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{{ | '''Signal transduction protein CBL-C''' is a [[protein]] that in humans is encoded by the ''CBLC'' [[gene]].<ref name="pmid10362357">{{cite journal | vauthors = Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S | title = cbl-3: a new mammalian cbl family protein | journal = Oncogene | volume = 18 | issue = 22 | pages = 3365–75 |date=Jun 1999 | pmid = 10362357 | pmc = | doi = 10.1038/sj.onc.1202753 }}</ref><ref name="pmid10571044">{{cite journal | vauthors = Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T | title = Molecular cloning and characterization of a novel cbl-family gene, cbl-c | journal = Gene | volume = 239 | issue = 1 | pages = 145–54 |date=Dec 1999 | pmid = 10571044 | pmc = | doi =10.1016/S0378-1119(99)00356-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624| accessdate = }}</ref> | ||
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| summary_text = CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]<ref name="entrez" | | summary_text = CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
CBLC has been shown to [[Protein-protein interaction|interact]] with [[FYN]]<ref name=autogenerated2>{{cite journal |last=Kim |first=M |author2=Tezuka T|author3=Suziki Y|author4=Sugano S|author5=Hirai M|author6=Yamamoto T |date=Oct 1999 |title=Molecular cloning and characterization of a novel cbl-family gene, cbl-c |journal=Gene |volume=239 |issue=1 |pages=145–54 |publisher= |location = NETHERLANDS| issn = 0378-1119| pmid = 10571044 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0378-1119(99)00356-X }}</ref> and [[Epidermal growth factor receptor]].<ref name=pmid10571044/><ref name=autogenerated1>{{cite journal |last=Keane |first=M M |author2=Ettenberg S A|author3=Nau M M|author4=Banerjee P|author5=Cuello M|author6=Penninger J|author7=Lipkowitz S |date=Jun 1999 |title=cbl-3: a new mammalian cbl family protein |journal=Oncogene |volume=18 |issue=22 |pages=3365–75 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10362357 |doi = 10.1038/sj.onc.1202753 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CBLC}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Ollendorff V, Mattei M, Fournier E |title=A third human CBL gene is on chromosome 19 |journal=Int. J. Oncol. |volume=13 |issue= 6 |pages= 1159–61 |year= 1999 |pmid= 9824625 |doi= 10.3892/ijo.13.6.1159|display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Irby RB, Mao W, Coppola D |title=Activating SRC mutation in a subset of advanced human colon cancers |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 187–90 |year= 1999 |pmid= 9988270 |doi= 10.1038/5971 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ettenberg SA, Keane MM, Nau MM |title=Cbl-b inhibits epidermal growth factor receptor signaling |journal=Oncogene |volume=18 |issue= 10 |pages= 1855–66 |year= 1999 |pmid= 10086340 |doi= 10.1038/sj.onc.1202499 |display-authors=etal}} | ||
*{{cite journal | vauthors=Loreto MP, Berry DM, McGlade CJ |title=Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4241–55 |year= 2002 |pmid= 12024036 |doi=10.1128/MCB.22.12.4241-4255.2002 | pmc=133880 }} | |||
*{{cite journal | vauthors=Szymkiewicz I, Kowanetz K, Soubeyran P |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666–72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Courbard JR, Fiore F, Adélaïde J |title=Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45267–75 |year= 2003 |pmid= 12226085 |doi= 10.1074/jbc.M206460200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Wong ES, Fong CW, Lim J |title=Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling |journal=EMBO J. |volume=21 |issue= 18 |pages= 4796–808 |year= 2002 |pmid= 12234920 |doi=10.1093/emboj/cdf493 | pmc=126289 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Taher TE, Tjin EP, Beuling EA |title=C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3793–800 |year= 2002 |pmid= 12244174 |doi= 10.4049/jimmunol.169.7.3793|display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Nau MM, Lipkowitz S |title=Comparative genomic organization of the cbl genes |journal=Gene |volume=308 |issue= |pages= 103–13 |year= 2003 |pmid= 12711395 |doi=10.1016/S0378-1119(03)00471-2 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kim M, Tezuka T, Tanaka K, Yamamoto T |title=Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation |journal=Oncogene |volume=23 |issue= 9 |pages= 1645–55 |year= 2004 |pmid= 14661060 |doi= 10.1038/sj.onc.1207298 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kassenbrock CK, Anderson SM |title=Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28017–27 |year= 2004 |pmid= 15117950 |doi= 10.1074/jbc.M404114200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | ||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Revision as of 09:13, 30 August 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.[1][2][3]
CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][3]
Interactions
CBLC has been shown to interact with FYN[4] and Epidermal growth factor receptor.[2][5]
References
- ↑ Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357.
- ↑ 2.0 2.1 Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044.
- ↑ 3.0 3.1 "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".
- ↑ Kim, M; Tezuka T; Suziki Y; Sugano S; Hirai M; Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. NETHERLANDS. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044.
- ↑ Keane, M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. ENGLAND. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357.
External links
- Human CBLC genome location and CBLC gene details page in the UCSC Genome Browser.
Further reading
- Ollendorff V, Mattei M, Fournier E, et al. (1999). "A third human CBL gene is on chromosome 19". Int. J. Oncol. 13 (6): 1159–61. doi:10.3892/ijo.13.6.1159. PMID 9824625.
- Irby RB, Mao W, Coppola D, et al. (1999). "Activating SRC mutation in a subset of advanced human colon cancers". Nat. Genet. 21 (2): 187–90. doi:10.1038/5971. PMID 9988270.
- Ettenberg SA, Keane MM, Nau MM, et al. (1999). "Cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. PMID 10086340.
- Loreto MP, Berry DM, McGlade CJ (2002). "Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
- Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
- Courbard JR, Fiore F, Adélaïde J, et al. (2003). "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH". J. Biol. Chem. 277 (47): 45267–75. doi:10.1074/jbc.M206460200. PMID 12226085.
- Wong ES, Fong CW, Lim J, et al. (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
- Taher TE, Tjin EP, Beuling EA, et al. (2002). "C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J. Immunol. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nau MM, Lipkowitz S (2003). "Comparative genomic organization of the cbl genes". Gene. 308: 103–13. doi:10.1016/S0378-1119(03)00471-2. PMID 12711395.
- Kim M, Tezuka T, Tanaka K, Yamamoto T (2004). "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation". Oncogene. 23 (9): 1645–55. doi:10.1038/sj.onc.1207298. PMID 14661060.
- Kassenbrock CK, Anderson SM (2004). "Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations". J. Biol. Chem. 279 (27): 28017–27. doi:10.1074/jbc.M404114200. PMID 15117950.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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