DYNLRB1: Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
m (Bot: HTTP→HTTPS) |
||
Line 1: | Line 1: | ||
{{Underlinked|date=May 2016}} | |||
{{ | {{Infobox_gene}} | ||
| | '''Dynein light chain roadblock-type 1''' is a [[protein]] that in humans is encoded by the ''DYNLRB1'' [[gene]].<ref name="pmid11750132">{{cite journal | vauthors = Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S | title = Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients | journal = Gene | volume = 281 | issue = 1–2 | pages = 103–13 |date=Dec 2001 | pmid = 11750132 | pmc = | doi =10.1016/S0378-1119(01)00787-9 }}</ref><ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=Nov 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83658| accessdate = }}</ref> | ||
}} | |||
| | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.<ref name="entrez" | | summary_text = This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |display-authors=etal}} | ||
*{{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Susalka SJ, Nikulina K, Salata MW |title=The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32939–46 |year= 2002 |pmid= 12077152 |doi= 10.1074/jbc.M205510200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Huang YS, Carson JH, Barbarese E, Richter JD |title=Facilitation of dendritic mRNA transport by CPEB |journal=Genes Dev. |volume=17 |issue= 5 |pages= 638–53 |year= 2003 |pmid= 12629046 |doi= 10.1101/gad.1053003 | pmc=196011 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Saito Y, Doi K, Yamagishi N |title=Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 396–402 |year= 2004 |pmid= 14733918 |doi=10.1016/j.bbrc.2003.12.108 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Campbell IG, Phillips WA, Choong DY |title=Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers |journal=Clin. Cancer Res. |volume=12 |issue= 12 |pages= 3713–5 |year= 2006 |pmid= 16778097 |doi= 10.1158/1078-0432.CCR-06-0800 }} | ||
*{{cite journal | vauthors=Pérez-González A, Rodriguez A, Huarte M |title=hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator |journal=J. Mol. Biol. |volume=362 |issue= 5 |pages= 887–900 |year= 2007 |pmid= 16950395 |doi= 10.1016/j.jmb.2006.07.085 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Liu JF, Wang ZX, Wang XQ |title=Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74 |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 3 |pages= 1125–9 |year= 2006 |pmid= 16970917 |doi= 10.1016/j.bbrc.2006.08.161 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kang HC, Kim IJ, Kim K |title=km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers |journal=Cancer Genet. Cytogenet. |volume=175 |issue= 2 |pages= 173–4 |year= 2007 |pmid= 17556076 |doi= 10.1016/j.cancergencyto.2007.02.004 |display-authors=etal}} | ||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
*{{cite journal | vauthors=Wanschers B, van de Vorstenbosch R, Fransen J |title=Rab6 family proteins interact with the dynein light chain protein DYNLRB1 |journal=Cell Motil. Cytoskeleton |volume= 65 |issue= 3 |pages= 183–96 |year= 2008 |pmid= 18044744 |doi= 10.1002/cm.20254|display-authors=etal}} | |||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=83658}} | |||
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | |||
{{PBB_Controls | |||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{ | {{gene-20-stub}} | ||
Latest revision as of 18:47, 30 August 2017
This article needs more links to other articles to help integrate it into the encyclopedia. (May 2016) (Learn how and when to remove this template message) |
VALUE_ERROR (nil) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
|
| |||||
Ensembl |
|
| |||||
UniProt |
|
| |||||
RefSeq (mRNA) |
|
| |||||
RefSeq (protein) |
|
| |||||
Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
|
Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.[1][2][3]
This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[3]
References
- ↑ Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID 11750132.
- ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
- ↑ 3.0 3.1 "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1".
Further reading
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Susalka SJ, Nikulina K, Salata MW, et al. (2002). "The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain". J. Biol. Chem. 277 (36): 32939–46. doi:10.1074/jbc.M205510200. PMID 12077152.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
- Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Campbell IG, Phillips WA, Choong DY (2006). "Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers". Clin. Cancer Res. 12 (12): 3713–5. doi:10.1158/1078-0432.CCR-06-0800. PMID 16778097.
- Pérez-González A, Rodriguez A, Huarte M, et al. (2007). "hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator". J. Mol. Biol. 362 (5): 887–900. doi:10.1016/j.jmb.2006.07.085. PMID 16950395.
- Liu JF, Wang ZX, Wang XQ, et al. (2006). "Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74". Biochem. Biophys. Res. Commun. 349 (3): 1125–9. doi:10.1016/j.bbrc.2006.08.161. PMID 16970917.
- Kang HC, Kim IJ, Kim K, et al. (2007). "km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers". Cancer Genet. Cytogenet. 175 (2): 173–4. doi:10.1016/j.cancergencyto.2007.02.004. PMID 17556076.
- Wanschers B, van de Vorstenbosch R, Fransen J, et al. (2008). "Rab6 family proteins interact with the dynein light chain protein DYNLRB1". Cell Motil. Cytoskeleton. 65 (3): 183–96. doi:10.1002/cm.20254. PMID 18044744.
![]() | This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it. |
Categories:
- Pages with broken file links
- Articles with too few wikilinks from May 2016
- Articles with invalid date parameter in template
- All articles with too few wikilinks
- Articles covered by WikiProject Wikify from May 2016
- All articles covered by WikiProject Wikify
- Genes on human chromosome
- All stub articles
- Human chromosome 20 gene stubs