ST13: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{about|the gene and protein|the Star Trek 13 film|Star Trek Beyond|the ST13 postcode|ST postcode area}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Hsc70-interacting protein''' also known as '''suppression of tumorigenicity 13''' (ST13) is a [[protein]] that in humans is encoded by the ''ST13'' [[gene]].<ref name="pmid9925927">{{cite journal | vauthors = Zhang Y, Cai X, Schlegelberger B, Zheng S | title = Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 83 | issue = 1–2 | pages = 56–7 |date=Mar 1999 | pmid = 9925927 | pmc =  | doi =10.1159/000015125  }}</ref><ref name="pmid8721986">{{cite journal | vauthors = Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF | title = Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein | journal = Mol Endocrinol | volume = 10 | issue = 4 | pages = 420–31 |date=Oct 1996 | pmid = 8721986 | pmc = | doi =10.1210/me.10.4.420  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6767| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
| HGNCid = 11343
| Symbol = ST13
| AltSymbols =; HIP; AAG2; FAM10A1; FAM10A4; FLJ27260; HOP; HSPABP; HSPABP1; MGC129952; P48; PRO0786; SNC6
| OMIM = 606796
| ECnumber = 
| Homologene = 2921
| MGIid = 1917606
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6767
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003923
    | Hs_RefseqmRNA = NM_003932
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 70356
    | Mm_Ensembl = ENSMUSG00000022403
    | Mm_RefseqmRNA = NM_133726
    | Mm_RefseqProtein = NP_598487
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 81192295
    | Mm_GenLoc_end = 81226949
    | Mm_Uniprot = Q3TGW8
  }}
}}
'''Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)''', also known as '''ST13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6767| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is an [[Signal transducing adaptor protein|adaptor protein]] that mediates the association of the heat shock proteins [[HSP70]] and [[HSP90]]. This protein has been shown to be involved in the assembly process of [[glucocorticoid receptor]], which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in [[colorectal carcinoma]] tissue suggesting that is a candidate [[tumor suppressor gene]].<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.<ref name="entrez">{{cite web | title = Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6767| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Prapapanich V, Chen S, Toran EJ, etal |title=Mutational analysis of the hsp70-interacting protein Hip |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6200–7 |year= 1996 |pmid= 8887650 |doi= | pmc=231623 }}
| citations =
*{{cite journal   |vauthors=Cao J, Cai X, Zheng L, etal |title=Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening |journal=J. Cancer Res. Clin. Oncol. |volume=123 |issue= 8 |pages= 447–51 |year= 1997 |pmid= 9292708 |doi=10.1007/BF01372549 }}
*{{cite journal | author=Prapapanich V, Chen S, Nair SC, ''et al.'' |title=Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. |journal=Mol. Endocrinol. |volume=10 |issue= 4 |pages= 420-31 |year= 1996 |pmid= 8721986 |doi=  }}
*{{cite journal  | vauthors=Mo Y, Zheng S, Shen D |title=[Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa] |journal=Zhonghua Zhong Liu Za Zhi |volume=18 |issue= 4 |pages= 241–3 |year= 1998 |pmid= 9387309 |doi=  }}
*{{cite journal | author=Prapapanich V, Chen S, Toran EJ, ''et al.'' |title=Mutational analysis of the hsp70-interacting protein Hip. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6200-7 |year= 1996 |pmid= 8887650 |doi=  }}
*{{cite journal  | vauthors=Johnson BD, Schumacher RJ, Ross ED, Toft DO |title=Hop modulates Hsp70/Hsp90 interactions in protein folding |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3679–86 |year= 1998 |pmid= 9452498 |doi=10.1074/jbc.273.6.3679 }}
*{{cite journal  | author=Cao J, Cai X, Zheng L, ''et al.'' |title=Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. |journal=J. Cancer Res. Clin. Oncol. |volume=123 |issue= 8 |pages= 447-51 |year= 1997 |pmid= 9292708 |doi=  }}
*{{cite journal   |vauthors=Zheng S, Cai X, Cao J, etal |title=Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes |journal=Chin. Med. J. |volume=110 |issue= 7 |pages= 543–7 |year= 1998 |pmid= 9594214 |doi=  }}
*{{cite journal  | author=Mo Y, Zheng S, Shen D |title=[Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa] |journal=Zhonghua Zhong Liu Za Zhi |volume=18 |issue= 4 |pages= 241-3 |year= 1998 |pmid= 9387309 |doi=  }}
*{{cite journal  | vauthors=Chen S, Smith DF |title=Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35194–200 |year= 1999 |pmid= 9857057 |doi=10.1074/jbc.273.52.35194 }}
