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{{Infobox_gene}}
{{PBB_Controls
'''80 kDa MCM3-associated protein''' is a [[protein]] that in humans is encoded by the ''MCM3AP'' [[gene]].<ref name="pmid9712829">{{cite journal | vauthors = Takei Y, Tsujimoto G | title = Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization | journal = J. Biol. Chem. | volume = 273 | issue = 35 | pages = 22177–80  | date = September 1998 | pmid = 9712829 | pmc = | doi = 10.1074/jbc.273.35.22177 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8888| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
| HGNCid = 6946
| Symbol = MCM3AP
| AltSymbols =; FLJ44336; FLJ45306; GANP; KIAA0572; MAP80
| OMIM = 603294
| ECnumber = 
| Homologene = 2902
| MGIid = 1930089
| GeneAtlas_image1 = PBB_GE_MCM3AP_212269_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MCM3AP_215581_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006606 |text = protein import into nucleus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8888
    | Hs_Ensembl = ENSG00000160294
    | Hs_RefseqProtein = NP_003897
    | Hs_RefseqmRNA = NM_003906
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 46479476
    | Hs_GenLoc_end = 46529664
    | Hs_Uniprot = O60318
    | Mm_EntrezGene = 54387
    | Mm_Ensembl = ENSMUSG00000001150
    | Mm_RefseqmRNA = NM_019434
    | Mm_RefseqProtein = NP_062307
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 75912643
    | Mm_GenLoc_end = 75959569
    | Mm_Uniprot = Q6NWV4
  }}
}}
'''MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein''', also known as '''MCM3AP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8888| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.<ref name="entrez">{{cite web | title = Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8888| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MCM3AP has been shown to [[Protein-protein interaction|interact]] with:
* [[MCM3]]<ref name = pmid9712829 /><ref name = pmid12226073>{{cite journal | vauthors = Takei Y, Assenberg M, Tsujimoto G, Laskey R | title = The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43121–5  | date = November 2002 | pmid = 12226073 | doi = 10.1074/jbc.C200442200 }}</ref><ref name = pmid10733502>{{cite journal | vauthors = Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N | title = A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication | journal = Blood | volume = 95 | issue = 7 | pages = 2321–8  | date = April 2000 | pmid = 10733502 | doi =  }}</ref>  and
* [[TRIB3]].<ref name = pmid18276110>{{cite journal | vauthors = Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F | title = E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3 | journal = Cell. Signal. | volume = 20 | issue = 5 | pages = 942–8  | date = May 2008 | pmid = 18276110 | doi = 10.1016/j.cellsig.2008.01.010 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 1 | pages = 31–9 | year = 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 }}
| citations =
* {{cite journal | vauthors = Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N | title = A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication | journal = Blood | volume = 95 | issue = 7 | pages = 2321–8 | year = 2000 | pmid = 10733502 | doi =  }}
*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins ''in vitro''. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
* {{cite journal | vauthors = Abe E, Kuwahara K, Yoshida M, Suzuki M, Terasaki H, Matsuo Y, Takahashi EI, Sakaguchi N | title = Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication | journal = Gene | volume = 255 | issue = 2 | pages = 219–27 | year = 2000 | pmid = 11024281 | doi = 10.1016/S0378-1119(00)00336-X }}
*{{cite journal  | author=Takei Y, Tsujimoto G |title=Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22177-80 |year= 1998 |pmid= 9712829 |doi=  }}
* {{cite journal | vauthors = Takei Y, Swietlik M, Tanoue A, Tsujimoto G, Kouzarides T, Laskey R | title = MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3 | journal = EMBO Rep. | volume = 2 | issue = 2 | pages = 119–23 | year = 2001 | pmid = 11258703 | pmc = 1083822 | doi = 10.1093/embo-reports/kve026 }}
*{{cite journal | author=Kuwahara K, Yoshida M, Kondo E, ''et al.'' |title=A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. |journal=Blood |volume=95 |issue= 7 |pages= 2321-8 |year= 2000 |pmid= 10733502 |doi=  }}
