MAPRE1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Microtubule-associated protein RP/EB family member 1''' is a [[protein]] that in humans is encoded by the ''MAPRE1'' [[gene]].<ref name="pmid7606712">{{cite journal | vauthors = Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW | title = APC binds to the novel protein EB1 | journal = Cancer Res. | volume = 55 | issue = 14 | pages = 2972–7 | date = Aug 1995 | pmid = 7606712 | pmc =  | doi =  }}</ref><ref name="pmid9724749">{{cite journal | vauthors = Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE | title = The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules | journal = Proc. Natl. Acad. Sci. USA | volume = 95 | issue = 18 | pages = 10596–601 | date = Sep 1998 | pmid = 9724749 | pmc = 27940 | doi = 10.1073/pnas.95.18.10596 | bibcode = 1998PNAS...9510596B }}</ref><ref name="pmid11470413">{{cite journal | vauthors = Nakamura M, Zhou XZ, Lu KP | title = Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization | journal = Curr. Biol. | volume = 11 | issue = 13 | pages = 1062–7 | date = Jul 2001 | pmid = 11470413 | pmc =  | doi = 10.1016/S0960-9822(01)00297-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22919| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAPRE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pa7.
| PDB = {{PDB2|1pa7}}, {{PDB2|1txq}}, {{PDB2|1ueg}}, {{PDB2|1v5k}}, {{PDB2|1vka}}, {{PDB2|1wu9}}, {{PDB2|1yib}}, {{PDB2|1yig}}, {{PDB2|2hkq}}, {{PDB2|2hl5}}
| Name = Microtubule-associated protein, RP/EB family, member 1
| HGNCid = 6890
| Symbol = MAPRE1
| AltSymbols =; EB1; MGC117374; MGC129946
| OMIM = 603108
| ECnumber = 
| Homologene = 56129
| MGIid = 891995
| GeneAtlas_image1 = PBB_GE_MAPRE1_200713_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAPRE1_200712_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0051010 |text = microtubule plus-end binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005819 |text = spindle}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0030981 |text = cortical microtubule cytoskeleton}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0031115 |text = negative regulation of microtubule polymerization}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22919
    | Hs_Ensembl = ENSG00000101367
    | Hs_RefseqProtein = NP_036457
    | Hs_RefseqmRNA = NM_012325
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 30871395
    | Hs_GenLoc_end = 30901872
    | Hs_Uniprot = Q15691
    | Mm_EntrezGene = 13589
    | Mm_Ensembl = ENSMUSG00000027479
    | Mm_RefseqmRNA = XM_974846
    | Mm_RefseqProtein = XP_979940
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 153432791
    | Mm_GenLoc_end = 153458971
    | Mm_Uniprot = Q3U4H0
  }}
}}
'''Microtubule-associated protein, RP/EB family, member 1''', also known as '''MAPRE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22919| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene was first identified by its binding to the APC ([[Adenomatous polyposis coli]]) protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.<ref name="entrez">{{cite web | title = Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22919| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAPRE1 has been shown to [[Protein-protein interaction|interact]] with [[TERF1]].<ref name=pmid11943150>{{cite journal | vauthors = Nakamura M, Zhou XZ, Kishi S, Lu KP | title = Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle | journal = FEBS Lett. | volume = 514 | issue = 2–3 | pages = 193–8 | date = Mar 2002 | pmid = 11943150 | doi = 10.1016/S0014-5793(02)02363-3 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tirnauer JS, Bierer BE | title = EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. | journal = J. Cell Biol. | volume = 149 | issue = 4 | pages = 761–6 | year = 2000 | pmid = 10811817 | pmc = 2174556 | doi = 10.1083/jcb.149.4.761 }}
| citations =
* {{cite journal | vauthors = Morrison EE, Wardleworth BN, Askham JM, Markham AF, Meredith DM | title = EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. | journal = Oncogene | volume = 17 | issue = 26 | pages = 3471–7 | year = 1999 | pmid = 10030671 | doi = 10.1038/sj.onc.1202247 }}
*{{cite journal | author=Tirnauer JS, Bierer BE |title=EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. |journal=J. Cell Biol. |volume=149 |issue= 4 |pages= 761-6 |year= 2000 |pmid= 10811817 |doi=  }}
* {{cite journal | vauthors = Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C | title = EB/RP gene family encodes tubulin binding proteins. | journal = Int. J. Cancer | volume = 81 | issue = 2 | pages = 275–84 | year = 1999 | pmid = 10188731 | doi = 10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z }}
