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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Splicing factor 3A subunit 2''' is a [[protein]] that in humans is encoded by the ''SF3A2'' [[gene]].<ref name="pmid8211113">{{cite journal | vauthors = Bennett M, Reed R | title = Correspondence between a mammalian spliceosome component and an essential yeast splicing factor | journal = Science | volume = 262 | issue = 5130 | pages = 105–8 | date = October 1993 | pmid = 8211113 | pmc =  | doi = 10.1126/science.8211113 }}</ref><ref name="pmid8541848">{{cite journal | vauthors = Dresser DW, Hacker A, Lovell-Badge R, Guerrier D | title = The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous | journal = Human Molecular Genetics | volume = 4 | issue = 9 | pages = 1613–8 | date = September 1995 | pmid = 8541848 | pmc =  | doi = 10.1093/hmg/4.9.1613 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8175| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Splicing factor 3a, subunit 2, 66kDa
| HGNCid = 10766
| Symbol = SF3A2
| AltSymbols =; PRP11; PRPF11; SAP62; SF3a66
| OMIM = 600796
| ECnumber = 
| Homologene = 5184
| MGIid = 104912
| GeneAtlas_image1 = PBB_GE_SF3A2_37462_i_at_tn.png
| GeneAtlas_image2 = PBB_GE_SF3A2_209381_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0030532 |text = small nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0000389 |text = nuclear mRNA 3'-splice site recognition}} {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8175
    | Hs_Ensembl = ENSG00000104897
    | Hs_RefseqProtein = NP_009096
    | Hs_RefseqmRNA = NM_007165
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 2187816
    | Hs_GenLoc_end = 2199677
    | Hs_Uniprot = Q15428
    | Mm_EntrezGene = 20222
    | Mm_Ensembl = ENSMUSG00000020211
    | Mm_RefseqmRNA = NM_013651
    | Mm_RefseqProtein = NP_038679
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80201713
    | Mm_GenLoc_end = 80208051
    | Mm_Uniprot = Q62203
  }}
}}
'''Splicing factor 3a, subunit 2, 66kDa''', also known as '''SF3A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8175| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.<ref name="entrez">{{cite web | title = Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8175| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SF3A2 has been shown to [[Protein-protein interaction|interact]] with [[DDX46]].<ref name=pmid12234937>{{cite journal | vauthors = Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R | title = Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein | journal = The EMBO Journal | volume = 21 | issue = 18 | pages = 4978–88 | date = September 2002 | pmid = 12234937 | pmc = 126279 | doi = 10.1093/emboj/cdf480 }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== References ==
| citations =
{{reflist|33em}}
*{{cite journal | author=Chiara MD, Champion-Arnaud P, Buvoli M, ''et al.'' |title=Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6403-7 |year= 1994 |pmid= 8022796 |doi=  }}
 
