PPP1R13L: Difference between revisions

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{{Infobox_gene}}
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'''RelA-associated inhibitor''' is a [[protein]] that in humans is encoded by the ''PPP1R13L'' [[gene]].<ref name="pmid10336463">{{cite journal |vauthors=Yang JP, Hori M, Sanda T, Okamoto T | title = Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor | journal = J Biol Chem | volume = 274 | issue = 22 | pages = 15662–70 |date=Jun 1999 | pmid = 10336463 | pmc =  | doi =10.1074/jbc.274.22.15662 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10848| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 13 like
| HGNCid = 18838
| Symbol = PPP1R13L
| AltSymbols =; RAI; IASPP; NKIP1; iASPP gene
| OMIM = 607463
| ECnumber = 
| Homologene = 84635
| MGIid = 3525053
| GeneAtlas_image1 = PBB_GE_PPP1R13L_218849_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10848
    | Hs_Ensembl = ENSG00000104881
    | Hs_RefseqProtein = NP_006654
    | Hs_RefseqmRNA = NM_006663
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 50574741
    | Hs_GenLoc_end = 50601410
    | Hs_Uniprot = Q8WUF5
    | Mm_EntrezGene = 333654
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = NM_001010836
    | Mm_RefseqProtein = NP_001010836
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 13 like''', also known as '''PPP1R13L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10848| accessdate = }}</ref>