*{{cite journal  | author=Su LK, Burrell M, Hill DE, ''et al.'' |title=APC binds to the novel protein EB1. |journal=Cancer Res. |volume=55 |issue= 14 |pages= 2972-7 |year= 1995 |pmid= 7606712 |doi= }}
* {{cite journal | vauthors = Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE | title = The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. | journal = Curr. Biol. | volume = 9 | issue = 8 | pages = 425–8 | year = 1999 | pmid = 10226031 | doi = 10.1016/S0960-9822(99)80190-0 }}
*{{cite journal  | author=Berrueta L, Kraeft SK, Tirnauer JS, ''et al.'' |title=The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10596-601 |year= 1998 |pmid= 9724749 |doi=  }}
* {{cite journal | vauthors = Nakagawa H, Koyama K, Murata Y, Morito M, Akiyama T, Nakamura Y | title = EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. | journal = Oncogene | volume = 19 | issue = 2 | pages = 210–6 | year = 2000 | pmid = 10644998 | doi = 10.1038/sj.onc.1203308 }}
*{{cite journal | author=Morrison EE, Wardleworth BN, Askham JM, ''et al.'' |title=EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. |journal=Oncogene |volume=17 |issue= 26 |pages= 3471-7 |year= 1999 |pmid= 10030671 |doi= 10.1038/sj.onc.1202247 }}
* {{cite journal | vauthors = Askham JM, Moncur P, Markham AF, Morrison EE | title = Regulation and function of the interaction between the APC tumour suppressor protein and EB1. | journal = Oncogene | volume = 19 | issue = 15 | pages = 1950–8 | year = 2000 | pmid = 10773885 | doi = 10.1038/sj.onc.1203498 }}
*{{cite journal | author=Juwana JP, Henderikx P, Mischo A, ''et al.'' |title=EB/RP gene family encodes tubulin binding proteins. |journal=Int. J. Cancer |volume=81 |issue= 2 |pages= 275-84 |year= 1999 |pmid= 10188731 |doi= }}
* {{cite journal | vauthors = Mimori-Kiyosue Y, Shiina N, Tsukita S | title = The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. | journal = Curr. Biol. | volume = 10 | issue = 14 | pages = 865–8 | year = 2000 | pmid = 10899006 | doi = 10.1016/S0960-9822(00)00600-X }}
*{{cite journal | author=Berrueta L, Tirnauer JS, Schuyler SC, ''et al.'' |title=The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. |journal=Curr. Biol. |volume=9 |issue= 8 |pages= 425-8 |year= 1999 |pmid= 10226031 |doi= }}
* {{cite journal | vauthors = Zhou XZ, Lu KP | title = The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. | journal = Cell | volume = 107 | issue = 3 | pages = 347–59 | year = 2001 | pmid = 11701125 | doi = 10.1016/S0092-8674(01)00538-4 }}
*{{cite journal | author=Nakagawa H, Koyama K, Murata Y, ''et al.'' |title=EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. |journal=Oncogene |volume=19 |issue= 2 |pages= 210-6 |year= 2000 |pmid= 10644998 |doi= 10.1038/sj.onc.1203308 }}
* {{cite journal | vauthors = Nakamura M, Zhou XZ, Kishi S, Lu KP | title = Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle | journal = FEBS Lett. | volume = 514 | issue = 2–3 | pages = 193–8 | year = 2002 | pmid = 11943150 | doi = 10.1016/S0014-5793(02)02363-3 }}
*{{cite journal | author=Askham JM, Moncur P, Markham AF, Morrison EE |title=Regulation and function of the interaction between the APC tumour suppressor protein and EB1. |journal=Oncogene |volume=19 |issue= 15 |pages= 1950-8 |year= 2000 |pmid= 10773885 |doi= 10.1038/sj.onc.1203498 }}
* {{cite journal | vauthors = Askham JM, Vaughan KT, Goodson HV, Morrison EE | title = Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. | journal = Mol. Biol. Cell | volume = 13 | issue = 10 | pages = 3627–45 | year = 2003 | pmid = 12388762 | pmc = 129971 | doi = 10.1091/mbc.E02-01-0061 }}
*{{cite journal | author=Mimori-Kiyosue Y, Shiina N, Tsukita S |title=The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. |journal=Curr. Biol. |volume=10 |issue= 14 |pages= 865-8 |year= 2000 |pmid= 10899006 |doi= }}
* {{cite journal | vauthors = Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ | title = EB1 targets to kinetochores with attached, polymerizing microtubules. | journal = Mol. Biol. Cell | volume = 13 | issue = 12 | pages = 4308–16 | year = 2003 | pmid = 12475954 | pmc = 138635 | doi = 10.1091/mbc.E02-04-0236 }}
*{{cite journal  | author=Nakamura M, Zhou XZ, Lu KP |title=Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. |journal=Curr. Biol. |volume=11 |issue= 13 |pages= 1062-7 |year= 2001 |pmid= 11470413 |doi=  }}
* {{cite journal | vauthors = Ligon LA, Shelly SS, Tokito M, Holzbaur EL | title = The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. | journal = Mol. Biol. Cell | volume = 14 | issue = 4 | pages = 1405–17 | year = 2003 | pmid = 12686597 | pmc = 153110 | doi = 10.1091/mbc.E02-03-0155 }}
