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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Lin-7 homolog B''' is a [[protein]] that in humans is encoded by the ''LIN7B'' [[gene]].<ref name="pmid10341223">{{cite journal | vauthors = Jo K, Derin R, Li M, Bredt DS | title = Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex | journal = J Neurosci | volume = 19 | issue = 11 | pages = 4189–99 | date = Jun 1999 | pmid = 10341223 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LIN7B lin-7 homolog B (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64130| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_LIN7B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y74.
| PDB = {{PDB2|1y74}}, {{PDB2|2dkr}}
| Name = Lin-7 homolog B (C. elegans)
| HGNCid = 17788
| Symbol = LIN7B
| AltSymbols =; LIN-7B; MALS-2; VELI2
| OMIM = 
| ECnumber = 
| Homologene = 22648
| MGIid = 1330858
| GeneAtlas_image1 = PBB_GE_LIN7B_219760_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64130
    | Hs_Ensembl = ENSG00000104863
    | Hs_RefseqProtein = NP_071448
    | Hs_RefseqmRNA = NM_022165
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 54309430
    | Hs_GenLoc_end = 54313529
    | Hs_Uniprot = Q9HAP6
    | Mm_EntrezGene = 22342
    | Mm_Ensembl = ENSMUSG00000003872
    | Mm_RefseqmRNA = XM_001002360
    | Mm_RefseqProtein = XP_001002360
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 45235934
    | Mm_GenLoc_end = 45238625
    | Mm_Uniprot = O88951
  }}
}}
'''Lin-7 homolog B (C. elegans)''', also known as '''LIN7B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LIN7B lin-7 homolog B (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64130| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
LIN7B has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[ACCN3]],<ref name = pmid15317815>{{cite journal | vauthors = Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ | title = PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current | journal = J. Biol. Chem. | volume = 279 | issue = 45 | pages = 46962–8 | date = Nov 2004 | pmid = 15317815 | doi = 10.1074/jbc.M405874200 }}</ref>
| section_title =  
* [[GRIN2B]],<ref name = pmid10341223 />
| summary_text =  
* [[KCNJ12]]<ref name = pmid15024025>{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}</ref><ref name = pmid14960569>{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | date = Apr 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}</ref> and
}}
* [[KCNJ4]].<ref name = pmid11742811>{{cite journal | vauthors = Olsen O, Liu H, Wade JB, Merot J, Welling PA | title = Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 1 | pages = C183-95 | date = Jan 2002 | pmid = 11742811 | doi = 10.1152/ajpcell.00249.2001 }}</ref>


