TOMM34: Difference between revisions

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{{Infobox_gene}}
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'''Mitochondrial import receptor subunit TOM34''' is a [[protein]] that in humans is encoded by the ''TOMM34'' [[gene]].<ref name="pmid9324309">{{cite journal | vauthors = Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ | title = hTom34: a novel translocase for the import of proteins into human mitochondria | journal = DNA Cell Biol | volume = 16 | issue = 9 | pages = 1067–74 |date=Oct 1997 | pmid = 9324309 | pmc =  | doi =10.1089/dna.1997.16.1067 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10953| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Translocase of outer mitochondrial membrane 34
| HGNCid = 15746
| Symbol = TOMM34
| AltSymbols =; HTOM34P; TOM34; URCC3
| OMIM =
| ECnumber =
| Homologene = 4956
| MGIid = 1914395
  | GeneAtlas_image1 = PBB_GE_TOMM34_201870_at_tn.png
  | Function = {{GNF_GO|id=GO:0005048 |text = signal sequence binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006626 |text = protein targeting to mitochondrion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10953
    | Hs_Ensembl = ENSG00000025772
    | Hs_RefseqProtein = NP_006800
    | Hs_RefseqmRNA = NM_006809
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 43004185
    | Hs_GenLoc_end = 43022541
    | Hs_Uniprot = Q15785
    | Mm_EntrezGene = 67145
    | Mm_Ensembl = ENSMUSG00000018322
    | Mm_RefseqmRNA = NM_025996
    | Mm_RefseqProtein = NP_080272
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 163744982
    | Mm_GenLoc_end = 163762543
    | Mm_Uniprot = Q812F1
  }}
}}
'''Translocase of outer mitochondrial membrane 34''', also known as '''TOMM34''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10953| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.<ref name="entrez">{{cite web | title = Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10953| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ |title=hTom34: a novel translocase for the import of proteins into human mitochondria. |journal=DNA Cell Biol. |volume=16 |issue= 9 |pages= 1067-74 |year= 1997 |pmid= 9324309 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Young JC, Obermann WM, Hartl FU |title=Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90 |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18007–10 |year= 1998 |pmid= 9660753 |doi=10.1074/jbc.273.29.18007 }}
*{{cite journal  | author=Young JC, Obermann WM, Hartl FU |title=Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18007-10 |year= 1998 |pmid= 9660753 |doi=  }}
*{{cite journal   |vauthors=Chewawiwat N, Yano M, Terada K, etal |title=Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells |journal=J. Biochem. |volume=125 |issue= 4 |pages= 721–7 |year= 1999 |pmid= 10101285 |doi=  10.1093/oxfordjournals.jbchem.a022342}}
*{{cite journal | author=Chewawiwat N, Yano M, Terada K, ''et al.'' |title=Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells. |journal=J. Biochem. |volume=125 |issue= 4 |pages= 721-7 |year= 1999 |pmid= 10101285 |doi=  }}
*{{cite journal   |vauthors=Fossey SC, Mychaleckyj JC, Pendleton JK, etal |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 |journal=Genomics |volume=76 |issue= 1–3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, ''et al.'' |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45-57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Mukhopadhyay A, Avramova LV, Weiner H |title=Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins |journal=Arch. Biochem. Biophys. |volume=400 |issue= 1 |pages= 97–104 |year= 2002 |pmid= 11913975 |doi= 10.1006/abbi.2002.2777 }}
*{{cite journal  | author=Mukhopadhyay A, Avramova LV, Weiner H |title=Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. |journal=Arch. Biochem. Biophys. |volume=400 |issue= 1 |pages= 97-104 |year= 2002 |pmid= 11913975 |doi= 10.1006/abbi.2002.2777 }}
*{{cite journal  | vauthors=Yang CS, Weiner H |title=Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol |journal=Arch. Biochem. Biophys. |volume=400 |issue= 1 |pages= 105–10 |year= 2002 |pmid= 11913976 |doi= 10.1006/abbi.2002.2778 }}
*{{cite journal  | author=Yang CS, Weiner H |title=Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. |journal=Arch. Biochem. Biophys. |volume=400 |issue= 1 |pages= 105-10 |year= 2002 |pmid= 11913976 |doi= 10.1006/abbi.2002.2778 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Shimokawa T, Matsushima S, Tsunoda T, etal |title=Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 381–6 |year= 2006 |pmid= 16820880 |doi=  10.3892/ijo.29.2.381}}
*{{cite journal | author=Shimokawa T, Matsushima S, Tsunoda T, ''et al.'' |title=Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 381-6 |year= 2006 |pmid= 16820880 |doi=  }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 12:08, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.[1][2]

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.[2]

References

  1. ↑ Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (Oct 1997). "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol. 16 (9): 1067–74. doi:10.1089/dna.1997.16.1067. PMID 9324309.
  2. ↑ 2.0 2.1 "Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34".

Further reading



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