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{{Infobox_gene}}
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'''Mitochondrial import receptor subunit TOM22 homolog''' is a [[protein]] that in humans is encoded by the ''TOMM22'' [[gene]].<ref name="pmid10982837">{{cite journal | vauthors = Yano M, Hoogenraad N, Terada K, Mori M | title = Identification and functional analysis of human Tom22 for protein import into mitochondria | journal = Mol Cell Biol | volume = 20 | issue = 19 | pages = 7205–13 |date=Oct 2000 | pmid = 10982837 | pmc = 86274 | doi =10.1128/MCB.20.19.7205-7213.2000 }}</ref><ref name="pmid10900208">{{cite journal | vauthors = Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K | title = Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane | journal = J Biol Chem | volume = 275 | issue = 41 | pages = 31996–2002 |date=Nov 2000 | pmid = 10900208 | pmc =  | doi = 10.1074/jbc.M004794200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56993| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Translocase of outer mitochondrial membrane 22 homolog (yeast)
| HGNCid = 18002
| Symbol = TOMM22
| AltSymbols =; 1C9-2; MST065; MSTP065; TOM22
| OMIM = 607046
| ECnumber =
| Homologene = 10638
| MGIid = 2450248
| GeneAtlas_image1 = PBB_GE_TOMM22_217960_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}  
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005742 |text = mitochondrial outer membrane translocase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}}
| Process = {{GNF_GO|id=GO:0006626 |text = protein targeting to mitochondrion}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56993
    | Hs_Ensembl = ENSG00000100216
    | Hs_RefseqProtein = NP_064628
    | Hs_RefseqmRNA = NM_020243
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 37407900
    | Hs_GenLoc_end = 37410709
    | Hs_Uniprot = Q9NS69
    | Mm_EntrezGene = 223696
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_172609
    | Mm_RefseqProtein = NP_766197
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Translocase of outer mitochondrial membrane 22 homolog (yeast)''', also known as '''TOMM22''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56993| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.<ref name="entrez">{{cite web | title = Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56993| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.<ref name="entrez">{{cite web | title = Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56993| accessdate = }}</ref>
}}
}}
==See also==
* [[Translocase of the outer membrane|Mitochondria Outer Membrane Translocase]]
* [[TOMM20]]
* [[TOMM40]]
* [[TOMM70A]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Saeki K, Suzuki H, Tsuneoka M, ''et al.'' |title=Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31996-2002 |year= 2000 |pmid= 10900208 |doi= 10.1074/jbc.M004794200 }}
*{{cite journal   |vauthors=Suzuki H, Okazawa Y, Komiya T, etal |title=Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37930–6 |year= 2001 |pmid= 10980201 |doi= 10.1074/jbc.M006558200 }}
*{{cite journal | author=Suzuki H, Okazawa Y, Komiya T, ''et al.'' |title=Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37930-6 |year= 2001 |pmid= 10980201 |doi= 10.1074/jbc.M006558200 }}
*{{cite journal   |vauthors=Johnston AJ, Hoogenraad J, Dougan DA, etal |title=Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42197–204 |year= 2003 |pmid= 12198123 |doi= 10.1074/jbc.M205613200 }}
*{{cite journal | author=Yano M, Hoogenraad N, Terada K, Mori M |title=Identification and functional analysis of human Tom22 for protein import into mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 19 |pages= 7205-13 |year= 2000 |pmid= 10982837 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Johnston AJ, Hoogenraad J, Dougan DA, ''et al.'' |title=Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42197-204 |year= 2003 |pmid= 12198123 |doi= 10.1074/jbc.M205613200 }}
*{{cite journal  | vauthors=Yano M, Terada K, Mori M |title=AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins |journal=J. Cell Biol. |volume=163 |issue= 1 |pages= 45–56 |year= 2003 |pmid= 14557246 |doi= 10.1083/jcb.200305051 | pmc=2173431 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Yano M, Terada K, Mori M |title=Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10808–13 |year= 2004 |pmid= 14699115 |doi= 10.1074/jbc.M311710200 }}
*{{cite journal  | author=Yano M, Terada K, Mori M |title=AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. |journal=J. Cell Biol. |volume=163 |issue= 1 |pages= 45-56 |year= 2003 |pmid= 14557246 |doi= 10.1083/jcb.200305051 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Yano M, Terada K, Mori M |title=Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10808-13 |year= 2004 |pmid= 14699115 |doi= 10.1074/jbc.M311710200 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Humphries AD, Streimann IC, Stojanovski D, etal |title=Dissection of the mitochondrial import and assembly pathway for human Tom40 |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 11535–43 |year= 2005 |pmid= 15644312 |doi= 10.1074/jbc.M413816200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Humphries AD, Streimann IC, Stojanovski D, ''et al.'' |title=Dissection of the mitochondrial import and assembly pathway for human Tom40. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 11535-43 |year= 2005 |pmid= 15644312 |doi= 10.1074/jbc.M413816200 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Bellot G, Cartron PF, Er E, etal |title=TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax |journal=Cell Death Differ. |volume=14 |issue= 4 |pages= 785–94 |year= 2007 |pmid= 17096026 |doi= 10.1038/sj.cdd.4402055 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Bellot G, Cartron PF, Er E, ''et al.'' |title=TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. |journal=Cell Death Differ. |volume=14 |issue= 4 |pages= 785-94 |year= 2007 |pmid= 17096026 |doi= 10.1038/sj.cdd.4402055 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 12:08, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.[1][2][3]

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.[3]

See also

References

  1. ↑ Yano M, Hoogenraad N, Terada K, Mori M (Oct 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol Cell Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
  2. ↑ Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K (Nov 2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane". J Biol Chem. 275 (41): 31996–2002. doi:10.1074/jbc.M004794200. PMID 10900208.
  3. ↑ 3.0 3.1 "Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)".

Further reading



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