CBY1: Difference between revisions

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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Revision as of 02:34, 27 October 2017

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.^[1]^[2]^[3]

Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

CBY1 has been shown to interact with Beta-catenin.^[4]

References

↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
↑ Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699.
↑ ^3.0 ^3.1 "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)".
↑ Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.

External links

Human CBY1 genome location and CBY1 gene details page in the UCSC Genome Browser.

Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.
Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P, Laurent-Puig P (2004). "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?". BMC Cancer. 4: 31. doi:10.1186/1471-2407-4-31. PMC 471554. PMID 15245581.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK (2006). "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines". World J. Gastroenterol. 12 (10): 1529–35. PMID 16570344.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K (2007). "Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling". Mol. Cell. Biol. 27 (12): 4347–54. doi:10.1128/MCB.01640-06. PMC 1900052. PMID 17403895.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[pmid10591208-1] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

[pmid15194699-2] Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)".

[pmid12712206-4] Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Protein chibby homolog 1''' is a [[protein]] that in humans is encoded by the ''CBY1'' [[gene]].<ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | pmc =  | doi = 10.1038/990031 }}</ref><ref name="pmid15194699">{{cite journal | vauthors = Hidaka S, Könecke V, Osten L, Witzgall R | title = PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2 | journal = J Biol Chem | volume = 279 | issue = 33 | pages = 35009–16 | date = Aug 2004 | pmid = 15194699 | pmc =  | doi = 10.1074/jbc.M314206200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CBY1 chibby homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25776| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Chibby homolog 1 (Drosophila)
- | HGNCid = 1307
- | Symbol = CBY1
- | AltSymbols =; C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14; arb1
- | OMIM = 607757
- | ECnumber =
- | Homologene = 12514
- | MGIid = 1920989
- | GeneAtlas_image1 = PBB_GE_CBY1_203450_at_tn.png
- | Function = {{GNF_GO|id=GO:0008013 |text = beta-catenin binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}}
- | Process = {{GNF_GO|id=GO:0008104 |text = protein localization}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 25776
-    | Hs_Ensembl = ENSG00000100211
-    | Hs_RefseqProtein = NP_001002880
-    | Hs_RefseqmRNA = NM_001002880
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 22
-    | Hs_GenLoc_start = 37382604
-    | Hs_GenLoc_end = 37399795
-    | Hs_Uniprot = Q9Y3M2
-    | Mm_EntrezGene = 73739
-    | Mm_Ensembl = ENSMUSG00000022428
-    | Mm_RefseqmRNA = NM_028634
-    | Mm_RefseqProtein = NP_082910
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 79486482
-    | Mm_GenLoc_end = 79494915
-    | Mm_Uniprot = Q9D1C2
-  }}
-}}
-'''Chibby homolog 1 (Drosophila)''', also known as '''CBY1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CBY1 chibby homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25776| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Beta-catenin]] is a transcriptional activator and [[oncoprotein]] involved in the development of several cancers. The protein encoded by this gene interacts directly with the [[C-terminal]] region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with [[transcription factor]]s for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CBY1 chibby homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25776| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+CBY1 has been shown to [[Protein-protein interaction|interact]] with [[Beta-catenin]].<ref name=pmid12712206>{{cite journal | vauthors = Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT | title = Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway | language =  | journal = [[Nature (journal)|Nature]] | volume = 422 | issue = 6934 | pages = 905–9 | date = Apr 2003 | pmid = 12712206 | doi = 10.1038/nature01570 }}</ref>
+== References ==
+{{reflist}}
+==External links==
+* {{UCSC gene info|CBY1}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
-| citations =
+* {{cite journal | vauthors = Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S | title = Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes | journal = Genome Res. | volume = 11 | issue = 5 | pages = 677–84 | year = 2001 | pmid = 11337467 | pmc = 311086 | doi = 10.1101/gr.164001 }}
-*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
+* {{cite journal | vauthors = Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I | title = Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22 | journal = Genome Res. | volume = 13 | issue = 1 | pages = 27–36 | year = 2003 | pmid = 12529303 | pmc = 430954 | doi = 10.1101/gr.695703 }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+* {{cite journal | vauthors = Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT | title = Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway | journal = Nature | volume = 422 | issue = 6934 | pages = 905–9 | year = 2003 | pmid = 12712206 | doi = 10.1038/nature01570 }}
-*{{cite journal  | author=Suzuki Y, Tsunoda T, Sese J, ''et al.'' |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677-84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 }}
+* {{cite journal | vauthors = Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P, Laurent-Puig P | title = Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? | journal = BMC Cancer | volume = 4 | pages = 31 | year = 2004 | pmid = 15245581 | pmc = 471554 | doi = 10.1186/1471-2407-4-31 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
-*{{cite journal  | author=Collins JE, Goward ME, Cole CG, ''et al.'' |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27-36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 }}
+* {{cite journal | vauthors = Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK | title = Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines | journal = World J. Gastroenterol. | volume = 12 | issue = 10 | pages = 1529–35 | year = 2006 | pmid = 16570344 | doi =  }}
-*{{cite journal  | author=Takemaru K, Yamaguchi S, Lee YS, ''et al.'' |title=Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. |journal=Nature |volume=422 |issue= 6934 |pages= 905-9 |year= 2003 |pmid= 12712206 |doi= 10.1038/nature01570 }}
+* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Hidaka S, Könecke V, Osten L, Witzgall R |title=PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 35009-16 |year= 2004 |pmid= 15194699 |doi= 10.1074/jbc.M314206200 }}
+* {{cite journal | vauthors = Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K | title = Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling | journal = Mol. Cell. Biol. | volume = 27 | issue = 12 | pages = 4347–54 | year = 2007 | pmid = 17403895 | pmc = 1900052 | doi = 10.1128/MCB.01640-06 }}
-*{{cite journal  | author=Gad S, Teboul D, Lièvre A, ''et al.'' |title=Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? |journal=BMC Cancer |volume=4 |issue=  |pages= 31 |year= 2004 |pmid= 15245581 |doi= 10.1186/1471-2407-4-31 }}
-*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Schuierer MM, Graf E, Takemaru K, ''et al.'' |title=Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines. |journal=World J. Gastroenterol. |volume=12 |issue= 10 |pages= 1529-35 |year= 2006 |pmid= 16570344 |doi=  }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Li FQ, Singh AM, Mofunanya A, ''et al.'' |title=Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=27 |issue= 12 |pages= 4347-54 |year= 2007 |pmid= 17403895 |doi= 10.1128/MCB.01640-06 }}
-}}
 {{refend}}
 {{gene-22-stub}}
-{{WikiDoc Sources}}

CBY1: Difference between revisions

Revision as of 02:34, 27 October 2017

Contents

Function

Interactions

References

External links

Further reading

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