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{{ | '''Glutathione S-transferase theta-2''' is an [[enzyme]] that in humans is encoded by the ''GSTT2'' [[gene]].<ref name="pmid7789971">{{cite journal |vauthors=Tan KL, Webb GC, Baker RT, Board PG | title = Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22 | journal = Genomics | volume = 25 | issue = 2 | pages = 381–7 |date=Jul 1995 | pmid = 7789971 | pmc = | doi =10.1016/0888-7543(95)80037-M }}</ref><ref name="pmid9729470">{{cite journal |vauthors=Coggan M, Whitbread L, Whittington A, Board P | title = Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex | journal = Biochem J | volume = 334 | issue = 3| pages = 617–23 |date=Nov 1998 | pmid = 9729470 | pmc = 1219731 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = }}</ref> | ||
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| summary_text = Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.<ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = | | summary_text = Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.<ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Hussey AJ, Hayes JD |title=Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. |journal=Biochem. J. |volume=286 |issue= 3|pages= 929–35 |year= 1992 |pmid= 1417752 |doi= | pmc=1132992 }} | ||
*{{cite journal |vauthors=Whittington AT, Webb GC, Baker RT, Board PG |title=Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. |journal=Genomics |volume=33 |issue= 1 |pages= 105–11 |year= 1996 |pmid= 8617493 |doi= 10.1006/geno.1996.0165 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Webb G, Vaska V, Coggan M, Board P |title=Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1). |journal=Genomics |volume=33 |issue= 1 |pages= 121–3 |year= 1996 |pmid= 8617495 |doi= 10.1006/geno.1996.0167 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Mainwaring GW, Williams SM, Foster JR, etal |title=The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. |journal=Biochem. J. |volume=318 |issue= 1|pages= 297–303 |year= 1996 |pmid= 8761485 |doi= | pmc=1217621 }} | ||
*{{cite journal | *{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Chelvanayagam G, Wilce MC, Parker MW, etal |title=Homology model for the human GSTT2 Theta class glutathione transferase. |journal=Proteins |volume=27 |issue= 1 |pages= 118–30 |year= 1997 |pmid= 9037717 |doi=10.1002/(SICI)1097-0134(199701)27:1<118::AID-PROT12>3.0.CO;2-Q }} | ||
*{{cite journal | *{{cite journal |vauthors=Rossjohn J, McKinstry WJ, Oakley AJ, etal |title=Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. |journal=Structure |volume=6 |issue= 3 |pages= 309–22 |year= 1998 |pmid= 9551553 |doi=10.1016/S0969-2126(98)00034-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=de Bruin WC, Wagenmans MJ, Board PG, Peters WH |title=Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers. |journal=Carcinogenesis |volume=20 |issue= 8 |pages= 1453–7 |year= 1999 |pmid= 10426791 |doi=10.1093/carcin/20.8.1453 }} | ||
*{{cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }} | |||
*{{cite journal | | *{{cite journal |vauthors=de Bruin WC, Wagenmans MJ, Peters WH |title=Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 3 |pages= 310–6 |year= 2000 |pmid= 10760690 |doi= 10.1111/j.1349-7006.2000.tb00946.x}} | ||
*{{cite journal | *{{cite journal |vauthors=Sprenger R, Schlagenhaufer R, Kerb R, etal |title=Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. |journal=Pharmacogenetics |volume=10 |issue= 6 |pages= 557–65 |year= 2001 |pmid= 10975610 |doi=10.1097/00008571-200008000-00009 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Venter JC, Adams MD, Myers EW, etal |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=De Maria F, Pedersen JZ, Caccuri AM, etal |title=The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42283–93 |year= 2004 |pmid= 12871945 |doi= 10.1074/jbc.M305568200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jang SG, Kim IJ, Kang HC, etal |title=GSTT2 promoter polymorphisms and colorectal cancer risk. |journal=BMC Cancer |volume=7|pages= 16 |year= 2007 |pmid= 17250773 |doi= 10.1186/1471-2407-7-16 | pmc=1793996 }} | ||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=2953}} | |||
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Species | Human | Mouse | |||||
Entrez |
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Location (UCSC) | n/a | n/a | |||||
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Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.[1][2][3]
Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]
References
- ↑ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.
- ↑ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. PMC 1219731. PMID 9729470.
- ↑ 3.0 3.1 "Entrez Gene: GSTT2 glutathione S-transferase theta 2".
Further reading
- Hussey AJ, Hayes JD (1992). "Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate". Biochem. J. 286 (3): 929–35. PMC 1132992. PMID 1417752.
- Whittington AT, Webb GC, Baker RT, Board PG (1996). "Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1". Genomics. 33 (1): 105–11. doi:10.1006/geno.1996.0165. PMID 8617493.
- Webb G, Vaska V, Coggan M, Board P (1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
- Mainwaring GW, Williams SM, Foster JR, et al. (1996). "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human". Biochem. J. 318 (1): 297–303. PMC 1217621. PMID 8761485.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Chelvanayagam G, Wilce MC, Parker MW, et al. (1997). "Homology model for the human GSTT2 Theta class glutathione transferase". Proteins. 27 (1): 118–30. doi:10.1002/(SICI)1097-0134(199701)27:1<118::AID-PROT12>3.0.CO;2-Q. PMID 9037717.
- Rossjohn J, McKinstry WJ, Oakley AJ, et al. (1998). "Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site". Structure. 6 (3): 309–22. doi:10.1016/S0969-2126(98)00034-3. PMID 9551553.
- de Bruin WC, Wagenmans MJ, Board PG, Peters WH (1999). "Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers". Carcinogenesis. 20 (8): 1453–7. doi:10.1093/carcin/20.8.1453. PMID 10426791.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- de Bruin WC, Wagenmans MJ, Peters WH (2000). "Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract". Jpn. J. Cancer Res. 91 (3): 310–6. doi:10.1111/j.1349-7006.2000.tb00946.x. PMID 10760690.
- Sprenger R, Schlagenhaufer R, Kerb R, et al. (2001). "Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation". Pharmacogenetics. 10 (6): 557–65. doi:10.1097/00008571-200008000-00009. PMID 10975610.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- De Maria F, Pedersen JZ, Caccuri AM, et al. (2004). "The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide". J. Biol. Chem. 278 (43): 42283–93. doi:10.1074/jbc.M305568200. PMID 12871945.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Jang SG, Kim IJ, Kang HC, et al. (2007). "GSTT2 promoter polymorphisms and colorectal cancer risk". BMC Cancer. 7: 16. doi:10.1186/1471-2407-7-16. PMC 1793996. PMID 17250773.
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