 4 |pages= 2066-78 |year= 2005 |pmid= 15681409 |doi= 10.1128/JVI.79.4.2066-2078.2005 }}
*{{cite journal | author=Dong X, Li H, Derdowski A, ''et al.'' |title=AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. |journal=Cell |volume=120 |issue= 5 |pages= 663-74 |year= 2005 |pmid= 15766529 |doi= 10.1016/j.cell.2004.12.023 }}
*{{cite journal | author=Theos AC, Tenza D, Martina JA, ''et al.'' |title=Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. |journal=Mol. Biol. Cell |volume=16 |issue= 11 |pages= 5356-72 |year= 2006 |pmid= 16162817 |doi= 10.1091/mbc.E05-07-0626 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-19-stub}}

Revision as of 18:06, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.[1][2][3]

Function

AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM][3]

Interactions

AP3D1 has been shown to interact with SYBL1.[4]

References

  1. ↑ Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC 2139840. PMID 9151686.
  2. ↑ Ooi CE, Moreira JE, Dell'Angelica EC, Poy G, Wassarman DA, Bonifacino JS (Aug 1997). "Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet". The EMBO Journal. 16 (15): 4508–18. doi:10.1093/emboj/16.15.4508. PMC 1170077. PMID 9303295.
  3. ↑ 3.0 3.1 "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit".
  4. ↑ Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proceedings of the National Academy of Sciences of the United States of America. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=AP3D1&oldid=1418700"