*{{cite journal  | author=Bennett M, Reed R |title=Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. |journal=Science |volume=262 |issue= 5130 |pages= 105-8 |year= 1993 |pmid= 8211113 |doi= }}
== Further reading ==
*{{cite journal  | author=Dresser DW, Hacker A, Lovell-Badge R, Guerrier D |title=The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous. |journal=Hum. Mol. Genet. |volume=4 |issue= 9 |pages= 1613-8 |year= 1996 |pmid= 8541848 |doi=  }}
{{refbegin|33em}}
*{{cite journal | author=Rain JC, Tartakoff AM, Krämer A, Legrain P |title=Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. |journal=RNA |volume=2 |issue= 6 |pages= 535-50 |year= 1996 |pmid= 8718683 |doi=  }}
* {{cite journal | vauthors = Chiara MD, Champion-Arnaud P, Buvoli M, Nadal-Ginard B, Reed R | title = Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 14 | pages = 6403–7 | date = July 1994 | pmid = 8022796 | pmc = 44210 | doi = 10.1073/pnas.91.14.6403 }}
*{{cite journal | author=Hong W, Bennett M, Xiao Y, ''et al.'' |title=Association of U2 snRNP with the spliceosomal complex E. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 354-61 |year= 1997 |pmid= 9016565 |doi= }}
* {{cite journal | vauthors = Rain JC, Tartakoff AM, Krämer A, Legrain P | title = Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution | journal = Rna | volume = 2 | issue = 6 | pages = 535–50 | date = June 1996 | pmid = 8718683 | pmc = 1369393 | doi =  }}
*{{cite journal | author=Moraitou M, Patrinou-Georgoula M, Guialis A |title=Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles. |journal=Biochem. J. |volume=332 ( Pt 1) |issue= |pages= 135-44 |year= 1998 |pmid= 9576861 |doi=  }}
* {{cite journal | vauthors = Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R | title = Association of U2 snRNP with the spliceosomal complex E | journal = Nucleic Acids Research | volume = 25 | issue = 2 | pages = 354–61 | date = January 1997 | pmid = 9016565 | pmc = 146436 | doi = 10.1093/nar/25.2.354 }}
*{{cite journal | author=Yan D, Perriman R, Igel H, ''et al.'' |title=CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5000-9 |year= 1998 |pmid= 9710584 |doi=  }}
* {{cite journal | vauthors = Moraitou M, Patrinou-Georgoula M, Guialis A | title = Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles | journal = The Biochemical Journal | volume = 332 ( Pt 1) | issue = 1 | pages = 135–44 | date = May 1998 | pmid = 9576861 | pmc = 1219461 | doi =  }}
*{{cite journal | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
* {{cite journal | vauthors = Yan D, Perriman R, Igel H, Howe KJ, Neville M, Ares M | title = CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif | journal = Molecular and Cellular Biology | volume = 18 | issue = 9 | pages = 5000–9 | date = September 1998 | pmid = 9710584 | pmc = 109085 | doi =  }}
*{{cite journal | author=Krämer A, Grüter P, Gröning K, Kastner B |title=Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP. |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1355-68 |year= 1999 |pmid= 10385517 |doi= }}
* {{cite journal | vauthors = Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M | title = Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex | journal = Nature Genetics | volume = 20 | issue = 1 | pages = 46–50 | date = September 1998 | pmid = 9731529 | doi = 10.1038/1700 }}
*{{cite journal | author=Das R, Zhou Z, Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779-87 |year= 2000 |pmid= 10882114 |doi= }}
* {{cite journal | vauthors = Krämer A, Grüter P, Gröning K, Kastner B | title = Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP | journal = The Journal of Cell Biology | volume = 145 | issue = 7 | pages = 1355–68 | date = June 1999 | pmid = 10385517 | pmc = 2133165 | doi = 10.1083/jcb.145.7.1355 }}
*{{cite journal | author=Will CL, Schneider C, MacMillan AM, ''et al.'' |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536-46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536 }}
* {{cite journal | vauthors = Das R, Zhou Z, Reed R | title = Functional association of U2 snRNP with the ATP-independent spliceosomal complex E | journal = Molecular Cell | volume = 5 | issue = 5 | pages = 779–87 | date = May 2000 | pmid = 10882114 | doi = 10.1016/S1097-2765(00)80318-4 }}
*{{cite journal | author=Nesic D, Krämer A |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6406-17 |year= 2001 |pmid= 11533230 |doi= }}
* {{cite journal | vauthors = Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC | title = A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site | journal = The EMBO Journal | volume = 20 | issue = 16 | pages = 4536–46 | date = August 2001 | pmid = 11500380 | pmc = 125580 | doi = 10.1093/emboj/20.16.4536 }}
*{{cite journal | author=Dresser DW, Jamin SP, Atkins CJ, Guerrier D |title=An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. |journal=Gene |volume=277 |issue= 1-2 |pages= 163-73 |year= 2001 |pmid= 11602354 |doi= }}
* {{cite journal | vauthors = Nesic D, Krämer A | title = Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation | journal = Molecular and Cellular Biology | volume = 21 | issue = 19 | pages = 6406–17 | date = October 2001 | pmid = 11533230 | pmc = 99788 | doi = 10.1128/MCB.21.19.6406-6417.2001 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi= }}
* {{cite journal | vauthors = Dresser DW, Jamin SP, Atkins CJ, Guerrier D | title = An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH | journal = Gene | volume = 277 | issue = 1-2 | pages = 163–73 | date = October 2001 | pmid = 11602354 | doi = 10.1016/S0378-1119(01)00690-4 }}
*{{cite journal | author=Will CL, Urlaub H, Achsel T, ''et al.'' |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978-88 |year= 2002 |pmid= 12234937 |doi= }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = Rna | volume = 8 | issue = 4 | pages = 426–39 | date = April 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R | title = Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein | journal = The EMBO Journal | volume = 21 | issue = 18 | pages = 4978–88 | date = September 2002 | pmid = 12234937 | pmc = 126279 | doi = 10.1093/emboj/cdf480 }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
* {{cite journal | vauthors = Takenaka K, Nakagawa H, Miyamoto S, Miki H | title = The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein | journal = The Biochemical Journal | volume = 382 | issue = Pt 1 | pages = 223–30 | date = August 2004 | pmid = 15142036 | pmc = 1133934 | doi = 10.1042/BJ20040521 }}
*{{cite journal | author=Takenaka K, Nakagawa H, Miyamoto S, Miki H |title=The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein. |journal=Biochem. J. |volume=382 |issue= Pt 1 |pages= 223-30 |year= 2005 |pmid= 15142036 |doi= 10.1042/BJ20040521 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Nesic D, Tanackovic G, Krämer A | title = A role for Cajal bodies in the final steps of U2 snRNP biogenesis | journal = Journal of Cell Science | volume = 117 | issue = Pt 19 | pages = 4423–33 | date = September 2004 | pmid = 15316075 | doi = 10.1242/jcs.01308 }}
*{{cite journal | author=Nesic D, Tanackovic G, Krämer A |title=A role for Cajal bodies in the final steps of U2 snRNP biogenesis. |journal=J. Cell. Sci. |volume=117 |issue= Pt 19 |pages= 4423-33 |year= 2005 |pmid= 15316075 |doi= 10.1242/jcs.01308 }}
}}
{{refend}}
{{refend}}


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Revision as of 06:11, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene.[1][2][3]

Function

This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.[3]

Interactions

SF3A2 has been shown to interact with DDX46.[4]

References

  1. ↑ Bennett M, Reed R (October 1993). "Correspondence between a mammalian spliceosome component and an essential yeast splicing factor". Science. 262 (5130): 105–8. doi:10.1126/science.8211113. PMID 8211113.
  2. ↑ Dresser DW, Hacker A, Lovell-Badge R, Guerrier D (September 1995). "The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous". Human Molecular Genetics. 4 (9): 1613–8. doi:10.1093/hmg/4.9.1613. PMID 8541848.
  3. ↑ 3.0 3.1 "Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa".
  4. ↑ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SF3A2&oldid=1418751"