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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Kinesin light chain 3''' is a [[protein]] that in humans is encoded by the ''KLC3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLC3 kinesin light chain 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147700| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kinesin light chain 3
| HGNCid = 20717
| Symbol = KLC3
| AltSymbols =; KLC2; KLC2L; KLCt; KNS2B
| OMIM = 601334
| ECnumber = 
| Homologene = 14899
| MGIid = 1277971
| Function = {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0008808 |text = cardiolipin synthase activity}} {{GNF_GO|id=GO:0019894 |text = kinesin binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005871 |text = kinesin complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0009434 |text = microtubule-based flagellum}} {{GNF_GO|id=GO:0035253 |text = ciliary rootlet}} {{GNF_GO|id=GO:0043005 |text = neuron projection}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 147700
    | Hs_Ensembl = ENSG00000104892
    | Hs_RefseqProtein = NP_803136
    | Hs_RefseqmRNA = NM_177417
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 50540498
    | Hs_GenLoc_end = 50546618
    | Hs_Uniprot = Q6P597
    | Mm_EntrezGene = 232943
    | Mm_Ensembl = ENSMUSG00000040714
    | Mm_RefseqmRNA = NM_146182
    | Mm_RefseqProtein = NP_666294
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 18552965
    | Mm_GenLoc_end = 18558400
    | Mm_Uniprot = Q91W40
  }}
}}
'''Kinesin light chain 3''', also known as '''KLC3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLC3 kinesin light chain 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147700| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.<ref name="entrez">{{cite web | title = Entrez Gene: KLC3 kinesin light chain 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147700| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
KLC3 has been shown to [[Protein-protein interaction|interact]] with [[YWHAH]].<ref name=pmid11969417>{{cite journal | vauthors = Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T | title = Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein | journal = Biochemistry | volume = 41 | issue = 17 | pages = 5566–72 | date = Apr 2002 | pmid = 11969417 | doi = 10.1021/bi015946f }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
| citations =
* {{cite journal | vauthors = Zhang Y, Oko R, van der Hoorn FA | title = Rat kinesin light chain 3 associates with spermatid mitochondria | journal = Developmental Biology | volume = 275 | issue = 1 | pages = 23–33 | date = Nov 2004 | pmid = 15464570 | pmc = 3138780 | doi = 10.1016/j.ydbio.2004.07.014 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn FA | title = Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16159–68 | date = May 2003 | pmid = 12594206 | pmc = 3178653 | doi = 10.1074/jbc.M213126200 }}
*{{cite journal  | author=Zhang Y, Oko R, van der Hoorn FA |title=Rat kinesin light chain 3 associates with spermatid mitochondria. |journal=Dev. Biol. |volume=275 |issue= 1 |pages= 23-33 |year= 2004 |pmid= 15464570 |doi= 10.1016/j.ydbio.2004.07.014 }}
* {{cite journal | vauthors = Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T | title = Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet | journal = The Journal of Cell Biology | volume = 159 | issue = 3 | pages = 431–40 | date = Nov 2002 | pmid = 12427867 | pmc = 2173070 | doi = 10.1083/jcb.200207153 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
* {{cite journal | vauthors = Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T | title = Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein | journal = Biochemistry | volume = 41 | issue = 17 | pages = 5566–72 | date = Apr 2002 | pmid = 11969417 | doi = 10.1021/bi015946f }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA | title = Kinesin light-chain KLC3 expression in testis is restricted to spermatids | journal = Biology of Reproduction | volume = 64 | issue = 5 | pages = 1320–30 | date = May 2001 | pmid = 11319135 | pmc = 3161965 | doi = 10.1095/biolreprod64.5.1320 }}
*{{cite journal  | author=Bhullar B, Zhang Y, Junco A, ''et al.'' |title=Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16159-68 |year= 2003 |pmid= 12594206 |doi= 10.1074/jbc.M213126200 }}
* {{cite journal | vauthors = Rahman A, Kamal A, Roberts EA, Goldstein LS | title = Defective kinesin heavy chain behavior in mouse kinesin light chain mutants | journal = The Journal of Cell Biology | volume = 146 | issue = 6 | pages = 1277–88 | date = Sep 1999 | pmid = 10491391 | pmc = 2156125 | doi = 10.1083/jcb.146.6.1277 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rahman A, Friedman DS, Goldstein LS | title = Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 25 | pages = 15395–403 | date = Jun 1998 | pmid = 9624122 | doi = 10.1074/jbc.273.25.15395 }}
*{{cite journal  | author=Yang J, Liu X, Yue G, ''et al.'' |title=Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. |journal=J. Cell Biol. |volume=159 |issue= 3 |pages= 431-40 |year= 2002 |pmid= 12427867 |doi= 10.1083/jcb.200207153 }}
* {{cite journal | vauthors = Lamerdin JE, Stilwagen SA, Ramirez MH, Stubbs L, Carrano AV | title = Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes | journal = Genomics | volume = 34 | issue = 3 | pages = 399–409 | date = Jun 1996 | pmid = 8786141 | doi = 10.1006/geno.1996.0303 }}
*{{cite journal | author=Ichimura T, Wakamiya-Tsuruta A, Itagaki C, ''et al.'' |title=Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. |journal=Biochemistry |volume=41 |issue= 17 |pages= 5566-72 |year= 2002 |pmid= 11969417 |doi= }}
*{{cite journal | author=Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA |title=Kinesin light-chain KLC3 expression in testis is restricted to spermatids. |journal=Biol. Reprod. |volume=64 |issue= 5 |pages= 1320-30 |year= 2001 |pmid= 11319135 |doi= }}
*{{cite journal | author=Rahman A, Kamal A, Roberts EA, Goldstein LS |title=Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. |journal=J. Cell Biol. |volume=146 |issue= 6 |pages= 1277-88 |year= 1999 |pmid= 10491391 |doi= }}
*{{cite journal | author=Rahman A, Friedman DS, Goldstein LS |title=Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15395-403 |year= 1998 |pmid= 9624122 |doi= }}
*{{cite journal | author=Lamerdin JE, Stilwagen SA, Ramirez MH, ''et al.'' |title=Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. |journal=Genomics |volume=34 |issue= 3 |pages= 399-409 |year= 1996 |pmid= 8786141 |doi= 10.1006/geno.1996.0303 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 03:11, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.[1]

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.[1]

Interactions

KLC3 has been shown to interact with YWHAH.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: KLC3 kinesin light chain 3".
  2. ↑ Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

Further reading


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