*{{cite journal | author=Johnson BD, Schumacher RJ, Ross ED, Toft DO |title=Hop modulates Hsp70/Hsp90 interactions in protein folding. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3679-86 |year= 1998 |pmid= 9452498 |doi=  }}
*{{cite journal   |vauthors=Scanlan MJ, Gordan JD, Williamson B, etal |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal  | author=Zheng S, Cai X, Cao J, ''et al.'' |title=Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes. |journal=Chin. Med. J. |volume=110 |issue= 7 |pages= 543-7 |year= 1998 |pmid= 9594214 |doi=  }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Chen S, Smith DF |title=Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35194-200 |year= 1999 |pmid= 9857057 |doi=  }}
*{{cite journal   |vauthors=Morishima Y, Kanelakis KC, Silverstein AM, etal |title=The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 6894–900 |year= 2000 |pmid= 10702249 |doi=10.1074/jbc.275.10.6894 }}
*{{cite journal | author=Zhang Y, Cai X, Schlegelberger B, Zheng S |title=Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 56-7 |year= 1999 |pmid= 9925927 |doi= }}
*{{cite journal  | vauthors=Rajapandi T, Greene LE, Eisenberg E |title=The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22597–604 |year= 2000 |pmid= 10781595 |doi= 10.1074/jbc.M002035200 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi=  }}
*{{cite journal  | vauthors=Agarraberes FA, Dice JF |title=A molecular chaperone complex at the lysosomal membrane is required for protein translocation |journal=J. Cell Sci. |volume=114 |issue= Pt 13 |pages= 2491–9 |year= 2002 |pmid= 11559757 |doi=  }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | vauthors=Velten M, Gomez-Vrielynck N, Chaffotte A, Ladjimi MM |title=Domain structure of the HSC70 cochaperone, HIP |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 259–66 |year= 2002 |pmid= 11687574 |doi= 10.1074/jbc.M106881200 }}
*{{cite journal  | author=Morishima Y, Kanelakis KC, Silverstein AM, ''et al.'' |title=The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 6894-900 |year= 2000 |pmid= 10702249 |doi=  }}
*{{cite journal  | vauthors=Fan GH, Yang W, Sai J, Richmond A |title=Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6590–7 |year= 2002 |pmid= 11751889 |doi= 10.1074/jbc.M110588200 | pmc=2665275 }}
*{{cite journal  | author=Rajapandi T, Greene LE, Eisenberg E |title=The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22597-604 |year= 2000 |pmid= 10781595 |doi= 10.1074/jbc.M002035200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Agarraberes FA, Dice JF |title=A molecular chaperone complex at the lysosomal membrane is required for protein translocation. |journal=J. Cell. Sci. |volume=114 |issue= Pt 13 |pages= 2491-9 |year= 2002 |pmid= 11559757 |doi=  }}
*{{cite journal   |vauthors=Nelson GM, Prapapanich V, Carrigan PE, etal |title=The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor |journal=Mol. Endocrinol. |volume=18 |issue= 7 |pages= 1620–30 |year= 2005 |pmid= 15071092 |doi= 10.1210/me.2004-0054 }}
*{{cite journal | author=Velten M, Gomez-Vrielynck N, Chaffotte A, Ladjimi MM |title=Domain structure of the HSC70 cochaperone, HIP. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 259-66 |year= 2002 |pmid= 11687574 |doi= 10.1074/jbc.M106881200 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal | author=Fan GH, Yang W, Sai J, Richmond A |title=Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6590-7 |year= 2002 |pmid= 11751889 |doi= 10.1074/jbc.M110588200 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84  | pmc=545604 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Nelson GM, Prapapanich V, Carrigan PE, ''et al.'' |title=The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor. |journal=Mol. Endocrinol. |volume=18 |issue= 7 |pages= 1620-30 |year= 2005 |pmid= 15071092 |doi= 10.1210/me.2004-0054 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Revision as of 20:54, 8 November 2017

This article is about the gene and protein. For the Star Trek 13 film, see Star Trek Beyond. For the ST13 postcode, see ST postcode area.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.[1][2][3]

Function

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.[3]

References

  1. ↑ Zhang Y, Cai X, Schlegelberger B, Zheng S (Mar 1999). "Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 56–7. doi:10.1159/000015125. PMID 9925927.
  2. ↑ Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF (Oct 1996). "Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein". Mol Endocrinol. 10 (4): 420–31. doi:10.1210/me.10.4.420. PMID 8721986.
  3. ↑ 3.0 3.1 "Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=ST13&oldid=1419972"