HNRPUL1: Difference between revisions

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{{Infobox_gene}}
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'''Heterogeneous nuclear ribonucleoprotein U-like protein 1''' is a [[protein]] that in humans is encoded by the ''HNRNPUL1'' [[gene]].<ref name="pmid9733834">{{cite journal |vauthors=Gabler S, Schutt H, Groitl P, Wolf H, Shenk T, Dobner T | title = E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs | journal = J Virol | volume = 72 | issue = 10 | pages = 7960–71 |date=Oct 1998 | pmid = 9733834 | pmc = 110131 | doi =  }}</ref><ref name="pmid12489984">{{cite journal |vauthors=Kzhyshkowska J, Rusch A, Wolf H, Dobner T | title = Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7 | journal = Biochem J | volume = 371 | issue = Pt 2 | pages = 385–93 |date=Apr 2003 | pmid = 12489984 | pmc = 1223277 | doi = 10.1042/BJ20021281 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11100| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Heterogeneous nuclear ribonucleoprotein U-like 1
| HGNCid = 17011
| Symbol = HNRPUL1
| AltSymbols =; E1B-AP5; E1BAP5; FLJ12944
| OMIM = 605800
| ECnumber = 
| Homologene = 31419
| MGIid = 2443517
| GeneAtlas_image1 = PBB_GE_HNRPUL1_208713_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNRPUL1_209675_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11100
    | Hs_Ensembl = ENSG00000105323
    | Hs_RefseqProtein = NP_653334
    | Hs_RefseqmRNA = NM_144733
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 46460264
    | Hs_GenLoc_end = 46505438
    | Hs_Uniprot = Q9BUJ2
    | Mm_EntrezGene = 232989
    | Mm_Ensembl = ENSMUSG00000040725
    | Mm_RefseqmRNA = XM_990520
    | Mm_RefseqProtein = XP_995614
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 25430244
    | Mm_GenLoc_end = 25463450
    | Mm_Uniprot = Q8VDM6
  }}
}}
'''Heterogeneous nuclear ribonucleoprotein U-like 1''', also known as '''HNRPUL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11100| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
HNRPUL1 has been shown to [[Protein-protein interaction|interact]] with [[BRD7]]<ref name=pmid12489984 /> and [[PRMT2]].<ref name=pmid11513728>{{cite journal |doi=10.1042/0264-6021:3580305 |last=Kzhyshkowska |first=J |authorlink= |author2=Schütt H |author3=Liss M |author4=Kremmer E |author5=Stauber R |author6=Wolf H |author7=Dobner T  |date=Sep 2001 |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue=Pt 2 |pages=305–14 |publisher= |location = England| issn = 0264-6021| pmid = 11513728 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1222062 }}</ref>
| section_title =  
| summary_text = This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11100| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Gabler S, Schütt H, Groitl P, ''et al.'' |title=E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. |journal=J. Virol. |volume=72 |issue= 10 |pages= 7960-71 |year= 1998 |pmid= 9733834 |doi=  }}
*{{cite journal   |vauthors=Bachi A, Braun IC, Rodrigues JP, etal |title=The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. |journal=RNA |volume=6 |issue= 1 |pages= 136–58 |year= 2000 |pmid= 10668806 |doi=10.1017/S1355838200991994  | pmc=1369901 }}
*{{cite journal | author=Bachi A, Braun IC, Rodrigues JP, ''et al.'' |title=The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. |journal=RNA |volume=6 |issue= 1 |pages= 136-58 |year= 2000 |pmid= 10668806 |doi=  }}
*{{cite journal   |vauthors=Herold A, Suyama M, Rodrigues JP, etal |title=TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8996–9008 |year= 2000 |pmid= 11073998 |doi=10.1128/MCB.20.23.8996-9008.2000 | pmc=86553  }}
*{{cite journal | author=Herold A, Suyama M, Rodrigues JP, ''et al.'' |title=TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8996-9008 |year= 2000 |pmid= 11073998 |doi=  }}
*{{cite journal   |vauthors=Kzhyshkowska J, Schütt H, Liss M, etal |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 305–14 |year= 2001 |pmid= 11513728 |doi=10.1042/0264-6021:3580305  | pmc=1222062 }}
*{{cite journal | author=Kzhyshkowska J, Schütt H, Liss M, ''et al.'' |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 305-14 |year= 2001 |pmid= 11513728 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Kzhyshkowska J, Rusch A, Wolf H, Dobner T |title=Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 385-93 |year= 2003 |pmid= 12489984 |doi= 10.1042/BJ20021281 }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal   |vauthors=Kzhyshkowska J, Kremmer E, Hofmann M, etal |title=Protein arginine methylation during lytic adenovirus infection. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 259–65 |year= 2005 |pmid= 15242333 |doi= 10.1042/BJ20040210  | pmc=1134066 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal | author=Kzhyshkowska J, Kremmer E, Hofmann M, ''et al.'' |title=Protein arginine methylation during lytic adenovirus infection. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 259-65 |year= 2005 |pmid= 15242333 |doi= 10.1042/BJ20040210 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Barral PM, Rusch A, Turnell AS, etal |title=The interaction of the hnRNP family member E1B-AP5 with p53. |journal=FEBS Lett. |volume=579 |issue= 13 |pages= 2752–8 |year= 2005 |pmid= 15907477 |doi= 10.1016/j.febslet.2005.03.095 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Barral PM, Rusch A, Turnell AS, ''et al.'' |title=The interaction of the hnRNP family member E1B-AP5 with p53. |journal=FEBS Lett. |volume=579 |issue= 13 |pages= 2752-8 |year= 2005 |pmid= 15907477 |doi= 10.1016/j.febslet.2005.03.095 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Shiffman D, Rowland CM, Louie JZ, etal |title=Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=26 |issue= 7 |pages= 1613–8 |year= 2006 |pmid= 16690874 |doi= 10.1161/01.ATV.0000226543.77214.e4 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Shiffman D, Rowland CM, Louie JZ, ''et al.'' |title=Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=26 |issue= 7 |pages= 1613-8 |year= 2006 |pmid= 16690874 |doi= 10.1161/01.ATV.0000226543.77214.e4 }}
*{{cite journal  |vauthors=Kollers S, Musilova P, Rubes J, Rocha D |title=Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. |journal=Anim. Genet. |volume=37 |issue= 6 |pages= 595–6 |year= 2007 |pmid= 17121608 |doi= 10.1111/j.1365-2052.2006.01516.x }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Kollers S, Musilova P, Rubes J, Rocha D |title=Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. |journal=Anim. Genet. |volume=37 |issue= 6 |pages= 595-6 |year= 2007 |pmid= 17121608 |doi= 10.1111/j.1365-2052.2006.01516.x }}
}}
}}
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Revision as of 13:58, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.[1][2][3]

This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.[3]

Interactions

HNRPUL1 has been shown to interact with BRD7[2] and PRMT2.[4]

References

  1. ↑ Gabler S, Schutt H, Groitl P, Wolf H, Shenk T, Dobner T (Oct 1998). "E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs". J Virol. 72 (10): 7960–71. PMC 110131. PMID 9733834.
  2. ↑ 2.0 2.1 Kzhyshkowska J, Rusch A, Wolf H, Dobner T (Apr 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277. PMID 12489984.
  3. ↑ 3.0 3.1 "Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1".
  4. ↑ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. England. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728.

Further reading



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