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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''C-type lectin domain family 11 member A''' is a [[protein]] that in humans is encoded by the ''CLEC11A'' [[gene]].<ref name="pmid9207134">{{cite journal | vauthors = Hiraoka A, Sugimura A, Seki T, Nagasawa T, Ohta N, Shimonishi M, Hagiya M, Shimizu S | title = Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 14 | pages = 7577–82 | date = July 1997 | pmid = 9207134 | pmc = 23864 | doi = 10.1073/pnas.94.14.7577 }}</ref><ref name="pmid9442024">{{cite journal | vauthors = Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC | title = Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 1911–6 | date = January 1998 | pmid = 9442024 | pmc =  | doi = 10.1074/jbc.273.4.1911 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLEC11A C-type lectin domain family 11, member A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6320| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = C-type lectin domain family 11, member A
| HGNCid = 10576
| Symbol = CLEC11A
| AltSymbols =; P47; CLECSF3; LSLCL; SCGF
| OMIM = 604713
| ECnumber = 
| Homologene = 2236
| MGIid = 1298219
| GeneAtlas_image1 = PBB_GE_CLEC11A_205131_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_CLEC11A_210783_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CLEC11A_211709_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6320
    | Hs_Ensembl = ENSG00000105472
    | Hs_RefseqProtein = NP_002966
    | Hs_RefseqmRNA = NM_002975
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 55918456
    | Hs_GenLoc_end = 55920536
    | Hs_Uniprot = Q9Y240
    | Mm_EntrezGene = 20256
    | Mm_Ensembl = ENSMUSG00000004473
    | Mm_RefseqmRNA = NM_009131
    | Mm_RefseqProtein = NP_033157
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 44172299
    | Mm_GenLoc_end = 44174944
    | Mm_Uniprot = O88200
  }}
}}
'''C-type lectin domain family 11, member A''', also known as '''CLEC11A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLEC11A C-type lectin domain family 11, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6320| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the C-type [[lectin]] superfamily. The encoded protein is a secreted sulfated [[glycoprotein]] and functions as a growth factor for primitive [[hematopoietic]] [[progenitor cell]]s. An alternative splice variant has been described but its biological nature has not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CLEC11A C-type lectin domain family 11, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6320| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hiraoka A, Ohkubo T, Fukuda M | title = Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody | journal = Cancer Research | volume = 47 | issue = 19 | pages = 5025–30 | date = October 1987 | pmid = 3304620 | doi =  }}
| citations =
* {{cite journal | vauthors = Mio H, Kagami N, Yokokawa S, Kawai H, Nakagawa S, Takeuchi K, Sekine S, Hiraoka A | title = Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily | journal = Biochemical and Biophysical Research Communications | volume = 249 | issue = 1 | pages = 124–30 | date = August 1998 | pmid = 9705843 | doi = 10.1006/bbrc.1998.9073 }}
*{{cite journal | author=Hiraoka A, Ohkubo T, Fukuda M |title=Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody. |journal=Cancer Res. |volume=47 |issue= 19 |pages= 5025-30 |year= 1987 |pmid= 3304620 |doi=  }}
* {{cite journal | vauthors = Bannwarth S, Giordanengo V, Grosgeorge J, Turc-Carel C, Lefebvre JC | title = Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling | journal = Genomics | volume = 57 | issue = 2 | pages = 316–7 | date = April 1999 | pmid = 10198175 | doi = 10.1006/geno.1999.5762 }}
*{{cite journal | author=Hiraoka A, Sugimura A, Seki T, ''et al.'' |title=Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7577-82 |year= 1997 |pmid= 9207134 |doi=  }}
* {{cite journal | vauthors = Gehling UM, Ergün S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, Kluge K, Schäfer B, Hossfeld DK, Fiedler W | title = In vitro differentiation of endothelial cells from AC133-positive progenitor cells | journal = Blood | volume = 95 | issue = 10 | pages = 3106–12 | date = May 2000 | pmid = 10807776 | doi =  }}
*{{cite journal  | author=Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC |title=Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 1911-6 |year= 1998 |pmid= 9442024 |doi=  }}
* {{cite journal | vauthors = Perrin C, Bayle J, Bannwarth S, Michiels JF, Heudier P, Lefebvre JC, Giordanengo V | title = Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils | journal = Comptes Rendus de l'Académie des Sciences. Série III, Sciences de la Vie | volume = 324 | issue = 12 | pages = 1125–32 | date = December 2001 | pmid = 11803813 | doi = 10.1016/s0764-4469(01)01392-0 }}
*{{cite journal  | author=Mio H, Kagami N, Yokokawa S, ''et al.'' |title=Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 1 |pages= 124-30 |year= 1998 |pmid= 9705843 |doi= 10.1006/bbrc.1998.9073 }}
* {{cite journal | vauthors = Hiraoka A, Yano Ki K, Kagami N, Takeshige K, Mio H, Anazawa H, Sugimoto S | title = Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells | journal = The Hematology Journal | volume = 2 | issue = 5 | pages = 307–15 | year = 2002 | pmid = 11920266 | doi = 10.1038/sj/thj/6200118 | doi-broken-date = 2017-08-23 }}
*{{cite journal | author=Bannwarth S, Giordanengo V, Grosgeorge J, ''et al.'' |title=Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling. |journal=Genomics |volume=57 |issue= 2 |pages= 316-7 |year= 1999 |pmid= 10198175 |doi= 10.1006/geno.1999.5762 }}
* {{cite journal | vauthors = Ito C, Sato H, Ando K, Watanabe S, Yoshiba F, Kishi K, Furuya A, Shitara K, Sugimoto S, Kohno H, Hiraoka A, Hotta T | title = Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation | journal = Bone Marrow Transplantation | volume = 32 | issue = 4 | pages = 391–8 | date = August 2003 | pmid = 12900775 | doi = 10.1038/sj.bmt.1704152 }}
*{{cite journal | author=Gehling UM, Ergün S, Schumacher U, ''et al.'' |title=In vitro differentiation of endothelial cells from AC133-positive progenitor cells. |journal=Blood |volume=95 |issue= 10 |pages= 3106-12 |year= 2000 |pmid= 10807776 |doi=  }}
* {{cite journal | vauthors = Lee E, Min HK, Oskeritzian CA, Kambe N, Schwartz LB, Wook Chang H | title = Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4 | journal = Cellular Immunology | volume = 226 | issue = 1 | pages = 30–6 | date = November 2003 | pmid = 14746805 | doi = 10.1016/j.cellimm.2003.11.001 }}
*{{cite journal | author=Perrin C, Bayle J, Bannwarth S, ''et al.'' |title=Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils. |journal=C. R. Acad. Sci. III, Sci. Vie |volume=324 |issue= 12 |pages= 1125-32 |year= 2002 |pmid= 11803813 |doi= }}
* {{cite journal | vauthors = Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC | title = Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway | journal = The Journal of Surgical Research | volume = 120 | issue = 2 | pages = 288–94 | date = August 2004 | pmid = 15234225 | doi = 10.1016/j.jss.2004.01.005 }}
*{{cite journal | author=Hiraoka A, Yano Ki K, Kagami N, ''et al.'' |title=Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells. |journal=Hematol. J. |volume=2 |issue= 5 |pages= 307-15 |year= 2002 |pmid= 11920266 |doi= 10.1038/sj/thj/6200118 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ito C, Sato H, Ando K, ''et al.'' |title=Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation. |journal=Bone Marrow Transplant. |volume=32 |issue= 4 |pages= 391-8 |year= 2004 |pmid= 12900775 |doi= 10.1038/sj.bmt.1704152 }}
*{{cite journal | author=Lee E, Min HK, Oskeritzian CA, ''et al.'' |title=Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4. |journal=Cell. Immunol. |volume=226 |issue= 1 |pages= 30-6 |year= 2004 |pmid= 14746805 |doi= }}
*{{cite journal | author=Hollenbeck ST, Sakakibara K, Faries PL, ''et al.'' |title=Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway. |journal=J. Surg. Res. |volume=120 |issue= 2 |pages= 288-94 |year= 2004 |pmid= 15234225 |doi= 10.1016/j.jss.2004.01.005 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC gene info|CLEC11A}}
 
