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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Endophilin-A2''' is a [[protein]] that in humans is encoded by the ''SH3GL1'' [[gene]].<ref name="pmid9169142">{{cite journal | vauthors = Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N | title = A novel SH3-containing human gene family preferentially expressed in the central nervous system | journal = Genomics | volume = 41 | issue = 3 | pages = 427–34 |date=Jul 1997 | pmid = 9169142 | pmc = | doi =10.1006/geno.1997.4645 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH3GL1 SH3-domain GRB2-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6455| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = SH3-domain GRB2-like 1
| HGNCid = 10830
| Symbol = SH3GL1
| AltSymbols =; CNSA1; EEN; MGC111371; SH3D2B; SH3P8
| OMIM = 601768
| ECnumber = 
| Homologene = 55709
| MGIid = 700010
| GeneAtlas_image1 = PBB_GE_SH3GL1_201851_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6455
    | Hs_Ensembl = ENSG00000141985
    | Hs_RefseqProtein = NP_003016
    | Hs_RefseqmRNA = NM_003025
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 4311370
    | Hs_GenLoc_end = 4351496
    | Hs_Uniprot = Q99961
    | Mm_EntrezGene = 20405
    | Mm_Ensembl = ENSMUSG00000003200
    | Mm_RefseqmRNA = NM_013664
    | Mm_RefseqProtein = NP_038692
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 55610043
    | Mm_GenLoc_end = 55629869
    | Mm_Uniprot = Q3TJB4
  }}
}}
'''SH3-domain GRB2-like 1''', also known as '''SH3GL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH3GL1 SH3-domain GRB2-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6455| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=So CW, Caldas C, Liu MM, ''et al.'' |title=EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2563-8 |year= 1997 |pmid= 9122235 |doi=  }}
*{{cite journal   |vauthors=So CW, Caldas C, Liu MM, etal |title=EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2563–8 |year= 1997 |pmid= 9122235 |doi=10.1073/pnas.94.6.2563  | pmc=20128 }}
*{{cite journal  | author=Giachino C, Lantelme E, Lanzetti L, ''et al.'' |title=A novel SH3-containing human gene family preferentially expressed in the central nervous system. |journal=Genomics |volume=41 |issue= 3 |pages= 427-34 |year= 1997 |pmid= 9169142 |doi=  }}
*{{cite journal  | vauthors=Ringstad N, Nemoto Y, De Camilli P |title=The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8569–74 |year= 1997 |pmid= 9238017 |doi=10.1073/pnas.94.16.8569  | pmc=23017 }}
*{{cite journal | author=Ringstad N, Nemoto Y, De Camilli P |title=The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8569-74 |year= 1997 |pmid= 9238017 |doi= }}
*{{cite journal   |vauthors=Cestra G, Castagnoli L, Dente L, etal |title=The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32001–7 |year= 1999 |pmid= 10542231 |doi=10.1074/jbc.274.45.32001  }}
*{{cite journal | author=Cestra G, Castagnoli L, Dente L, ''et al.'' |title=The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32001-7 |year= 1999 |pmid= 10542231 |doi=  }}
*{{cite journal   |vauthors=So CW, So CK, Cheung N, etal |title=The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. |journal=Leukemia |volume=14 |issue= 4 |pages= 594–601 |year= 2000 |pmid= 10764144 |doi=10.1038/sj.leu.2401692 }}
*{{cite journal | author=So CW, So CK, Cheung N, ''et al.'' |title=The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. |journal=Leukemia |volume=14 |issue= 4 |pages= 594-601 |year= 2000 |pmid= 10764144 |doi=  }}
*{{cite journal   |vauthors=So CW, Sham MH, Chew SL, etal |title=Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. |journal=Biochem. J. |volume=348 |issue= 2|pages= 447–58 |year= 2000 |pmid= 10816441 |doi=10.1042/0264-6021:3480447  | pmc=1221085 }}
*{{cite journal | author=So CW, Sham MH, Chew SL, ''et al.'' |title=Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. |journal=Biochem. J. |volume=348 Pt 2 |issue= |pages= 447-58 |year= 2000 |pmid= 10816441 |doi= }}
