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{{ | '''Ras association domain-containing protein 2''' is a [[protein]] that in humans is encoded by the ''RASSF2'' [[gene]].<ref name="pmid8724849">{{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 3 | issue = 1 | pages = 17–24 |date=Nov 1996 | pmid = 8724849 | pmc = | doi =10.1093/dnares/3.1.17 }}</ref><ref name="pmid15806169">{{cite journal |vauthors=Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F | title = CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations | journal = Oncogene | volume = 24 | issue = 24 | pages = 3987–94 |date=Jun 2005 | pmid = 15806169 | pmc = | doi = 10.1038/sj.onc.1208566 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9770| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.<ref name="entrez" | | summary_text = This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
RASSF2 has been shown to [[Protein-protein interaction|interact]] with [[KRAS]].<ref name=pmid12732644>{{cite journal |last=Vos |first=Michele D |authorlink= |author2=Ellis Chad A |author3=Elam Candice |author4=Ulku Aylin S |author5=Taylor Barbara J |author6=Clark Geoffrey J |date=Jul 2003 |title=RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor |journal=J. Biol. Chem. |volume=278 |issue=30 |pages=28045–51 |publisher= |location = United States| issn = 0021-9258| pmid = 12732644 |doi = 10.1074/jbc.M300554200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} | |||
*{{cite journal | *{{cite journal |vauthors=Comincini S, Castiglioni BM, Foti GM, etal |title=Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene |journal=Mamm. Genome |volume=12 |issue= 2 |pages= 150–6 |year= 2001 |pmid= 11210185 |doi=10.1007/s003350010239 }} | ||
*{{cite journal | *{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Vos MD, Ellis CA, Elam C, etal |title=RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28045–51 |year= 2003 |pmid= 12732644 |doi= 10.1074/jbc.M300554200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Fujita H, Fukuhara S, Sakurai A, etal |title=Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 5022–31 |year= 2005 |pmid= 15569673 |doi= 10.1074/jbc.M409701200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Akino K, Toyota M, Suzuki H, etal |title=The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer |journal=Gastroenterology |volume=129 |issue= 1 |pages= 156–69 |year= 2005 |pmid= 16012945 |doi=10.1053/j.gastro.2005.03.051 }} | ||
*{{cite journal | *{{cite journal |vauthors=Endoh M, Tamura G, Honda T, etal |title=RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer |journal=Br. J. Cancer |volume=93 |issue= 12 |pages= 1395–9 |year= 2006 |pmid= 16265349 |doi= 10.1038/sj.bjc.6602854 | pmc=2361541 }} | ||
*{{cite journal |vauthors=Zhang Z, Sun D, Van do N, etal |title=Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma |journal=Int. J. Cancer |volume=120 |issue= 1 |pages= 32–8 |year= 2007 |pmid= 17013896 |doi= 10.1002/ijc.22185 }} | |||
*{{cite journal | *{{cite journal |vauthors=Park HW, Kang HC, Kim IJ, etal |title=Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers |journal=Int. J. Cancer |volume=120 |issue= 1 |pages= 7–12 |year= 2007 |pmid= 17013898 |doi= 10.1002/ijc.22276 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kumari G, Singhal PK, Rao MR, Mahalingam S |title=Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals |journal=J. Mol. Biol. |volume=367 |issue= 5 |pages= 1294–311 |year= 2007 |pmid= 17320110 |doi= 10.1016/j.jmb.2007.01.026 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kaira K, Sunaga N, Tomizawa Y, etal |title=Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers |journal=Int. J. Oncol. |volume=31 |issue= 1 |pages= 169–73 |year= 2007 |pmid= 17549418 |doi= 10.3892/ijo.31.1.169}} | ||
*{{cite journal | | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Revision as of 08:56, 10 September 2017
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Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[1][2][3]
This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[3]
Interactions
RASSF2 has been shown to interact with KRAS.[4]
References
- ↑ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
- ↑ Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169.
- ↑ 3.0 3.1 "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2".
- ↑ Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. United States. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Comincini S, Castiglioni BM, Foti GM, et al. (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene". Mamm. Genome. 12 (2): 150–6. doi:10.1007/s003350010239. PMID 11210185.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vos MD, Ellis CA, Elam C, et al. (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. PMID 12732644.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fujita H, Fukuhara S, Sakurai A, et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.
- Akino K, Toyota M, Suzuki H, et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. 129 (1): 156–69. doi:10.1053/j.gastro.2005.03.051. PMID 16012945.
- Endoh M, Tamura G, Honda T, et al. (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer". Br. J. Cancer. 93 (12): 1395–9. doi:10.1038/sj.bjc.6602854. PMC 2361541. PMID 16265349.
- Zhang Z, Sun D, Van do N, et al. (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma". Int. J. Cancer. 120 (1): 32–8. doi:10.1002/ijc.22185. PMID 17013896.
- Park HW, Kang HC, Kim IJ, et al. (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers". Int. J. Cancer. 120 (1): 7–12. doi:10.1002/ijc.22276. PMID 17013898.
- Kumari G, Singhal PK, Rao MR, Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals". J. Mol. Biol. 367 (5): 1294–311. doi:10.1016/j.jmb.2007.01.026. PMID 17320110.
- Kaira K, Sunaga N, Tomizawa Y, et al. (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers". Int. J. Oncol. 31 (1): 169–73. doi:10.3892/ijo.31.1.169. PMID 17549418.
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