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{{Infobox_gene}}
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'''Follistatin-related protein 3''' is a [[protein]] that in humans is encoded by the ''FSTL3'' [[gene]].<ref name="pmid9671416">{{cite journal |vauthors=Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R | title = FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders | journal = Oncogene | volume = 16 | issue = 22 | pages = 2949–54 |date=Aug 1998 | pmid = 9671416 | pmc =  | doi = 10.1038/sj.onc.1201807 }}</ref><ref name="pmid15527507">{{cite journal |vauthors=Glusman G, Kaur A, Hood L, Rowen L | title = An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution | journal = BMC Evol Biol | volume = 4| pages = 43 |date=Nov 2004 | pmid = 15527507 | pmc = 533870 | doi = 10.1186/1471-2148-4-43 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10272| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Follistatin-like 3 (secreted glycoprotein)
| HGNCid = 3973
| Symbol = FSTL3
| AltSymbols =; FLRG; FSRP
| OMIM = 605343
| ECnumber =
| Homologene = 4280
| MGIid = 1890391
  | GeneAtlas_image1 = PBB_GE_FSTL3_203592_s_at_tn.png
| Function = {{GNF_GO|id=GO:0017106 |text = activin inhibitor activity}} {{GNF_GO|id=GO:0048185 |text = activin binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0030514 |text = negative regulation of BMP signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10272
    | Hs_Ensembl = ENSG00000070404
    | Hs_RefseqProtein = NP_005851
    | Hs_RefseqmRNA = NM_005860
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 627403
    | Hs_GenLoc_end = 634385
    | Hs_Uniprot = O95633
    | Mm_EntrezGene = 83554
    | Mm_Ensembl = ENSMUSG00000020325
    | Mm_RefseqmRNA = NM_031380
    | Mm_RefseqProtein = NP_113557
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79180402
    | Mm_GenLoc_end = 79185523
    | Mm_Uniprot = Q542M9
  }}
}}
'''Follistatin-like 3 (secreted glycoprotein)''', also known as '''FSTL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10272| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10272| accessdate = }}</ref>
| summary_text = Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10272| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maguer-Satta V, Rimokh R |title=FLRG, member of the follistatin family, a new player in hematopoiesis. |journal=Mol. Cell. Endocrinol. |volume=225 |issue= 1-2 |pages= 109-18 |year= 2005 |pmid= 15451575 |doi= 10.1016/j.mce.2004.07.009 }}
*{{cite journal  |vauthors=Maguer-Satta V, Rimokh R |title=FLRG, member of the follistatin family, a new player in hematopoiesis. |journal=Mol. Cell. Endocrinol. |volume=225 |issue= 1–2 |pages= 109–18 |year= 2005 |pmid= 15451575 |doi= 10.1016/j.mce.2004.07.009 }}
*{{cite journal  | author=Hayette S, Gadoux M, Martel S, ''et al.'' |title=FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. |journal=Oncogene |volume=16 |issue= 22 |pages= 2949-54 |year= 1998 |pmid= 9671416 |doi= 10.1038/sj.onc.1201807 }}
*{{cite journal  |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  |display-authors=etal}}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
*{{cite journal  |vauthors=Tortoriello DV, Sidis Y, Holtzman DA |title=Human follistatin-related protein: a structural homologue of follistatin with nuclear localization |journal=Endocrinology |volume=142 |issue= 8 |pages= 3426–34 |year= 2001 |pmid= 11459787 |doi=10.1210/en.142.8.3426  |display-authors=etal}}
*{{cite journal  | author=Tortoriello DV, Sidis Y, Holtzman DA, ''et al.'' |title=Human follistatin-related protein: a structural homologue of follistatin with nuclear localization. |journal=Endocrinology |volume=142 |issue= 8 |pages= 3426-34 |year= 2001 |pmid= 11459787 |doi= }}
*{{cite journal  |vauthors=Bartholin L, Maguer-Satta V, Hayette S |title=FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins |journal=Oncogene |volume=20 |issue= 39 |pages= 5409–19 |year= 2001 |pmid= 11571638 |doi= 10.1038/sj.onc.1204720 |display-authors=etal}}
*{{cite journal  | author=Bartholin L, Maguer-Satta V, Hayette S, ''et al.'' |title=FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins. |journal=Oncogene |volume=20 |issue= 39 |pages= 5409-19 |year= 2001 |pmid= 11571638 |doi= 10.1038/sj.onc.1204720 }}
*{{cite journal  |vauthors=Bartholin L, Maguer-Satta V, Hayette S |title=Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function |journal=Oncogene |volume=21 |issue= 14 |pages= 2227–35 |year= 2002 |pmid= 11948405 |doi= 10.1038/sj.onc.1205294 |display-authors=etal}}
*{{cite journal  | author=Bartholin L, Maguer-Satta V, Hayette S, ''et al.'' |title=Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. |journal=Oncogene |volume=21 |issue= 14 |pages= 2227-35 |year= 2002 |pmid= 11948405 |doi= 10.1038/sj.onc.1205294 }}
*{{cite journal  |vauthors=Hill JJ, Davies MV, Pearson AA |title=The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40735–41 |year= 2002 |pmid= 12194980 |doi= 10.1074/jbc.M206379200 |display-authors=etal}}