 
{{gene-19-stub}}

Revision as of 02:47, 9 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.[1][2][3]

Function

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.[3]

References

  1. ↑ Hiraoka A, Sugimura A, Seki T, Nagasawa T, Ohta N, Shimonishi M, Hagiya M, Shimizu S (July 1997). "Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7577–82. doi:10.1073/pnas.94.14.7577. PMC 23864. PMID 9207134.
  2. ↑ Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC (January 1998). "Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells". The Journal of Biological Chemistry. 273 (4): 1911–6. doi:10.1074/jbc.273.4.1911. PMID 9442024.
  3. ↑ 3.0 3.1 "Entrez Gene: CLEC11A C-type lectin domain family 11, member A".

Further reading

  • Hiraoka A, Ohkubo T, Fukuda M (October 1987). "Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody". Cancer Research. 47 (19): 5025–30. PMID 3304620.
  • Mio H, Kagami N, Yokokawa S, Kawai H, Nakagawa S, Takeuchi K, Sekine S, Hiraoka A (August 1998). "Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily". Biochemical and Biophysical Research Communications. 249 (1): 124–30. doi:10.1006/bbrc.1998.9073. PMID 9705843.
  • Bannwarth S, Giordanengo V, Grosgeorge J, Turc-Carel C, Lefebvre JC (April 1999). "Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling". Genomics. 57 (2): 316–7. doi:10.1006/geno.1999.5762. PMID 10198175.
  • Gehling UM, Ergün S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, Kluge K, Schäfer B, Hossfeld DK, Fiedler W (May 2000). "In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106–12. PMID 10807776.
  • Perrin C, Bayle J, Bannwarth S, Michiels JF, Heudier P, Lefebvre JC, Giordanengo V (December 2001). "Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils". Comptes Rendus de l'Académie des Sciences. Série III, Sciences de la Vie. 324 (12): 1125–32. doi:10.1016/s0764-4469(01)01392-0. PMID 11803813.
  • Hiraoka A, Yano Ki K, Kagami N, Takeshige K, Mio H, Anazawa H, Sugimoto S (2002). "Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells". The Hematology Journal. 2 (5): 307–15. doi:10.1038/sj/thj/6200118 (inactive 2017-08-23). PMID 11920266.
  • Ito C, Sato H, Ando K, Watanabe S, Yoshiba F, Kishi K, Furuya A, Shitara K, Sugimoto S, Kohno H, Hiraoka A, Hotta T (August 2003). "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow Transplantation. 32 (4): 391–8. doi:10.1038/sj.bmt.1704152. PMID 12900775.
  • Lee E, Min HK, Oskeritzian CA, Kambe N, Schwartz LB, Wook Chang H (November 2003). "Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4". Cellular Immunology. 226 (1): 30–6. doi:10.1016/j.cellimm.2003.11.001. PMID 14746805.
  • Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). "Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway". The Journal of Surgical Research. 120 (2): 288–94. doi:10.1016/j.jss.2004.01.005. PMID 15234225.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CLEC11A&oldid=1419016"