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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Bcl-2-interacting killer''' is a [[protein]] that in humans is encoded by the ''BIK'' [[gene]].<ref name="pmid7478623">{{cite journal | vauthors = Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ | title = Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins | journal = Oncogene | volume = 11 | issue = 9 | pages = 1921–8 | date = Dec 1995 | pmid = 7478623 | pmc =  | doi =  }}</ref><ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | pmc = | doi = 10.1038/990031 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638| accessdate = }}</ref>
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| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2-interacting killer (apoptosis-inducing)
| HGNCid = 1051
| Symbol = BIK
| AltSymbols =; BIP1; BP4; NBK
| OMIM = 603392
| ECnumber = 
| Homologene = 924
| MGIid = 1206591
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005740 |text = mitochondrial envelope}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 638
    | Hs_Ensembl = ENSG00000100290
    | Hs_RefseqProtein = NP_001188
    | Hs_RefseqmRNA = NM_001197
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 41836701
    | Hs_GenLoc_end = 41855661
    | Hs_Uniprot = Q13323
    | Mm_EntrezGene = 12124
    | Mm_Ensembl = ENSMUSG00000016758
    | Mm_RefseqmRNA = XM_001001652
    | Mm_RefseqProtein = XP_001001652
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 83354629
    | Mm_GenLoc_end = 83372401
    | Mm_Uniprot = 
  }}
}}
'''BCL2-interacting killer (apoptosis-inducing)''', also known as '''BIK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as [[Bcl-2|BCL2]] and the [[Epstein-Barr virus]] in order to enhance programmed cell death.  Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins.  This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death.  Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins.  This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.<ref name="entrez">{{cite web | title = Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Boyd JM, Gallo GJ, Elangovan B, ''et al.'' |title=Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. |journal=Oncogene |volume=11 |issue= 9 |pages= 1921-8 |year= 1995 |pmid= 7478623 |doi=  }}
*{{cite journal  | author=Chittenden T, Flemington C, Houghton AB, ''et al.'' |title=A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5589-96 |year= 1996 |pmid= 8521816 |doi=  }}
*{{cite journal  | author=Han J, Sabbatini P, White E |title=Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5857-64 |year= 1996 |pmid= 8816500 |doi=  }}
*{{cite journal  | author=Inohara N, Ding L, Chen S, Núñez G |title=harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). |journal=EMBO J. |volume=16 |issue= 7 |pages= 1686-94 |year= 1997 |pmid= 9130713 |doi= 10.1093/emboj/16.7.1686 }}
*{{cite journal  | author=Huang DC, Adams JM, Cory S |title=The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. |journal=EMBO J. |volume=17 |issue= 4 |pages= 1029-39 |year= 1998 |pmid= 9463381 |doi= 10.1093/emboj/17.4.1029 }}
*{{cite journal  | author=Hegde R, Srinivasula SM, Ahmad M, ''et al.'' |title=Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7783-6 |year= 1998 |pmid= 9525867 |doi=  }}
*{{cite journal  | author=Ohi N, Tokunaga A, Tsunoda H, ''et al.'' |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314-25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493 }}
*{{cite journal  | author=Holmgreen SP, Huang DC, Adams JM, Cory S |title=Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. |journal=Cell Death Differ. |volume=6 |issue= 6 |pages= 525-32 |year= 1999 |pmid= 10381646 |doi= 10.1038/sj.cdd.4400519 }}
*{{cite journal  | author=Castells A, Ino Y, Louis DN, ''et al.'' |title=Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. |journal=Gastroenterology |volume=117 |issue= 4 |pages= 831-7 |year= 1999 |pmid= 10500065 |doi=  }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=Verma S, Budarf ML, Emanuel BS, Chinnadurai G |title=Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences. |journal=Gene |volume=254 |issue= 1-2 |pages= 157-62 |year= 2000 |pmid= 10974546 |doi=  }}
*{{cite journal  | author=Jiang A, Clark EA |title=Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6025-33 |year= 2001 |pmid= 11342619 |doi=  }}
*{{cite journal  | author=Federici M, Hribal M, Perego L, ''et al.'' |title=High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. |journal=Diabetes |volume=50 |issue= 6 |pages= 1290-301 |year= 2001 |pmid= 11375329 |doi=  }}
*{{cite journal  | author=Zou Y, Peng H, Zhou B, ''et al.'' |title=Systemic tumor suppression by the proapoptotic gene bik. |journal=Cancer Res. |volume=62 |issue= 1 |pages= 8-12 |year= 2002 |pmid= 11782349 |doi=  }}
*{{cite journal  | author=Germain M, Mathai JP, Shore GC |title=BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 18053-60 |year= 2002 |pmid= 11884414 |doi= 10.1074/jbc.M201235200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gillissen B, Essmann F, Graupner V, ''et al.'' |title=Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3580-90 |year= 2003 |pmid= 12853473 |doi= 10.1093/emboj/cdg343 }}
*{{cite journal  | author=Arena V, Martini M, Luongo M, ''et al.'' |title=Mutations of the BIK gene in human peripheral B-cell lymphomas. |journal=Genes Chromosomes Cancer |volume=38 |issue= 1 |pages= 91-6 |year= 2003 |pmid= 12874789 |doi= 10.1002/gcc.10245 }}
*{{cite journal  | author=Hur J, Chesnes J, Coser KR, ''et al.'' |title=The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2351-6 |year= 2004 |pmid= 14983013 |doi=  }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
}}
{{refend}}