*{{cite journal  | author=Hill JJ, Davies MV, Pearson AA, ''et al.'' |title=The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40735-41 |year= 2002 |pmid= 12194980 |doi= 10.1074/jbc.M206379200 }}
*{{cite journal  |vauthors=Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R |title=Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells |journal=Mol. Hum. Reprod. |volume=8 |issue= 11 |pages= 992–7 |year= 2003 |pmid= 12397211 |doi=10.1093/molehr/8.11.992  }}
*{{cite journal  | author=Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R |title=Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells. |journal=Mol. Hum. Reprod. |volume=8 |issue= 11 |pages= 992-7 |year= 2003 |pmid= 12397211 |doi= }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Maguer-Satta V, Bartholin L, Jeanpierre S |title=Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family |journal=Exp. Cell Res. |volume=282 |issue= 2 |pages= 110–20 |year= 2003 |pmid= 12531697 |doi=10.1016/S0014-4827(02)00013-7  |display-authors=etal}}
*{{cite journal  | author=Maguer-Satta V, Bartholin L, Jeanpierre S, ''et al.'' |title=Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family. |journal=Exp. Cell Res. |volume=282 |issue= 2 |pages= 110-20 |year= 2003 |pmid= 12531697 |doi=  }}
*{{cite journal  |vauthors=Wang HQ, Takebayashi K, Tsuchida K |title=Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 9 |pages= 4432–9 |year= 2003 |pmid= 12970321 |doi=10.1210/jc.2002-021758 |display-authors=etal}}
*{{cite journal  | author=Wang HQ, Takebayashi K, Tsuchida K, ''et al.'' |title=Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 9 |pages= 4432-9 |year= 2003 |pmid= 12970321 |doi=  }}
*{{cite journal  |vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  |vauthors=Xia Y, Sidis Y, Schneyer A |title=Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice |journal=Mol. Endocrinol. |volume=18 |issue= 4 |pages= 979–94 |year= 2004 |pmid= 14739256 |doi= 10.1210/me.2003-0364 }}
*{{cite journal  | author=Xia Y, Sidis Y, Schneyer A |title=Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice. |journal=Mol. Endocrinol. |volume=18 |issue= 4 |pages= 979-94 |year= 2004 |pmid= 14739256 |doi= 10.1210/me.2003-0364 }}
*{{cite journal  |vauthors=Florio P, Ciarmela P, Toti P |title=Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide |journal=Mol. Cell. Endocrinol. |volume=218 |issue= 1–2 |pages= 129–35 |year= 2004 |pmid= 15130517 |doi= 10.1016/j.mce.2003.12.019 |display-authors=etal}}
*{{cite journal  | author=Florio P, Ciarmela P, Toti P, ''et al.'' |title=Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide. |journal=Mol. Cell. Endocrinol. |volume=218 |issue= 1-2 |pages= 129-35 |year= 2004 |pmid= 15130517 |doi= 10.1016/j.mce.2003.12.019 }}
*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Saito S, Sidis Y, Mukherjee A |title=Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3 |journal=Endocrinology |volume=146 |issue= 12 |pages= 5052–62 |year= 2006 |pmid= 16150905 |doi= 10.1210/en.2005-0833 |display-authors=etal}}
*{{cite journal  | author=Glusman G, Kaur A, Hood L, Rowen L |title=An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. |journal=BMC Evol. Biol. |volume=4 |issue= |pages= 43 |year= 2005 |pmid= 15527507 |doi= 10.1186/1471-2148-4-43 }}
*{{cite journal  |vauthors=Okamoto A, Endo H, Kalionis B |title=IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta |journal=Placenta |volume=27 |issue= 2–3 |pages= 317–21 |year= 2006 |pmid= 16338475 |doi= 10.1016/j.placenta.2004.12.007 |display-authors=etal}}
*{{cite journal  | author=Saito S, Sidis Y, Mukherjee A, ''et al.'' |title=Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. |journal=Endocrinology |volume=146 |issue= 12 |pages= 5052-62 |year= 2006 |pmid= 16150905 |doi= 10.1210/en.2005-0833 }}
*{{cite journal  | author=Okamoto A, Endo H, Kalionis B, ''et al.'' |title=IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta. |journal=Placenta |volume=27 |issue= 2-3 |pages= 317-21 |year= 2006 |pmid= 16338475 |doi= 10.1016/j.placenta.2004.12.007 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|FSTL3}}
* {{UCSC gene details|FSTL3}}
 
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Latest revision as of 04:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.[1][2][3]

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.[3]

References

  1. ↑ Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R (Aug 1998). "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders". Oncogene. 16 (22): 2949–54. doi:10.1038/sj.onc.1201807. PMID 9671416.
  2. ↑ Glusman G, Kaur A, Hood L, Rowen L (Nov 2004). "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution". BMC Evol Biol. 4: 43. doi:10.1186/1471-2148-4-43. PMC 533870. PMID 15527507.
  3. ↑ 3.0 3.1 "Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)".

Further reading

External links



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