EPN1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Epsin-1''' is a [[protein]] that in humans is encoded by the ''EPN1'' [[gene]].<ref name="pmid9723620">{{cite journal | vauthors = Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P | title = Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | journal = Nature | volume = 394 | issue = 6695 | pages = 793–7 |date=Sep 1998 | pmid = 9723620 | pmc =  | doi = 10.1038/29555 }}</ref><ref name="pmid10557078">{{cite journal | vauthors = Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A | title = Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis | journal = Oncogene | volume = 18 | issue = 43 | pages = 5915–22 |date=Dec 1999 | pmid = 10557078 | pmc =  | doi = 10.1038/sj.onc.1202974 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EPN1 epsin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29924| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1edu.
| PDB = {{PDB2|1edu}}, {{PDB2|1eyh}}, {{PDB2|1h0a}}, {{PDB2|1inz}}
| Name = Epsin 1
| HGNCid = 21604
| Symbol = EPN1
| AltSymbols =;
| OMIM = 607262
| ECnumber =
| Homologene = 32172
| MGIid = 1333763
  | Function = {{GNF_GO|id=GO:0008289 |text = lipid binding}}  
| Component =
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29924
    | Hs_Ensembl = ENSG00000063245
    | Hs_RefseqProtein = NP_037465
    | Hs_RefseqmRNA = NM_013333
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 60878404
    | Hs_GenLoc_end = 60898944
    | Hs_Uniprot = Q9Y6I3
    | Mm_EntrezGene = 13854
    | Mm_Ensembl = ENSMUSG00000035203
    | Mm_RefseqmRNA = XM_977106
    | Mm_RefseqProtein = XP_982200
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 4683380
    | Mm_GenLoc_end = 4701263
    | Mm_Uniprot = Q80VP1
  }}
}}
'''Epsin 1''', also known as '''EPN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EPN1 epsin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29924| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EPN1 epsin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29924| accessdate = }}</ref>
| summary_text = EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM]<ref name="entrez" />
}}
}}
==Interactions==
EPN1 has been shown to [[Protein-protein interaction|interact]] with [[REPS2]],<ref name=pmid10557078 /> [[AP2A2]]<ref name=pmid9723620 /> and [[EPS15]].<ref name=pmid9723620/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chen H, Fre S, Slepnev VI, ''et al.'' |title=Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. |journal=Nature |volume=394 |issue= 6695 |pages= 793-7 |year= 1998 |pmid= 9723620 |doi= 10.1038/29555 }}
*{{cite journal  | vauthors=Drake MT, Downs MA, Traub LM |title=Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6479–89 |year= 2000 |pmid= 10692452 |doi=10.1074/jbc.275.9.6479 }}
*{{cite journal  | author=Morinaka K, Koyama S, Nakashima S, ''et al.'' |title=Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. |journal=Oncogene |volume=18 |issue= 43 |pages= 5915-22 |year= 1999 |pmid= 10557078 |doi= 10.1038/sj.onc.1202974 }}
*{{cite journal  | author=Kariya K |title=Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18399–406 |year= 2000 |pmid= 10764745 |doi= 10.1074/jbc.M000521200 |name-list-format=vanc| author2=Koyama S  | author3=Nakashima S  | display-authors=3  | last4=Oshiro  | first4=T  | last5=Morinaka  | first5=K  | last6=Kikuchi  | first6=A }}
*{{cite journal  | author=Drake MT, Downs MA, Traub LM |title=Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6479-89 |year= 2000 |pmid= 10692452 |doi=  }}
*{{cite journal  | author=Hyman J |title=Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf) |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 537–46 |year= 2000 |pmid= 10791968 |doi=10.1083/jcb.149.3.537  | pmc=2174850  |name-list-format=vanc| author2=Chen H  | author3=Di Fiore PP  | display-authors=3  | last4=De Camilli  | first4=P  | last5=Brunger  | first5=AT }}
*{{cite journal  | author=Kariya K, Koyama S, Nakashima S, ''et al.'' |title=Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18399-406 |year= 2000 |pmid= 10764745 |doi= 10.1074/jbc.M000521200 }}
*{{cite journal  | vauthors=Drake MT, Traub LM |title=Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28700–9 |year= 2001 |pmid= 11382783 |doi= 10.1074/jbc.M104226200 }}
*{{cite journal  | author=Hyman J, Chen H, Di Fiore PP, ''et al.'' |title=Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 537-46 |year= 2000 |pmid= 10791968 |doi=  }}
*{{cite journal  | author=Ford MG |title=Curvature of clathrin-coated pits driven by epsin |journal=Nature |volume=419 |issue= 6905 |pages= 361–6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020 |name-list-format=vanc| author2=Mills IG  | author3=Peter BJ  | display-authors=3  | last4=Vallis  | first4=Yvonne  | last5=Praefcke  | first5=Gerrit J. K.  | last6=Evans  | first6=Philip R.  | last7=McMahon  | first7=Harvey T. }}
*{{cite journal  | author=Drake MT, Traub LM |title=Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28700-9 |year= 2001 |pmid= 11382783 |doi= 10.1074/jbc.M104226200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Ford MG, Mills IG, Peter BJ, ''et al.'' |title=Curvature of clathrin-coated pits driven by epsin. |journal=Nature |volume=419 |issue= 6905 |pages= 361-6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020 }}
*{{cite journal  | vauthors=Koshiba S, Kigawa T, Kikuchi A, Yokoyama S |title=Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin |journal=J. Struct. Funct. Genomics |volume=2 |issue= 1 |pages= 1–8 |year= 2003 |pmid= 12836669 |doi=10.1023/A:1011397007366 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Koshiba S, Kigawa T, Kikuchi A, Yokoyama S |title=Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin. |journal=J. Struct. Funct. Genomics |volume=2 |issue= 1 |pages= 1-8 |year= 2003 |pmid= 12836669 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Timsit YE, Miller SL, Mohney RP, O'Bryan JP |title=The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 550–9 |year= 2005 |pmid= 15694383 |doi= 10.1016/j.bbrc.2005.01.022 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Schmid EM |title=Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 | pmc=1540706  |name-list-format=vanc| author2=Ford MG  | author3=Burtey A  | display-authors=3  | last4=Praefcke  | first4=Gerrit J. K.  | last5=Peak-Chew  | first5=Sew-Yeu  | last6=Mills  | first6=Ian G.  | last7=Benmerah  | first7=Alexandre  | last8=McMahon  | first8=Harvey T. }}
*{{cite journal  | author=Timsit YE, Miller SL, Mohney RP, O'Bryan JP |title=The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 550-9 |year= 2005 |pmid= 15694383 |doi= 10.1016/j.bbrc.2005.01.022 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Schmid EM, Ford MG, Burtey A, ''et al.'' |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=29924}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{gene-19-stub}}
{{WikiDoc Sources}}

Latest revision as of 00:33, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.[1][2][3]

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM][3]

Interactions

EPN1 has been shown to interact with REPS2,[2] AP2A2[1] and EPS15.[1]

References

  1. ↑ 1.0 1.1 1.2 Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
  2. ↑ 2.0 2.1 Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078.
  3. ↑ 3.0 3.1 "Entrez Gene: EPN1 epsin 1".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=EPN1&oldid=1418999"