PCSK4: Difference between revisions

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{{Underlinked|date=June 2016}}
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'''Proprotein convertase subtilisin/kexin type 4''' is an [[enzyme]] that in humans is encoded by the ''PCSK4'' [[gene]].<ref name="pmid7782070">{{cite journal | vauthors = Mbikay M, Seidah NG, Chretien M, Simpson EM | title = Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human | journal = Genomics | volume = 26 | issue = 1 | pages = 123–9 |date=Jul 1995 | pmid = 7782070 | pmc =  | doi =10.1016/0888-7543(95)80090-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54760| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Proprotein convertase subtilisin/kexin type 4
| HGNCid = 8746
| Symbol = PCSK4
| AltSymbols =; PC4; DKFZp434B217; MGC34749; SPC5
| OMIM = 600487
| ECnumber = 
| Homologene = 22495
| MGIid = 97514
| Function = {{GNF_GO|id=GO:0004289 |text = subtilase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54760
    | Hs_Ensembl = ENSG00000115257
    | Hs_RefseqProtein = NP_060043
    | Hs_RefseqmRNA = NM_017573
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 1432427
    | Hs_GenLoc_end = 1441407
    | Hs_Uniprot = Q6UW60
    | Mm_EntrezGene = 18551
    | Mm_Ensembl = ENSMUSG00000020131
    | Mm_RefseqmRNA = NM_008793
    | Mm_RefseqProtein = NP_032819
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79724431
    | Mm_GenLoc_end = 79732602
    | Mm_Uniprot = Q7TT02
  }}
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'''Proprotein convertase subtilisin/kexin type 4''', also known as '''PCSK4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54760| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Seidah NG, Chrétien M, Day R |title=The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. |journal=Biochimie |volume=76 |issue= 3-4 |pages= 197-209 |year= 1995 |pmid= 7819324 |doi=  }}
*{{cite journal  | vauthors=Seidah NG, Chrétien M, Day R |title=The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. |journal=Biochimie |volume=76 |issue= 3–4 |pages= 197–209 |year= 1995 |pmid= 7819324 |doi=10.1016/0300-9084(94)90147-3 }}
*{{cite journal  | author=Bassi DE, Mahloogi H, Klein-Szanto AJ |title=The proprotein convertases furin and PACE4 play a significant role in tumor progression. |journal=Mol. Carcinog. |volume=28 |issue= 2 |pages= 63-9 |year= 2000 |pmid= 10900462 |doi= }}
*{{cite journal  | vauthors=Bassi DE, Mahloogi H, Klein-Szanto AJ |title=The proprotein convertases furin and PACE4 play a significant role in tumor progression |journal=Mol. Carcinog. |volume=28 |issue= 2 |pages= 63–9 |year= 2000 |pmid= 10900462 |doi=10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C }}
*{{cite journal  | author=Mbikay M, Seidah NG, Chrétien M, Simpson EM |title=Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. |journal=Genomics |volume=26 |issue= 1 |pages= 123-9 |year= 1995 |pmid= 7782070 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Malik S, Guermah M, Roeder RG |title=A dynamic model for PC4 coactivator function in RNA polymerase II transcription |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2192–7 |year= 1998 |pmid= 9482861 |doi=10.1073/pnas.95.5.2192  | pmc=19292 }}
*{{cite journal  | author=Malik S, Guermah M, Roeder RG |title=A dynamic model for PC4 coactivator function in RNA polymerase II transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2192-7 |year= 1998 |pmid= 9482861 |doi=  }}
*{{cite journal  | vauthors=Wang Z, Roeder RG |title=DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III |journal=Mol. Cell |volume=1 |issue= 5 |pages= 749–57 |year= 1998 |pmid= 9660958 |doi=10.1016/S1097-2765(00)80074-X }}
*{{cite journal  | author=Wang Z, Roeder RG |title=DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 749-57 |year= 1998 |pmid= 9660958 |doi=  }}
*{{cite journal   |vauthors=Li M, Mbikay M, Nakayama K, etal |title=Prohormone convertase PC4 processes the precursor of PACAP in the testis |journal=Ann. N. Y. Acad. Sci. |volume=921 |issue=  |pages= 333–9 |year= 2001 |pmid= 11193847 |doi=10.1111/j.1749-6632.2000.tb06988.x }}
*{{cite journal | author=Li M, Mbikay M, Nakayama K, ''et al.'' |title=Prohormone convertase PC4 processes the precursor of PACAP in the testis. |journal=Ann. N. Y. Acad. Sci. |volume=921 |issue=  |pages= 333-9 |year= 2001 |pmid= 11193847 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Qiu Q, Basak A, Mbikay M, etal |title=Role of pro-IGF-II processing by proprotein convertase 4 in human placental development |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 31 |pages= 11047–52 |year= 2005 |pmid= 16040806 |doi= 10.1073/pnas.0502357102 | pmc=1182422 }}
*{{cite journal | author=Qiu Q, Basak A, Mbikay M, ''et al.'' |title=Role of pro-IGF-II processing by proprotein convertase 4 in human placental development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 31 |pages= 11047-52 |year= 2005 |pmid= 16040806 |doi= 10.1073/pnas.0502357102 }}
}}
}}
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Latest revision as of 17:46, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.[1][2]


References

  1. ↑ Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.
  2. ↑ "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

Further reading



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