{{gene-22-stub}}
Bcl-2-interacting killer has been shown to [[Protein-protein interaction|interact]] with [[BCL2-like 1 (gene)|BCL2-like 1]]<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid15694340>{{cite journal | vauthors = Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC | title = Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | journal = Mol. Cell | volume = 17 | issue = 3 | pages = 393–403 | date = February 2005 | pmid = 15694340 | doi = 10.1016/j.molcel.2004.12.030 }}</ref><ref name = pmid12853473>{{cite journal | vauthors = Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT | title = Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway | journal = EMBO J. | volume = 22 | issue = 14 | pages = 3580–90 | date = July 2003 | pmid = 12853473 | pmc = 165613 | doi = 10.1093/emboj/cdg343 }}</ref><ref name = pmid11342619>{{cite journal | vauthors = Jiang A, Clark EA | title = Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis | journal = J. Immunol. | volume = 166 | issue = 10 | pages = 6025–33 | date = May 2001 | pmid = 11342619 | doi = 10.4049/jimmunol.166.10.6025 }}</ref> and [[Bcl-2]].<ref name = pmid15694340/><ref name = pmid12853473/>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
==External links==
* {{UCSC gene info|BIK}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ | title = A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. | journal = EMBO J. | volume = 14 | issue = 22 | pages = 5589–96 | year = 1996 | pmid = 8521816 | pmc = 394673 | doi =  }}
* {{cite journal | vauthors = Han J, Sabbatini P, White E | title = Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5857–64 | year = 1996 | pmid = 8816500 | pmc = 231587 | doi =  }}
* {{cite journal | vauthors = Inohara N, Ding L, Chen S, Núñez G | title = harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). | journal = EMBO J. | volume = 16 | issue = 7 | pages = 1686–94 | year = 1997 | pmid = 9130713 | pmc = 1169772 | doi = 10.1093/emboj/16.7.1686 }}
* {{cite journal | vauthors = Huang DC, Adams JM, Cory S | title = The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. | journal = EMBO J. | volume = 17 | issue = 4 | pages = 1029–39 | year = 1998 | pmid = 9463381 | pmc = 1170452 | doi = 10.1093/emboj/17.4.1029 }}
* {{cite journal | vauthors = Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES | title = Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. | journal = J. Biol. Chem. | volume = 273 | issue = 14 | pages = 7783–6 | year = 1998 | pmid = 9525867 | doi = 10.1074/jbc.273.14.7783 }}
* {{cite journal | vauthors = Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T | title = A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. | journal = Cell Death Differ. | volume = 6 | issue = 4 | pages = 314–25 | year = 1999 | pmid = 10381623 | doi = 10.1038/sj.cdd.4400493 }}
* {{cite journal | vauthors = Holmgreen SP, Huang DC, Adams JM, Cory S | title = Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. | journal = Cell Death Differ. | volume = 6 | issue = 6 | pages = 525–32 | year = 1999 | pmid = 10381646 | doi = 10.1038/sj.cdd.4400519 }}
* {{cite journal | vauthors = Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK | title = Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. | journal = Gastroenterology | volume = 117 | issue = 4 | pages = 831–7 | year = 1999 | pmid = 10500065 | doi = 10.1016/S0016-5085(99)70341-0 }}
