AP1B1: Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
m (Bot: HTTP→HTTPS) |
||
| Line 1: | Line 1: | ||
{{Infobox gene}} | |||
{{ | '''AP-1 complex subunit beta-1''' is a [[protein]] that in humans is encoded by the ''AP1B1'' [[gene]].<ref name="pmid7987321">{{cite journal |vauthors=Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP | title = Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene | journal = Hum Mol Genet | volume = 3 | issue = 8 | pages = 1393–9 |date=January 1995 | pmid = 7987321 | pmc = | doi =10.1093/hmg/3.8.1393 }}</ref><ref name="pmid8812422">{{cite journal |vauthors=Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP | title = Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12 | journal = Genomics | volume = 36 | issue = 1 | pages = 112–7 |date=February 1997 | pmid = 8812422 | pmc = | doi = 10.1006/geno.1996.0431 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=162| accessdate = }}</ref> | ||
}} | |||
| | |||
| | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.<ref name="entrez" | | summary_text = Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate [[meningioma]] gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
AP1B1 has been shown to [[Protein-protein interaction|interact]] with [[KIF13A]]<ref name=pmid11106728>{{cite journal |last=Nakagawa |first=T |authorlink= |author2=Setou M |author3=Seog D |author4=Ogasawara K |author5=Dohmae N |author6=Takio K |author7=Hirokawa N |date=November 2000 |title=A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex |journal=Cell |volume=103 |issue=4 |pages=569–81 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 11106728 |doi=10.1016/S0092-8674(00)00161-6 }}</ref> and [[AP1G1]].<ref name=pmid9733768>{{cite journal |last=Takatsu |first=H |authorlink= |author2=Sakurai M |author3=Shin H W |author4=Murakami K |author5=Nakayama K |date=September 1998 |title=Identification and characterization of novel clathrin adaptor-related proteins |journal=J. Biol. Chem. |volume=273 |issue=38 |pages=24693–700 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9733768 |doi=10.1074/jbc.273.38.24693 }}</ref><ref name=pmid10535737>{{cite journal |last=Fölsch |first=H |authorlink= |author2=Ohno H |author3=Bonifacino J S |author4=Mellman I |date=October 1999 |title=A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells |journal=Cell |volume=99 |issue=2 |pages=189–98 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 10535737 |doi=10.1016/S0092-8674(00)81650-5 }}</ref><ref name=pmid7593184>{{cite journal |last=Page |first=L J |authorlink= |author2=Robinson M S |date=November 1995 |title=Targeting signals and subunit interactions in coated vesicle adaptor complexes |journal=J. Cell Biol. |volume=131 |issue=3 |pages=619–30 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 7593184 |doi=10.1083/jcb.131.3.619 |pmc=2120623 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue= |pages= | *{{cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue= |pages= 699–727 |year= 2000 |pmid= 10966473 |doi= 10.1146/annurev.biochem.69.1.699 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141 | pmc=1083955 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100–6 |year= 2003 |pmid= 12836198 |doi= 10.1051/medsci/2003191100}} | ||
*{{cite journal |vauthors=Lim DS, Kirsch DG, Canman CE |title=ATM binds to beta-adaptin in cytoplasmic vesicles. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10146–51 |year= 1998 |pmid= 9707615 |doi=10.1073/pnas.95.17.10146 | pmc=21476 |display-authors=etal}} | |||
*{{cite journal |vauthors=Takatsu H, Sakurai M, Shin HW |title=Identification and characterization of novel clathrin adaptor-related proteins. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24693–700 |year= 1998 |pmid= 9733768 |doi=10.1074/jbc.273.38.24693 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal |vauthors=Craig HM, Pandori MW, Guatelli JC |title=Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11229–34 |year= 1998 |pmid= 9736718 |doi=10.1073/pnas.95.19.11229 | pmc=21624 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bresnahan PA, Yonemoto W, Ferrell S |title=A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1235–8 |year= 1999 |pmid= 9811606 |doi=10.1016/S0960-9822(07)00517-9 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Greenberg M, DeTulleo L, Rapoport I |title=A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1239–42 |year= 1999 |pmid= 9811611 |doi=10.1016/S0960-9822(07)00518-0 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Laporte SA, Oakley RH, Zhang J |title=The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3712–7 |year= 1999 |pmid= 10097102 |doi=10.1073/pnas.96.7.3712 | pmc=22359 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Fölsch H, Ohno H, Bonifacino JS, Mellman I |title=A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. |journal=Cell |volume=99 |issue= 2 |pages= 189–98 |year= 1999 |pmid= 10535737 |doi=10.1016/S0092-8674(00)81650-5 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=10.1074/jbc.274.53.37538 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Lai MM, Luo HR, Burnett PE |title=The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34017–20 |year= 2000 |pmid= 10931822 |doi= 10.1074/jbc.C000429200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Nakagawa T, Setou M, Seog D |title=A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. |journal=Cell |volume=103 |issue= 4 |pages= 569–81 |year= 2001 |pmid= 11106728 |doi=10.1016/S0092-8674(00)00161-6 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Takatsu H, Futatsumori M, Yoshino K |title=Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 4 |pages= 1083–9 |year= 2001 |pmid= 11409905 |doi= 10.1006/bbrc.2001.5081 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Doray B, Kornfeld S |title=Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly. |journal=Mol. Biol. Cell |volume=12 |issue= 7 |pages= 1925–35 |year= 2001 |pmid= 11451993 |doi= 10.1091/mbc.12.7.1925| pmc=55640 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Jardine H, MacNee W, Donaldson K, Rahman I |title=Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21158–66 |year= 2002 |pmid= 11912197 |doi= 10.1074/jbc.M112145200 }} | ||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=162}} | |||
==External links== | |||
* {{UCSC gene info|AP1B1}} | |||
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | |||
{{PBB_Controls | |||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{gene-22-stub}} | {{gene-22-stub}} | ||
Latest revision as of 18:04, 29 August 2017
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.[1][2][3]
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.[3]
Interactions
AP1B1 has been shown to interact with KIF13A[4] and AP1G1.[5][6][7]
References
- ↑ Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP (January 1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum Mol Genet. 3 (8): 1393–9. doi:10.1093/hmg/3.8.1393. PMID 7987321.
- ↑ Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP (February 1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics. 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID 8812422.
- ↑ 3.0 3.1 "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit".
- ↑ Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; Takio K; Hirokawa N (November 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. UNITED STATES. 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. ISSN 0092-8674. PMID 11106728.
- ↑ Takatsu, H; Sakurai M; Shin H W; Murakami K; Nakayama K (September 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. UNITED STATES. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. ISSN 0021-9258. PMID 9733768.
- ↑ Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. UNITED STATES. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737.
- ↑ Page, L J; Robinson M S (November 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. UNITED STATES. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184.
Further reading
- Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
- Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
- Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
- Lim DS, Kirsch DG, Canman CE, et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. doi:10.1073/pnas.95.17.10146. PMC 21476. PMID 9707615.
- Takatsu H, Sakurai M, Shin HW, et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
- Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. doi:10.1073/pnas.95.19.11229. PMC 21624. PMID 9736718.
- Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. doi:10.1016/S0960-9822(07)00517-9. PMID 9811606.
- Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. doi:10.1016/S0960-9822(07)00518-0. PMID 9811611.
- Laporte SA, Oakley RH, Zhang J, et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. doi:10.1073/pnas.96.7.3712. PMC 22359. PMID 10097102.
- Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
- Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
- Lai MM, Luo HR, Burnett PE, et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
- Nakagawa T, Setou M, Seog D, et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728.
- Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
- Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Mol. Biol. Cell. 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC 55640. PMID 11451993.
- Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197.
External links
- Human AP1B1 genome location and AP1B1 gene details page in the UCSC Genome Browser.
 | This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |