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{{Infobox_gene}}
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'''Sulfotransferase family cytosolic 2B member 1''' is an [[enzyme]] that in humans is encoded by the ''SULT2B1'' [[gene]].<ref name="pmid9799594">{{cite journal | vauthors = Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM | title = Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene | journal = Genomics | volume = 53 | issue = 3 | pages = 284–95 |date=Dec 1998 | pmid = 9799594 | pmc = | doi = 10.1006/geno.1998.5518 }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SULT2B1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q1q.
| PDB = {{PDB2|1q1q}}, {{PDB2|1q1z}}, {{PDB2|1q20}}, {{PDB2|1q22}}
| Name = Sulfotransferase family, cytosolic, 2B, member 1
| HGNCid = 11459
| Symbol = SULT2B1
| AltSymbols =; HSST2
| OMIM = 604125
| ECnumber = 
| Homologene = 49487
| MGIid = 1926342
| GeneAtlas_image1 = PBB_GE_SULT2B1_205759_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004027 |text = alcohol sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0050294 |text = steroid sulfotransferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000103 |text = sulfate assimilation}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6820
    | Hs_Ensembl = ENSG00000088002
    | Hs_RefseqProtein = NP_004596
    | Hs_RefseqmRNA = NM_004605
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 53747241
    | Hs_GenLoc_end = 53794495
    | Hs_Uniprot = O00204
    | Mm_EntrezGene = 54200
    | Mm_Ensembl = ENSMUSG00000003271
    | Mm_RefseqmRNA = NM_017465
    | Mm_RefseqProtein = NP_059493
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 45598025
    | Mm_GenLoc_end = 45627564
    | Mm_Uniprot = O35400
  }}
}}
'''Sulfotransferase family, cytosolic, 2B, member 1''', also known as '''SULT2B1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6820| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6820| accessdate = }}</ref>
| summary_text = [[Sulfotransferase]] [[enzyme]]s [[catalyze]] the [[sulfate]] conjugation of many [[hormone]]s, [[neurotransmitter]]s, [[drug]]s, and [[xenobiotic]] [[chemical compound]]s. These [[cytosol]]ic enzymes are different in their tissue distributions and [[substrate (biochemistry)|substrate specificities]]. The gene structure (number and length of [[exon]]s) is similar among family members. This gene sulfates [[dehydroepiandrosterone]] but not [[4-nitrophenol]], a typical substrate for the [[phenol]] and [[estrogen]] sulfotransferase subfamilies. Two alternatively spliced variants that encode different [[isoform]]s have been described.<ref name="entrez">{{cite web | title = Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6820| accessdate = }}</ref>
}}
}}
==See also==
* [[Steroid sulfotransferase]]
* [[Steroidogenic enzyme]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal   |vauthors=Weinshilboum RM, Otterness DM, Aksoy IA, etal |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341-8 |year= 2000 |pmid= 10720750 |doi=  }}
*{{cite journal   |vauthors=Glatt H, Engelke CE, Pabel U, etal |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3 }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141-70 |year= 2001 |pmid= 11154739 |doi=  }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1–2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=10.1016/S0009-2797(00)00202-7 }}
*{{cite journal | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi=  }}
*{{cite journal   |vauthors=Glatt H, Boeing H, Engelke CE, etal |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects |journal=Mutat. Res. |volume=482 |issue= 1–2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi=  10.1016/S0027-5107(01)00207-X}}
*{{cite journal  | author=Her C, Wood TC, Eichler EE, ''et al.'' |title=Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. |journal=Genomics |volume=53 |issue= 3 |pages= 284-95 |year= 1998 |pmid= 9799594 |doi= 10.1006/geno.1998.5518 }}
*{{cite journal  | vauthors=Meloche CA, Falany CN |title=Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b) |journal=J. Steroid Biochem. Mol. Biol. |volume=77 |issue= 4–5 |pages= 261–9 |year= 2001 |pmid= 11457664 |doi=10.1016/S0960-0760(01)00064-4 }}