* {{cite journal | vauthors = Verma S, Budarf ML, Emanuel BS, Chinnadurai G | title = Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences. | journal = Gene | volume = 254 | issue = 1–2 | pages = 157–62 | year = 2000 | pmid = 10974546 | doi = 10.1016/S0378-1119(00)00276-6 }}
* {{cite journal | vauthors = Jiang A, Clark EA | title = Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis | journal = J. Immunol. | volume = 166 | issue = 10 | pages = 6025–33 | year = 2001 | pmid = 11342619 | doi = 10.4049/jimmunol.166.10.6025 }}
* {{cite journal | vauthors = Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F | title = High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program | journal = Diabetes | volume = 50 | issue = 6 | pages = 1290–301 | year = 2001 | pmid = 11375329 | doi = 10.2337/diabetes.50.6.1290 }}
* {{cite journal | vauthors = Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC | title = Systemic tumor suppression by the proapoptotic gene bik | journal = Cancer Res. | volume = 62 | issue = 1 | pages = 8–12 | year = 2002 | pmid = 11782349 | doi =  }}
* {{cite journal | vauthors = Germain M, Mathai JP, Shore GC | title = BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria | journal = J. Biol. Chem. | volume = 277 | issue = 20 | pages = 18053–60 | year = 2002 | pmid = 11884414 | doi = 10.1074/jbc.M201235200 }}
* {{cite journal | vauthors = Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT | title = Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway | journal = EMBO J. | volume = 22 | issue = 14 | pages = 3580–90 | year = 2003 | pmid = 12853473 | pmc = 165613 | doi = 10.1093/emboj/cdg343 }}
* {{cite journal | vauthors = Arena V, Martini M, Luongo M, Capelli A, Larocca LM | title = Mutations of the BIK gene in human peripheral B-cell lymphomas | journal = Genes Chromosomes Cancer | volume = 38 | issue = 1 | pages = 91–6 | year = 2003 | pmid = 12874789 | doi = 10.1002/gcc.10245 }}
* {{cite journal | vauthors = Hur J, Chesnes J, Coser KR, Lee RS, Geck P, Isselbacher KJ, Shioda T | title = The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 8 | pages = 2351–6 | year = 2004 | pmid = 14983013 | pmc = 356954 | doi = 10.1073/pnas.0307337101 }}
* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
{{Refend}}
 
 
{{Gene-22-stub}}

Latest revision as of 04:07, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene.[1][2][3]

Function

The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.[3]

Interactions

Bcl-2-interacting killer has been shown to interact with BCL2-like 1[4][5][6][7] and Bcl-2.[5][6]

References

  1. ↑ Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ (Dec 1995). "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins". Oncogene. 11 (9): 1921–8. PMID 7478623.
  2. ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  3. ↑ 3.0 3.1 "Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ 5.0 5.1 Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
  6. ↑ 6.0 6.1 Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT (July 2003). "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway". EMBO J. 22 (14): 3580–90. doi:10.1093/emboj/cdg343. PMC 165613. PMID 12853473.
  7. ↑ Jiang A, Clark EA (May 2001). "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis". J. Immunol. 166 (10): 6025–33. doi:10.4049/jimmunol.166.10.6025. PMID 11342619.

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=Bcl-2-interacting_killer&oldid=1419961"