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{{Infobox_gene}}
{{PBB_Controls
'''Proline-rich AKT1 substrate 1''' (PRAS) is a [[protein]] that in humans is encoded by the ''AKT1S1'' [[gene]].<ref name="pmid12524439">{{cite journal | vauthors = Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA | title = Identification of a proline-rich Akt substrate as a 14-3-3 binding partner | journal = The Journal of Biological Chemistry | volume = 278 | issue = 12 | pages = 10189–94 | date = Mar 2003 | pmid = 12524439 | pmc =  | doi = 10.1074/jbc.M210837200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84335| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = AKT1 substrate 1 (proline-rich)
| HGNCid = 28426
| Symbol = AKT1S1
| AltSymbols =; Lobe; MGC2865; PRAS40
| OMIM = 610221
| ECnumber = 
| Homologene = 12162
| MGIid = 1914855
| GeneAtlas_image1 = PBB_GE_AKT1S1_gnf1h00760_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0044445 |text = cytosolic part}}
| Process = {{GNF_GO|id=GO:0043526 |text = neuroprotection}} {{GNF_GO|id=GO:0045884 |text = regulation of survival gene product activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84335
    | Hs_Ensembl = ENSG00000204673
    | Hs_RefseqProtein = NP_115751
    | Hs_RefseqmRNA = NM_032375
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 55064113
    | Hs_GenLoc_end = 55068364
    | Hs_Uniprot = Q96B36
    | Mm_EntrezGene = 67605
    | Mm_Ensembl = ENSMUSG00000011096
    | Mm_RefseqmRNA = NM_026270
    | Mm_RefseqProtein = NP_080546
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 44717269
    | Mm_GenLoc_end = 44723452
    | Mm_Uniprot = Q9D1F4
  }}
}}
'''AKT1 substrate 1 (proline-rich)''', also known as '''AKT1S1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84335| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==External links==
{{PBB_Summary
* {{UCSC gene info|AKT1S1}}
| section_title =
| summary_text =
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH | title = Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor | journal = The Journal of Neuroscience | volume = 24 | issue = 7 | pages = 1584–93 | date = Feb 2004 | pmid = 14973226 | doi = 10.1523/JNEUROSCI.5209-03.2004 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Kovacina KS, Park GY, Bae SS, ''et al.'' |title=Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10189-94 |year= 2003 |pmid= 12524439 |doi= 10.1074/jbc.M210837200 }}
* {{cite journal | vauthors = Huang B, Porter G | title = Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis | journal = Acta Pharmacologica Sinica | volume = 26 | issue = 10 | pages = 1253–8 | date = Oct 2005 | pmid = 16174443 | doi = 10.1111/j.1745-7254.2005.00184.x }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Saito A, Narasimhan P, Hayashi T, ''et al.'' |title=Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. |journal=J. Neurosci. |volume=24 |issue= 7 |pages= 1584-93 |year= 2004 |pmid= 14973226 |doi= 10.1523/JNEUROSCI.5209-03.2004 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH | title = Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 | journal = Nature Cell Biology | volume = 9 | issue = 3 | pages = 316–23 | date = Mar 2007 | pmid = 17277771 | doi = 10.1038/ncb1547 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
* {{cite journal | vauthors = Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM | title = PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase | journal = Molecular Cell | volume = 25 | issue = 6 | pages = 903–15 | date = Mar 2007 | pmid = 17386266 | doi = 10.1016/j.molcel.2007.03.003 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Wang L, Harris TE, Roth RA, Lawrence JC | title = PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding | journal = The Journal of Biological Chemistry | volume = 282 | issue = 27 | pages = 20036–44 | date = Jul 2007 | pmid = 17510057 | doi = 10.1074/jbc.M702376200 }}
*{{cite journal  | author=Huang B, Porter G |title=Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis. |journal=Acta Pharmacol. Sin. |volume=26 |issue= 10 |pages= 1253-8 |year= 2006 |pmid= 16174443 |doi= }}
* {{cite journal | vauthors = Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG | title = PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex | journal = The Journal of Biological Chemistry | volume = 282 | issue = 34 | pages = 24514–24 | date = Aug 2007 | pmid = 17604271 | doi = 10.1074/jbc.M704406200 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Vander Haar E, Lee SI, Bandhakavi S, ''et al.'' |title=Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. |journal=Nat. Cell Biol. |volume=9 |issue= 3 |pages= 316-23 |year= 2007 |pmid= 17277771 |doi= 10.1038/ncb1547 }}
*{{cite journal | author=Sancak Y, Thoreen CC, Peterson TR, ''et al.'' |title=PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. |journal=Mol. Cell |volume=25 |issue= 6 |pages= 903-15 |year= 2007 |pmid= 17386266 |doi= 10.1016/j.molcel.2007.03.003 }}
*{{cite journal | author=Wang L, Harris TE, Roth RA, Lawrence JC |title=PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. |journal=J. Biol. Chem. |volume=282 |issue= 27 |pages= 20036-44 |year= 2007 |pmid= 17510057 |doi= 10.1074/jbc.M702376200 }}
*{{cite journal | author=Fonseca BD, Smith EM, Lee VH, ''et al.'' |title=PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. |journal=J. Biol. Chem. |volume=282 |issue= 34 |pages= 24514-24 |year= 2007 |pmid= 17604271 |doi= 10.1074/jbc.M704406200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-19-stub}}

Latest revision as of 17:56, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.[1][2]

References

  1. ↑ Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.
  2. ↑ "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

External links

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor". The Journal of Neuroscience. 24 (7): 1584–93. doi:10.1523/JNEUROSCI.5209-03.2004. PMID 14973226.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Huang B, Porter G (Oct 2005). "Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis". Acta Pharmacologica Sinica. 26 (10): 1253–8. doi:10.1111/j.1745-7254.2005.00184.x. PMID 16174443.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology. 9 (3): 316–23. doi:10.1038/ncb1547. PMID 17277771.
  • Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007.03.003. PMID 17386266.
  • Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding". The Journal of Biological Chemistry. 282 (27): 20036–44. doi:10.1074/jbc.M702376200. PMID 17510057.
  • Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). "PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex". The Journal of Biological Chemistry. 282 (34): 24514–24. doi:10.1074/jbc.M704406200. PMID 17604271.


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