HRC (gene): Difference between revisions

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{{Infobox_gene}}
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'''Sarcoplasmic reticulum histidine-rich calcium-binding protein''' is a [[protein]] that in humans is encoded by the ''HRC'' [[gene]].<ref name="pmid2037293">{{cite journal | vauthors = Hofmann SL, Topham M, Hsieh CL, Francke U | title = cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7 | journal = Genomics | volume = 9 | issue = 4 | pages = 656–69 | date = Apr 1991 | pmid = 2037293 | pmc =  | doi = 10.1016/0888-7543(91)90359-M }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HRC histidine rich calcium binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3270| accessdate = }}</ref>
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Histidine rich calcium binding protein
| HGNCid = 5178
| Symbol = HRC
| AltSymbols =; MGC133236
| OMIM = 142705
| ECnumber = 
| Homologene = 1622
| MGIid = 96226
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005790 |text = smooth endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3270
    | Hs_Ensembl = ENSG00000130528
    | Hs_RefseqProtein = NP_002143
    | Hs_RefseqmRNA = NM_002152
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 54346270
    | Hs_GenLoc_end = 54350493
    | Hs_Uniprot = P23327
    | Mm_EntrezGene = 15464
    | Mm_Ensembl = ENSMUSG00000038239
    | Mm_RefseqmRNA = NM_010473
    | Mm_RefseqProtein = NP_034603
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 45203332
    | Mm_GenLoc_end = 45207012
    | Mm_Uniprot = 
  }}
}}
'''Histidine rich calcium binding protein''', also known as '''HRC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HRC histidine rich calcium binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3270| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity<ref name="entrez">{{cite web | title = Entrez Gene: HRC histidine rich calcium binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3270| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Anderson NL, Anderson NG | title = The human plasma proteome: history, character, and diagnostic prospects | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 11 | pages = 845–67 | date = Nov 2002 | pmid = 12488461 | doi = 10.1074/mcp.R200007-MCP200 }}
| citations =
* {{cite journal | vauthors = Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL | title = Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins | journal = The Journal of Biological Chemistry | volume = 264 | issue = 14 | pages = 8260–70 | date = May 1989 | pmid = 2498310 | doi =  }}
*{{cite journal | author=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell Proteomics |volume=1 |issue= 11 |pages= 845-67 |year= 2003 |pmid= 12488461 |doi= }}
* {{cite journal | vauthors = Ridgeway AG, Petropoulos H, Siu A, Ball JK, Skerjanc IS | title = Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein | journal = FEBS Letters | volume = 456 | issue = 3 | pages = 399–402 | date = Aug 1999 | pmid = 10462052 | doi = 10.1016/S0014-5793(99)00993-X }}
*{{cite journal  | author=Hofmann SL, Topham M, Hsieh CL, Francke U |title=cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. |journal=Genomics |volume=9 |issue= 4 |pages= 656-69 |year= 1991 |pmid= 2037293 |doi=  }}
* {{cite journal | vauthors = Lee HG, Kang H, Kim DH, Park WJ | title = Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39533–8 | date = Oct 2001 | pmid = 11504710 | doi = 10.1074/jbc.M010664200 }}
*{{cite journal | author=Hofmann SL, Brown MS, Lee E, ''et al.'' |title=Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins. |journal=J. Biol. Chem. |volume=264 |issue= 14 |pages= 8260-70 |year= 1989 |pmid= 2498310 |doi=  }}
* {{cite journal | vauthors = Sacchetto R, Damiani E, Turcato F, Nori A, Margreth A | title = Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region | journal = Biochemical and Biophysical Research Communications | volume = 289 | issue = 5 | pages = 1125–34 | date = Dec 2001 | pmid = 11741309 | doi = 10.1006/bbrc.2001.6126 }}
*{{cite journal | author=Ridgeway AG, Petropoulos H, Siu A, ''et al.'' |title=Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein. |journal=FEBS Lett. |volume=456 |issue= 3 |pages= 399-402 |year= 1999 |pmid= 10462052 |doi= }}
* {{cite journal | vauthors = Kim E, Shin DW, Hong CS, Jeong D, Kim DH, Park WJ | title = Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein) | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 1 | pages = 192–6 | date = Jan 2003 | pmid = 12480542 | doi = 10.1016/S0006-291X(02)02829-2 }}
*{{cite journal | author=Lee HG, Kang H, Kim DH, Park WJ |title=Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39533-8 |year= 2001 |pmid= 11504710 |doi= 10.1074/jbc.M010664200 }}
* {{cite journal | vauthors = Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG | title = Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 12 | pages = 947–55 | date = Dec 2002 | pmid = 12543931 | doi = 10.1074/mcp.M200066-MCP200 }}
*{{cite journal | author=Sacchetto R, Damiani E, Turcato F, ''et al.'' |title=Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 5 |pages= 1125-34 |year= 2002 |pmid= 11741309 |doi= 10.1006/bbrc.2001.6126 }}
* {{cite journal | vauthors = Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL | title = HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo | journal = Molecular and Cellular Biology | volume = 24 | issue = 9 | pages = 3757–68 | date = May 2004 | pmid = 15082771 | pmc = 387749 | doi = 10.1128/MCB.24.9.3757-3768.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG | title = Regulation of myocardial function by histidine-rich, calcium-binding protein | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 287 | issue = 4 | pages = H1705-11 | date = Oct 2004 | pmid = 15191886 | doi = 10.1152/ajpheart.01211.2003 }}
*{{cite journal  | author=Kim E, Shin DW, Hong CS, ''et al.'' |title=Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein). |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 1 |pages= 192-6 |year= 2003 |pmid= 12480542 |doi= }}
* {{cite journal | vauthors = Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG | title = Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 293 | issue = 3 | pages = H1581-9 | date = Sep 2007 | pmid = 17526652 | doi = 10.1152/ajpheart.00278.2007 }}
*{{cite journal | author=Adkins JN, Varnum SM, Auberry KJ, ''et al.'' |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell Proteomics |volume=1 |issue= 12 |pages= 947-55 |year= 2003 |pmid= 12543931 |doi= }}
* {{cite journal | vauthors = Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG | title = Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein | journal = Journal of the American Heart Association | volume = 2 | issue = 5 | pages = e000460 | year = 2013 | pmid = 24125847 | pmc = 3835262 | doi = 10.1161/JAHA.113.000460 }}
*{{cite journal | author=Anderson JP, Dodou E, Heidt AB, ''et al.'' |title=HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 9 |pages= 3757-68 |year= 2004 |pmid= 15082771 |doi= }}
*{{cite journal | author=Fan GC, Gregory KN, Zhao W, ''et al.'' |title=Regulation of myocardial function by histidine-rich, calcium-binding protein. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=287 |issue= 4 |pages= H1705-11 |year= 2004 |pmid= 15191886 |doi= 10.1152/ajpheart.01211.2003 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Arvanitis DA, Vafiadaki E, Fan GC, ''et al.'' |title=Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=293 |issue= 3 |pages= H1581-9 |year= 2007 |pmid= 17526652 |doi= 10.1152/ajpheart.00278.2007 }}
}}
{{refend}}
{{refend}}
 
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Latest revision as of 03:16, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sarcoplasmic reticulum histidine-rich calcium-binding protein is a protein that in humans is encoded by the HRC gene.[1][2]

Function

Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity[2]

References

  1. ↑ Hofmann SL, Topham M, Hsieh CL, Francke U (Apr 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics. 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.
  2. ↑ 2.0 2.1 "Entrez Gene: HRC histidine rich calcium binding protein".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=HRC_(gene)&oldid=1418959"