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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''AP-1 complex subunit mu-2''' is a [[protein]] that in humans is encoded by the ''AP1M2'' [[gene]].<ref name="pmid10338135">{{cite journal | vauthors = Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T, Bonifacino JS | title = Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells | journal = FEBS Letters | volume = 449 | issue = 2-3 | pages = 215–20 | date = Apr 1999 | pmid = 10338135 | pmc =  | doi = 10.1016/S0014-5793(99)00432-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10053| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adaptor-related protein complex 1, mu 2 subunit
| HGNCid = 558
| Symbol = AP1M2
| AltSymbols =; HSMU1B; MU-1B; MU1B
| OMIM = 607309
| ECnumber = 
| Homologene = 55906
| MGIid = 1336974
| GeneAtlas_image1 = PBB_GE_AP1M2_65517_at_tn.png
| GeneAtlas_image2 = PBB_GE_AP1M2_218261_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0030125 |text = clathrin vesicle coat}}
| Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0006903 |text = vesicle targeting}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10053
    | Hs_Ensembl = ENSG00000129354
    | Hs_RefseqProtein = NP_005489
    | Hs_RefseqmRNA = NM_005498
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 10544348
    | Hs_GenLoc_end = 10558991
    | Hs_Uniprot = Q9Y6Q5
    | Mm_EntrezGene = 11768
    | Mm_Ensembl = ENSMUSG00000003309
    | Mm_RefseqmRNA = NM_009678
    | Mm_RefseqProtein = NP_033808
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 21045863
    | Mm_GenLoc_end = 21062713
    | Mm_Uniprot = Q8C9K8
  }}
}}
'''Adaptor-related protein complex 1, mu 2 subunit''', also known as '''AP1M2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10053| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.<ref name="entrez">{{cite web | title = Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10053| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
AP1M2 has been shown to [[Protein-protein interaction|interact]] with [[AP2B1]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hirst J, Robinson MS | title = Clathrin and adaptors | journal = Biochimica et Biophysica Acta | volume = 1404 | issue = 1-2 | pages = 173–93 | date = Aug 1998 | pmid = 9714795 | doi = 10.1016/S0167-4889(98)00056-1 }}
| citations =
* {{cite journal | vauthors = Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS | title = Interaction of tyrosine-based sorting signals with clathrin-associated proteins | journal = Science | volume = 269 | issue = 5232 | pages = 1872–5 | date = Sep 1995 | pmid = 7569928 | doi = 10.1126/science.7569928 }}
*{{cite journal | author=Hirst J, Robinson MS |title=Clathrin and adaptors. |journal=Biochim. Biophys. Acta |volume=1404 |issue= 1-2 |pages= 173-93 |year= 1998 |pmid= 9714795 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Ohno H, Stewart J, Fournier MC, ''et al.'' |title=Interaction of tyrosine-based sorting signals with clathrin-associated proteins. |journal=Science |volume=269 |issue= 5232 |pages= 1872-5 |year= 1995 |pmid= 7569928 |doi= }}
* {{cite journal | vauthors = Seaman MN, Sowerby PJ, Robinson MS | title = Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25446–51 | date = Oct 1996 | pmid = 8810314 | doi = 10.1074/jbc.271.41.25446 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Seaman MN, Sowerby PJ, Robinson MS |title=Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25446-51 |year= 1996 |pmid= 8810314 |doi= }}
* {{cite journal | vauthors = Stephens DJ, Banting G | title = Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120 | journal = The Biochemical Journal | volume = 335 | issue = 3 | pages = 567–72 | date = Nov 1998 | pmid = 9794796 | pmc = 1219817 | doi =  10.1042/bj3350567}}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi =  }}
*{{cite journal | author=Stephens DJ, Banting G |title=Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120. |journal=Biochem. J. |volume=335 ( Pt 3) |issue= |pages= 567-72 |year= 1998 |pmid= 9794796 |doi=  }}
* {{cite journal | vauthors = Fölsch H, Ohno H, Bonifacino JS, Mellman I | title = A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells | journal = Cell | volume = 99 | issue = 2 | pages = 189–98 | date = Oct 1999 | pmid = 10535737 | doi = 10.1016/S0092-8674(00)81650-5 }}
*{{cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, ''et al.'' |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350-61 |year= 1999 |pmid= 9882340 |doi=  }}
* {{cite journal | vauthors = Nakatsu F, Kadohira T, Gilbert DJ, Jenkins NA, Kakuta H, Copeland NG, Saito T, Ohno H | title = Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2) | journal = Cytogenetics and Cell Genetics | volume = 87 | issue = 1-2 | pages = 53–8 | year = 2000 | pmid = 10640811 | doi = 10.1159/000015391 }}
*{{cite journal  | author=Ohno H, Tomemori T, Nakatsu F, ''et al.'' |title=Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. |journal=FEBS Lett. |volume=449 |issue= 2-3 |pages= 215-20 |year= 1999 |pmid= 10338135 |doi=  }}
