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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''U6 snRNA-associated Sm-like protein LSm4''' is a [[protein]] that in humans is encoded by the ''LSM4'' [[gene]].<ref name="pmid10369684">{{cite journal |vauthors=Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B | title = Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin | journal = EMBO J | volume = 18 | issue = 12 | pages = 3451–62 |date=Aug 1999 | pmid = 10369684 | pmc = 1171424 | doi = 10.1093/emboj/18.12.3451 }}</ref><ref name="pmid10523320">{{cite journal |vauthors=Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R | title = A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro | journal = EMBO J | volume = 18 | issue = 20 | pages = 5789–802 |date=Dec 1999 | pmid = 10523320 | pmc = 1171645 | doi = 10.1093/emboj/18.20.5789 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25804| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
| HGNCid = 17259
| Symbol = LSM4
| AltSymbols =; YER112W
| OMIM = 607284
| ECnumber =
| Homologene = 5837
| MGIid = 1354692
| GeneAtlas_image1 = PBB_GE_LSM4_202736_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_LSM4_202737_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005688 |text = snRNP U6}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25804
    | Hs_Ensembl = ENSG00000130520
    | Hs_RefseqProtein = NP_036453
    | Hs_RefseqmRNA = NM_012321
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 18278720
    | Hs_GenLoc_end = 18294958
    | Hs_Uniprot = Q9Y4Z0
    | Mm_EntrezGene = 50783
    | Mm_Ensembl = ENSMUSG00000031848
    | Mm_RefseqmRNA = NM_015816
    | Mm_RefseqProtein = NP_056631
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 73605544
    | Mm_GenLoc_end = 73607440
    | Mm_Uniprot = Q9CY46
  }}
}}
'''LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)''', also known as '''LSM4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25804| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25804| accessdate = }}</ref>
| summary_text = Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Singer J, Roberts-Ems J, Luthardt FW, Riggs AD |title=Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit. |journal=Nucleic Acids Res. |volume=7 |issue= 8 |pages= 2369-85 |year= 1980 |pmid= 523320 |doi=  }}
*{{cite journal  |vauthors=Singer J, Roberts-Ems J, Luthardt FW, Riggs AD |title=Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit |journal=Nucleic Acids Res. |volume=7 |issue= 8 |pages= 2369–85 |year= 1980 |pmid= 523320 |doi=10.1093/nar/7.8.2369 | pmc=342390  }}
*{{cite journal  | author=Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B |title=Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3451-62 |year= 1999 |pmid= 10369684 |doi= 10.1093/emboj/18.12.3451 }}
*{{cite journal  |vauthors=Friesen WJ, Dreyfuss G |title=Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26370–5 |year= 2000 |pmid= 10851237 |doi= 10.1074/jbc.M003299200 }}
*{{cite journal | author=Achsel T, Brahms H, Kastner B, ''et al.'' |title=A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5789-802 |year= 1999 |pmid= 10523320 |doi= 10.1093/emboj/18.20.5789 }}
*{{cite journal   |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 }}
*{{cite journal  | author=Friesen WJ, Dreyfuss G |title=Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26370-5 |year= 2000 |pmid= 10851237 |doi= 10.1074/jbc.M003299200 }}
*{{cite journal   |vauthors=Eystathioy T, Peebles CL, Hamel JC, etal |title=Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera |journal=Arthritis Rheum. |volume=46 |issue= 3 |pages= 726–34 |year= 2002 |pmid= 11920408 |doi= 10.1002/art.10220 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Eystathioy T, Peebles CL, Hamel JC, ''et al.'' |title=Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera. |journal=Arthritis Rheum. |volume=46 |issue= 3 |pages= 726-34 |year= 2002 |pmid= 11920408 |doi= 10.1002/art.10220 }}
*{{cite journal  |vauthors=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi= 10.1017/S1355838202021726| pmc=1370355 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489-501 |year= 2003 |pmid= 12515382 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal   |vauthors=Fürst J, Schedlbauer A, Gandini R, etal |title=ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4 |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 31276–82 |year= 2005 |pmid= 15905169 |doi= 10.1074/jbc.M500541200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Fürst J, Schedlbauer A, Gandini R, ''et al.'' |title=ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 31276-82 |year= 2005 |pmid= 15905169 |doi= 10.1074/jbc.M500541200 }}
*{{cite journal   |vauthors=Yang ZQ, Streicher KL, Ray ME, etal |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632–43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Yang ZQ, Streicher KL, Ray ME, ''et al.'' |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632-43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:10, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.[1][2][3]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][3]

References

  1. ↑ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  2. ↑ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  3. ↑ 3.0 3.1 "Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Further reading



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