*{{cite journal | author=Zhou XZ, Lu KP |title=The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. |journal=Cell |volume=107 |issue= 3 |pages= 347-59 |year= 2001 |pmid= 11701125 |doi=  }}
* {{cite journal | vauthors = Hayashi I, Ikura M | title = Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). | journal = J. Biol. Chem. | volume = 278 | issue = 38 | pages = 36430–4 | year = 2003 | pmid = 12857735 | doi = 10.1074/jbc.M305773200 }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Bu W, Su LK | title = Characterization of functional domains of human EB1 family proteins. | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49721–31 | year = 2004 | pmid = 14514668 | doi = 10.1074/jbc.M306194200 }}
*{{cite journal | author=Nakamura M, Zhou XZ, Kishi S, Lu KP |title=Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 193-8 |year= 2002 |pmid= 11943150 |doi= }}
* {{cite journal | vauthors = Bieling P, Laan L, Schek H, Munteanu EL, Sandblad L, Dogterom M, Brunner D, Surrey T | title = Reconstitution of a microtubule plus-end tracking system in vitro | journal = Nature | volume =  450| issue = 7172 | pages = 1100–5 | year = 2007 | pmid = 18059460 | doi = 10.1038/nature06386 | bibcode = 2007Natur.450.1100B }}
*{{cite journal | author=Askham JM, Vaughan KT, Goodson HV, Morrison EE |title=Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3627-45 |year= 2003 |pmid= 12388762 |doi= 10.1091/mbc.E02-01-0061 }}
* {{cite journal | vauthors = Maurer SP, Fourniol FJ, Bohner G, Moores CA, Surrey T | title = EBs recognize a nucleotide-dependent structural cap at growing microtubule ends | journal = Cell | volume = 149 | issue = 2 | pages = 371–82 | year = 2012 | pmid = 22500803 | pmc = 3368265 | doi = 10.1016/j.cell.2012.02.049 }}
*{{cite journal | author=Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ |title=EB1 targets to kinetochores with attached, polymerizing microtubules. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4308-16 |year= 2003 |pmid= 12475954 |doi= 10.1091/mbc.E02-04-0236 }}
* {{cite journal | vauthors = Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y | title = Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells | journal = PLoS ONE | volume = 7 | issue = 12 | pages = e51442 | year = 2012 | pmid = 23251535 | pmc = 3520847 | doi = 10.1371/journal.pone.0051442 | bibcode = 2012PLoSO...751442N }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Zanic M, Widlund PO, Hyman AA, Howard J | title = Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels. | journal = Nat. Cell Biol. | volume = 15 | issue = 6 | pages = 688–93 | year = 2013 | pmid = 23666085 | doi = 10.1038/ncb2744 }}
*{{cite journal  | author=Ligon LA, Shelly SS, Tokito M, Holzbaur EL |title=The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. |journal=Mol. Biol. Cell |volume=14 |issue= 4 |pages= 1405-17 |year= 2003 |pmid= 12686597 |doi= 10.1091/mbc.E02-03-0155 }}
* {{cite journal | vauthors = Jie, Chen| title =  Phosphoregulation of the dimerization and functions of end-binding protein 1 | journal = Protein & Cell. | volume = 5 | issue = 10 | pages = 795–799 | year = 2014 |doi=10.1007/s13238-014-0081-9 |pmc=4180461 | pmid=25048701}}
*{{cite journal | author=Hayashi I, Ikura M |title=Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36430-4 |year= 2003 |pmid= 12857735 |doi= 10.1074/jbc.M305773200 }}
*{{cite journal | author=Bu W, Su LK |title=Characterization of functional domains of human EB1 family proteins. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49721-31 |year= 2004 |pmid= 14514668 |doi= 10.1074/jbc.M306194200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=22919}}
{{WikiDoc Sources}}
 
 
{{gene-20-stub}}

Latest revision as of 02:30, 11 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene.[1][2][3][4]

Function

The protein encoded by this gene was first identified by its binding to the APC (Adenomatous polyposis coli) protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.[4]

Interactions

MAPRE1 has been shown to interact with TERF1.[5]

References

  1. ↑ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Aug 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712.
  2. ↑ Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE (Sep 1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. Sci. USA. 95 (18): 10596–601. Bibcode:1998PNAS...9510596B. doi:10.1073/pnas.95.18.10596. PMC 27940. PMID 9724749.
  3. ↑ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413.
  4. ↑ 4.0 4.1 "Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1".
  5. ↑ Nakamura M, Zhou XZ, Kishi S, Lu KP (Mar 2002). "Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle". FEBS Lett. 514 (2–3): 193–8. doi:10.1016/S0014-5793(02)02363-3. PMID 11943150.

Further reading


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