*{{cite journal   |vauthors=Petrelli A, Gilestro GF, Lanzardo S, etal |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met |journal=Nature |volume=416 |issue= 6877 |pages= 187–90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a }}
*{{cite journal | author=Petrelli A, Gilestro GF, Lanzardo S, ''et al.'' |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. |journal=Nature |volume=416 |issue= 6877 |pages= 187-90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a }}
*{{cite journal   |vauthors=Chatellard-Causse C, Blot B, Cristina N, etal |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108–15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 }}
*{{cite journal | author=Chatellard-Causse C, Blot B, Cristina N, ''et al.'' |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108-15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Yam JW, Jin DY, So CW, Chan LC |title=Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein |journal=Blood |volume=103 |issue= 4 |pages= 1445–53 |year= 2004 |pmid= 14551139 |doi= 10.1182/blood-2003-07-2452 }}
*{{cite journal | author=Yam JW, Jin DY, So CW, Chan LC |title=Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. |journal=Blood |volume=103 |issue= 4 |pages= 1445-53 |year= 2004 |pmid= 14551139 |doi= 10.1182/blood-2003-07-2452 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Liu H, Chen B, Xiong H, etal |title=Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein |journal=Oncogene |volume=23 |issue= 19 |pages= 3385–94 |year= 2004 |pmid= 15077184 |doi= 10.1038/sj.onc.1207402 }}
*{{cite journal | author=Liu H, Chen B, Xiong H, ''et al.'' |title=Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. |journal=Oncogene |volume=23 |issue= 19 |pages= 3385-94 |year= 2004 |pmid= 15077184 |doi= 10.1038/sj.onc.1207402 }}
*{{cite journal   |vauthors=Cheung N, So CW, Yam JW, etal |title=Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia |journal=Biochem. J. |volume=383 |issue= Pt 1 |pages= 27–35 |year= 2005 |pmid= 15214844 |doi= 10.1042/BJ20040041  | pmc=1134040 }}
*{{cite journal | author=Cheung N, So CW, Yam JW, ''et al.'' |title=Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia. |journal=Biochem. J. |volume=383 |issue= Pt 1 |pages= 27-35 |year= 2005 |pmid= 15214844 |doi= 10.1042/BJ20040041 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Yin X, Warner DR, Roberts EA, etal |title=Identification of novel CBP interacting proteins in embryonic orofacial tissue |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 3 |pages= 1010–7 |year= 2005 |pmid= 15752756 |doi= 10.1016/j.bbrc.2005.02.075 }}
*{{cite journal | author=Yin X, Warner DR, Roberts EA, ''et al.'' |title=Identification of novel CBP interacting proteins in embryonic orofacial tissue. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 3 |pages= 1010-7 |year= 2005 |pmid= 15752756 |doi= 10.1016/j.bbrc.2005.02.075 }}
*{{cite journal  | vauthors=Lua BL, Low BC |title=Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain |journal=J. Cell Sci. |volume=118 |issue= Pt 12 |pages= 2707–21 |year= 2005 |pmid= 15944398 |doi= 10.1242/jcs.02383 }}
*{{cite journal  | author=Lua BL, Low BC |title=Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. |journal=J. Cell. Sci. |volume=118 |issue= Pt 12 |pages= 2707-21 |year= 2005 |pmid= 15944398 |doi= 10.1242/jcs.02383 }}
*{{cite journal   |vauthors=Ralser M, Nonhoff U, Albrecht M, etal |title=Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways |journal=Hum. Mol. Genet. |volume=14 |issue= 19 |pages= 2893–909 |year= 2005 |pmid= 16115810 |doi= 10.1093/hmg/ddi321 }}
*{{cite journal | author=Ralser M, Nonhoff U, Albrecht M, ''et al.'' |title=Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. |journal=Hum. Mol. Genet. |volume=14 |issue= 19 |pages= 2893-909 |year= 2005 |pmid= 16115810 |doi= 10.1093/hmg/ddi321 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
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Revision as of 20:49, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.[1][2]


References

  1. ↑ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
  2. ↑ "Entrez Gene: SH3GL1 SH3-domain GRB2-like 1".

Further reading



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