NLRP2: Difference between revisions

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NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.^[1]^[2]^[3]

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM]^[3]

References

↑ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
↑ Bertin J, DiStefano PS (Mar 2001). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
↑ ^3.0 ^3.1 "Entrez Gene: NLRP2 NLR family, pyrin domain containing 2".

Teng SC, Wu KJ, Tseng SF, et al. (2007). "Importin KPNA2, NBS1, DNA repair and tumorigenesis". J. Mol. Histol. 37 (5–7): 293–9. doi:10.1007/s10735-006-9032-y. PMID 16752129.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Martinon F, Hofmann K, Tschopp J (2001). "The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation". Curr. Biol. 11 (4): R118–20. doi:10.1016/S0960-9822(01)00056-2. PMID 11250163.
Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Agostini L, Martinon F, Burns K, et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder". Immunity. 20 (3): 319–25. doi:10.1016/S1074-7613(04)00046-9. PMID 15030775.
Bruey JM, Bruey-Sedano N, Newman R, et al. (2005). "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages". J. Biol. Chem. 279 (50): 51897–907. doi:10.1074/jbc.M406741200. PMID 15456791.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kinoshita T, Wang Y, Hasegawa M, et al. (2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion". J. Biol. Chem. 280 (23): 21720–5. doi:10.1074/jbc.M410057200. PMID 15817483.
Rink L, Slupianek A, Stoklosa T, et al. (2007). "Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells". Blood. 110 (2): 651–60. doi:10.1182/blood-2006-08-042630. PMC 1924483. PMID 17431132.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid12563287-1] Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.

[pmid11270363-2] Bertin J, DiStefano PS (Mar 2001). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.