==References==
== References ==
{{reflist|2}}
{{reflist|2}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Butz S, Okamoto M, Südhof TC | title = A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. | journal = Cell | volume = 94 | issue = 6 | pages = 773–82 | year = 1998 | pmid = 9753324 | doi = 10.1016/S0092-8674(00)81736-5 }}
| citations =
* {{cite journal | vauthors = Olsen O, Liu H, Wade JB, Merot J, Welling PA | title = Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 1 | pages = C183–95 | year = 2002 | pmid = 11742811 | doi = 10.1152/ajpcell.00249.2001 }}
*{{cite journal | author=Butz S, Okamoto M, Südhof TC |title=A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. |journal=Cell |volume=94 |issue= 6 |pages= 773-82 |year= 1998 |pmid= 9753324 |doi= }}
* {{cite journal | vauthors = Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C | title = Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. | journal = J. Neurosci. | volume = 22 | issue = 15 | pages = 6426–36 | year = 2002 | pmid = 12151522 }}
*{{cite journal  | author=Jo K, Derin R, Li M, Bredt DS |title=Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. |journal=J. Neurosci. |volume=19 |issue= 11 |pages= 4189-99 |year= 1999 |pmid= 10341223 |doi=  }}
* {{cite journal | vauthors = Hori K, Konno D, Maruoka H, Sobue K | title = MALS is a binding partner of IRSp53 at cell-cell contacts. | journal = FEBS Lett. | volume = 554 | issue = 1-2 | pages = 30–4 | year = 2003 | pmid = 14596909 | doi = 10.1016/S0014-5793(03)01074-3 }}
*{{cite journal | author=Olsen O, Liu H, Wade JB, ''et al.'' |title=Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. |journal=Am. J. Physiol., Cell Physiol. |volume=282 |issue= 1 |pages= C183-95 |year= 2002 |pmid= 11742811 |doi= 10.1152/ajpcell.00249.2001 }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | year = 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
*{{cite journal | author=Coussen F, Normand E, Marchal C, ''et al.'' |title=Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. |journal=J. Neurosci. |volume=22 |issue= 15 |pages= 6426-36 |year= 2002 |pmid= 12151522 |doi= 20026623 }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | year = 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ | title = PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. | journal = J. Biol. Chem. | volume = 279 | issue = 45 | pages = 46962–8 | year = 2004 | pmid = 15317815 | doi = 10.1074/jbc.M405874200 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW | title = Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. | journal = J. Biol. Chem. | volume = 280 | issue = 47 | pages = 39653–64 | year = 2006 | pmid = 16192269 | doi = 10.1074/jbc.M510187200 }}
*{{cite journal | author=Hori K, Konno D, Maruoka H, Sobue K |title=MALS is a binding partner of IRSp53 at cell-cell contacts. |journal=FEBS Lett. |volume=554 |issue= 1-2 |pages= 30-4 |year= 2003 |pmid= 14596909 |doi= }}
* {{cite journal | vauthors = Kawai S, Fukuda C, Mukai T, Murata K | title = MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase. | journal = J. Biol. Chem. | volume = 280 | issue = 47 | pages = 39200–7 | year = 2006 | pmid = 16192277 | doi = 10.1074/jbc.M506426200 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Radeke CM, ''et al.'' |title=A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19051-63 |year= 2004 |pmid= 14960569 |doi= 10.1074/jbc.M400284200 }}
* {{cite journal | vauthors = Li Z, Benard O, Margolskee RF | title = Ggamma13 interacts with PDZ domain-containing proteins. | journal = J. Biol. Chem. | volume = 281 | issue = 16 | pages = 11066–73 | year = 2006 | pmid = 16473877 | doi = 10.1074/jbc.M600113200 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Anderson S, ''et al.'' |title=Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22331-46 |year= 2004 |pmid= 15024025 |doi= 10.1074/jbc.M400285200 }}
* {{cite journal | vauthors = Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K | title = Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. | journal = Neurosci. Res. | volume = 56 | issue = 4 | pages = 347–55 | year = 2007 | pmid = 16979770 | doi = 10.1016/j.neures.2006.08.003 }}
*{{cite journal | author=Hruska-Hageman AM, Benson CJ, Leonard AS, ''et al.'' |title=PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46962-8 |year= 2004 |pmid= 15317815 |doi= 10.1074/jbc.M405874200 }}
*{{cite journal | author=Okuhira K, Fitzgerald ML, Sarracino DA, ''et al.'' |title=Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39653-64 |year= 2006 |pmid= 16192269 |doi= 10.1074/jbc.M510187200 }}
*{{cite journal | author=Kawai S, Fukuda C, Mukai T, Murata K |title=MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39200-7 |year= 2006 |pmid= 16192277 |doi= 10.1074/jbc.M506426200 }}
*{{cite journal | author=Li Z, Benard O, Margolskee RF |title=Ggamma13 interacts with PDZ domain-containing proteins. |journal=J. Biol. Chem. |volume=281 |issue= 16 |pages= 11066-73 |year= 2006 |pmid= 16473877 |doi= 10.1074/jbc.M600113200 }}
*{{cite journal | author=Sudo K, Ito H, Iwamoto I, ''et al.'' |title=Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 347-55 |year= 2007 |pmid= 16979770 |doi= 10.1016/j.neures.2006.08.003 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=64130}}
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{{gene-19-stub}}

Latest revision as of 02:30, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.[1][2]

Interactions

LIN7B has been shown to interact with:

References

  1. ↑ 1.0 1.1 Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. PMID 10341223.
  2. ↑ "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".
  3. ↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
  4. ↑ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  5. ↑ Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  6. ↑ Olsen O, Liu H, Wade JB, Merot J, Welling PA (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Further reading

  • Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324.
  • Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.
  • Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C (2002). "Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes". J. Neurosci. 22 (15): 6426–36. PMID 12151522.
  • Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909.
  • Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  • Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  • Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
  • Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. doi:10.1074/jbc.M510187200. PMID 16192269.
  • Kawai S, Fukuda C, Mukai T, Murata K (2006). "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase". J. Biol. Chem. 280 (47): 39200–7. doi:10.1074/jbc.M506426200. PMID 16192277.
  • Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi:10.1074/jbc.M600113200. PMID 16473877.
  • Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (2007). "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons". Neurosci. Res. 56 (4): 347–55. doi:10.1016/j.neures.2006.08.003. PMID 16979770.


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