* {{cite journal | vauthors = Umeda A, Meyerholz A, Ungewickell E | title = Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation | journal = European Journal of Cell Biology | volume = 79 | issue = 5 | pages = 336–42 | date = May 2000 | pmid = 10887964 | doi = 10.1078/S0171-9335(04)70037-0 }}
*{{cite journal | author=Fölsch H, Ohno H, Bonifacino JS, Mellman I |title=A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. |journal=Cell |volume=99 |issue= 2 |pages= 189-98 |year= 1999 |pmid= 10535737 |doi= }}
* {{cite journal | vauthors = Fölsch H, Pypaert M, Schu P, Mellman I | title = Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells | journal = The Journal of Cell Biology | volume = 152 | issue = 3 | pages = 595–606 | date = Feb 2001 | pmid = 11157985 | pmc = 2195989 | doi = 10.1083/jcb.152.3.595 }}
*{{cite journal | author=Nakatsu F, Kadohira T, Gilbert DJ, ''et al.'' |title=Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 53-8 |year= 2000 |pmid= 10640811 |doi= }}
* {{cite journal | vauthors = Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M | title = The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] | journal = Journal of Virology | volume = 75 | issue = 6 | pages = 2982–92 | date = Mar 2001 | pmid = 11222723 | pmc = 115924 | doi = 10.1128/JVI.75.6.2982-2992.2001 }}
*{{cite journal | author=Umeda A, Meyerholz A, Ungewickell E |title=Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation. |journal=Eur. J. Cell Biol. |volume=79 |issue= 5 |pages= 336-42 |year= 2000 |pmid= 10887964 |doi= }}
* {{cite journal | vauthors = Ohka S, Ohno H, Tohyama K, Nomoto A | title = Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells | journal = Biochemical and Biophysical Research Communications | volume = 287 | issue = 4 | pages = 941–8 | date = Oct 2001 | pmid = 11573956 | doi = 10.1006/bbrc.2001.5660 }}
*{{cite journal | author=Fölsch H, Pypaert M, Schu P, Mellman I |title=Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. |journal=J. Cell Biol. |volume=152 |issue= 3 |pages= 595-606 |year= 2001 |pmid= 11157985 |doi= }}
* {{cite journal | vauthors = Korolchuk VI, Banting G | title = CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles | journal = Traffic | volume = 3 | issue = 6 | pages = 428–39 | date = Jun 2002 | pmid = 12010461 | doi = 10.1034/j.1600-0854.2002.30606.x }}
*{{cite journal | author=Wyss S, Berlioz-Torrent C, Boge M, ''et al.'' |title=The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]. |journal=J. Virol. |volume=75 |issue= 6 |pages= 2982-92 |year= 2001 |pmid= 11222723 |doi= 10.1128/JVI.75.6.2982-2992.2001 }}
* {{cite journal | vauthors = Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ | title = Molecular architecture and functional model of the endocytic AP2 complex | journal = Cell | volume = 109 | issue = 4 | pages = 523–35 | date = May 2002 | pmid = 12086608 | doi = 10.1016/S0092-8674(02)00735-3 }}
*{{cite journal | author=Ohka S, Ohno H, Tohyama K, Nomoto A |title=Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 4 |pages= 941-8 |year= 2001 |pmid= 11573956 |doi= 10.1006/bbrc.2001.5660 }}
* {{cite journal | vauthors = Sugimoto H, Sugahara M, Fölsch H, Koide Y, Nakatsu F, Tanaka N, Nishimura T, Furukawa M, Mullins C, Nakamura N, Mellman I, Ohno H | title = Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells | journal = Molecular Biology of the Cell | volume = 13 | issue = 7 | pages = 2374–82 | date = Jul 2002 | pmid = 12134076 | pmc = 117320 | doi = 10.1091/mbc.E01-10-0096 }}
*{{cite journal | author=Korolchuk VI, Banting G |title=CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles. |journal=Traffic |volume=3 |issue= 6 |pages= 428-39 |year= 2003 |pmid= 12010461 |doi= }}
*{{cite journal | author=Collins BM, McCoy AJ, Kent HM, ''et al.'' |title=Molecular architecture and functional model of the endocytic AP2 complex. |journal=Cell |volume=109 |issue= 4 |pages= 523-35 |year= 2002 |pmid= 12086608 |doi= }}
*{{cite journal | author=Sugimoto H, Sugahara M, Fölsch H, ''et al.'' |title=Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2374-82 |year= 2003 |pmid= 12134076 |doi= 10.1091/mbc.E01-10-0096 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|AP1M2}}
* {{UCSC gene details|AP1M2}}
 
 
{{gene-19-stub}}

Latest revision as of 18:05, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.[1][2]

Function

This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.[2]

Interactions

AP1M2 has been shown to interact with AP2B1.[3]

References

  1. ↑ Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T, Bonifacino JS (Apr 1999). "Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells". FEBS Letters. 449 (2–3): 215–20. doi:10.1016/S0014-5793(99)00432-9. PMID 10338135.
  2. ↑ 2.0 2.1 "Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

External links


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