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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SUMO-activating enzyme subunit 1''' is a [[protein]] that in humans is encoded by the ''SAE1'' [[gene]].<ref name="pmid10187858">{{cite journal | vauthors = Desterro JM, Rodriguez MS, Kemp GD, Hay RT | title = Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1 | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 10618–24  | date = May 1999 | pmid = 10187858 | pmc =  | doi = 10.1074/jbc.274.15.10618 }}</ref><ref name="pmid9920803">{{cite journal | vauthors = Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H | title = In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2 | journal = Biochem. Biophys. Res. Commun. | volume = 254 | issue = 3 | pages = 693–8  | date = Mar 1999 | pmid = 9920803 | pmc =  | doi = 10.1006/bbrc.1998.9995 }}</ref><ref name="pmid10217437">{{cite journal | vauthors = Gong L, Li B, Millas S, Yeh ET | title = Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex | journal = FEBS Lett. | volume = 448 | issue = 1 | pages = 185–9  | date = Jun 1999 | pmid = 10217437 | pmc =  | doi = 10.1016/S0014-5793(99)00367-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10055| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SAE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y8q.
| PDB = {{PDB2|1y8q}}, {{PDB2|1y8r}}
| Name = SUMO1 activating enzyme subunit 1
| HGNCid = 30660
| Symbol = SAE1
| AltSymbols =; AOS1; FLJ3091; HSPC140; SUA1
| OMIM = 
| ECnumber = 
| Homologene = 4019
| MGIid = 1929264
| GeneAtlas_image1 = PBB_GE_SAE1_217946_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004839 |text = ubiquitin activating enzyme activity}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0043008 |text = ATP-dependent protein binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10055
    | Hs_Ensembl = ENSG00000142230
    | Hs_RefseqProtein = NP_005491
    | Hs_RefseqmRNA = NM_005500
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 52325960
    | Hs_GenLoc_end = 52405287
    | Hs_Uniprot = Q9UBE0
    | Mm_EntrezGene = 56459
    | Mm_Ensembl = ENSMUSG00000052833
    | Mm_RefseqmRNA = NM_019748
    | Mm_RefseqProtein = NP_062722
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 15485575
    | Mm_GenLoc_end = 15546309
    | Mm_Uniprot = Q9R1T2
  }}
}}
'''SUMO1 activating enzyme subunit 1''', also known as '''SAE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10055| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SAE1 has been shown to [[Protein-protein interaction|interact]] with [[SAE2]].<ref name=pmid10187858 /><ref name=pmid10217437 /><ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | year = 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
| citations =
* {{cite journal | vauthors = Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT | title = Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9 | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35368–74 | year = 2001 | pmid = 11451954 | doi = 10.1074/jbc.M104214200 }}
*{{cite journal | author=Okuma T, Honda R, Ichikawa G, ''et al.'' |title=In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 693-8 |year= 1999 |pmid= 9920803 |doi= 10.1006/bbrc.1998.9995 }}
* {{cite journal | vauthors = Azuma Y, Tan SH, Cavenagh MM, Ainsztein AM, Saitoh H, Dasso M | title = Expression and regulation of the mammalian SUMO-1 E1 enzyme | journal = FASEB J. | volume = 15 | issue = 10 | pages = 1825–7 | year = 2001 | pmid = 11481243 | doi = 10.1096/fj.00-0818fje }}
*{{cite journal | author=Desterro JM, Rodriguez MS, Kemp GD, Hay RT |title=Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10618-24 |year= 1999 |pmid= 10187858 |doi= }}
* {{cite journal | vauthors = Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y | title = Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation | journal = Biochemistry | volume = 42 | issue = 33 | pages = 9959–69 | year = 2003 | pmid = 12924945 | doi = 10.1021/bi0345283 }}
*{{cite journal | author=Gong L, Li B, Millas S, Yeh ET |title=Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. |journal=FEBS Lett. |volume=448 |issue= 1 |pages= 185-9 |year= 1999 |pmid= 10217437 |doi= }}
* {{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S | title = Complete sequencing and characterization of 21,243 full-length human cDNAs | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–5 | year = 2004 | pmid = 14702039 | doi = 10.1038/ng1285 }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
* {{cite journal | vauthors = Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, Hatakeyama S, Nakayama KI, Yamamoto H, Kikuchi A, Morohashi K | title = Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9 | journal = Mol. Endocrinol. | volume = 18 | issue = 10 | pages = 2451–62 | year = 2004 | pmid = 15192080 | doi = 10.1210/me.2004-0173 }}
*{{cite journal | author=Tatham MH, Jaffray E, Vaughan OA, ''et al.'' |title=Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35368-74 |year= 2001 |pmid= 11451954 |doi= 10.1074/jbc.M104214200 }}
* {{cite journal | vauthors = Salinas S, Briançon-Marjollet A, Bossis G, Lopez MA, Piechaczyk M, Jariel-Encontre I, Debant A, Hipskind RA | title = SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1 | journal = J. Cell Biol. | volume = 165 | issue = 6 | pages = 767–73 | year = 2004 | pmid = 15210726 | pmc = 2172397 | doi = 10.1083/jcb.200310136 }}
*{{cite journal  | author=Azuma Y, Tan SH, Cavenagh MM, ''et al.'' |title=Expression and regulation of the mammalian SUMO-1 E1 enzyme. |journal=FASEB J. |volume=15 |issue= 10 |pages= 1825-7 |year= 2001 |pmid= 11481243 |doi=  }}
* {{cite journal | vauthors = Lin JY, Ohshima T, Shimotohno K | title = Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53 | journal = FEBS Lett. | volume = 573 | issue = 1-3 | pages = 15–8 | year = 2004 | pmid = 15327968 | doi = 10.1016/j.febslet.2004.07.059 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S | title = A mechanism for inhibiting the SUMO pathway | journal = Mol. Cell | volume = 16 | issue = 4 | pages = 549–61 | year = 2004 | pmid = 15546615 | doi = 10.1016/j.molcel.2004.11.007 }}
*{{cite journal  | author=Tatham MH, Kim S, Yu B, ''et al.'' |title=Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. |journal=Biochemistry |volume=42 |issue= 33 |pages= 9959-69 |year= 2003 |pmid= 12924945 |doi= 10.1021/bi0345283 }}
* {{cite journal | vauthors = Lois LM, Lima CD | title = Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 | journal = EMBO J. | volume = 24 | issue = 3 | pages = 439–51 | year = 2005 | pmid = 15660128 | pmc = 548657 | doi = 10.1038/sj.emboj.7600552 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Komatsu T, Mizusaki H, Mukai T, ''et al.'' |title=Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. |journal=Mol. Endocrinol. |volume=18 |issue= 10 |pages= 2451-62 |year= 2005 |pmid= 15192080 |doi= 10.1210/me.2004-0173 }}
* {{cite journal | vauthors = Klenk C, Humrich J, Quitterer U, Lohse MJ | title = SUMO-1 controls the protein stability and the biological function of phosducin | journal = J. Biol. Chem. | volume = 281 | issue = 13 | pages = 8357–64 | year = 2006 | pmid = 16421094 | doi = 10.1074/jbc.M513703200 }}
*{{cite journal | author=Salinas S, Briançon-Marjollet A, Bossis G, ''et al.'' |title=SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. |journal=J. Cell Biol. |volume=165 |issue= 6 |pages= 767-73 |year= 2004 |pmid= 15210726 |doi= 10.1083/jcb.200310136 }}
* {{cite journal | vauthors = Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB | title = A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers | journal = Arch. Biochem. Biophys. | volume = 453 | issue = 1 | pages = 70–4 | year = 2006 | pmid = 16620772 | doi = 10.1016/j.abb.2006.03.002 }}
*{{cite journal | author=Lin JY, Ohshima T, Shimotohno K |title=Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53. |journal=FEBS Lett. |volume=573 |issue= 1-3 |pages= 15-8 |year= 2004 |pmid= 15327968 |doi= 10.1016/j.febslet.2004.07.059 }}
* {{cite journal | vauthors = Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X | title = Ubc9 interacts with SOX4 and represses its transcriptional activity | journal = Biochem. Biophys. Res. Commun. | volume = 344 | issue = 3 | pages = 727–34 | year = 2006 | pmid = 16631117 | doi = 10.1016/j.bbrc.2006.03.194 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Boggio R, Colombo R, Hay RT, ''et al.'' |title=A mechanism for inhibiting the SUMO pathway. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 549-61 |year= 2005 |pmid= 15546615 |doi= 10.1016/j.molcel.2004.11.007 }}
*{{cite journal | author=Lois LM, Lima CD |title=Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. |journal=EMBO J. |volume=24 |issue= 3 |pages= 439-51 |year= 2005 |pmid= 15660128 |doi= 10.1038/sj.emboj.7600552 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Klenk C, Humrich J, Quitterer U, Lohse MJ |title=SUMO-1 controls the protein stability and the biological function of phosducin. |journal=J. Biol. Chem. |volume=281 |issue= 13 |pages= 8357-64 |year= 2006 |pmid= 16421094 |doi= 10.1074/jbc.M513703200 }}
*{{cite journal | author=Li T, Santockyte R, Shen RF, ''et al.'' |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70-4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002 }}
*{{cite journal | author=Pan X, Li H, Zhang P, ''et al.'' |title=Ubc9 interacts with SOX4 and represses its transcriptional activity. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 727-34 |year= 2006 |pmid= 16631117 |doi= 10.1016/j.bbrc.2006.03.194 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|SAE1}}
* {{UCSC gene details|SAE1}}
 
{{PDB Gallery|geneid=10055}}
 
 
{{gene-19-stub}}

Latest revision as of 02:09, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.[1][2][3][4]

Interactions

SAE1 has been shown to interact with SAE2.[1][3][5][6]

References

  1. ↑ 1.0 1.1 Desterro JM, Rodriguez MS, Kemp GD, Hay RT (May 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. doi:10.1074/jbc.274.15.10618. PMID 10187858.
  2. ↑ Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H (Mar 1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.
  3. ↑ 3.0 3.1 Gong L, Li B, Millas S, Yeh ET (Jun 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. doi:10.1016/S0014-5793(99)00367-1. PMID 10217437.
  4. ↑ "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1".
  5. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  6. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT (2001). "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9". J. Biol. Chem. 276 (38): 35368–74. doi:10.1074/jbc.M104214200. PMID 11451954.
  • Azuma Y, Tan SH, Cavenagh MM, Ainsztein AM, Saitoh H, Dasso M (2001). "Expression and regulation of the mammalian SUMO-1 E1 enzyme". FASEB J. 15 (10): 1825–7. doi:10.1096/fj.00-0818fje. PMID 11481243.
  • Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y (2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry. 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.
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