*{{cite journal  | author=Meloche CA, Falany CN |title=Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). |journal=J. Steroid Biochem. Mol. Biol. |volume=77 |issue= 4-5 |pages= 261-9 |year= 2001 |pmid= 11457664 |doi=  }}
*{{cite journal  | vauthors=Geese WJ, Raftogianis RB |title=Biochemical characterization and tissue distribution of human SULT2B1 |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 1 |pages= 280–9 |year= 2001 |pmid= 11594786 |doi= 10.1006/bbrc.2001.5746 }}
*{{cite journal  | author=Geese WJ, Raftogianis RB |title=Biochemical characterization and tissue distribution of human SULT2B1. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 1 |pages= 280-9 |year= 2001 |pmid= 11594786 |doi= 10.1006/bbrc.2001.5746 }}
*{{cite journal   |vauthors=Fuda H, Lee YC, Shimizu C, etal |title=Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36161–6 |year= 2002 |pmid= 12145317 |doi= 10.1074/jbc.M207165200 }}
*{{cite journal | author=Fuda H, Lee YC, Shimizu C, ''et al.'' |title=Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36161-6 |year= 2002 |pmid= 12145317 |doi= 10.1074/jbc.M207165200 }}
*{{cite journal   |vauthors=Pai TG, Sugahara T, Suiko M, etal |title=Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases |journal=Biochim. Biophys. Acta |volume=1573 |issue= 2 |pages= 165–70 |year= 2003 |pmid= 12399026 |doi=  10.1016/s0304-4165(02)00416-6}}
*{{cite journal | author=Pai TG, Sugahara T, Suiko M, ''et al.'' |title=Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases. |journal=Biochim. Biophys. Acta |volume=1573 |issue= 2 |pages= 165-70 |year= 2003 |pmid= 12399026 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Lee KA, Fuda H, Lee YC, etal |title=Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44593–9 |year= 2004 |pmid= 12923182 |doi= 10.1074/jbc.M308312200 }}
*{{cite journal | author=Lee KA, Fuda H, Lee YC, ''et al.'' |title=Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44593-9 |year= 2004 |pmid= 12923182 |doi= 10.1074/jbc.M308312200 }}
*{{cite journal   |vauthors=Yanai H, Javitt NB, Higashi Y, etal |title=Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets |journal=Circulation |volume=109 |issue= 1 |pages= 92–6 |year= 2004 |pmid= 14676143 |doi= 10.1161/01.CIR.0000108925.95658.8D }}
*{{cite journal | author=Yanai H, Javitt NB, Higashi Y, ''et al.'' |title=Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets. |journal=Circulation |volume=109 |issue= 1 |pages= 92-6 |year= 2004 |pmid= 14676143 |doi= 10.1161/01.CIR.0000108925.95658.8D }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=He D, Meloche CA, Dumas NA, etal |title=Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate |journal=Biochem. J. |volume=379 |issue= Pt 3 |pages= 533–40 |year= 2004 |pmid= 14741047 |doi= 10.1042/BJ20031524 | pmc=1224114 }}
*{{cite journal | author=He D, Meloche CA, Dumas NA, ''et al.'' |title=Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate. |journal=Biochem. J. |volume=379 |issue= Pt 3 |pages= 533-40 |year= 2004 |pmid= 14741047 |doi= 10.1042/BJ20031524 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Higashi Y, Fuda H, Yanai H, etal |title=Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1207–13 |year= 2004 |pmid= 15140224 |doi= 10.1111/j.0022-202X.2004.22416.x }}
*{{cite journal | author=Higashi Y, Fuda H, Yanai H, ''et al.'' |title=Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1207-13 |year= 2004 |pmid= 15140224 |doi= 10.1111/j.0022-202X.2004.22416.x }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6820}}
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Latest revision as of 07:17, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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PubMed searchn/an/a
Wikidata
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Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.[1][2]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.[2]

See also

References

  1. ↑ Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998). "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene". Genomics. 53 (3): 284–95. doi:10.1006/geno.1998.5518. PMID 9799594.
  2. ↑ 2.0 2.1 "Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1".

Further reading



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