[entrez-3] 3.0 ^3.1 "Entrez Gene: NLRP2 NLR family, pyrin domain containing 2".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-{{GNF_Protein_box
+{{Underlinked|date=June 2016}}
- | image =
+{{Infobox_gene}}
- | image_source =
+'''NACHT, LRR and PYD domains-containing protein 2''' is a [[protein]] that in humans is encoded by the ''NLRP2'' [[gene]].<ref name="pmid12563287">{{cite journal | vauthors = Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | pmc =  | doi = 10.1038/nrm1019 }}</ref><ref name="pmid11270363">{{cite journal | vauthors = Bertin J, DiStefano PS | title = The PYRIN domain: a novel motif found in apoptosis and inflammation proteins | journal = Cell Death Differ | volume = 7 | issue = 12 | pages = 1273–4 |date=Mar 2001 | pmid = 11270363 | pmc =  | doi = 10.1038/sj.cdd.4400774 }}</ref><ref name="entrez"/>
- | PDB =
- | Name = NLR family, pyrin domain containing 2
- | HGNCid = 22948
- | Symbol = NLRP2
- | AltSymbols =; NBS1; CLR19.9; FLJ20510; NALP2; PAN1; PYPAF2
- | OMIM = 609364
- | ECnumber =
- | Homologene = 56789
- | MGIid = 3041206
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0032090 |text = Pyrin domain binding}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
-  | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0043280 |text = positive regulation of caspase activity}} {{GNF_GO|id=GO:0050718 |text = positive regulation of interleukin-1 beta secretion}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 55655
-    | Hs_Ensembl = ENSG00000022556
-    | Hs_RefseqProtein = NP_060322
-    | Hs_RefseqmRNA = NM_017852
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 60168465
-    | Hs_GenLoc_end = 60204313
-    | Hs_Uniprot = Q9NX02
-    | Mm_EntrezGene = 232827
-    | Mm_Ensembl = ENSMUSG00000035177
-    | Mm_RefseqmRNA = NM_177690
-    | Mm_RefseqProtein = NP_808358
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 4901639
-    | Mm_GenLoc_end = 4954122
-    | Mm_Uniprot =
-  }}
-}}
-'''NLR family, pyrin domain containing 2''', also known as '''NLRP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NLRP2 NLR family, pyrin domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55655| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NLRP2 NLR family, pyrin domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55655| accessdate = }}</ref>
+| summary_text = NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NLRP2 NLR family, pyrin domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55655| accessdate = }}</ref>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 50: / Line 16: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Bertin J, DiStefano PS |title=The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. |journal=Cell Death Differ. |volume=7 |issue= 12 |pages= 1273-4 |year= 2001 |pmid= 11270363 |doi= 10.1038/sj.cdd.4400774 }}
+*{{cite journal   |vauthors=Teng SC, Wu KJ, Tseng SF, etal |title=Importin KPNA2, NBS1, DNA repair and tumorigenesis. |journal=J. Mol. Histol. |volume=37 |issue= 5–7 |pages= 293–9 |year= 2007 |pmid= 16752129 |doi= 10.1007/s10735-006-9032-y }}
-*{{cite journal  | author=Tschopp J, Martinon F, Burns K |title=NALPs: a novel protein family involved in inflammation. |journal=Nat. Rev. Mol. Cell Biol. |volume=4 |issue= 2 |pages= 95-104 |year= 2003 |pmid= 12563287 |doi= 10.1038/nrm1019 }}
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Teng SC, Wu KJ, Tseng SF, ''et al.'' |title=Importin KPNA2, NBS1, DNA repair and tumorigenesis. |journal=J. Mol. Histol. |volume=37 |issue= 5-7 |pages= 293-9 |year= 2007 |pmid= 16752129 |doi= 10.1007/s10735-006-9032-y }}
+*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | vauthors=Martinon F, Hofmann K, Tschopp J |title=The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation |journal=Curr. Biol. |volume=11 |issue= 4 |pages= R118–20 |year= 2001 |pmid= 11250163 |doi=10.1016/S0960-9822(01)00056-2  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal   |vauthors=Wang L, Manji GA, Grenier JM, etal |title=PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29874–80 |year= 2002 |pmid= 12019269 |doi= 10.1074/jbc.M203915200 }}
-*{{cite journal  | author=Martinon F, Hofmann K, Tschopp J |title=The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. |journal=Curr. Biol. |volume=11 |issue= 4 |pages= R118-20 |year= 2001 |pmid= 11250163 |doi=  }}
+*{{cite journal   |vauthors=Grenier JM, Wang L, Manji GA, etal |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1 |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 73–8 |year= 2002 |pmid= 12387869 |doi=10.1016/S0014-5793(02)03416-6  }}
-*{{cite journal  | author=Wang L, Manji GA, Grenier JM, ''et al.'' |title=PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29874-80 |year= 2002 |pmid= 12019269 |doi= 10.1074/jbc.M203915200 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Grenier JM, Wang L, Manji GA, ''et al.'' |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. |journal=FEBS Lett. |volume=530 |issue= 1-3 |pages= 73-8 |year= 2002 |pmid= 12387869 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Agostini L, Martinon F, Burns K, etal |title=NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder |journal=Immunity |volume=20 |issue= 3 |pages= 319–25 |year= 2004 |pmid= 15030775 |doi=10.1016/S1074-7613(04)00046-9  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Bruey JM, Bruey-Sedano N, Newman R, etal |title=PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 51897–907 |year= 2005 |pmid= 15456791 |doi= 10.1074/jbc.M406741200 }}
-*{{cite journal  | author=Agostini L, Martinon F, Burns K, ''et al.'' |title=NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. |journal=Immunity |volume=20 |issue= 3 |pages= 319-25 |year= 2004 |pmid= 15030775 |doi=  }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Bruey JM, Bruey-Sedano N, Newman R, ''et al.'' |title=PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 51897-907 |year= 2005 |pmid= 15456791 |doi= 10.1074/jbc.M406741200 }}
+*{{cite journal   |vauthors=Kinoshita T, Wang Y, Hasegawa M, etal |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720–5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Rink L, Slupianek A, Stoklosa T, etal |title=Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells |journal=Blood |volume=110 |issue= 2 |pages= 651–60 |year= 2007 |pmid= 17431132 |doi= 10.1182/blood-2006-08-042630  | pmc=1924483 }}
-*{{cite journal  | author=Kinoshita T, Wang Y, Hasegawa M, ''et al.'' |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720-5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 }}
-*{{cite journal  | author=Rink L, Slupianek A, Stoklosa T, ''et al.'' |title=Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells. |journal=Blood |volume=110 |issue= 2 |pages= 651-60 |year= 2007 |pmid= 17431132 |doi= 10.1182/blood-2006-08-042630 }}
 }}
 {{refend}}
+{{NOD-like receptors}}
-{{protein-stub}}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
 {{PBB_Controls
@@ Line 77: / Line 41: @@
 | update_citations = yes
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 [[Category:LRR proteins]]
-{{WikiDoc Sources}}
+[[Category:NOD-like receptors]]
+{{gene-19-stub}}

v t e NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

NLRP2: Difference between revisions

Revision as of 13:05, 5 September 2017

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