* {{cite journal | vauthors = Kuwahara K, Tomiyasu S, Fujimura S, Nomura K, Xing Y, Nishiyama N, Ogawa M, Imajoh-Ohmi S, Izuta S, Sakaguchi N | title = Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10279–83 | year = 2001 | pmid = 11526238 | pmc = 56952 | doi = 10.1073/pnas.181335698 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
* {{cite journal | vauthors = EL-Gazzar MA, Maeda K, Nomiyama H, Nakao M, Kuwahara K, Sakaguchi N | title = PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48000–8 | year = 2001 | pmid = 11641399 | doi = 10.1074/jbc.M106696200 }}
*{{cite journal  | author=Abe E, Kuwahara K, Yoshida M, ''et al.'' |title=Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication. |journal=Gene |volume=255 |issue= 2 |pages= 219-27 |year= 2000 |pmid= 11024281 |doi= }}
* {{cite journal | vauthors = Kono Y, Maeda K, Kuwahara K, Yamamoto H, Miyamoto E, Yonezawa K, Takagi K, Sakaguchi N | title = MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR | journal = Genes Cells | volume = 7 | issue = 8 | pages = 821–34 | year = 2002 | pmid = 12167160 | doi = 10.1046/j.1365-2443.2002.00562.x }}
*{{cite journal | author=Takei Y, Swietlik M, Tanoue A, ''et al.'' |title=MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. |journal=EMBO Rep. |volume=2 |issue= 2 |pages= 119-23 |year= 2001 |pmid= 11258703 |doi= 10.1093/embo-reports/kve026 }}
* {{cite journal | vauthors = Takei Y, Assenberg M, Tsujimoto G, Laskey R | title = The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43121–5 | year = 2002 | pmid = 12226073 | doi = 10.1074/jbc.C200442200 }}
*{{cite journal | author=Kuwahara K, Tomiyasu S, Fujimura S, ''et al.'' |title=Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10279-83 |year= 2001 |pmid= 11526238 |doi= 10.1073/pnas.181335698 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal | author=EL-Gazzar MA, Maeda K, Nomiyama H, ''et al.'' |title=PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48000-8 |year= 2002 |pmid= 11641399 |doi= 10.1074/jbc. M106696200 }}
* {{cite journal | vauthors = Sakaguchi N, Fujimura S, Kuwahara K | title = Involvement of GANP in B cell activation in T cell-dependent antigen response | journal = Dev. Immunol. | volume = 9 | issue = 3 | pages = 169–72 | year = 2002 | pmid = 12885157 | pmc = 2276099 | doi = 10.1080/1044667031000137647 }}
*{{cite journal | author=Kono Y, Maeda K, Kuwahara K, ''et al.'' |title=MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. |journal=Genes Cells |volume=7 |issue= 8 |pages= 821-34 |year= 2003 |pmid= 12167160 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Takei Y, Assenberg M, Tsujimoto G, Laskey R |title=The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43121-5 |year= 2003 |pmid= 12226073 |doi= 10.1074/jbc. C200442200 }}
* {{cite journal | vauthors = Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M | title = Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins | journal = BMC Genomics | volume = 7 | pages = 155 | year = 2006 | pmid = 16780588 | pmc = 1526728 | doi = 10.1186/1471-2164-7-155 }}
*{{cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sakaguchi N, Fujimura S, Kuwahara K |title=Involvement of GANP in B cell activation in T cell-dependent antigen response. |journal=Dev. Immunol. |volume=9 |issue= 3 |pages= 169-72 |year= 2003 |pmid= 12885157 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hu YH, Warnatz HJ, Vanhecke D, ''et al.'' |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7 |issue=  |pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:16, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.[1][2]

Function

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.[2]

Interactions

MCM3AP has been shown to interact with:

References

  1. ↑ 1.0 1.1 Takei Y, Tsujimoto G (September 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi:10.1074/jbc.273.35.22177. PMID 9712829.
  2. ↑ 2.0 2.1 "Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein".
  3. ↑ Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi:10.1074/jbc.C200442200. PMID 12226073.
  4. ↑ Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. PMID 10733502.
  5. ↑ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading


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