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==Interactions==
PPP1R13L has been shown to [[Protein-protein interaction|interact]] with [[Sp1 transcription factor]]<ref name=pmid12134007>{{cite journal |last=Takada |first=Norio |authorlink= |author2=Sanda Takaomi |author3=Okamoto Hiroshi |author4=Yang Jian-Ping |author5=Asamitsu Kaori |author6=Sarol Lilen |author7=Kimura Genjiro |author8=Uranishi Hiroaki |author9=Tetsuka Toshifumi |author10=Okamoto Takashi  |date=Aug 2002 |title=RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-κB and Sp1 Actions |journal=J. Virol. |volume=76 |issue=16 |pages=8019–30 |publisher= |location = United States| issn = 0022-538X| pmid = 12134007 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/JVI.76.16.8019-8030.2002 |pmc=155123 }}</ref> and [[RELA]].<ref name=pmid10336463 /><ref name=pmid12134007/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53. |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77-80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002 }}
*{{cite journal  |vauthors=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53 |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77–80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002 }}
*{{cite journal | author=Yang JP, Hori M, Sanda T, Okamoto T |title=Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15662-70 |year= 1999 |pmid= 10336463 |doi=  }}
*{{cite journal   |vauthors=Takada N, Sanda T, Okamoto H, etal |title=RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-κB and Sp1 Actions |journal=J. Virol. |volume=76 |issue= 16 |pages= 8019–30 |year= 2002 |pmid= 12134007 |doi=10.1128/JVI.76.16.8019-8030.2002  | pmc=155123 }}
*{{cite journal  | author=Takada N, Sanda T, Okamoto H, ''et al.'' |title=RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions. |journal=J. Virol. |volume=76 |issue= 16 |pages= 8019-30 |year= 2002 |pmid= 12134007 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Bergamaschi D, Samuels Y, O'Neil NJ, etal |title=iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human |journal=Nat. Genet. |volume=33 |issue= 2 |pages= 162–7 |year= 2003 |pmid= 12524540 |doi= 10.1038/ng1070 }}
*{{cite journal | author=Bergamaschi D, Samuels Y, O'Neil NJ, ''et al.'' |title=iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. |journal=Nat. Genet. |volume=33 |issue= 2 |pages= 162-7 |year= 2003 |pmid= 12524540 |doi= 10.1038/ng1070 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Slee EA, Gillotin S, Bergamaschi D, etal |title=The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization |journal=Oncogene |volume=23 |issue= 56 |pages= 9007–16 |year= 2005 |pmid= 15489900 |doi= 10.1038/sj.onc.1208088 }}
*{{cite journal | author=Slee EA, Gillotin S, Bergamaschi D, ''et al.'' |title=The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. |journal=Oncogene |volume=23 |issue= 56 |pages= 9007-16 |year= 2005 |pmid= 15489900 |doi= 10.1038/sj.onc.1208088 }}
*{{cite journal   |vauthors=Issaeva N, Bozko P, Enge M, etal |title=Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors |journal=Nat. Med. |volume=10 |issue= 12 |pages= 1321–8 |year= 2005 |pmid= 15558054 |doi= 10.1038/nm1146 }}
*{{cite journal | author=Issaeva N, Bozko P, Enge M, ''et al.'' |title=Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. |journal=Nat. Med. |volume=10 |issue= 12 |pages= 1321-8 |year= 2005 |pmid= 15558054 |doi= 10.1038/nm1146 }}
*{{cite journal   |vauthors=Zhang X, Wang M, Zhou C, etal |title=The expression of iASPP in acute leukemias |journal=Leuk. Res. |volume=29 |issue= 2 |pages= 179–83 |year= 2005 |pmid= 15607367 |doi= 10.1016/j.leukres.2004.07.001 }}
*{{cite journal | author=Zhang X, Wang M, Zhou C, ''et al.'' |title=The expression of iASPP in acute leukemias. |journal=Leuk. Res. |volume=29 |issue= 2 |pages= 179-83 |year= 2005 |pmid= 15607367 |doi= 10.1016/j.leukres.2004.07.001 }}
*{{cite journal   |vauthors=Laska MJ, Nexø BA, Vistisen K, etal |title=Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer |journal=Cancer Lett. |volume=225 |issue= 2 |pages= 245–51 |year= 2005 |pmid= 15885892 |doi= 10.1016/j.canlet.2005.03.021 }}
*{{cite journal | author=Laska MJ, Nexø BA, Vistisen K, ''et al.'' |title=Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. |journal=Cancer Lett. |volume=225 |issue= 2 |pages= 245-51 |year= 2005 |pmid= 15885892 |doi= 10.1016/j.canlet.2005.03.021 }}
*{{cite journal   |vauthors=Skjelbred CF, Saebø M, Nexø BA, etal |title=Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study |journal=BMC Cancer |volume=6|pages= 175 |year= 2006 |pmid= 16817948 |doi= 10.1186/1471-2407-6-175 | pmc=1533843 }}
*{{cite journal | author=Skjelbred CF, Saebø M, Nexø BA, ''et al.'' |title=Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. |journal=BMC Cancer |volume=6 |issue=  |pages= 175 |year= 2006 |pmid= 16817948 |doi= 10.1186/1471-2407-6-175 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Bergamaschi D, Samuels Y, Sullivan A, etal |title=iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53 |journal=Nat. Genet. |volume=38 |issue= 10 |pages= 1133–41 |year= 2006 |pmid= 16964264 |doi= 10.1038/ng1879 }}
*{{cite journal | author=Bergamaschi D, Samuels Y, Sullivan A, ''et al.'' |title=iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. |journal=Nat. Genet. |volume=38 |issue= 10 |pages= 1133-41 |year= 2006 |pmid= 16964264 |doi= 10.1038/ng1879 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Zhang X, Diao S, Rao Q, etal |title=Identification of a novel isoform of iASPP and its interaction with p53 |journal=J. Mol. Biol. |volume=368 |issue= 4 |pages= 1162–71 |year= 2007 |pmid= 17391696 |doi= 10.1016/j.jmb.2007.03.001 }}
*{{cite journal | author=Zhang X, Diao S, Rao Q, ''et al.'' |title=Identification of a novel isoform of iASPP and its interaction with p53. |journal=J. Mol. Biol. |volume=368 |issue= 4 |pages= 1162-71 |year= 2007 |pmid= 17391696 |doi= 10.1016/j.jmb.2007.03.001 }}
*{{cite journal   |vauthors=Laska MJ, Strandbygård D, Kjeldgaard A, etal |title=Expression of the RAI gene is conducive to apoptosis: studies of induction and interference |journal=Exp. Cell Res. |volume=313 |issue= 12 |pages= 2611–21 |year= 2007 |pmid= 17570360 |doi= 10.1016/j.yexcr.2007.05.006 }}
*{{cite journal | author=Laska MJ, Strandbygård D, Kjeldgaard A, ''et al.'' |title=Expression of the RAI gene is conducive to apoptosis: studies of induction and interference. |journal=Exp. Cell Res. |volume=313 |issue= 12 |pages= 2611-21 |year= 2007 |pmid= 17570360 |doi= 10.1016/j.yexcr.2007.05.006 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:33, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene.[1][2]


Interactions

PPP1R13L has been shown to interact with Sp1 transcription factor[3] and RELA.[1][3]

References

  1. ↑ 1.0 1.1 Yang JP, Hori M, Sanda T, Okamoto T (Jun 1999). "Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor". J Biol Chem. 274 (22): 15662–70. doi:10.1074/jbc.274.22.15662. PMID 10336463.
  2. ↑ "Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like".
  3. ↑ 3.0 3.1 Takada, Norio; Sanda Takaomi; Okamoto Hiroshi; Yang Jian-Ping; Asamitsu Kaori; Sarol Lilen; Kimura Genjiro; Uranishi Hiroaki; Tetsuka Toshifumi; Okamoto Takashi (Aug 2002). "RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-κB and Sp1 Actions". J. Virol. United States. 76 (16): 8019–30. doi:10.1128/JVI.76.16.8019-8030.2002. ISSN 0022-538X. PMC 155123. PMID 12134007.

Further reading



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