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'''Sialic acid-binding Ig-like lectin 9''' is a [[protein]] that in humans is encoded by the ''SIGLEC9'' [[gene]].<ref name="pmid10903842">{{cite journal | vauthors = Foussias G, Yousef GM, Diamandis EP | title = Identification and molecular characterization of a novel member of the siglec family (SIGLEC9) | journal = Genomics | volume = 67 | issue = 2 | pages = 171–8 |date=Aug 2000 | pmid = 10903842 | pmc =  | doi = 10.1006/geno.2000.6208 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27180| accessdate = }}</ref>
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| image = 
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| PDB =
| Name = Sialic acid binding Ig-like lectin 9
| HGNCid = 10878
| Symbol = SIGLEC9
| AltSymbols =; CDw329; OBBP-LIKE
| OMIM = 605640
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_SIGLEC9_210569_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27180
    | Hs_Ensembl = ENSG00000129450
    | Hs_RefseqProtein = NP_055256
    | Hs_RefseqmRNA = NM_014441
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 56319977
    | Hs_GenLoc_end = 56325378
    | Hs_Uniprot = Q9Y336
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
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'''Sialic acid binding Ig-like lectin 9''', also known as '''SIGLEC9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27180| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yousef GM, Luo LY, Diamandis EP |title=Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. |journal=Anticancer Res. |volume=19 |issue= 4B |pages= 2843-52 |year= 2000 |pmid= 10652563 |doi=  }}
*{{cite journal  | vauthors=Yousef GM, Luo LY, Diamandis EP |title=Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4 |journal=Anticancer Res. |volume=19 |issue= 4B |pages= 2843–52 |year= 2000 |pmid= 10652563 |doi=  }}
*{{cite journal  | author=Angata T, Varki A |title=Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22127-35 |year= 2000 |pmid= 10801860 |doi= 10.1074/jbc.M002775200 }}
*{{cite journal  | vauthors=Angata T, Varki A |title=Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22127–35 |year= 2000 |pmid= 10801860 |doi= 10.1074/jbc.M002775200 }}
*{{cite journal  | author=Zhang JQ, Nicoll G, Jones C, Crocker PR |title=Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22121-6 |year= 2000 |pmid= 10801862 |doi= 10.1074/jbc.M002788200 }}
*{{cite journal  | vauthors=Zhang JQ, Nicoll G, Jones C, Crocker PR |title=Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22121–6 |year= 2000 |pmid= 10801862 |doi= 10.1074/jbc.M002788200 }}
*{{cite journal | author=Foussias G, Yousef GM, Diamandis EP |title=Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). |journal=Genomics |volume=67 |issue= 2 |pages= 171-8 |year= 2000 |pmid= 10903842 |doi= 10.1006/geno.2000.6208 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Sonnenburg JL, Altheide TK, Varki A |title=A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor |journal=Glycobiology |volume=14 |issue= 4 |pages= 339–46 |year= 2004 |pmid= 14693915 |doi= 10.1093/glycob/cwh039 }}
*{{cite journal  | author=Sonnenburg JL, Altheide TK, Varki A |title=A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. |journal=Glycobiology |volume=14 |issue= 4 |pages= 339-46 |year= 2004 |pmid= 14693915 |doi= 10.1093/glycob/cwh039 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | vauthors=Ikehara Y, Ikehara SK, Paulson JC |title=Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9 |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 43117–25 |year= 2004 |pmid= 15292262 |doi= 10.1074/jbc.M403538200 }}
*{{cite journal  | author=Ikehara Y, Ikehara SK, Paulson JC |title=Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 43117-25 |year= 2004 |pmid= 15292262 |doi= 10.1074/jbc.M403538200 }}
*{{cite journal   |vauthors=Avril T, Floyd H, Lopez F, etal |title=The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells |journal=J. Immunol. |volume=173 |issue= 11 |pages= 6841–9 |year= 2005 |pmid= 15557178 |doi=  10.4049/jimmunol.173.11.6841}}
*{{cite journal | author=Avril T, Floyd H, Lopez F, ''et al.'' |title=The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. |journal=J. Immunol. |volume=173 |issue= 11 |pages= 6841-9 |year= 2005 |pmid= 15557178 |doi=  }}
*{{cite journal   |vauthors=von Gunten S, Yousefi S, Seitz M, etal |title=Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment |journal=Blood |volume=106 |issue= 4 |pages= 1423–31 |year= 2005 |pmid= 15827126 |doi= 10.1182/blood-2004-10-4112 }}
*{{cite journal | author=von Gunten S, Yousefi S, Seitz M, ''et al.'' |title=Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. |journal=Blood |volume=106 |issue= 4 |pages= 1423-31 |year= 2005 |pmid= 15827126 |doi= 10.1182/blood-2004-10-4112 }}
*{{cite journal   |vauthors=Rapoport EM, Pazynina GV, Sablina MA, etal |title=Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides |journal=Biochemistry Mosc. |volume=71 |issue= 5 |pages= 496–504 |year= 2006 |pmid= 16732727 |doi=10.1134/S0006297906050051 }}
*{{cite journal | author=Rapoport EM, Pazynina GV, Sablina MA, ''et al.'' |title=Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides. |journal=Biochemistry Mosc. |volume=71 |issue= 5 |pages= 496-504 |year= 2006 |pmid= 16732727 |doi=  }}
*{{cite journal  | vauthors=Biedermann B, Gil D, Bowen DT, Crocker PR |title=Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors |journal=Leuk. Res. |volume=31 |issue= 2 |pages= 211–20 |year= 2007 |pmid= 16828866 |doi= 10.1016/j.leukres.2006.05.026 }}
*{{cite journal  | author=Biedermann B, Gil D, Bowen DT, Crocker PR |title=Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. |journal=Leuk. Res. |volume=31 |issue= 2 |pages= 211-20 |year= 2007 |pmid= 16828866 |doi= 10.1016/j.leukres.2006.05.026 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 06:21, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.[1][2]


References

  1. ↑ Foussias G, Yousef GM, Diamandis EP (Aug 2000). "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)". Genomics. 67 (2): 171–8. doi:10.1006/geno.2000.6208. PMID 10903842.
  2. ↑ "Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9".

Further reading



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