MAP1LC3A: Difference between revisions
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{{ | '''Microtubule-associated proteins 1A/1B light chain 3A''' is a [[protein]] that in humans is encoded by the ''MAP1LC3A'' [[gene]].<ref name="pmid8833088">{{cite journal |vauthors=Mann SS, Hammarback JA | title = Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B | journal = J Neurosci Res | volume = 43 | issue = 5 | pages = 535–44 |date=May 1997 | pmid = 8833088 | pmc = | doi = 10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J }}</ref><ref name="pmid17580304">{{cite journal |vauthors=Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T | title = p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy | journal = J Biol Chem | volume = 282 | issue = 33 | pages = 24131–45 |date=Aug 2007 | pmid = 17580304 | pmc = | doi = 10.1074/jbc.M702824200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84557| accessdate = }}</ref> Two transcript variants encoding different isoforms have been found for this gene. | ||
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== Function == | |||
[[MAP1A]] and [[MAP1B]] are [[microtubule]]-associated proteins which mediate the physical interactions between microtubules and components of the [[cytoskeleton]]. [[MAP1A]] and [[MAP1B]] each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.<ref name="entrez"/> | |||
MAPLC3A is one of the mammalian homologues of yeast [[ATG8]], an important marker and effector of [[autophagy]].<ref>{{Cite journal|pmc = 4127242|title = Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer|vauthors=Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C |date = 2014|journal = Biomed Res Int|doi = 10.1155/2014/462658|pmid = 25136588|volume = 2014|page = 462658}}</ref> | |||
== Regulation == | |||
MAP1LC3A is regulated by several [[post-translational modification]]s. These include covalent linkage of the [[C-terminus]] to [[phosphatidylethanolamine]] in autophagic membranes, and [[phosphorylation]] by [[protein kinase A]],<ref name="pmid20713600">{{cite journal |vauthors=Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT | title = Regulation of the autophagy protein LC3 by phosphorylation | journal = J. Cell Biol. | volume = 190 | issue = 4 | pages = 533–9 |date=August 2010 | pmid = 20713600 | pmc = 2928022 | doi = 10.1083/jcb.201002108 }}</ref> which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to [[Protein-protein interaction|interact]] with [[sequestosome 1]].<ref name="pmid18653543">{{cite journal |vauthors=Shvets E, Fass E, Scherz-Shouval R, Elazar Z | title = The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes | journal = J. Cell Sci. | volume = 121 | issue = Pt 16 | pages = 2685–95 |date=August 2008 | pmid = 18653543 | doi = 10.1242/jcs.026005 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
*{{cite journal |vauthors=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227–30 |year= 1997 |pmid= 8997639 |doi= 10.1007/BF02818986}} | |||
*{{cite journal |vauthors=Wallin M, Deinum J, Goobar L, Danielson UH |title=Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases |journal=J. Gen. Virol. |volume=71 |issue= 9|pages= 1985–91 |year= 1990 |pmid= 2212989 |doi=10.1099/0022-1317-71-9-1985 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Schoenfeld TA, McKerracher L, Obar R, Vallee RB |title=MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS |journal=J. Neurosci. |volume=9 |issue= 5 |pages= 1712–30 |year= 1989 |pmid= 2470876 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Mann SS, Hammarback JA |title=Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11492–7 |year= 1994 |pmid= 7908909 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bonnet C, Boucher D, Lazereg S, etal |title=Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12839–48 |year= 2001 |pmid= 11278895 |doi= 10.1074/jbc.M011380200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=He H, Dang Y, Dai F, etal |title=Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29278–87 |year= 2003 |pmid= 12740394 |doi= 10.1074/jbc.M303800200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Tanida I, Sou YS, Ezaki J, etal |title=HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36268–76 |year= 2004 |pmid= 15187094 |doi= 10.1074/jbc.M401461200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kouno T, Mizuguchi M, Tanida I, etal |title=1H, 13C, and 15N resonance assignments of human microtubule-associated protein light chain-3 |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 415–6 |year= 2005 |pmid= 15213446 |doi= 10.1023/B:JNMR.0000032505.99071.ea }} | ||
*{{cite journal | *{{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kouno T, Mizuguchi M, Tanida I, etal |title=Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24610–7 |year= 2005 |pmid= 15857831 |doi= 10.1074/jbc.M413565200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sou YS, Tanida I, Komatsu M, etal |title=Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16 |journal=J. Biol. Chem. |volume=281 |issue= 6 |pages= 3017–24 |year= 2006 |pmid= 16303767 |doi= 10.1074/jbc.M505888200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }} | ||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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{{gene-20-stub}} |
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.[1][2][3] Two transcript variants encoding different isoforms have been found for this gene.
Function
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.[3]
MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy.[4]
Regulation
MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A,[5] which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.[6]
References
- ↑ Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res. 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088.
- ↑ Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem. 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.
- ↑ 3.0 3.1 "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha".
- ↑ Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". Biomed Res Int. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
- ↑ Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT (August 2010). "Regulation of the autophagy protein LC3 by phosphorylation". J. Cell Biol. 190 (4): 533–9. doi:10.1083/jcb.201002108. PMC 2928022. PMID 20713600.
- ↑ Shvets E, Fass E, Scherz-Shouval R, Elazar Z (August 2008). "The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes". J. Cell Sci. 121 (Pt 16): 2685–95. doi:10.1242/jcs.026005. PMID 18653543.
Further reading
- Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. doi:10.1007/BF02818986. PMID 8997639.
- Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases". J. Gen. Virol. 71 (9): 1985–91. doi:10.1099/0022-1317-71-9-1985. PMID 2212989.
- Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. PMID 2470876.
- Mann SS, Hammarback JA (1994). "Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B". J. Biol. Chem. 269 (15): 11492–7. PMID 7908909.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Bonnet C, Boucher D, Lazereg S, et al. (2001). "Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation". J. Biol. Chem. 276 (16): 12839–48. doi:10.1074/jbc.M011380200. PMID 11278895.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- He H, Dang Y, Dai F, et al. (2003). "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B". J. Biol. Chem. 278 (31): 29278–87. doi:10.1074/jbc.M303800200. PMID 12740394.
- Tanida I, Sou YS, Ezaki J, et al. (2004). "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates". J. Biol. Chem. 279 (35): 36268–76. doi:10.1074/jbc.M401461200. PMID 15187094.
- Kouno T, Mizuguchi M, Tanida I, et al. (2005). "1H, 13C, and 15N resonance assignments of human microtubule-associated protein light chain-3". J. Biomol. NMR. 29 (3): 415–6. doi:10.1023/B:JNMR.0000032505.99071.ea. PMID 15213446.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Kouno T, Mizuguchi M, Tanida I, et al. (2005). "Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains". J. Biol. Chem. 280 (26): 24610–7. doi:10.1074/jbc.M413565200. PMID 15857831.
- Sou YS, Tanida I, Komatsu M, et al. (2006). "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16". J. Biol. Chem. 281 (6): 3017–24. doi:10.1074/jbc.M505888200. PMID 16303767.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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